• Natural Product Sciences
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• v.20 no.4
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• pp.301-305
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• 2014

The aim of our study is to investigate the anti-nociceptive and anti-inflammatory properties of an ethanol extract of the leaf and stem of Aralia cordata. Writhing responses induced by acetic acid, tail immersion test, and formalin-induced paw pain response for nociception and formalin-induced paw edema for inflammation were evaluated in mice. A. cordata (50 - 200 mg/kg, p.o.) and ibuprofen (100 mg/kg, p.o.), a positive non-steroidal anti-inflammatory drugs (NSAIDs), inhibited the acetic acid-induced writhing response, but they did not protect the thermal nociception in tail immersion test. However, morphine (5 mg/kg, s.c.) used as positive opioid control alleviated both the acetic acid-induced writhing response and thermal nociception in tail immersion test. In the formalin test, A. cordata (50 - 200mg/kg) and ibuprofen (200mg/kg) inhibited the second phase response (peripheral inflammatory response), but not the first phase response (central response), whereas morphine inhibited both phase pain responses. Both A. cordata (100 mg/kg) and ibuprofen (200 mg/kg) significantly alleviated the formalin-induced increase of paw thickness, the index of inflammation. These results show for the first time that the leaf and stem of A. cordata has a significant anti-nociceptive effect that seems to be peripheral, but not central. A. cordata also displays an anti-inflammatory activity in an acute inflammation model. The present study supports a possible use of the leaf and stem of A. cordata to treat pain and inflammation.

• Advances in Traditional Medicine
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• v.5 no.3
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• pp.195-200
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• 2005

In order to examine the effectiveness of moxibustion stimulation for climacteric disturbance, we administered moxibustion stimulation to ovariectomized (OVX) rats, and compared the tail surface temperature, laboratory parameters, and the level of locomotor activity with those of untreated rats. Twenty-four female Wistar rats (8 weeks old, 160 - 180 g) were divided into three groups. The rats in the OVX-M group underwent moxibustion stimulation after ovariectomy. The rats in the OVX-C group underwent ovariectomy but did not receive moxibustion stimulation. The rats in the Normal group received neither ovariectomy nor moxibustion stimulation. The level of locomotor activity was determined by a metabolism measuring system. The tail surface temperature was significantly lower in the OVX rats before moxibustion stimulation than in the Normal group. In the OVX rats before moxibustion stimulation, there was no clear difference in the level of locomotor activity between the active and resting phases, and the pattern of locomotor activity was irregular. After moxibustion stimulation, the tail surface temperature of the OVX-M group did not significantly differ from that of the Normal group, and the pattern of locomotor activity of the OVX-M group became diphasic with clear active and resting phases, similar to that observed in the Normal group. These results demonstrate that moxibustion stimulation is effective for the treatment of climacteric disturbance.

• Journal of Astronomy and Space Sciences
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• v.6 no.1
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• pp.1-15
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• 1989

Magnetospheic substorm in the magnetotail region is studied numerically by means of a three dimensional MHD code. The analytic solution for the quiet magnetotail is employed as an initial configuration. The localized solar wind is modeled to enter the simulation domain through the boundaries located in the magnetotail lobe region. As a result of the interaction between the solar wind and the magnetosphere, the magnetic field lines are stretched, and the plasma sheet becomes thinner and thinner. When the current driven resistivity is generated, magnetic reconnection is triggered by this resistivity. The resulting plasma jetting is found to be super-magnetosonic. Although the plasmoid formation and its tailward motion is not quite clear as in the two dimensional simulation, which is mainly because of the numerical model chosen for the present simulation, the rarification of the plasmas near the x-point is observed. Field aligned currents are observed in the late expansive stage of the magnetospheric substorm. These field aligned currents flow from the tail toward the ionosphere on the dawn side from the ionosphere to ward the tail on the dusk side, namely in the same sense of the region 1 current. As the field aligned currents develop, it is found that the cross tail current in the earth side midnight section of the magnetic x-point is reduced.

• Journal of the Korea Society for Simulation
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• v.9 no.4
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• pp.51-58
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• 2000

The control of the data retention time is a main issue for realizing future high density dynamic random access memory. The novel junction process scheme in sub-micron DRAM cell with STI(Shallow Trench Isolation) has been investigated to improve the tail component in the retention time distribution which is of great importance in DRAM characteristics. In this' paper, we propose the new implantation scheme by gate-related ion beam shadowing effect and buffer-enhanced ${\Delta}Rp$ (projected standard deviation) increase using buffered N-implantation with tilt and 4X(4 times)-rotation that is designed on the basis of the local-field-enhancement model of the tail component. We report an excellent tail improvement of the retention time distribution attributed to the reduction of electric field across the cell junction due to the redistribution of N-concentration which is Intentionally caused by ion Beam Shadowing and Buffering Effect using tilt implantation with 4X-rotation. And also, we suggest the least requirements for adoption of this new implantation scheme and the method to optimize the key parameters such as tilt angle, rotation number, Rp compensation and Nd/Na ratio. We used MEDICI Simulator to confirm the junction device characteristics. And measured the refresh time using the ADVAN Probe tester.

• Communications for Statistical Applications and Methods
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• v.9 no.3
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• pp.649-663
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• 2002

We consider an unlimited fluid queueing model which has Fractional Brownian motion(FBM) as an input and a single server of constant service rate. By using the result of Duffield and O'Connell(6), we investigate the asymptotic tail-distribution of the stationary work-load. When there are multiple homogeneous FBM inputs, the workload distribution is similar to that of the queue with one FBM input; whereas for the heterogeneous sources the asymptotic work-load distributions is dominated by the source with the largest Hurst parameter.

• Journal of applied mathematics & informatics
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• v.23 no.1_2
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• pp.87-99
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• 2007

In this paper, we consider the Sparre Andersen risk model modified by the inclusion of interest on the surplus. By using the techniques of Cai and Dickson [Ins.: Math. Econ. 32(2003)], we give the functional and also the exponential type upper bounds for the tail probability of the deficit at ruin. Some special cases are also discussed.

• Journal of Oriental Neuropsychiatry
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• v.21 no.2
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• pp.61-73
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• 2010

Objectives : The purpose of this study was to assess anti-depressive effects of Bee Venom(BV) on an Animal Model of Depression induced immobility stress. Methods : There was 2 pre-experiments MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and Western blot test and 3 main experiments ; forced swimming test, tail suspension test and Y-maze task. Male rats were used for main experiment. The subject was divided into 4 groups(1. control group injected only saline, without immobility stress 2. Negative group injected saline after 2 hours immobility stress 3. Positive group injected Amitriptyline after 2 hours immobility stress 4. BV group injected Bee Venom after 2 hours immobility stress). Each group consisted of 6 rats. Forced swimming test, tail suspension test, Y-maze task were used to evaluate anti-depressive effect of Bee Venom. Results : In MTT assay, as the density of BV increased, the existence rate of primary neuronal cell increased. In Western blot test, the density of CREB and AKT was increasing as time went by. In forced swimming test, BV group showed immobility decreased more than Normal group and Positive group. In tail suspension test, Normal group and Positive group showed immobility decreased more than BV group. In Y-maze task, BV group showed immobility decreased more than Normal group, but Positive group showed immobility decreased more than BV group. Conclusions : These results suggest that Bee Venom may have anti-depressive effect on depression.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.5
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• pp.1-9
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• 2003

Detailed flow of a shrouded tail rotor in hover is studied by using a compressible inviscid flow solver on unstructured meshes. The numerical method is based on a cell-centered finite-volume discretization and an implicit Gauss-Seidel time integration. Numerical simulation is made for a single blade attached to the center body and guide by the duct by imposing a periodic boundary condition between adjacent rotor blades. The results show that the performance of an isolated rotor without shroud compares well with experiment. In case of a shrouded rotor, correction of the collective pitch angle is made such that the overall performance matches with experiment to account for the uncertainties of the experimental model configuration. Details of the flow field compare well with the experiment confirming the validity of the present method.

• Geomechanics and Engineering
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• v.29 no.3
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• pp.291-300
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• 2022

Tunnel boring machines combined with the earth pressure balanced shield method (EPB shield TBMs) have been adopted in urban areas as they allow excavation of tunnels with limited ground deformation through continuous and repetitive excavation and support. Nevertheless, the expansion of TBM construction requires much more minor and exquisitely controlled surface settlement to prevent economic loss. Several parametric studies controlling the tunnel's geometry, ground properties, and TBM operational factors assuming ordinary conditions for EPB shield TBM excavation have been conducted, but the impact of excessive excavation on the induced settlement has not been adequately studied. This study conducted a numerical evaluation of surface settlement induced by the ground loss from face imbalance, excessive excavation, and tail void grouting. The numerical model was constructed using FLAC3D and validated by comparing its result with the field data from literature. Then, parametric studies were conducted by controlling the ground stiffness, face pressure, tail void grouting pressure, and additional volume of muck discharge. As a result, the contribution of these operational factors to the surface settlement appeared differently depending on the ground stiffness. Except for the ground stiffness as the dominant factor, the order of variation of surface settlement was investigated, and the volume of additional muck discharge was found to be the largest, followed by the face pressure and tail void grouting pressure. The results from this study are expected to contribute to the development of settlement prediction models and understanding the surface settlement behavior induced by TBM excavation.

• Korean Journal of Medicinal Crop Science
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• v.22 no.3
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• pp.196-202
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• 2014

Depression is one of the most common neuropsychiatric disorders and has been associated with the neuroendocrine system and alterations in behavior. Schisandra chinensis Baillon is one of major medicinal plants used as a Korea medicine and food sources, and has been processed in the fields of various food products and medicinal herbs. The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviors in laboratory mice or rat. The CMS procedure induced some behavioral changes that are compatible with the common expectations, i.e. 'anhedonic' behavior and can affect corticosterone level. The present study, Schisandra chinensis extract administration by daily gavage from the 3 weeks exhibited an antidepressant-like effect on CMS-induced depression in mice. Schisandra chinensis extract administration at dose of 200mg/kg significantly increased the sucrose consumption, and decreased the immobility durations in forced swim test and tail suspension test. Furthermore the corticosterone level decreased than control group. In conclusion, Schisandra chinensis extract showed antidepressant-like effects on sucrose preference test, forced swimming test and tail suspension test based on CMS model.