Journal of The Korean Dental Society of Anesthesiology (대한치과마취과학회지)

The Korean Dental Society of Anesthsiology (대한치과마취과학회)
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EC50 of Remifentanil to Prevent Propofol Injection Pain

  • Hong, Hun Pyo (Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University) ;
  • Ko, Hyun Min (Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University) ;
  • Yoon, Ji Young (Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University) ;
  • Yoon, Ji Uk (Department of Anesthesia and Pain Medicine School of Medicine, Pusan National University) ;
  • Park, Kun Hyo (Department of Oral and Maxillofacial Surgery School of Dentistry, Pusan National University) ;
  • Roh, Young Chea (Department of Oral and Maxillofacial Surgery School of Dentistry, Pusan National University)
  • Received : 2013.09.12
  • Accepted : 2013.10.01
  • Published : 2013.09.30
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Abstract

Background: Various strategies have been studied to reduce the propofol injection pain. This study was designed to find out effect-site target concentration (Ce) of remifentanil at which there was a 50% probability of preventing the propofol injection pain (EC50). Methods: Anesthesia was induced with a remifentanil TCI (Minto model). The Ce of remifentanil for the first patient started from 2.0 ng/ml. The Ce of remifentanil for each subsequent patient was determined by the response of the previous patient by Dixon up-and-down method with the interval of 0.5 ng/ml. After the remifentanil reached target concentrations, propofol was administered via a target-controlled infusion system based on a Marsh pharmacokinetic model using a TCI device (Orchestra$^{(R)}$; Fresenius-Vial, Brezins, France). The dose of propofol was effect site target-controlled infusion (TCI) of $3{\mu}g/ml$. Results: The EC50 of remifentanil to prevent the propofol injection pain was $1.80{\pm}0.35ng/ml$ by Dixon's up and down method. Conclusions: The EC50 of remifentanil to blunt the pain responses to propofol injection was $1.80{\pm}0.35ng/ml$ for propofol TCI anesthesia.

Keywords

References

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