• KSBB Journal
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• v.22 no.4
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• pp.260-264
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• 2007

Peptides are frequently studied as candidates for new drug development. Recently, synthesized peptide library is screened for a certain functionality on a microarray biochip format. In this study, in order to replace the conventional cellulose membrane with glass for a microarray chip substrate for peptide library screening, we modified the glass surface from amines to thiols and covalently immobilized the peptides. Using trypsin-FITC (fluorescein isothiocyanate) conjugate that could specifically bind to a trypsin binding domain consisting of a 7-amino acid peptide, we checked the degree of surface modification. Because of the relatively lower hydrophilicity and reduced surface roughness, the conjugation reaction to the glass required a longer reaction time and a higher temperature. It took approximately 12 hr for the reaction to be completed. From the fluorescence signal intensity, we could differentiate between the target and the control peptides. This difference was confirmed by a separate experiment using QCM. Furthermore, a smaller volume and higher concentration of a spot showed a higher fluorescence intensity. These data would provide the basic conditions for the development of microarray peptide biochips.

• Journal of the Semiconductor & Display Technology
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• v.20 no.1
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• pp.108-112
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• 2021

Undesired reflection removal from an image captured through glass window is widely needed with the prevalence of camera. In this paper, we present and implement a reflection removal algorithm, which is specially designed for smart devices. Our implementation requires smart phone application to take two input pictures of the same target, one with flash light on and another with flash light off. Then, we find a flash spot in the picture, match the features to align the input pictures, transform the color space, and finally combine the pictures. As the result, we get a resulting image with removed reflection, achieving the visually pleasant.

• Nuclear Engineering and Technology
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• v.55 no.3
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• pp.919-926
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• 2023

To analyze the cause of the destruction of thin, carbon-backed lithium fluoride targets during a measurement of the fusion of ⁷Li and ¹⁷O, we estimate theoretically the lifetimes of carbon and LiF films due to sputtering, thermal evaporation, and lattice damage and compare them with the lifetime observed in the experiment. Sputtering yields and thermal evaporation rates in carbon and LiF films are too low to play significant roles in the destruction of the targets. We estimate the lifetime of the target due to lattice damage of the carbon backing and the LiF film using a previously reported model. In the experiment, elastically scattered target and beam ions were detected by surface silicon barrier (SSB) detectors so that the product of the beam flux and the target density could be monitored during the experiment. The areas of the targets exposed to different beam intensities and fluences were degraded and then perforated, forming holes with a diameter around the beam spot size. Overall, the target thickness tends to decrease linearly as a function of the beam fluence. However, the thickness also exhibits an increasing interval after SSB counts per beam ion decreases linearly, extending the target lifetime. The lifetime of thin LiF film as determined by lattice damage is calculated for the first time using a lattice damage model, and the calculated lifetime agrees well with the observed target lifetime during the experiment. In experiments using a thin LiF target to induce nuclear reactions, this study suggests methods to predict the lifetime of the LiF film and arrange the experimental plan for maximum efficiency.

• Journal of Korean Society of Transportation
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• v.26 no.3
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• pp.67-74
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• 2008

Even though the efficiency of a point based black spot improvement project has been low, none of solid methodology, which is based on section not point, and is considered as one of the promising substitute, has not been come up with yet. Thus, this research aims at proposing the adequate length of a hazardous section and a method to set segment length over which the project needs to be performed on rural highways by analyzing the distances from project-conducted sites to new black spots in the following year and distances between project needed but not conducted sites and new black spots in the following year. According to the analysis, the probability of being a new black spot near the project conducted intersection is higher than that of a non-conducted intersection within 2km, however, no strong relationships between project types and distance distribution have been found. Based on those findings, a method to determine the target segment including adjacent black spots within 2 kilometers-range was proposed.

• Journal of The Korean Society of Agricultural Engineers
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• v.62 no.6
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• pp.21-31
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• 2020

This study analyzed the spatio-temporal change pattern of greenhouse areas for Sangnam-myeon and Samrangjin-eup of Miryang-si in Gyeongnam, which is one of major greenhouse area. First, in order to overcome the lack of statistical data of the distribution of greenhouses, aerial and satellite images were interpreted from 1987 to 2018, and the spatial distribution of the greenhouse parcels which has continuously increased was mapped based on the digital cadastral map. Next, through the emerging hot spot tool in ArcGIS Desktop, the spatio-temporal change in transition from open-field to greenhouse cultivation was classified into 9 clusters. About 67.7% of the target area was categorized as a hot spot, and the pattern of New hot spot, which were recently converted to greenhouse parcels, covered about 34.1%. While, about 11.3% of parcels were expected to keep the existing open-field cultivation practice for a while. Overall, the greenhouse parcels have been densely developed along a river and were lately expanding even to the far neighbor. It implied that, in the future, the competition of water intake among farms would be more serious and the environmental responsibility in consideration of water quality as well as quantity would be getting strengthened due to increasing pollution loads and river intake.

• Journal of the Korean Magnetics Society
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• v.25 no.2
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• pp.52-57
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• 2015

The focal spot of electron beam depending on the anode angle in the structure and major parts of the X-ray tube was investigated by the OPERA-3D/SCALAR simulation program. The simulation worked on four spaces with with two spaces, including anode and cathode of X-ray tube, by applying the finite element method analysis. The analytical model and dimension for the emission orbit of thermal electrons made from one filament of the focused X-ray cathode is affected to the penumbra of detector for the X-ray depending on any real focal spot size. The model shape of focusing cap and focusing tube with an anode target angle and a cathode filament is analyzed by the current density distribution of thermal electrons. The focusing width of thermal electrons for the X-ray tube depended on the anode angle (${\theta}$). The focusing value of electron beams at a region of anode angle having $10^{\circ}{\sim}17^{\circ}$ maintained to below value of $70{\mu}m$. The minimum focal size of the electron beam was $40{\mu}m$ at an anode angle of $15^{\circ}$. The focused X-ray tube of many variables depended on the thermionic emission of hot electrons from the target trajectory. The focusing tube will contribute to the real design of X-ray for the development of future diagnosis medical device.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.1677-1682
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• 2015

Cancer progression is attained by uncontrolled cell division and metastasis. Increase in tumor size triggers different vascular channel formation to address cell nutritional demands. These channels are responsible for transferring of nutrients and gaseous to the cancer cells. Cancer vascularization is regulated by numerous factors including vascular endothelial growth factors (VEGFs). These factors play an important role during embryonic development. Members included in this group are VEGFA, VEGFB, VEGFC, PIGF and VEGFD which markedly influence cellular growth and apoptosis. Being freely diffusible these proteins act in both autocrine and paracrine fashions. In this review, genetic characterization these molecules and their putative role in cancer staging has been elaborated. Prognostic significance of these molecules along with different stages of cancer has also been summarized. Brief outline of ongoing efforts to target hot spot target sites against these VEGFs and their cognate limitations for therapeutic implications are also highlighted.

• Journal of The Korean Digital Architecture Interior Association
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• v.11 no.2
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• pp.61-70
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• 2011

This study aims to establish the concept about a new approaching method dor remodeling in the planning step. also, this study sets up the way how to approach in a dimensional way by classifying the conceptual composition of the target housing as a method. The dimensional definition is as below. The one dimensional approach: the spot. the two dimensional approach: the line, the three dimensional approach: the apatial mass, the four dimensional approach: space + time, the n dimensional (multi-dimensional) approach: the space + time + emotion. The research findings are as follows : For the purpose of remodeling, the old housing should be viewed in the three dimensional shape and space. It is defined as multi-dimensional module method to design the shape and space of the target housing in a multi-dimensional point, considering the three dimensional space composition, the emotion of the user, the housing itself. and the time of the user.

• Laser Solutions
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• v.2 no.3
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• pp.52-61
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• 1999

The laser induced forward transfer(LIFT) technique employs a pulsed laser to transfer parts of a thin metal film from an optically transparent target onto an arbitrary substrate in close proximity to the metal film on the target. In this work, a two-step method, the combination of LIFT process, in which a Au film deposited on the $Al_2$O$_3$ substrate by Nd:YAG laser and subsequent Au electroless metal plating on the by LIFT process generated Au seed, was presented. The influence of laser parameters, wavelength, laser power, film thickness and overlap ratio of pulse tracks, on the shapes of deposit and conductor line after electroless plating is experimentally studied. As a results, the threshold power densities for ablation, deposition and metallization were determined and comparison of threshold value between the wave length 1064nm and the second harmonic generated 532nm. In odor to determine a possible application in the electronic industry, a smallest conduct spot size, line width and isolated line space were generated.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.05a
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• pp.1165-1169
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• 2003

This paper presents an approach to optimally design the air-bearing surface (ABS) of the optical flying head for near-field recording technology (NFR). NFR is an optical recording technology using very small beam spot size by overcoming the limit of beam diffraction. One of the most Important problems in NFR is a head disk interface (HDI) issue over the recording band during the operation. A multi-criteria optimization problem is formulated to enhance the flying performances over the entire recording band during the steady state. The optimal solution of the slider, whose target flying height is 50 nm, is automatically obtained. The flying height during the steady state operation becomes closer to the target values than those fur the initial one. The pitch and roll angles are also kept within suitable ranges over the recording band. Especially, all of the air-bearing stiffness are drastically increased by the optimized geometry of the air bearing surface.