• 동의신경정신과학회지
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• 제21권1호
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• pp.109-124
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• 2010

Objectives: This experiment was designed to investigate the effect of the InSamYangYoung-tang(Renshenyangrongtang) extract on $A{\beta}$-induced AD model. Methods: The effects of the InSamYangYoung-tang(Renshenyangrongtang) extract on neural damages of cultured PC12 cells induced by $A{\beta}$ were investigated. The effects of the InSamYangYoung-tang(Renshenyangrongtang) extract on neural damages of hippocampal and cortical neurons in the mouse induced by $\beta$-amyloid were investigated. Results: 1. $A{\beta}$ treatment into neuronal cells activated cell death pathway when analyzed by MTT assay and by histological analysis. Then InSamYangYoung-tang(Renshenyangrongtang) treatment improved cell survival to a similar level as in normal group. 2. $A{\beta}$ treatment increased caspase 3 protein levels but decreased phospho-Erk1/2 in neuronal cells. InSamYangYoung-tang(Renshenyangrongtang) treatment reversed the production levels of two proteins close to those in normal group. 3. $A{\beta}$ treatment induced the atrophy of neuronal cells in terms of neuronal processes and cell body shrinkage, but InSamYangYoung-tang(Renshenyangrongtang) greatly improved their morphology. 4. Neuroprotective activity, as observed in InSamYangYoung-tang(Renshenyangrongtang)-treated groups, was similarly observed in cells treated with galantamine which was used as a positive control. Moreover, overall recovery pattern by InSamYangYoung-tang(Renshenyangrongtang) was similar between cultured PC12 cells and in vivo hippocampal and cerebral cortical neurons in the mouse brain. Conclusions: This experiment shows that the InSamYangYoung-tang(Renshenyangrongtang) may play a protective role in neural tissues damaged by cytotoxic substances. Since neuronal damage seen in degenerative brains such as AD are largely unknown, the current data may provide possible insight into therapeutic strategies for AD treatments. InSamYangYoung-tang(Renshenyangrongtang) might be effective for the treatment of AD. Investigation into the clinical use of the InSamYangYoung-tang(Renshenyangrongtang) for AD is suggested for future research.

• 약학회지
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• 제41권4호
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• pp.492-497
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• 1997

A difference in ethanol metabolism between premature and young adult rats was examined. Female SD rats, either 4wk or 12wk old, were injected with a single dose of ethanol (1.5g /kg) through jugular vein and the blood ethanol level was monitored for 300 min using a gas chromatographic method. Reduction of blood ethanol level per unit of time was less and the area under the blood concentration-time curve (AUC) was significantly greater in young adults compared to premature rats. Activity of hepatic alcohol dehydrogenase was not influenced by the age increase. Total cytochrome P-450, cytochrome $b_5$. or aminopyrine N-demethylation was not different between premature rats and young adult rats. However, p-nitrophenol hydroxylation and p-nitroanisole O-demethylation activities were significantly higher in premature rats. The relative liver weight was 45% greater in premature rats leading to an overall increase in ethanol metabolizing activity in these animals. The results indicate that the reduction in ethanol elimination in young adult rats appears to be mostly associated with the decrease in relative liver weight as the age of animals increases.

• 지역연구
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• 제35권2호
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• pp.49-57
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• 2019

생애주기단계에서 청년층은 그 사회적위치가 빠르게 변화하는 연령대로, 본 연구는 청년층의 인구이동에 주목하고 주택시장요인을 포함한 지역특성요인과 청년층 인구이동의 관계를 서울지역을 중심으로 실증 분석하였다. 분석결과, 청년층의 이동은 거리와 일자리는 중요한 이동의 원인이 되고 있다. 이외에 주택시장에서의 전세가격이나 주택공급이 청년층 이동에 유의한 영향 요인으로 작용하는 것으로 분석되었다. 또한 서울시내 개별 지역과 이동의 기원지간의 전세가격과 같은 가격의 차이가 커질수록, 주택공급 차이가 커질수록 서울시 청년층의 순전출이 지속될 수 있음을 유추할 수 있다. 분석 결과 일자리의 경우, 청년층 유입을 증가시키는 데 기여하고 있어 고용중심지 주변에서의 청년층 주거수요는 높아질 것으로 예상된다. 따라서 현재 서울시나 정부에서 추진하고 있는 일자리가 많은 지역주변이나 역세권 주변에서의 청년층을 대상으로 한 공공주택을 비롯한 민간의 주택공급이 원활하게 이루어질 필요가 있으며, 저렴한 가격으로 거주할 수 있는 공적 주택이나 민간임대 주택 공급이 지속된다면, 서울시 청년층 전출을 줄이는 데 기여할 수 있을 것으로 기대된다.

• 한국생활과학회지
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• 제14권4호
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• pp.521-529
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• 2005

The present study was to find out the differences of fathers' involvement in parenting, role satisfaction, and young children's social competence according to fathers' socio-demographic variables, and the relationships among fathers' involvement in parenting, role satisfaction and young children's social competence. The subjects of the study were 175 five-year-old children and their fathers from public kindergartens in Chongju, Jecheon, and Danyang. Questionnaires used in the study were the measures of father's involvement in parenting(Lee, 1999), role satisfaction(Cho, 1998), and young children's social competence(Han, 1997). Data were analyzed with frequency and percentage, mean and standard deviation, t-test, F-test, LSD post hoc test, and Pearson's correlation coefficient using SPSS program. Results of the study were as follows: First, there were differences in father's involvement in parenting, role satisfaction, and young children's social competence according to father's level of education, job, and income. Second, there were significant positive correlations among father's involvement in parenting, role satisfaction, and young children's social competence.

• 한국생활과학회지
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• 제15권1호
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• pp.71-81
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• 2006

The purpose of this study is to examine the differences in young children's multiple intelligence and social behaviors based not only on Montessori and general programs of day care centers but also on their gender and social- demographic factors. The subjects were 329 young children (182 boys and 147 girls aged from four to five) from two day care centers in Cheongju city. The instruments used in this study were HAPI (Hillside assessment of Perceived Intelligence) to measure the surveyee's multiple intelligence and Park & Lee's scale to measure their social behaviors. The frequencies, percentiles, mean, standard deviations, Cronbach a, t-teat, F and LSD were used to analyze the collected data through SPSS WIN program. The results of this study are as follows: 1) As for young children's multiple intelligence, there are differences according to young children's gender, order of birth, parents' level of education and teacher's working period out of social-demographic factors. 2) As for the young children's social behavior, there are differences according to young children's gender, mother's level of education and teacher's working period out of social-demographic factors.

• 한국생활과학회지
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• 제23권6호
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• pp.1089-1104
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• 2014

The objective of this research is to find out the relationship among resilience of young children, their interactive peer play, and mothers' overprotective parenting attitudes. The research was conducted for 455 children aged 3~5 and their mothers of day care centers in the cities of Kimje and Iksan. To measure resilience of young children, the rating scale for parents and teachers(Koo, 2010) adapting DECA(1999) was used. And the interactive peer play scale of Choi and Shin(2008) adapting PIPPS(1998) and the Parental Protectiveness of Do and Falbo(1999) was used. The results from this research are as follows. First, there is a generally significant positive correlation between resilience and interactive peer play of young children. Resilience of young children gets higher as interactive peer play of young children gets higher. Second, there is low negative correlation between resilience and mothers' overprotective parenting attitudes. Resilience of young children gets higher as mothers' overprotective parenting attitudes get low.

• 한국가족관계학회지
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• 제21권4호
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• pp.75-98
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• 2017

Objectives: The purpose of this study was to examine the effects of parent-young adult relationship and self-differentiation on interpersonal problems among 20s. Method: The subjects were 504(195 male, 309 female) young adults in their twenties. The questionnaire was consisted of measures on the Parent-Child Relationship Instrument, Self-Differentiation Inventory, and Short form of Korean Inventory of Interpersonal Problems Circumplex. Descriptive, t-test, correlation, and hierarchical regression analyses were conducted with SPSS 23.0. Results: The major findings are as follow. First, the result showed that there were gender differences in the level of self-differentiation and interpersonal problems, while there were no differences between male and female in parent-young adult relationship. Second, correlational analyses results indicated that parent-young adult relationship was positively related with the level of self-differentiation. However parent-young adult relationship and the level of self-differentiation were negatively related with the interpersonal problems. Third, hierarchical regression analyses showed that parent-young adult relationship and the level of self-differentiation had significant influences on the interpersonal problems(moving toward people, moving against people and moving away from people among 20s). Conclusions: The results indicate that both parent-young adult relationship and the level of self-differentiation need to be considered to reduce young adults' interpersonal problems in counseling situations.

• 디자인학연구
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• 제21권
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• pp.195-204
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• 1997

현대 소비재의 조형 이미지를 한국과 일본의 양국 젊은 세대를 놓고 비교 분석하였다. 그 결과로 한국 젊은 남성과 여성들은 $\ulcorner$정치(精緻)-단순(單純)$\lrcorner$$\ulcorner$실질(實質)-비실질(非實質)$\lrcorner$$\ulcorner$경(輕)-중(重)$\lrcorner$$\ulcorner$화려-수수$\lrcorner$$\ulcorner$우미(優美)-투박$\lrcorner$의 3인자의 이미지로 설명할 수 있다. 현대 소비재에 대하여 한국의 남녀는 동일한 이미지 구조를 갖고 있으며 그에 반해 일본의 남.녀는 이미지 구조에 차이가 있다. 이것은 성별에 따라 중시하는 조형요소가 다르기 때문이라고 본다. 한국의 젊은 남녀는 현대 소비재에 있어 소비재 표면에 처리되어 있는 문양, 장식, 색상의 조형요소에 민감하게 반응하며, 일본의 젊은 여성들도 소비재의 조형의 이미지를 파악할 때 한국의 젊은 남녀와 동일하게 소비재 표면에 처리되어 있는 요소에 민감하게 반응한다. 한편 일본 젊은 남성들은 소비재 표면의 요소보다는 소비재의 가치에 의미를 두고 조형이미지를 파악하고 있다.

• 센서학회지
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• 제25권1호
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• pp.20-26
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• 2016

The bioelectrical impedance (BI) for the young and the elderly was measured using bioelectrical impedance spectroscopy (BIS). First, while applying a current of $600{\mu}A$ to the foot and hand, BI was measured at 50 frequencies ranging from 5 to 1000 kHz. The BI for young subjects was considerably lower than that for old subjects since young subjects have more lean mass (hydration). The prediction marker was 0.74 for young subjects and 0.78 for old subjects. Second, a Cole-Cole diagram was obtained for young subjects and old subjects, indicating the different characteristic frequencies. At 50 kHz, the average phase angle was $7.8^{\circ}$ for young subjects whereas that was $6.1^{\circ}$ for old subjects. Third, BIVA was analyzed for young subjects and old subjects. The vector length was 210.89 [${\Omega}/m$] for young subjects and 326.12 [${\Omega}/m$] for old subjects. At 50 kHz, the resistance (R/H) and the reactance ($X_C/H$) divided by height were 208.94 [${\Omega}/m$] and 28.68 [${\Omega}/m$] for young subject, and 324.33 [${\Omega}/m$] and 34.09 [${\Omega}/m$] for old subjects.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2001년도 제21회 학술발표회 초록집
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• pp.152-152
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• 2001