• 한국임상약학회지
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• 제20권2호
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• pp.128-137
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• 2010

This review summarizes gender differences in pharmacokinetics, pharmacodynamics, and adverse drug reactions. Gender differences in pharmacokinetics are categorized by four major factors: absorption/bioavailability, distribution, metabolism, and elimination. There are sex-based differences in gastric emptying time, gastric alcohol dehydrogenase activity, apparent volume of distribution, ${\alpha}1$-acid glycoprotein level, phase I (CYP) and phase II metabolizing enzymes, glomerular filtration rate, and drug transporters. This review also reports gender differences in pharmacokinetics and pharmacodynamics of cardiovascular agents, central nervous system acting agents and antiviral agents. In addition, it has been reported that females experience more adverse reactions such as coughing, tachycardia, nausea, vomiting, rash, hypersensitivity, hepatotoxicity, and metabolic disorder after taking cardiovascular, central nervous system acting and antiviral agents. Therefore, in order to provide optimal drug dosage regimens both in male and female, gender differences in pharmacokinetics, pharmacodynamics, and adverse drug reactions must be considered.

• 지역사회간호학회지
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• 제13권1호
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• pp.30-38
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• 2002

The purpose of this study was to compare the Depression levels of the poor and elderly as well as the elderly who were residents in a community. The author studied the Depression levels of 117 poor and elderly individuals and 183 elderly individuals all 65 years or older living in Suwon City. This study has been done using a direct-interview structured Questionnaire and Korean Form of Geriatric Depression Scale (KGDS) from May to July in 1999. The results can be summarized as following: 1. With Case and Control group there was no significant difference with respect to gender, age, education level, or religion. But was significantly different regarding marriage state, if subjects were living together, type of residency, province, and place of toilet(P<0.05). 2. Smoking and Hwa-pyung was a large number of case group more than control group. and alcohol was more control group than case group(P<0.05). 3. There was a similiar taking medicine and kind of body symtom of case and control group. 4. The mean score of perceived KGDS of the poor elderlys was 17.87+/-5.97 out of 30. and that of the elderlys was 13.35+/-6.00 out of 30(P<0.001). 5. In a simple correlation analysis of elderlys. education, marital status. residency, son and daughter, position of toilet, elderly center, alcohol, Wha-byung, disease. 6. In a multiple regression analysis, Hwa-byung, elderly center, education, smoking, disease, son and daughter.

• 대한한의학원전학회지
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• 제29권1호
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• pp.65-76
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• 2016

Objectives : Generally, pulsation is influenced by climate change in the realms of nature. However, there is a theory explaining a phenomenon in which the pulse gets weaker and even absent for no reason, without affected by diseases; this is the Theory of South and North Politics with which medical practitioners need to be familiar when taking the pulse of patients. Methods : The researcher considered all the previous annotations and the original text of SuWen (素問) ZhiZhenYaoDaLun(至眞要大論). Results : In Five Elements' Evolutions, JiaJi(甲己) becomes Tu(土), which turns itself into the king, an honorable duty. JiaJi is a period of South Politics because it looks south to give an order while the rest eight years is a period of North Politics because they are headed north to receive an order. Conclusions : Since South Politics years look south as a standard, Cun(寸) is located at the south and Chi(尺) is at the north. Controlling the Heaven energy(司天) is located at the south and Effecting the Earth energy(在泉) is at the north. Therefore, if Sanyin is Controlling the Heaven energy(三陰司天), the Cun pulse is absent; if Shaoyin is Controlling the Heaven energy(少陰司天), Cun pulses on both wrists are not felt; if Jueyin is Controlling the Heaven energy(厥陰司天), the Cun pulse on the right wrist disappears; if Taiyin is Controlling the Heaven energy(太陰司天), the Cun pulse on the left wrist is not felt. In the case of Chi, if Sanyin is Effecting the Earth energy(三陰在泉), the Chi pulse is absent; if Shaoyin is Effecting the Earth energy(少陰在泉), Chi pulses on both wrists are not felt; if Jueyin is Effecting the Earth energy(厥陰在泉), the Chi pulse on the right wrist disappears; if Taiyin is Effecting the Earth energy(太陰在泉), the Chi pulse on the left wrist is not felt. North Politics years appears conversely as compared with South Politics years.

• Parasites, Hosts and Diseases
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• 제28권4호
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• pp.221-234
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• 1990

The present study was performed to know the epidemiological statug of echinostomiasis in the Chungju Reservoir and upper streams of Namhan River, together with an experimental study on the life history o( Echinostoma hortense. The stool specimens of 169 inhabitants and 473 junior high school students from 5 different villages revealed 3(0.5%) echinostomatid egg Positive cases. E. hortense adult worms were recovered from one patient after a treatment and purgation. For the other two patients, it was presumed that one had 2. hortense and another E. cinetorchis infection, based on the morphology of eggs. Five kinds of freshwater snails(168 Radix auricularia coreane, 534 Physa arutp, 144 Hippeutis cnntori, 56 Cipcngopaludina chinensis malleata and 125 Semiiulcospira nediila glebus) examined for the cercariae of echinostomes showed negative results. Ten kinds of freshwater fishes examined for E. herten-'emetacercariae revealed positive rates as Misgurnus anguillicaudatus 40.5%, Odentobutis obscura interrupta 20.3%, Moroco onycephalus 3.9%, and Coreoperca hawamebari 2.0%. In the experimental study, the metacercariae of E. horlense were infected to rats, eggs were collected from adult worms and cultivated, and miracidia were obtained. The miracidia were artificially infected to freshwater snails (R. auricularia), and cercarial shedding was studied. It was revealed that, when the snails were kept at a low temperature ($24^{\circ}C$), only 523 cercariae (on average) were produced during 24 hrs, while they were at a high temperature ($30^{\circ}C$), as many as 9, 990 cercariae (on average) were shed during the same time. The experimental infection of E. hortense cercariae to freshwater fishes was successful in 0. obscura interrupta 52.0%, M. anguillicaudatus 30.3%, C. kawamebari 27.0%, Cobitis lutheri 15.0%, M. cxycephazus 7.3%, Pseudogobio esocinus 4.3%, Squalidus cereanus 2.0%, Zccco platypus 1.3%, and Pungtungia herzi 1.3%. However, infection was not successful to snails, C. chinensis. It has been proved that the Chungju Reservoir and upper streams of Namhan riyrr are endemic areas of echinostomiasis, especially of E. horfense, and snails such as R. auritulerie coreana and fishes such as O. obscura interrupts, M. gnguillicgudgtus, and others are taking the role of 6rst and second intermediate hosts, respectively.

• Parasites, Hosts and Diseases
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• 제46권2호
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• pp.77-82
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• 2008

Fishborne zoonotic metacercariae have not been reported from brackish water and marine fish from Vietnam waters although these parasites are common in the country's freshwater fish. Both wild-caught and cultured grouper (Epinephelus coioides and Epinephelus bleekeri), and mullet (Mugil cephalus) from brackish and marine waters located in Khanh Hoa province in central coastal Vietnam were examined, and found positive for zoonotic trematode metacercariae. From grouper, Heterophyopsis continua and Procerovum varium were recovered. The prevalence of H. continua ranged from 2.0 to 6.0% and that for P. varium ranged from 11.6 to 15.8%. Mullet were infected with Pygidiopsis summa and H. continua; both of these species are new records for Vietnam. The prevalence of P. summa in mullet was generally high, ranging from 17.6 to 75.5%, and was significantly higher than the prevalence of H. continua (2.5 to 32.4%). There were no significant differences in the prevalence of metacercariae between grouper from natural or cultured habitats, indicating that the highest risk of infection occurs in the wild-caught state prior to their placement in culture. Further, there was no difference in metacercarial prevalence between the 2 species of grouper. Infected wild-caught seed were only observed from January to October. Monthly variation in prevalence suggests seasonal variation in mullet infections occurs in this region with the highest transmission taking place from October to December. Basic investigations on the ecology and epidemiology of these intestinal flukes need to be carried out to determine their significance as a public health problem and the aspects of their biology that may be vulnerable to control interventions.

• 대한지역사회영양학회지
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• 제15권2호
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• pp.275-283
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• 2010

There are few studies reporting optimal waist circumference that can be utilized to prevent the incidence of cardiovascular disease (CVD). We evaluated the association of waist circumference and waist and hip circumference ratio (WHR) with incident cases of CVD developed over 6 years in a population-based prospective study including Korean adults. Analyses for receiver-operating characteristic (ROC) curve were performed with data for 1,733 men and 1,579 women who were aged 40 to 69 years and were free of a physician-diagnosis of CVD at baseline. Information on the diagnosis of CVD was periodically reported using interviewer-administered questionnaires and anthropometric measures were obtained by biennial health examinations. We newly identified 77 cases of CVD during a follow-up period between 2003 and 2008. On the basis of measures of diagnostic accuracy including minimum distance to ROC curve and Youden index, waist circumference of 85 cm for men, in particular for male nonsmokers, and of 80 cm for women and WHR of 0.88 to 0.90 for men and of 0.83 for women were found to be optimal cutoff points to identify individuals at CVD risks. The study also found that the use of the suggested optimal values for waist circumference show higher sensitivity and lower specificity compared with 90 cm for men and 85 cm for women, which are waist cutoff points given by the Korean Society for the Study of Obesity to define abdominal obesity for Korean adults. Although lower cutoff points of waist circumference (83 cm) and WHR (0.87) were observed to be optimal for male smokers compared with male nonsmokers, whether suggesting waist cutoff points specific to smokers is needed warrants further studies. After taking into account other cardiovascular risk factors including smoking, men with waist circumference of 85 cm or greater and women with 80 cm or greater were at an increased risk of CVD. Thus, these cutoff points of waist circumference may be able to capture more individuals at CVD risks contributing to the prevention of future development of CVD.

• 한국콘텐츠학회논문지
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• 제17권3호
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• pp.274-284
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• 2017

우리 사회는 고령화에 따라 치매 유병률이 지속적으로 증가하여 사회적으로 큰 문제가 되고 있다. 국가적으로 장기 요양 보험 제도를 시행하고 있으나, 조건이 안되는 치매 노인은 기본적인 요양서비스도 이용할 수 없는 상황이다. 이러한 사회적 배경 아래 스마트폰 사용이 보편화되는 환경 하에서 현재 서비스되는 애플리케이션의 기능 분석과 대상자 설문조사를 토대로 초기(경증) 치매 노인에게 질병 관리 및 가족 간의 소통에 도움을 주는 애플리케이션에 대해 연구하고자 하였다. 연구 방법은 연구주제와 관련된 이론 연구를 배경으로 경증 치매 노인을 위해 서비스되는 애플리케이션 사용 환경을 분석하였으며, 이 분석을 통해 치매 노인을 위한 앱이 없다는 사실을 알게 되었다. 이 기본연구를 바탕으로 경도 치매 노인에게 필요한 약물 복용 관리, 신체 활동 관리, 두뇌 활동 관리, 치매 정보, 메모 등의 기능이 포함된 애플리케이션의 디자인기획 방향을 제시하였다. 나라에서 시행하는 제도적 지원에 이와 같은 서비스가 확대된다면, 애플리케이션 사용을 통해 수집된 데이터를 기반으로 경증 치매의 제도적 관리 선진화에 기여를 할 것으로 기대한다.

• 한국식생활문화학회지
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• 제28권2호
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• pp.125-134
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• 2013

This study investigated the effect of a health-related lifestyle on knowledge, attitude, control belief and behavior intention toward breast-feeding of male and female university students in order to develop a breast-feeding education program for students of childbearing age. The subjects were 445 university students (125 male and 325 female) residing in eight provinces in Korea. The overall percentage of subjects intending to breast-feed their baby was 80.7% (73.6% of males and 84.2% of females). Overall, 84.2% of the subjects had high concerns about their health status. Scores reflecting a positive attitude, knowledge, and control beliefs toward breast-feeding were significantly higher (p<0.05~p<0.001) in female students, students majoring in medicine, and higher grades. The students who scored high at attitude, knowledge, and control beliefs also had a significantly higher (p<0.001) intention to breast-feed. When we investigated the sub factors of attitudes toward breast-feeding, significantly more students taking nutrient supplements scored high for physiological factors (p<0.05) and health-related factors (p<0.01). Significantly more non-smoking and non-drinking students scored high for health-related factors (p<0.001) and physiological factors (p<0.001), respectively. The intention to breast-feed was found to be significantly higher (p<0.01) in students who did not smoke, but not with other health-related lifestyles. In summary, these results indicate that the majority of university students intend to breast-feed, with students having a positive attitude, higher knowledge, and stronger control beliefs having a higher intention to breast-feed. Although a student's health-related lifestyle affects their attitudes on the physiological and health-related aspects of breast-feeding, only smoking status had an observable connection on the intention to breast-feed. Thus, when developing breast-feeding education programs for students, we recommend efforts to enhance a favorable attitude, knowledge, and control beliefs toward breast-feeding.

• 보건의료산업학회지
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• 제6권1호
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• pp.27-38
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• 2012

This study is to find out the correlation among the predisposing, enabling, and need factors in Anderson Behavioral Model using the data from Korea Medical Panel Survey conducted in the early part (April 1 - October 31) of 2008. The findings are as follows. It was found that the utilization rate of western medical service was far higher. the influential factor to choose western or oriental medical service taking western medical institutions as the reference group, the influential factor to choose oriental medical institution has significantly increased when the patient who have covered by medical insurance has one accompanied disease and their age was between 45 - 74, compared to the people less than 45 years old. It also increased when the age of the patient was between 45-54 years old, and in the event those who are not covered by medical insurance have accompanied disease and that the disease mobility period is 2-4 years. reviewing the several characteristics of the utilization of western and oriental medical services by the patient with musculoskeletal system disorders, the number of accompanied disease is an influential factor for the utilization of oriental medical services. And, disease mobility period is a significant factor for the utilization of both western and oriental medical services together, though it is not identified in this study. Therefore, it is expected that mutual cooperation between western and oriental medical services is more required for the patient with musculoskeletal system disorders as the aging society rapidly develops. In order to foster oriental medicine, it is required to specialize in competitive disease such as musculoskeletal system disorders.

• 한국생활과학회지
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• 제17권4호
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• pp.797-805
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• 2008

The present study was investigated on type 2 diabetics' actual status of anti-diabetic functional food intake by patients who came to oriental medicine clinics in Daejeon. The male was 37.3% and female was 62.7% of the subjects. The onset of the disease was most common in the age of 50's. Also 40% of the subjects have been suffering for more than 5 years. 35.7% of men, 53.2% for women had family history. Also 61.5% of the patients chose to carry out both diabetic therapy and exercise at the same time. 69.3% of the subjects have had experiences in anti-diabetic functional foods. Anti-diabetic functional foods used to surveyed people were bean, ginseng, and ginseng steamed red of which efficacies were already well known. Besides these foods, other foods such as loach, crucian carp were also used as anti-diabetic foods, but their benefits as anti-diabetic functional foods are not yet fully investigated. Subjects first knew about the therapy because friends or relatives recommended to them and most of them have used for 6 months to 1 year. However, 78.9% of subjects answered 'not so effective' in a question about satisfaction of anti-diabetic functional food. Although many of the patients have tried taking functional foods, they only use them for short period of time and they don't show prominent effect. Therefore these results suggest that in order to use scientifically studied functional foods, education about anti-diabetic functional foods should taken.