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http://dx.doi.org/10.7783/KJMCS.2014.22.3.196

Antidepressant-like Effects of Schisandra chinensis Baillon Water Extract on Animal Model Induced by Chronic Mild Stress  

Kang, Min Gu (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine)
Kim, Young Hwa (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine)
Im, A Rang (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine)
Nam, Byung Soo (Infrastructure Management Team, Korea Institute of Oriental Medicine)
Chae, Sung Wook (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine)
Lee, Mi Young (KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Medicinal Crop Science / v.22, no.3, 2014 , pp. 196-202 More about this Journal
Abstract
Depression is one of the most common neuropsychiatric disorders and has been associated with the neuroendocrine system and alterations in behavior. Schisandra chinensis Baillon is one of major medicinal plants used as a Korea medicine and food sources, and has been processed in the fields of various food products and medicinal herbs. The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviors in laboratory mice or rat. The CMS procedure induced some behavioral changes that are compatible with the common expectations, i.e. 'anhedonic' behavior and can affect corticosterone level. The present study, Schisandra chinensis extract administration by daily gavage from the 3 weeks exhibited an antidepressant-like effect on CMS-induced depression in mice. Schisandra chinensis extract administration at dose of 200mg/kg significantly increased the sucrose consumption, and decreased the immobility durations in forced swim test and tail suspension test. Furthermore the corticosterone level decreased than control group. In conclusion, Schisandra chinensis extract showed antidepressant-like effects on sucrose preference test, forced swimming test and tail suspension test based on CMS model.
Keywords
Antidepressant; Schisandra chinensis Baillon; Chronic Mild Stress; Forced Swimming Test; Tail Suspension Test; Sucrose Preference Test;
Citations & Related Records
Times Cited By KSCI : 6  (Citation Analysis)
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1 Willner P. (1997). Validity, reliability and utility of the chronic mild stress model of depression: A 10-year review and evaluation. Psychopharmacology. 134:319-329.   DOI
2 Willner P. (2005). Chronic mild stress (CMS) revisited: Consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology. 52:90-110.   DOI   ScienceOn
3 Steru L, Chermat R, Thierry B and Simon P. (1985). The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology. 85:367-370.   DOI   ScienceOn
4 Steffens DC, Krishnan KR and Helms MJ. (1997). Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: A metaanalysis. Depression and Anxiety. 6:10-18.   DOI
5 Surget A, Wang Y, Leman S, Ibarguen-Vargas Y, Edgar N, Griebel G, Belzung C and Sibille E. (2009). Coricolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. Neuropsychopharmacology. 34:1363-1380.   DOI   ScienceOn
6 Tanti A and Belzung C. (2010). Open questions in current models of antidepressant action. British Journal of Pharmacology. 159:1187-1200.   DOI   ScienceOn
7 Tsigos C and Chrousos GP. (1994). Physiology of the hypothalamicpituitary- adrenal axis in health and dysregulation in psychiatric and autoimmune disorders. Endocrinology and Metabolism Clinics of North America. 23:451-466.
8 Vancassel S, Leman S, Hanonick L, Denis S, Roger J, Nollet M, Bodard S, Kousignian I, Belzung C and Chalon S. (2008). n-3 Polyunsaturated fatty acid supplementation reverses stress-induced modification on brain monoamine levels in mice. The Journal of Lipid Research. 49:340-348.   DOI
9 Willner P. (1984). The validity of animal models of depression. Psychopharmacology. 83:1-16.   DOI
10 Willner P, Towell A, Sampson D, Sophokleous S and Muscat R. (1987). Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology. 93:358-364.
11 Willner P, Muscat R and Papp M. (1992). Chronic mild stressinduced anhedonia: A realistic animal model of depression. Neuroscience & Biobehavioral Reviews. 16:525-534.   DOI   ScienceOn
12 Nemeroff CB. (2007). The burden of severe depression: A review of diagnostic challenges and treatment alternatives. Journal of Psychiatric Research. 41:189-206.   DOI   ScienceOn
13 Papp M, Willner P and Muscat R. (1991). An animal model of anhedonia: Attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress. Psychopharmacology(Berlin). 104:255-259.   DOI
14 Park JH, Kim JH, Kim DH, Mun HC, Lee HJ, Seo SM, Paik KH, Ryu LH, Park JI and Lee HY. (2004). Comparison of immuno-stimulatory activities by purification process of Schizandra chinensis Baillon fruits. Korean Journal of Medicinal Crop Science. 12:141-148.   과학기술학회마을
15 Patten SB. (2008). Major depression prevalence is very high, but the syndrome is a poor proxy for community populations'0 clinical treatment needs. Canadian Journal of Psychiatry. 53:411-419.   DOI
16 Sarko J. (2000). Antidepressants, old and new. A review of their adverse effects and toxicity in overdose. Emergency Medicine Clinics of North America. 18:637-654.   DOI
17 Panossian A and Wikman G. (2008). Pharmacology of Schisandra chinensis Bail: An overview of Russian research and uses in medicine. Journal of Ethnopharmacology. 118:183-212.   DOI   ScienceOn
18 Porsolt RD, Le Pichon M and Jalfre M. (1977). Depression: A new animal model sensitive to antidepressant treatments. Nature. 266:730-732.   DOI   ScienceOn
19 Sadako Y, Yoshikazu M and Hironaka K. (1993). Preventive effect of gomisin A, a lignan component of Schizandra fruits, on acetaminophen-induced hepatotoxicty in rats. Biochemical Pharmacology. 46:1801-1085.
20 Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE and Wang PS. (2003). The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication(NCS-R). The Journal of the American Medical Association. 289:3095-3105.   DOI   ScienceOn
21 Kennedy SH. (2006). A review of antidepressant treatments today. European Neuropsychopharmacology. 16:619-624.   DOI   ScienceOn
22 Kim CH, Kwon MC, Kim SH, Bae GJ, Ahn JH, Chio GP, Chio YB, Ko JR and Lee HY. (2007). Enhancement of immune activites of Kadsura japonica Dunal. through conventional fermentation process. Korean Journal of Medicinal Crop Science. 15:162-169.
23 Lee YM, Lee KS and Kim DK. (2009). Aqueous extract of Schizandra chinensis suppresses dextran sulfate sodium induced generation of IL-8 and ROS in the colonic epithelial cell line HT-29. Natural Product Sciences. 15:185-191.
24 Mutlu O, Ulak G, Laugeray A and Belzung C. (2009). Effects of neuronal and inducible NOS inhibitor 1-[2-(trifluoromethyl) phenyl] imidazole(TRIM) in unpredictable chronic mild stress procedure in mice. Pharmacology Biochemistry and Behavior. 92:82-87.   DOI   ScienceOn
25 Linde K, Berner M, Egger M and Mulrow C. (2005). St. John' wort for depression: Meta-analysis of randomized, controlled trials. The British Journal of Psychiatry. 184:99-107.
26 Luo DD, An SC and Zhang X. (2008). Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress. Brain Research Bulletin. 77:8-12.   DOI   ScienceOn
27 Mandrioli R, Mercolini L, Saracino MA and Raggi MA. (2012). Selective serotonin reuptake inhibitors(SSRIs): Therapeutic drug monitoring and pharmacological interactions. Current Medicinal Chemistry. 19:1846-1863.   DOI
28 Baek NI, Han JT, Ahn EM, Park JK, Cho SW, Jeon SG, Jang JS, Kim CK and Choi SY. (2000). Isolation of anticonvulsant compounds from the fruits of Schizandra chinensis Baill. Journal of the Korean Society of Agricultural Chemistry and Biotechnology. 43:72-77.
29 Bergstrom A, Jayatissa MN, Mork A and Wiborg O. (2008). Stress sensitivity and resilience in the chronic mild stress rat model of depression; an in situ hybridization study. Brain Research. 1196:41-52.   DOI   ScienceOn
30 Bouvier N, Trenque T and Millart H. (2003). Development of antidepressant drugs. Experience and prospects. Presse Medicale. 32:519-522.
31 Chae HJ, Hwang HI, Lee IS and Moon HY. (2005) Comparison of on rat intestinal digestive enzyme inhibitory activity and antioxidant enzyme activity of Korean and Chinese Schizandra chinensis. Journal of Experimental & Biomedical Sciences. 11:517-523.   과학기술학회마을
32 Kang M, Pyun KH, Jang CG, Kim H, Bae H and Shim I. (2005). Nelumbinis semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats. Journal of Pharmacy and Pharmacology. 57:651-656.   DOI   ScienceOn
33 Holsboer F and Barden N. (1996). Antidepressants and hypothalamicpituitary-adrenocortical regulation. Endocrine Reviews. 17:187-205.   DOI
34 Hwang SJ, Pyo BS, Lee HJ and Hwang B. (2004). Production of gomisin J from cell suspension cultures of Schisandra chinensis Baillon. Korean Journal of Medicinal Crop Science. 12:442-447.   과학기술학회마을
35 Ibarguen-Vargas Y, Surget A, Touma C, Palme R and Belzung C. (2008). Multifaceted strain-specic effects in a mouse model of depression and of antidepressant reversal. Psychoneuroendocrinology. 33:1357-1368.   DOI   ScienceOn
36 Kendler KS, Karkowski LM and Prescott CA. (1999). Causal relationship between stressful life events and the onset of major depression. The American Journal of Psychiatry. 156:837-841.   DOI   ScienceOn
37 Anderson IM. (1998). SSRIs versus tricyclic antidepressants in depressed inpatients: a meta-analysis of efficacy and tolerability. Depression and Anxiety. 7:11-17.   DOI
38 Schulz V. (2006). Safety of St. John' Wort extract compared to synthetic antidepressants. Phytomedicine. 13:199-204.   DOI   ScienceOn