• The Korean Journal of Pain
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• 제12권1호
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• pp.95-100
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• 1999

Background: About 75% of terminal cancer patients have severe pain. For the treatment of these patients, physicians usually use potent opioid analgesics. But many of the cancer patients were not controlled by IV or IM injection of opioids. In spite of the untreatable nature of the patient's illness, they should be hospitalized only for pain control. In that case, epidural opioid injection is one of the most effective methods in pain management. Methods: We retrospectively analyzed 126 terminal cancer patients who were treated with epidural morphine for pain management from 1993-97. In the routine procedure, an epidural catheter was inserted into the epidural space and tunnelled subcutaneously, exiting out from the anterior chest or abdomen. Morphine was used as the main analgesic and Multiday Infusor$^{(R)}$ (Baxter, 0.5 ml/h) as a continuous infusion system. Results: 1. Mean treatment time was 55 days (range; 3~373). 2. Mean daily epidural start mg dose of morphine was 8 mg (range; 2~20). 3. Mean daily dose at termination was 19 mg (range; 4~60) 4. 94 patients were controlled with continuous infusion but 32 patients needed additional bolus doses of morphine. 5. heter-associated subcutaneous infection occurred in 2 patients (1.6%). Conclusion: Terminal cancer pain management administered by a tunnelled epidural catheter is a simple, inexpensive method with a very small rate of infection.

• Biomolecules & Therapeutics
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• 제29권5호
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• pp.506-518
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• 2021

The imprinted tumour suppressor NOEY2 is downregulated in various cancer types, including ovarian cancers. Recent data suggest that NOEY2 plays an essential role in regulating the cell cycle, angiogenesis and autophagy in tumorigenesis. However, its detailed molecular function and mechanisms in ovarian tumours remain unclear. In this report, we initially demonstrated the inhibitory effect of NOEY2 on tumour growth by utilising a xenograft tumour model. NOEY2 attenuated the cell growth approximately fourfold and significantly reduced tumour vascularity. NOEY2 inhibited the phosphorylation of the signalling components downstream of phosphatidylinositol-3'-kinase (PI3K), including phosphoinositide-dependent protein kinase 1 (PDK-1), tuberous sclerosis complex 2 (TSC-2) and p70 ribosomal protein S6 kinase (p70S6K), during ovarian tumour progression via direct binding to vascular endothelial growth factor receptor-2 (VEGFR-2). Particularly, the N-terminal domain of NOEY2 (NOEY2-N) had a potent anti-angiogenic activity and dramatically downregulated VEGF and hypoxia-inducible factor-1α (HIF-1α), key regulators of angiogenesis. Since no X-ray or nuclear magnetic resonance structures is available for NOEY2, we constructed the three-dimensional structure of this protein via molecular modelling methods, such as homology modelling and molecular dynamic simulations. Thereby, Lys15 and Arg16 appeared as key residues in the N-terminal domain. We also found that NOEY2-N acts as a potent inhibitor of tumorigenesis and angiogenesis. These findings provide convincing evidence that NOEY2-N regulates endothelial cell function and angiogenesis by interrupting the VEGFR-2/PDK-1/GSK-3β signal transduction and thus strongly suggest that NOEY2-N might serve as a novel anti-tumour and anti-angiogenic agent against many diseases, including ovarian cancer.

• Journal of Hospice and Palliative Care
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• 제3권1호
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• pp.60-73
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• 2000

목적 : 연구의 목적은 말기 암환자의 총체적 고통의 내용과 총체적 고통의 관련요인을 파악하는 것이다. 방법 : 본 연구는 후향적 서술적 연구로 연구의 표본은 1단계에서는 1997년에 일개 대학에서 운영하는 호스피스 사업소에 등록된 환자전수를 대상으로 하였고 2단계에서는 4명의 호스피스 간호사에 의해 선정된 가장 고통이 심한 5명의 환자를 대상으로 하였다. 자료 수집 방법은 Twycross model의 분류 틀을 사용하여 호스피스 환자의 의무기록지를 분석하고 5명의 환자들을 담당하였던 호스피스 간호사와의 심층면담을 통해 의무기록지의 내용을 보충하였다. 또한 호스피스 정규 Team meeting시 사례연구를 통하여 고통의 내용과 관련요인을 확인하였다. 자료의 분석은 SPSS를 이용하여 서술적 통계를 사용하였고 간호사와의 심층 면담은 내용을 분석하였다. 결과 : 말기 암환자들이 주로 경험하는 주요문제들은 통증과 변비, 가족대응, 영적 고뇌(우울, 불안 등) 등으로 통증조절뿐만 아니라 가족의 대응 및 지지, 심리적 영적 지지와 함께 다른 증상조절에 필요한 적절한 간호중재가 요구됨을 나타내고 있다. Twycross model이 문화적인 차이가 있는 한국에도 정도의 차이는 있지만 죽음이라는 사실을 당면한 환자에게 유용한 총체적 고통 model로 사료된다. 결론 : 본 연구의 결과 Twycross model이 한국적 상황에서의 총체적 고통을 설명하는데 유용하였으나 새로운 요인들이 첨가되었으므로 한국의 말기 암환자에 대한 평가가 필요하다.

• Journal of Hospice and Palliative Care
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• 제11권3호
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• pp.131-135
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• 2008

The management of malignant ascites can be problematic for physicians and patients. The mass effect of ascites can cause symptoms of painful abdominal distention, nausea, vomiting, and bowel obstruction. Also patients often complain of shortness of breath and lower extremity edema. These symptoms not only are distressing, but also adversely affect quality of life in terminal cancer patients. We will introduce you how to treat ascites based on our cases.

• 종양간호연구
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• 제5권1호
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• pp.40-51
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• 2005

The purpose of this study was to explore the relationship between burden and burnout of the family care-givers for caring of terminal patients with cancer. A total of 99 convenience sample was recruited form hospitals. The data were collected by a direct interview with Questionnaire about family burden and burnout. The mean score of burnout of main care-givers was 2.98, and the mean score of burden was 3.03. The care-givers' burnout was significantly different by age, sex, job, duration of treatment, level of acceptance on the stage of death, and ability of daily living activities. The family care-givers' burden was significantly different by the jobs, complication of patients, level of acceptance on the stage of death, and ability of daily living activities. In conclusions, the burnout of family care-givers was highly and positively correlated with the burden.

• 대한한방내과학회지
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• 제29권3호
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• pp.567-573
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• 2008

암은 현대의 모든 선진국에서 가장 주요한 사망의 원인이다. 통상적인 암 치료의 낮은 효율과 삶의 질의 중요성의 측면에서, 보완대체의학은 말기의 암 환자들에게 전 세계적으로 널리 수용되어지고 있다. 한의학은 전통적으로 종양 자체뿐만 아니라 암을 지닌 몸 전체를 함께 강조해 왔으며, 그로 인하여 종양면역을 개선시키고 환자의 삶의 질을 개선시키며 생존기간을 연장하는데 일조한다고 여겨진다. 저자는 여기에서 전신에 전이가 이루어진 말기의 직장암 환자가 한방치료를 4년 정도 받으면서 양호한 임상경과를 보여 온 환자를 보고하는 바이다. 본 연구가 암성 질환에 있어 한의학의 임상적 효용성의 예를 통하여 한의학 기반의 암 치료법의 개발과 발전에 일조하길 희망한다.

• 보건행정학회지
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• 제15권2호
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• pp.1-15
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• 2005

The aim of this study was to compare medical cost of hospice care and that of conventional care during the last year of life, and identify factors that influenced the cost. From January to August 2003 592 terminal cancer patients receiving care from 5 hospice care units and 2 hospice care teams in general hospitals were enrolled to case group. Two hundreds and seventy two terminal cancer patients receiving conventional care from 7 general hospitals were enrolled to hospital-based control group, and 1,636 terminal cancer patients from 122 general hospitals located in same regions with the 7 hospitals were enrolled to community-based control. We used characteristics and medical cost from data of National Health Insurance Cooperation. Total medical cost per beneficiary in cases was about 10 millions won, 14.5 millions in hospital-based controls and 11.1 millions in community-based controls. The hospice care saved $45\%$ over the last year of life compared with hospital-based controls (p<0.0001). Saving of inpatient cost account for approximately $80\%$ of saving per beneficiary. Hospice care saved $29\%$ of medical cost per hospitalization day compared with hospital­based controls and $17\%$ compared with community-based controls (p<0.0001). Multiple regression analyses showed that hospice care significantly saved the medical cost. This study suggest that hospice care save medical cost compared with hospital-based control and community-based control. Most of saving of inpatient cost account for approximately $80\%$ of saving of medical cost.

• 한국농촌간호학회지
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• 제15권1호
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• pp.30-40
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• 2020

Purpose: This study was done to describe a community health practitioner's nursing case management for a terminal cancer patient registered in the public health post. Methods: For this purpose, data were collected through the patient and family through home visits, health clinic offices, and phone calls. The nursing process was carried out from August to November 2019. Results: The patient suffered the most from anorexia and lack of energy. Also he expressed psychologically uncertainty about disease and death anxiety caused by long-term treatment. In order to reduce the death anxiety, Community Health Practitioner (CHP) asked him to express his life stories and listened to him. CHP provided information of appropriate medications and alternative foods for symptoms such as gastrointestinal disorders and anorexia to the patient and family. Observing the situation of the patient and family, CHP guided the patient and family to prepare for death and has confirmed to them that the process was not with the patient alone. Conclusion: CHP's this experience has shown the possibility for CHP to help the terminal cancer patient and family to prepare peaceful death in their communities.

• 종양간호연구
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• 제2권1호
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• pp.36-49
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• 2002

The purpose of this study was to evaluate the effects of the pain management education on pain of the terminal cancer patients at home. For evaluating the effectiveness of the intervention modified Patient Outcome Questionnaire (APS, 1995) including patients concerns with cancer pain management, pain intensity, and interference of daily activities related to pain were measured before and after the education in control group and experimental group and the differences were compared with each other. Satisfaction with pain management was measured after the intervention. Pain management education was delivered to 16 experimental group patients by home care nurses, who were provided with 3-hour education on cancer pain management by one of the researchers. Pain management education included common misconceptions about cancer pain control and pharmacological and non-pharmacological interventions and emphasis was put on the importance of pain reports and patients' active participation in pain management. The results of the study were as follows. Patients concerns with pain management were decreased more greatly in the experimental group than those of the control group. The worst, average, and present pain intensities during the last 24 hours were decreased more greatly in the experimental group, and total score and each subcategory of the interference of daily living, except walking, were decreased more greatly in the experimental group. And satisfaction score with total pain management and nurses response to the pain reports were higher in the experimental group. The results of this study suggest that pain management education given to the patients by home care nurses is a very useful intervention to improve pain of the cancer patients at home. This positive result is thought to derive from patients' active pain report and participation in pain control and the use of powder form sustained release morphine for breakthrough pain control in part. Further studies with increased sample size from more institutions are recommended and early introduction of short acting morphine is strongly suggested for effective cancer pain control.

• Journal of Hospice and Palliative Care
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• 제15권4호
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• pp.183-187
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• 2012

말기암환자에 대한 완화의료의 중요성은 세계적으로 강조되고 있다. 이에 우리나라에서는 암정복10개년계획을 수립하면서 암에 대한 정책을 기획하였고, 추진되었다. 말기암환자 완화의료사업에 대한 법적 근거를 제시하는 암관리법과 제2기 암정복10개년 계획의 내용을 통해 현재 우리나라의 호스피스 완화의료 제도화 현황을 확인해보고자 한다. 호스피스 완화의료의 제도화는 국가암관리사업의 커다란 틀 안에서 발전되어 왔다. 완화의료기관의 확대 및 전문인력 양성과 질적 향상 등에 대해 2013년 완화의료 수가 본 사업이 시작된 이후에도 호스피스 완화의료의 지속적인 발전을 위하여 발전해야 할 것이다.