• 한국지진공학회논문집
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• 제18권2호
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• pp.73-78
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• 2014

In this paper, the stochastic 1D site response analysis method using Monte Carlo simulation and considering thespatial variation of shear wave velocity profile isproposed. To consider thespatial variation of shear wave velocity profile for 1D site response analysis, the proposed method generates random shear wave velocity profiles representing the target site, and Monte Carlo simulation is used to calculate theprobability distribution of the site response analysis results such as thepeak ground acceleration. Through the field application, The applicability of the proposed method is verified through field application.

• Molecules and Cells
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• 제42권5호
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• pp.386-396
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• 2019

Labeling of a protein with a specific dye or tag at defined positions is a critical step in tracing the subtle behavior of the protein and assessing its cellular function. Over the last decade, many strategies have been developed to achieve selective labeling of proteins in living cells. In particular, the site-specific unnatural amino acid (UAA) incorporation technique has gained increasing attention since it enables attachment of various organic probes to a specific position of a protein in a more precise way. In this review, we describe how the UAA incorporation technique has expanded our ability to achieve site-specific labeling and visualization of target proteins for functional analyses in live cells.

• 상하수도학회지
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• 제23권1호
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• pp.15-22
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• 2009

This study reports the serial use of a 3-D hydrodynamic model, EFDC-Hydro and a dynamic water quality model WASP7.2 that are maintained by USEPA. The 48 km section of the Geum River downstream between Daechung Dam and Gongju was selected as a sample study site. Topographical information was used to accurately represent morphology of the study site and boundary conditions were derived from governmental databases including WAMIS by Ministry of Land and Ocean and WEIS by Ministry of Environment. EFDC-Hydro was successfully calibrated for observed water level and WASP was calibrated using monthly observed water quality data obtained from the above sources. It was found that the current water quality target of BOD for the Geum River-H point could not be met on monthly basis though every other tributary of the area would meet its own water quality target as assigned in Korean TMDL. This study proposed the new target BOD water quality for the Gabcheon and Mihocheon as 4.3 and 3.6 mg/l, respectively so that the Geum River-H point can meet the target. When Sejong City is constructed, it is estimated that effluent discharge limit of BOD must be less than 4.5 mg/l to meet water quality of the point. This study shows that it is possible to carry out more precise modeling considering both water movement and water kinetics by using EFDC and WASP simultaneously.

• 대한치과마취과학회지
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• 제14권3호
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• pp.167-172
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• 2014

Background: Propofol is the most commonly used anesthetic for sedation and target-controlled infusion (TCI) is useful for dental treatment. However, it is important to assess and maintain an adequate depth of sedation in patients with severe intellectual disabilities Therefore, in this study we aimed to evaluate the adequate propofol target concentration for dental treatment in severely intellectually disabled patients. Methods: We undertook retrospective review of the sedation records of severely intellectually disabled patients who underwent dental treatment under TCI propofol sedation from September 2011 to April 2012. We evaluated the initial target concentration, stabilized concentration of propofol and monitored vital signs, including BIS score using sedation records. Results: Total 20 patients (10 male and 10 female patients) were included in the study. Every participant was severely intellectually disabled. The mean sedation duration was $70{\pm}16$ (45-100) minutes. The initial propofol target concentration infusion amount was $2.7{\pm}0.45$ (2.0-3.0) mcg/ml. The propofol effect site concentration (Ce) was $2.6{\pm}0.7$ (1.0-4.0) mcg/ml. The average value of BIS was $52.6{\pm}13$ (28-81). During the treatment period, there were no severe complications. Conclusions: The average propofol Ce for deep sedation without any complications in intellectually disabled patients was 2.6 mcg/ml.

• 대한원격탐사학회지
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• 제32권5호
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• pp.403-412
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• 2016

Compact Reconnaissance Imaging Spectrometer for Mars(CRISM)은 489개의 밴드를 가지는 화성정찰궤도선의 초분광 카메라로써 이를 이용한 화성 지표의 광물 분포에 대한 많은 연구가 진행되어 왔다. 본 연구에서는 USGS의 스펙트럼 라이브러리를 기반으로 화성 Gusev Crater의 Spirit(Mars Exploration Rover A) 로버 착륙지에 대한 CRISM 영상에 Matched Filter와 Adaptive Cosine Estimator(ACE) 표적 탐지 알고리즘을 적용하여 광물 분포를 확인하고자 하였다. 연구 결과 감람석, 휘석, 자철석 등의 광물들이 Gusev 크레이터의 Columbia Hills에서 탐지되어 Spirit 로버의 지상 탐사 결과와 일치하고 있음을 확인하였다. 본 연구는 그간 CRISM의 광물 분포 연구가 일부 몇 개 밴드의 반사도만을 통해 계산된 광물 지수에 의존하던 것에서 관측 파장 대역 전체를 활용하는 초분광 표적 탐지 알고리즘을 이용한 새로운 적용방법을 제시한 것에 의의가 있다고 할 수 있다.

• 대한치과마취과학회지
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• 제13권3호
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• pp.89-94
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• 2013

Background: Various strategies have been studied to reduce the propofol injection pain. This study was designed to find out effect-site target concentration (Ce) of remifentanil at which there was a 50% probability of preventing the propofol injection pain (EC50). Methods: Anesthesia was induced with a remifentanil TCI (Minto model). The Ce of remifentanil for the first patient started from 2.0 ng/ml. The Ce of remifentanil for each subsequent patient was determined by the response of the previous patient by Dixon up-and-down method with the interval of 0.5 ng/ml. After the remifentanil reached target concentrations, propofol was administered via a target-controlled infusion system based on a Marsh pharmacokinetic model using a TCI device (Orchestra$^{(R)}$; Fresenius-Vial, Brezins, France). The dose of propofol was effect site target-controlled infusion (TCI) of $3{\mu}g/ml$. Results: The EC50 of remifentanil to prevent the propofol injection pain was $1.80{\pm}0.35ng/ml$ by Dixon's up and down method. Conclusions: The EC50 of remifentanil to blunt the pain responses to propofol injection was $1.80{\pm}0.35ng/ml$ for propofol TCI anesthesia.

• 한국환경복원기술학회지
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• 제13권5호
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• pp.38-50
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• 2010

Expressways are often upgraded by widening the lanes and/or by reshaping the roads to be more linear for faster travel time. However, during the process of improving the route of the expressways, the areas where the old expressways used to be are often unused and abandoned. When these neglected sites are left alone, they often become dump sites causing pollution and impacting the surrounding environment. Therefore, it is important to restore the abandoned expressway sites to its full natural beauty. In this study, the abandoned expressway at the Soksa interchange in Pyungchang county, located in Kangwon province was studied for establishing the model of ecological restoration project. Considering the characteristics of the site, the target flora species was chosen to be Quercus species and the target fauna species as amphibians. After the target species were carefully chosen, each species' habitat requirements were studied in order to figure out the appropriate methods toward habitat restoration specifically for these species. In addition, to determine the most efficient method toward restoration of abandoned expressways, the study utilized the planting hole techniques, the crack techniques, and the colonization techniques. In terms of the spatial organization, public education program is incorporated at the main entrance area and the programs for experimenting, and developing vegetation and habitat restoration techniques are placed in the vicinity. In the master plan-to provide natural ecosystem at the site-ASCON (asphalt concrete) was removed first, then plans for restoration including species' habitat restoration were established. Furthermore, the project included plans for improving water quality polluted through non-point source considering the surrounding nearby road and farm lands. Finally, the study established a planning process that will experimentally apply to the abandoned expressway restoration method. In the future, there will be a continuous monitoring of the methods applied to verify if the restoration methods are effective. Also, new restoration techniques should be available according to a variety of abandoned expressways' characteristics.

• International Journal of Aeronautical and Space Sciences
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• 제17권2호
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• pp.253-259
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• 2016

The typical method for performing an absolute radiometric calibration of a Synthetic Aperture Radar (SAR) System is to analyze its response, without interference, to a target with a known Radar Cross Section (RCS). To minimize interference, an error-free calibration site for a Corner Reflector (CR) is required on a wide and flat plain or on an area without disturbance sources (such as ground objects). However, in reality, due to expense and lack of availability for long periods, it is difficult to identify such a site. An alternative solution is the use of a Triangular Trihedral Corner Reflector (TTCR) site, with a surrounding protection wall consisting of berms and a hollow. It is possible in this scenario, to create the minimum criteria for an effectively error-free site involving a conventional object-tip reflection applied to all beams. Sidelobe interference by the berm is considered to be the major disturbance factor. Total interference, including an object-tip reflection and a sidelobe interference, is analyzed experimentally with SAR images. The results provide a new guideline for the minimum criteria of TTCR site design that require, at least, the removal of all ground objects within the fifth sidelobe.

• 농약과학회지
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• 제9권3호
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• pp.191-198
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• 2005

신규 살충제 표적 단백질인 AnCE의 활성부위 잔기들과 상호작용 가능한 약리단 (pharmacophore)을 세 개의 펩타이드로 이루어진 ACE 기질 Hippuryl-L -histidyl-L-leucine (Hip-L-His-L-Leu, HHL) 분자의 구조를 모델로 하여 예측하였다. HHL의 분자구조, 용액장 내에서의 구조변화 그리고 약리단을 구성하는 원자들의 전하밀도 분석을 위해 순이론적인 양자화학 계산방법을 이용하여 구조 최적화, NMR 화학적 이동 및 NPA 계산을 수행하였다. 이론적인 NMR 화학적 이동 값들은 실험 결과와 잘 일치함을 보였고 전하밀도 계산 결과는 해당원자의 약리단을 분석하는데 사용되었다. 결과적으로 HHL 분자 구조를 통해 소수성(aromatic, aliphatic), 수소결합 주게, 수소결합 받게, 금속 아연 결합부위의 5개 약리단을 추출할 수 있었다.

• 한국경영과학회지
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• 제32권2호
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• pp.17-40
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• 2007

Most research on web site design has focused on technological factors, while visual aesthetic factors have been considered less important. In contrast, this study focuses on visual aesthetic factors in web site design. Findings of this study can be summarized as follows : (1) The result of SPSS-factor analysis shows that there are 3 distinct factors, 'classical aesthetics', 'expressive aesthetics', and 'usability' 'Classical aesthetics' and 'expressive aesthetics' can be described by visual aesthetic design, 'Visual aesthetic design' can be distinguished from 'usability'. This conceptual confusion relating to 'usability' and 'visual aesthetic design' can be clarified by these findings. (2) As a result of multiple regression analyses, 'classical aesthetics', 'expressive aesthetics', and 'usability' have a positive influence on 'interactivity' and 'web site evaluation'. This research clarifies the concepts of 'expectations' of Grier [18] and 'engagement' of Rosen and Purinton [33] as the 'interactivity' between users and web sites. Furthermore, this research suggests a valid model with high $R^2$(interactivity, 48% : web site evaluation, 68%). (3) Empirical tests show that the differences among users in 'entry point' are related to the characteristics of web sites and the personal characteristics of users. The differences among users in terms of 'scanning time' are closely related to the attitudes and evaluation tendencies of users with respect to web sites. These findings could contribute to the 'search phase' of the Faraday model [16], enabling it to be more precise and extensible. The managerial implication of this study is that customers' preferences regarding web site designs are differences, as their preferences are based on their individual characteristics. Therefore, marketing managers should consider promotional tools on web sites that are relevant to the target market. An optimal strategy for web design could be a carefully-selected combination of factors that are relevant to the 'interactivity' and 'evaluation' of web sites. Additionally, if marketing managers want to attract more favorable attitudes and more affirmative evaluations from users, web sites should be designed so that they are understood more quickly by users. finally, this study suggests that 'good design' for web sites depends on understanding how to attain the appropriate balance between 'classical aesthetics' and 'expressive aesthetics', based on the target customer.