• Journal of Periodontal and Implant Science
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• 제25권1호
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• pp.89-98
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• 1995

P. intermedia are considered an important pathogen in adult periodontitis, rapidly progressing periodontitis, refractory periodontitis, pregnancy gingivitis, acute necrotizing ulcerative gingivitis, pubertal gingivitis. So far 2 DNA homology groups and 3 serotypes of P. intermedia have been reported but there is no data available as yet regarding genetic diversity for the species P. intermedia. The purpose of this study is to investigate, using bacterial DNA restriction endonuclease analysis, genetic diversity between individual strains of P. intermedia which are indistinguishable by serotyping and biotyping, occurrence of an intrafamilial transmission and genetic heterogeneity between P. intermedia strains isolated within a patient and within the same serotypes. The families who have had no systemic disease, no experience of periodontal treatment for the previous 1 year and no experience of antibiotics for the previous 6 months were selected and subgingival plaque was collected at 4 sites in each person and incubated in the anaerobic chamber. P. intermedia were identified by colony shape, gram stain, biochemical test, SK-I03(Sunstar Inc.) test and IIF using monoclonal antibody was perfomed for the determination of serotypes. P. intermedia strains were grown in BHI broth and whole genomic DNA was extracted and digested by restriction endonuclease. The resulting DNA fragments were separated by agarose gel electrophoresis, stained and photographed under UV. As the results of this study, intrafamilial vertial transmissions could be assessed in 2 families and horizintal transmissions in another 2 families. There were different DNA digest patterns within a patient, so P. intermedia showed that individuals could be colonized by multiple clonal types at anyone time. And different serotypes could be found within a patient and in the same serotype within a patient, obvius genetic heterogeneity could not be assessed. But in the same serotype in different famies, there were differences in the DNA digest patterns.

• 한국노년학
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• 제40권1호
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• pp.73-89
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• 2020

본 연구는 정순둘 등(2015)이 개발한 연령통합척도를 Riley 등(1994)이 개념구성한 연령유연성과 연령다양성을 하위요인으로 한 단축형 연령통합척도로 척도의 타당성을 검증하여 척도의 실용성을 확보하고, 인구사회학적 특징에 따른 연령통합인식을 파악하는 것을 목적으로 하였다. 이를 위해 한국연구재단에서 지원한 사회과학역량강화지원사업(SSK)의 지원을 받아 수행된 '연령통합 및 세대통합 조사'자료의 총 1433명을 대상으로 분석하였다. 분석방법은 탐색적 요인분석, 확인적 요인분석, 다집단 요인분석, 평균비교 등의 방법을 활용하였다. 분석결과는 다음과 같다. 첫째, 척도는 총 28문항에서 13문항으로 수정되었으며, 연령다양성 8문항, 연령유연성 5문항으로 구성되었다. 둘째, 청년, 중년, 노년 집단으로 분류하여 다집단 요인분석에서 연령집단 간에 유의한 차이를 보이지 않는 것으로 나타나 전 연령에서 사용가능성이 확보되었다. 셋째, 연령집단 간 인구사회학적 특성에 따른 연령통합인식 차이에서 청년집단은 거주지역에서만 연령통합인식, 연령유연성, 연령다양성 차이를 보이는 것으로 나타났으며, 중년집단에서는 거주지역과 계층인식에서 연령통합인식, 연령 유연성, 연령다양성 차이를 보였다. 노년집단은 연령통합인식에서는 거주지역, 교육수준, 계층인식이 유의미하였으며, 연령유연성에서는 거주지역과 계층인식, 연령다양성에서는 거주지역과 교육수준에서 유의미한 차이를 보였다. 이러한 본 연구의 결과를 기반으로 향후 연령통합인식 향상을 위한 연구를 위한 방향과 정책 및 실천을 위한 함의를 제언하였다.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2001년도 총회 및 춘계학술발표회
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• pp.187-190
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• 2001

This study is concerned with the hydrodispersive characteristics of granite in Changwon area. A single-well injection/recovery tracer test was conducted to determine longitudinal dispersivity of the granite, using sodium chloride tracer The dispersivity values obtained from the injection phase are 0.48 m (for between PW-1 and OW-3) and 0.72 m (for between PW-1 and OW-4). That obtained from the recovery phase is 0.68 m. The result of the tracer test indicates that the anisotropy and heterogeneity of the granite and the direction of flow.

• 디지털융복합연구
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• 제15권10호
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• pp.233-241
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• 2017

본 연구는 중소기업의 기술 사업화 역량에 영향을 미치는 요인들에 대한 연구의 흐름을 다양화하기 위해 중소벤처 기업의 제조 역량과 시험 및 검사 역량이 외부 정보 네트워크의 다양성과 기술 사업화 역량 사이의 관계에 미치는 매개 효과를 실증 분석하였다. IBM SPSS 23을 사용하여 한국의 683개 중소벤처기업에 대해 실시한 최소자승 회귀분석, Sobel 검정과 Baron 및 Kenny 검정 결과를 통해 본 연구는 중소기업의 제조 역량과 시험 및 검사 역량의 역할에 대한 후속 연구에 유용한 세 가지 실증 분석 결과를 제공한다. 첫째, 중소벤처기업의 제조 역량은 중소벤처기업의 외부 정보 네트워크의 다양성이 기술 사업화 역량에 미치는 양(+)의 효과를 부분 매개하는 것으로 분석되었다. 둘째, 중소벤처기업의 시험 및 검사 역량은 이러한 양(+)의 효과를 부분 매개하는 것으로 밝혀졌다. 셋째, 중소기업의 제조 역량과 시험 및 검사 역량은 이러한 양(+)의 효과를 공동으로 부분 매개하는 것으로 분석되었다.

• Physical Therapy Rehabilitation Science
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• 제8권1호
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• pp.52-59
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• 2019

Objective: The purpose of this review was to investigate whether motor imagery training has an effect on the recovery of upper extremity function in individuals with hemiparetic stroke or not. Design: A systematic review and meta-analysis. Methods: PubMed and three other databases were searched up to December 18th, 2018 and randomized controlled trials (RCTs) evaluating motor imagery training on upper extremity function in persons with a diagnosis of hemiparetic stroke were included. This review selected the following information from each study: surname of the first author, published year, nation, population, intervention, therapeutic intensity of intervention, therapeutic comparison, outcome measures, additional therapy, summary of results, and descriptive statistics of outcome measures. Results: This review selected seventeen RCTs with 487 stroke survivors and the following intervention methods: six motor imagery training with additional therapeutic technology, two motor imagery training with additional modified constraint-induced therapy, four mirror therapy, and five motor imagery training. Ten RCTs were eligible for meta-analysis after systematic review. The motor imagery group were more effective than the control group based on the Fugl-Meyer assessment (3.43; 95% confidence interval [CI], 1.65 to 5.22; heterogeneity [$chi^2=8.03$, df=8, $I^2=0%$], test of overall effect Z=3.76; test for subgroup differences [$chi^2=2.56$, df=2, $I^2=21.8%$]) and the Action Research Arm Test (1.32; 95% CI, -8.12 to 10.76; heterogeneity [$Tau^2=70.74$, $chi^2=15.22$, df=3, $I^2=80%$], test of overall effect Z=3.76). Conclusions: The results of this review suggests that motor imagery shows positive effectiveness on improving upper extremity function in persons with hemiparetic stroke.

• Journal of Preventive Medicine and Public Health
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• 제46권1호
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• pp.10-18
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• 2013

Objectives: We investigated the association between particulate matter less than $10{\mu}m$ in aerodynamic diameter ($PM_{10}$) exposure and non-accidental mortality in Asian populations by meta-analysis, using both time-series and case-crossover analysis. Methods: Among the 819 published studies searched from PubMed and EMBASE using key words related to $PM_{10}$ exposure and non-accidental mortality in Asian countries, 8 time-series and 4 case-crossover studies were selected for meta-analysis after exclusion by selection criteria. We obtained the relative risk (RR) and 95% confidence intervals (CI) of non-accidental mortality per $10{\mu}g/m^3$ increase of daily $PM_{10}$ from each study. We used Q statistics to test the heterogeneity of the results among the different studies and evaluated for publication bias using Begg funnel plot and Egger test. Results: Testing for heterogeneity showed significance (p<0.001); thus, we applied a random-effects model. RR (95% CI) per $10{\mu}g/m^3$ increase of daily $PM_{10}$ for both the time-series and case-crossover studies combined, time-series studies relative risk only, and case-crossover studies only, were 1.0047 (1.0033 to 1.0062), 1.0057 (1.0029 to 1.0086), and 1.0027 (1.0010 to 1.0043), respectively. The non-significant Egger test suggested that this analysis was not likely to have a publication bias. Conclusions: We found a significant positive association between $PM_{10}$ exposure and non-accidental mortality among Asian populations. Continued investigations are encouraged to contribute to the health impact assessment and public health management of air pollution in Asian countries.

• Journal of Preventive Medicine and Public Health
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• 제55권1호
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• pp.37-48
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• 2022

Objectives: Depression is a frequent complication of type 2 diabetes mellitus. This study aimed to investigate the relationship between low social support and risk for depression in people with type 2 diabetes through a meta-analysis. Methods: PubMed, ProQuest, SpringerLink, ScienceDirect, Scopus, the Cochrane Library, Embase, and Google Scholar were searched for English-language articles published up to 2021. Pooled adjusted odds ratios (aORs) were calculated using a random-effect model with 95% confidence intervals (CIs). Heterogeneity was evaluated by using the Cochrane Q test and I² statistics. The risk of publication bias was estimated using a funnel plot, the Egger test, and the Begg test. The Joanna Briggs Institute Critical Appraisal Tools were used to assess the quality of evidence and the risk of bias. Results: Eleven studies were included in this meta-analysis, containing a total of 3151 people with type 2 diabetes mellitus. The pooled analysis showed that people with type 2 diabetes mellitus who had low social support had twice as high a risk of depression as those with high social support (aOR, 2.02; 95% CI, 1.51 to 2.70; p<0.001). A random-effect model was used because the heterogeneity was high (I² = 87%). Conclusions: Low social support was found to increase the risk of depression among people with type 2 diabetes mellitus. Further investigation into factors that may moderate this relationship is required.

• Applied Microscopy
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• 제42권1호
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• pp.49-52
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• 2012

For TEM study of biological samples or polymers that are contained in organic structure, it is often required that the sample is prepared by using ultramicrotome and stained with proper agents to increase the contrast of organic structure. In this study, we investigated an efficient TEM sample preparation method for ductile heterogeneity material by using ultramicrotomy. Cryo-ultramicrotomy is a suitable method that is capable of rendering sample hardness for various ductile materials. However, it has several factors to consider, such as experimental cost, working time and finding the optimal staining conditions. To satisfy these considerations, we prepared TEM sample by using ultramicrotome without cryofunction, and secured the sample hardness by applying the staining process prior to ultrathin sectioning. The cross-linked polyethylene structure in the sample was stained with the 2% $RuO_4$ solution in a sealed test tube for 24 hours at $4^{\circ}C$. After the sample staining, ultrathin sections of sample were prepared using ultramicrotome. As a result, it was revealed that the difficulties associated with staining of ultrathin sections prepared by low-temperature conditions were improved. In addition, appropriate staining depth of sample could be selected for sectioning process. The quality of TEM sample obtained by using this method was better than that of cryo-ultramicroscopy. Finally, it is expected that our method could be effectively applied in TEM sample preparation for a variety of nano-bio convergence materials.

• 디지털융복합연구
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• 제16권2호
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• pp.151-156
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• 2018

이 연구의 목적은 TPM을 대한 주제로 작성된 논문 중 검증이 가능한 18편의 논문을 대상으로 메타분석을 실시하는 것이다. 분석을 위해 5개의 가설을 설정하고 각 연구논문에서 제시한 t값을 투입하여 CMA로 메타분석을 실시하였다. 분석 결과 4개 가설에 있어서 I-square 값이 모두 75%이상인 것으로 나타나 이질성이 매우 큰 것으로 분석되었다. 따라서 모든 연구의 모집단 효과크기는 같다는 귀무가설은 기각되었다. 이질성의 원인은 분석에 사용된 개별연구의 응답자분포, 연구조건, 연구시기, 연구지역 등의 연구특성이 다르기 때문이다. 이러한 경우 효과크기의 차이를 분석하기 위해서는 연구특성별로 구분할 수 있는 개별연구들의 요약 통계량이 필요하다. 그러나 개별연구들에서는 효과차이를 분류할 수 있도록 하는 요약통계량이 제시되지 않아서 이질성의 원인에 대한 분석을 실시할 수 없는 것이 아쉬운 점이라 하겠다.

• Journal of the Korean Statistical Society
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• 제20권2호
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• pp.191-201
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• 1991

Given a set of data pxN$_{i}$, matrices X$_{i}$ observed from p-variate normal populations $\prod$$_{i}$~N($\mu$$_{I}$, $\Sigma$$_{i}$) for i=1, …, K, the test for equality form of the covariance matrices is to choose a hypothetical model which best explains the homogeneity/heterogeneity structure across the covariance matrices among the hypothesized class of models. This paper describes a test procedure for selecting the best model. The procedure is based on a synthesis of Bayesian and a cross-validation or sample reuse methodology that makes use of a one-at-a-time schema of observational omissions. Advantages of the test are argued on two grounds, and illustrative examples and simulation results are given.are given.