• 제목/요약/키워드: The skin safety

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한방목초액의 항산화 및 항 아토피 효과 (Anti-oxidation and Anti-atopic Dermatitis Effect of Herbal Wood Vinegar)

  • 김타곤;노화정;전상희;김강배;김동욱
    • Korean Chemical Engineering Research
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    • 제48권6호
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    • pp.690-694
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    • 2010
  • 본 연구에서는 대나무, 계피, 생강 등 8종의 한약재를 포함한 한방목초액의 소재특성을 시험하여 화장품 및 피부질 환용 의약품에의 응용가능성을 조사하였다. 목초액의 항산화력은 DPPH 자유라디칼 소거법으로 측정되었으며 $50{\mu}g/ml$의 농축목초액 농도에서 97%의 매우 높은 항산화능을 보여주었다. 목초액의 항균력은 원판확산법으로 시험되었으며, 피부상재균인 Staphylococcus aureus에 대해 우수한 항균력을 보여주었다. 목초액의 미백효과는 tyrosinase 활성억제시험법으로 측정되었으며 대조군인 비타민 C에 비해 매우 낮아서 미백효과는 미미하였다. 목초액의 안전성 시험은 MTT assay에 의해 측정되었으며, 세포 독성이 비교적 높은 것으로 나타났다. 목초액의 화장품소재 안정성 시험 결과 색, 향, 외관 및 pH에서 큰 변화가 없어서 매우 안정하였다. 무모생쥐를 이용한 항 아토피 시험결과, 목초액은 DNCB에 의해 유도된 피부염증을 9일 째 거의 정상상태로 회복시켰으며, 피부내 IgE의 농도도 대조군에 비해 30% 감소시켜 항 아토피 효과가 우수한 것으로 나타났다. 따라서 목초액은 항산화력, 항균력 및 항 아토피 효과가 우수하여 화장품소재나 피부질환치료제로서의 응용 가능성이 큼을 알 수 있었다.

주택 재건축 예비평가 자료분석을 통한 분야별 주요결함의 예방·조치방안 (The Management Method for Preventing Frequent Defect about Each Inspection Part from The Data Analysis of Pre-qualification of Residential Building Reconstruction)

  • 김천학;배철학
    • 한국건축시공학회:학술대회논문집
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    • 한국건축시공학회 2008년도 추계 학술논문 발표대회
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    • pp.181-186
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    • 2008
  • The purpose of this study is analyzing the frequent defect about each inspection part of Pre-qualification of residential building reconstruction and finding the cause of occurrence so that can supply a solution of the problem during the plalnning and constructure. The frequent defects are naturally following the deterioration and more occur in the structure body than a skin. The meaning that supply the cause and the managing method for preventing frequent defects about each inspection part is as follows. To prevent the defects, it is needed that the choice of the appropriate materials, giving a sufficient space for facilities, reliable constructure for the part of expecting the defects. The quality of life will go up due to making a good dwelling environment and extending the life cycle of structures from the inspection and managing the part of expecting defects.

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농약작업자의 농약에 대한 노출과 작업복 현황에 관한 분석 (Conditions of Chemicals Exposure and Work Clothing for Farm Workers Using Agricultural Chemicals)

  • 신정숙;김철주
    • 복식문화연구
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    • 제7권3호
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    • pp.142-153
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    • 1999
  • The objective of this study was to analysis the pesticide chemical-using of farm workers and working clothes for diminishing the possible damage by their improper chemicals usages. For the data Questionairs were collected 340 from the farm families of the 3 different districts in Yeoju, Kyonggido, and also inquired of the persons in charge of the chemicals and of the laundry in each family. Among the replies, 233 was classified as useful, and analyzed the frequency, the percentage and correlation. The results were as follows : 1. 64.3% of the farmers were using the chemicals for 5∼20 years, of whom 33.6% experienced stopping of chemicals-using for health. 2. The applicators experienced poisoning symptoms such as habitual fatigue, hadache, dizziness, chest discomfort, eye irritation, skin irritation, blurred vision, vomiting, nausea etc. after chemical work. 3. 74.7% answered they did not obtained educational information for the care of chemicals contaminated clothes. 69.1% said they need to obtain educational information about safety awareness of agricultural chemicals.

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Centrifuge modelling of rock-socketed drilled shafts under uplift load

  • Park, Sunji;Kim, Jae-Hyun;Kim, Seok-Jung;Park, Jae-Hyun;Kwak, Ki-Seok;Kim, Dong-Soo
    • Geomechanics and Engineering
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    • 제24권5호
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    • pp.431-441
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    • 2021
  • Rock-socketed drilled shafts are widely used to transfer the heavy loads from the superstructure especially in mountainous area. Extensive research has been done on the behavior of rock-socketed drilled shafts under compressive load. However, little attention has been paid to uplift behavior of drilled shaft in rock, which govern the overall behavior of the foundation system. In this paper, a series of centrifuge tests have been performed to investigate the uplift response of rock-socketed drilled shafts. The pull-out tests of drilled shafts installed in layered rocks having various strengths were conducted. The load-displacement response, axial load distributions in the shaft and the unit skin friction distribution under pull-out loads were investigated. The effects of the strength of rock socket on the initial stiffness, ultimate capacity and mobilization of friction of the foundation, were also examined. The results indicated that characteristics of rock-socket has a significant influence on the uplift behavior of drilled shaft. Most of the applied uplift load were carried by socketed rock when the drilled shaft was installed in the sand over rock layer, whereas substantial load was carried by both upper and lower rock layers when the drilled shaft was completely socketed into layered rock. The pattern of mobilized shaft friction and point where the maximum unit shaft friction occurred were also found to be affected by the socket condition surrounding the drilled shaft.

초소형 풍력터빈 복합재 블레이드 구조 설계에 관한 연구 (A Study on Structural Design and Test of 500W Class Micro Scale Composite Wind Turbine Blade)

  • 공창덕;김주일
    • 한국복합재료학회:학술대회논문집
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    • 한국복합재료학회 2005년도 추계학술발표대회 논문집
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    • pp.190-193
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    • 2005
  • The purpose of the present study is to design a 500W-class micro scale composite wind turbine blade. The blade airfoil of FFA-W3-211 was selected to meet Korean weather condition. The skin-spar-f Dam sandwich type structure was adopted for improving buckling and vibration damping characteristics. The design loads were determined at wind speed of 25m/s. and the structural analysis was performed to confirm safety and stability from strength. buckling and natural frequency using the finite element code. NISA II [6]. The prototype was manufactured using the hand-lay up method and it was experimently tested using the sand bag loading method. In order to evaluate the design results. it was compared with experimental results. According to comparison results. the estimated results such as compressible stress. max tip deflection natural frequency and buckling load factor were well agreed with the experimental results.

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Evaluation of Microbial Load in Oropharyngeal Mucosa from Tannery Workers

  • Castellanos-Arevalo, Diana C.;Castellanos-Arevalo, Andrea P.;Camarena-Pozos, David A.;Colli-Mull, Juan G.;Maldonado-Vega, Maria
    • Safety and Health at Work
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    • 제6권1호
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    • pp.62-70
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    • 2015
  • Background: Animal skin provides an ideal medium for the propagation of microorganisms and it is used like raw material in the tannery and footware industry. The aim of this study was to evaluate and identify the microbial load in oropharyngeal mucosa of tannery employees. Methods: The health risk was estimated based on the identification of microorganisms found in the oropharyngeal mucosa samples. The study was conducted in a tanners group and a control group. Samples were taken from oropharyngeal mucosa and inoculated on plates with selective medium. In the samples, bacteria were identified by 16S ribosomal DNA analysis and the yeasts through a presumptive method. In addition, the sensitivity of these microorganisms to antibiotics/antifungals was evaluated. Results: The identified bacteria belonged to the families Enterobacteriaceae, Pseudomonadaceae, Neisseriaceae, Alcaligenaceae, Moraxellaceae, and Xanthomonadaceae, of which some species are considered as pathogenic or opportunistic microorganisms; these bacteria were not present in the control group. Forty-two percent of bacteria identified in the tanners group are correlated with respiratory diseases. Yeasts were also identified, including the following species: Candida glabrata, Candida tropicalis, Candida albicans, and Candida krusei. Regarding the sensitivity test of bacteria identified in the tanners group, 90% showed sensitivity to piperacillin/tazobactam, 87% showed sensitivity to ticarcillin/clavulanic acid, 74% showed sensitivity to ampicillin/sulbactam, and 58% showed sensitivity to amoxicillin/clavulanic acid. Conclusion: Several of the bacteria and yeast identified in the oropharyngeal mucosa of tanners have been correlated with infections in humans and have already been reported as airborne microorganisms in this working environment, representing a health risk for workers.

1-브로모프로판의 노출 실태와 역학조사에 따른 노출기준 강화에 관한 연구 (Strengthening the Occupational Exposure Limit for 1-Bromopropane according to the Results of Epidemiological Studies and Exposure Status)

  • 하권철;김승원;피영규;이나루
    • 한국산업보건학회지
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    • 제30권3호
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    • pp.270-279
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    • 2020
  • Objective: The aim of this study was to propose revision of the occupational exposure limit(OEL) for 1-Bromopropane(1-BP) following a review of the appropriateness of the standard in light of increasing epidemiological data and handling risk. Materials and Methods: The results of toxicity and epidemiologic investigations for 1-BP and agencies' OELs were compared and reviewed through a literature review. In order to investigate the status of 1-BP handling in South Korea, data from work environment actual condition survey results and work environment measurement results were used. Results: The toxicity of 1-BP, such as central nervous system(CNS) damage, peripheral neuropathy, hematological adverse effects, and developmental and reproductive toxicity(male and female) has been reported. ACGIH recommends 0.1 ppm as a TLV-TWA value, but the OEL of South Korea stands at 25 ppm, which is 250 times higher than the TLV-TWA. Although 1-BP is a specially managed substance under the Industrial Safety and Health Law, the currently applied OEL cannot be said to be a safe level based on the results of epidemiological studies to date. In a work environment measurement in 2017, the total number of samples was 626, which were derived from 78 industries, and the average concentration was 1.173 ppm(standard deviation 2.88). Conclusions: To protect the health of workers handling 1-BP, estimated to be 780 in South Korea, it is necessary to strengthen the OEL(TWA) to a level of 0.3 ppm(lower than the 0.34 ppm with known toxic effects), which is believed to be safe as a result of epidemiological investigation. "Skin" notation should be recommended.

Structural Design on Joint Component of Composite Wing of WIG Craft

  • Lee, Younggyu;Park, Hyunbum
    • International Journal of Aerospace System Engineering
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    • 제8권2호
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    • pp.1-3
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    • 2021
  • This study proposed a specific preliminary structural design procedure of the main wing for a small scale WIG vehicle to meet the target weight of the system requirement. The high stiffness and strength Carbon-Epoxy material was used for lightness, and the foam sandwich type structure at the upper skin and the spar webs was adopted for improvement of structural stability. After structural design, wing joint part was designed. Through investigation on structural design result, design modification was performed. After design modification, even thought the designed wing weight was a little bit heavier than the target wing weight, the structural safety and stability of the final design feature was confirmed.

Hazards Caused by UV Rays of Xenon Light Based High Performance Solar Simulators

  • Dibowski, Gerd;Esser, Kai
    • Safety and Health at Work
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    • 제8권3호
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    • pp.237-245
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    • 2017
  • Background: Solar furnaces are used worldwide to conduct experiments to demonstrate the feasibility of solar-chemical processes with the aid of concentrated sunlight, or to qualify high temperature-resistant components. In recent years, high-flux solar simulators (HFSSs) based on short-arc xenon lamps are more frequently used. The emitted spectrum is very similar to natural sunlight but with dangerous portions of ultraviolet light as well. Due to special benefits of solar simulators the increase of construction activity for HFSS can be observed worldwide. Hence, it is quite important to protect employees against serious injuries caused by ultraviolet radiation (UVR) in a range of 100 nm to 400 nm. Methods: The UV measurements were made at the German Aerospace Center (DLR), Cologne and Paul-Scherrer-Institute (PSI), Switzerland, during normal operations of the HFSS, with a high-precision UV-A/B radiometer using different experiment setups at different power levels. Thus, the measurement results represent UV emissions which are typical when operating a HFSS. Therefore, the biological effects on people exposed to UVR was investigated systematically to identify the existing hazard potential. Results: It should be noted that the permissible workplace exposure limits for UV emissions significantly exceeded after a few seconds. One critical value was strongly exceeded by a factor of 770. Conclusion: The prevention of emissions must first and foremost be carried out by structural measures. Furthermore, unambiguous protocols have to be defined and compliance must be monitored. For short-term activities in the hazard area, measures for the protection of eyes and skin must be taken.

Gamma선 조사에 의한 의류제품의 멸균연구 (A Study on Sterilization of Medical Products by Gamma-irradiation.)

  • 정해원;정문식;문석형
    • 한국환경보건학회지
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    • 제5권1호
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    • pp.1-9
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    • 1978
  • Biological safety, physico-chemical and microbiological experiments were carried out in order to study the possibility of radiation sterilization on medical products, such as polyethylene and polystyrene bottles, gauze sponges and surgical silk suture. Results are as follows: 1. Biological test on plastic samples as to acute systemic toxicity, eye irritation, skin irritation, pyrogen, haemolysis showed satisfactory results. But physico-chemically, the oxidizable matter, nonvolatile residues, residue on ignition seemed to be increased slightly in irradiated samples, though the experimental results were within the range of U.S.P. 19, N.F. and K.P. III. 2. After irradiation, both plastic and gauze sponges showed considerable decrease in pH. 3. Most medical products were sterilized by 1.5 Mard. For the sterilization of the suigical silk suture, 4.5 Mrad is required dul to its radiation resistant micro-organisms. 4. Biologically, total dose of 2.5 Mrad was safe enough to sterilize the medical products, and physico-chemically the results are acceptable according to U.S.P. 19 and K.P. III. However, better results may be expected when the quality of material and additives are improved.

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