• 약학회지
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• 제48권3호
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• pp.197-201
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• 2004

Phosphodiesterases (PDEs) are enzymes that degrade intracellular cAMP. In the present study, pentoxifylline, a PDE inhibitor, induced osteoclast formation in co-cultures of mouse bone marrow cells and calvarial osteoblasts. To address the involvement of the osteoclast differentiation factor TNF-related activation-induced cytokine (TRANCE, identical to RANKL, ODF, and OPGL), mouse bone marrow cells and calvarial osteoblasts were co-cultured with pentoxifylline in the presence of OPG, a decoy receptor for TRANCE. The osteoclastogenic effect of pentoxifylline was completely blocked by addition of OPG, suggesting that TRANCE is involved in the osteoclast formation induced by pentoxifylline, Northern blot analysis revealed that pentoxifylline significantly induced TRANCE mRNA expression in calvarial osteoblasts. These results suggests that pentoxifylline regulates TRANCE expression in osteoblasts, which in turn controls osteoclast formation.

• Archives of Pharmacal Research
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• 제27권12호
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• pp.1258-1262
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• 2004

Phosphodiesterase (PDE) 4 is an enzyme that degrades intracellular cAMP. In the present study, the effect of rolipram, a specific phosphodiesterase (PDE) 4 inhibitor, on osteoclast formation was investigated. Rolipram induced osteoclast formation in cocultures of mouse bone marrow cells and calvarial osteoblasts. This activity was not observed in the absence of calvarial osteoblasts, suggesting that calvarial osteoblasts are likely target cells of rolipram. Osteoclast formation by rolipram was completely blocked by the addition of osteoprotegerin (OPG), a soluble decoy receptor for the osteoclast differentiation factor, TNF-related activation-induced cytokine (TRANCE, identical to RANKL, ODF, and OPGL). Northern blot analysis revealed the effect of rolipram to be associated with the increased expression of TRANCE mRNA in mouse calvarial osteoblasts. Collectively, these data indicate that PDE4 inhibitor up-regulates the TRANCE mRNA expression in osteoblasts, which in turn controls osteoclast formation.

• 약학회지
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• 제52권1호
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• pp.43-47
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• 2008

To determine the regulatory roles of PDE4 inhibitor on LPS-induced osteoclastogenesis, we investigated the effect of a PDE4 inhibitor on osteoclast formation in the presence of LPS. A specific PDE4 inhibitor, rolipram, increased LPS-induced osteoclast formation in cocultures. To verify that whether rolipram acts indirectly on osteoblasts, we investigated the TRANCE and COX-2 mRNA expression levels in osteoblasts. Treatment of rolipram increased the expression of TRANCE and COX-2 mRNA in osteoblasts stimulated by LPS. On the contrary, rolipram did not augment the number of osteoclasts differentiated from bone marrow cells by LPS. In conclusion, the stimulation of LPS-induced osteoclast formation by the PDE4 inhibitor are attributable to its indirect effect on osteoblasts, not to their direct effect on bone marrow-derived osteoclast precursors.

• 복식
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• 제36권
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• pp.167-181
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• 1998

This paper is the result of research about what imply the symbolic significance of the shamna's costume in Siberia and Central Asia by using plates, medias and exhibitions in JNME. The reselts of the present study are summarized as follows; 1) The researcher define the shamanism as incantation, religious phenomenon centering arround shaman who communicate with the existence of preternatualness by possession or trance. 2) Siberia and Central Asia's shamans are comunicated with the existence of preter naturalness by trance. 3) In Siberia and Central Asia, the shaman's costumes is presented in a shaman ritual are caps, jakets, ornaments, stick and shoes. They symbolize spiritual world, stupendous shaman and powerful animal. 4) A significant symbolic meaning of shaman's costumes is that they change shaman to the existence of preternatualness.

• 복식
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• 제28권
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• pp.169-186
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• 1996

Wangeja Chulgungdo (The Painting for a Crown Prince's Outgoing for Schooling to Sungkyunkwan) for this study which is held by the Korean university Museum is a kind of documentary paintings which not only have the value of art history but also give a glimpse of the court ceremonies for a Crown Prince. This painting offers various historical clues to understand the procedure for a Crown Prince's official entrance of Sungkyunkwan participants of the ceremony and other ceremony-related items$\ulcorner$Wangseja chulgungdo$\lrcorner$ was the painting drawn for a series of court procedures of Crown Prince Munjo's official en-trance of Sungkynkwan. When he was old enough to begin learning Sohak on March 11. 1817 that is ; he held Heonjakrye(a ceremony for offering drinks to the ancestors) at Munmyo passed Iphakye(a ceremony for en-trance of school) at Myungryundang and received Suharye the next day. $\ulcorner$Wangseja Chulgungdo$\lrcorner$ had the strong char-acteristics of documentary paintings in terms of art history which was intended to leave the historical event of a Crown Prince's entrance. It reflected the traits of documentary painting style in late Chosun Dynasty; a technique that strongly relieved the ceremonial scenes against the background such as mountains and rivers; a painting that not only captured the vivid actions of personalities ar the crucial moment of the ceremony but also depicted the cer-emonial vessels and items very realistically. Authors could confirm the ceremonial think-ing of the traditional society through a Crown Prince's entrance which controlled the details of every part of the performances of the court ceremony.

• 대한치과의사협회지
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• 제24권11호통권210호
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• pp.919-922
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• 1986

hypnosis(최면<술>)는 문자기록의 역사만큼이나 오래되었다. 1773년 Franz A.Mesmer는 의학분야에서 ‘최면술(mesmerism)'이란 용어를 사용하였으며, James Braid는 'hypnosis'란 용어를 최초로 사용하였고, Sigmund Frend는 치료의 한 형태로서 최면상태(hypnotic trance)를 연구하였으며, Hennon은 최과임상에서 사용되어지는 Hypnosis를 Hypnodontics라고 기술하였고, 실제 임상에 Hypnosis를 적용시키기 위해서는 따로 최면요법에 대한 수련을 쌓아야 한다고 하였다. 현재 임상에서 최면요법을 이용하고 있는 임상가는 그리 흔하지 않는 것 같으나 만약 습득만 한다면 행동조절의 한 방법으로서 유요하게 이용될 수 있으리라고 생각한다.

• 정신신체의학
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• 제5권2호
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• pp.218-222
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• 1997

저자는 화상 환자의 창상 처치 과정에서 동통 조절을 위한 최면적 개입을 성공적으로 경험하였기에 그 중에서 2명의 증례를 기술하고 최면과 동통, 해리 등에 관해 고찰함으로써 이와 관련된 연구에 대한 관심을 도모하고자 하였다.

• 한국과학교육학회지
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• 제32권8호
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• pp.1318-1332
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• 2012

This paper takes another approach in assessing students' perception of mathematics. Instead of asking for verbal description of the students' perception of mathematics, we asked the respondents who were all college students to draw their perception of mathematics. This relatively new approach enabled students to take a second look of how they perceived math and, at the same time, explored students' creativity and provided a less austere appearance to mathematics which was taken usually in a more formal and severe manner. This approach of assessing students' perception of mathematics generated new information that could not be normally gleaned from other approaches like Likert Scale. Some drawings of mathematics of the respondents reinforced their math affect towards mathematics. For those who hated math, their drawings revealed so the same is true with those who loved mathematics. Examining the visual representations of mathematics and looking for commonalities, the researcher found a number of interesting themes that may shed some light to educators' understanding of students' math affect.

• 대한기계학회논문집
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• 제15권5호
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• pp.1683-1696
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• 1991

본 연구에서는 정4각단면덕트 입구영역에서 층류맥동유동(laminar pulsating flows)의 유동특성을 이론 및 실험적으로 규명하기 위하여, 이론적 방법으로 덕트 입 구영역에서의 층류맥동유동에 대한 운동량방정식을 유도한 후 비선형인 대류항을 선형 화 시켜서 라플라스변환으로 속도분포식의 해를 구하였고, 실험적인 방법으로는 시험 덕트 크기는 횡단면의 가로*세로가 40mm*40mm이고, 길이가 4000mm인 정4각단면덕트 입구영역에서 송풍기에 의한 공기흡입유동으로 층류진동유동을 발생하며 이들 두유동 을 합성시켜 발생한 층류맥동유동에 대하여 열선유속계의 열선신호로부터 얻어진 속도 파형을 고찰하여 덕트내의 맥동유동에 대한 임계레이놀즈수를 결정하고 속도분포를 측 정하였다. 그리고 이론적으로 얻어진 속도분포식과 열선유속계로 측정한 속도분포를 비교검토하여 정확성을 검증하고, 이들 해석결과로 부터 층류맥동유동의 입구길이(en- trance lenght)식을 결정하여 제안하였다.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-1
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• pp.102-103
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• 2003

Osteoclast are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Regulation of osteoclast differentiation is central to the understanding of the pathogenesis and treatment of bone diseases such as osteoporosis. (omitted)