• The Journal of the Korean bone and joint tumor society
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• v.15 no.1
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• pp.7-12
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• 2009

Purpose: This study was aimed to assess TLE1 as a target molecule of synovial sarcoma. Method: We obtained tissue samples and clinical data from 36 patients who were diagnosed and treated for synovial sarcoma in our hospital. Immunohistochemical staining was performed to detect the expression of TLE1 in synovial sarcoma and normal tissues such as fat, skeletal muscle, peripheral nerve, vascular endothelium, and epithelium. Univariate survival analysis was performed to find whether overexpression of TLE1 is correlated to poor prognosis. Results: TLE1 was expressed in 35 (97%) cases (grade 1 was 5 cases, grade 2 was 28 cases, grade 3 was 2 cases.). Normal tissues from mesenchymal origin did not express TLE1. However, epithelial and endothelial cells showed weak expression (grade 1) of TLE1. The level of TLE1 expression did not have any prognostic significance according to univariate survival analysis. Conclusion: TLE1 may be a new molecular target of synovial sarcoma that differentiates synovial sarcoma from normal mesenchymal cells.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.10
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• pp.881-891
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• 2017

In this paper, we described the new TLE(Two Line Elements) generation method based on the compansation technique by using past TLEs(Two Line Elements) released by JSpOC(Joint Space Operation Center) in USA to reduce the orbit prediction error for long duration of SGP4(Simplified General Perturbations 4) which is a simplifed and analytical orbit propagator. The orbital residuals the orbital difference between two ephemeris for the first TLE only and for the all TLEs updated by JSpOC for the past some period was applied for this algorithm instead of general orbit determination software. Actually, in these orbital residuals, the trend of orbit prediction error from SGP4 is included. Thus, it is possible to make a simple residual function from these orbital residulas by using the fitting process. By using these residual functions with SGP4 prediction data for the currnet TLE data, the compansated orbit prediction can be reconstructed and the orbit prediction error for long duration of SGP4 is also reduced. And it is possible to generate new TLE data from it. In this paper, we demonstraed this algorithm in simple simulation, and the orbital error is decreased dramatically from 4km for the SGP4 propagation to 2km for it during 7 days as a result.

• Journal of Astronomy and Space Sciences
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• v.24 no.2
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• pp.145-154
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• 2007

Antenna pointing analysis for a geostationary satellite has been performed for using the NORAD Two-Line-Elements (TLE) converted from osculating Keplerian orbital elements. In order to check the possibility of the reception of the satellite signal, the antenna offset angles have been derived for the Communications, Ocean, and Meteorological Satellite (COMS) which carries out weekly East-West and North-South station-keeping maneuvers and twice a day thruster assisted momentum dumping. Throughout the analysis, it is shown that the use of converted NORAD TLE simplifies the antenna pointing related interfaces in satellite mission control system. For a highly eccentric transfer orbit cases, further analysis presents that the converted NORAD TLE from near apogee gives more favorable results.

• Journal of Gastric Cancer
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• v.16 no.1
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• pp.21-27
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• 2016

Purpose: Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the tumorigenesis of various tumors. We investigated the prognostic significance of TLE1 expression and its association with clinicopathological parameters in gastric cancer (GC) patients. Materials and Methods: Immunohistochemical analysis of six tissue microarrays was performed to examine TLE1 expression using 291 surgically resected GC specimens from the Soonchunhyang University Cheonan Hospital between July 2006 and December 2009. Results: In the non-neoplastic gastric mucosa, TLE1 expression was negative. In GC, 121 patients (41.6%) were positive for TLE1. The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P<0.001), early pathologic T-stage (P=0.012), and early American Joint Committee on Cancer stage (P=0.022). In the Kaplan-Meier analysis, the TLE1 expression was significantly associated with longer disease-free (P=0.022) and overall (P=0.001) survival rates. Conclusions: We suggested that TLE1 expression is a good prognostic indicator in GCs.

• Reproductive and Developmental Biology
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• v.35 no.1
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• pp.99-103
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• 2011

Transducin-like enhancer protein 1(TLE-1) is protein associated with cell proliferation. This study analyzed change of TLE-1 mRNA expression during in vivo and in vitro maturation in porcine oocytes. Oocytes and granulose cells were collected from follicles of <2 mm, 2~6 mm and >6 mm in diameter in slaughtered pig's ovaries. Oocytes collected from follicles of 2~6 mm in diameter were used after in vitro maturation for 0, 10, 20 and 44 h. Cumulus cells and granulose cells were collected after treatment with hyaluronidase. In results, TLE-1 mRNA expression in oocytes collected from follicle >6 mm in diameter is increased, TLE-1 RNA expression in cumulus cells and granulosa cells from follicles <2 mm, 2 mm 6 mm and >6 mm in diameter. However, there is no significant difference. On the other hand, TLE-1 mRNA expression from oocytes cultured for 10 hand 44 h is increased, TLE-1 mRNA in cumulus cells cultured for 10 h is significant increased(p<0.05) than other culture periods. In conclusion, these results show that TLE-1 is expressed in all cell types of oocytes, cumulus cells and granulose cells, and associated with oocyte maturation.

• Journal of Korean Neurosurgical Society
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• v.45 no.6
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• pp.329-335
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• 2009

Objective : Determining language lateralization is important for the presurgical evaluation of patients with medically intractable epilepsy. The Wada test has been the gold standard for lateralization of language dominance before epilepsy surgery. However, it is an invasive test with risk, and have some limitations. Methods : We compared the volumetric analysis with Wada test, and studied the clinical potential of volumetric analysis to assess language laterality in large surgical candidates with temporal lobe epilepsy (TLE). To examine the efficacy of volumetric analysis to determine language lateralization during presurgical evaluation, we compared the volumetric analysis of the bilateral planum temporale with the results of Wada test in 59 patients with chronic intractable TLE (rTLE, n=32; lTLE, n=27) who underwent epilepsy surgery. We measured the gray matter volumes of planum temporale (PT) of each patients using the VoxelPlus2 program (Mevisys, Daejeon, Korea). Results : Overall congruence of the volumetric analysis with the Wada test was 97.75% in rTLE patients and 81.5% in lTLE patients. There were more significant leftward asymmetry of the PT in rTLE patients than lTLE patients. In lTLE patients, relatively high proportion (37%) of the patients showed bilateral or right hemispheric language dominance. Conclusion : These results provide evidence that the volumetric analysis of the PT could be used as an alternatives in language lateralization. Also, the results of the Wada test suggested that there was considerable plasticity of language representation in the brains of patients with intractable TLE and it was associated with an earlier age of brain injury.

• Journal of Astronomy and Space Sciences
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• v.22 no.3
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• pp.243-248
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• 2005

NORAD Two Line Element (TLE) is very useful to simplify the ground station antenna pointing and mission operations. When a satellite operations facility has the capability to determine NORAD type TLE which is independent of NORAD, it is important to analyze the applicable tracking data arcs for obtaining the best possible orbit. The applicable tracking data arcs for NORAD independent TLE orbit determination of the KOMPSAT-1 using GPS navigation solutions was analyzed for the best possible orbit determination and propagation results. Data spans of the GPS navigation solutions from 1 day to 5 days were used for TLE orbit determination and the results were used as Initial orbit for SGP4 orbit propagation. The operational orbit determination results using KOMPSAT-1 Mission Analysis and Planning System(MAPS) were used as references for the comparisons. The best-matched orbit determination was obtained when 3 days of GPS navigation solutions were used. The resulting 4 days of orbit propagation results were within 2 km of the KOMPSAI-1 MAPS results.

• BMB Reports
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• v.44 no.3
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• pp.199-204
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• 2011

Ephrin signaling is involved in various morphogenetic events, such as axon guidance, hindbrain segmentation, and angiogenesis. We conducted a yeast two-hybrid screen using the intracellular domain (ICD) of EphrinB1 to gain biochemical insight into the function of the EphrinB1 ICD. We identified the transcriptional co-repressor xTLE1/Groucho as an EphrinB1 interacting protein. Whole-mount in situ hybridization of Xenopus embryos confirmed the co-localization of EphrinB1 and a Xenopus counterpart to TLE1, xTLE4, during various stages of development. The EphrinB1/xTLE4 interaction was confirmed by co-immunoprecipitation experiments. Further characterization of the interaction revealed that the carboxy-terminal PDZ binding motif of EphrinB1 and the SP domain of xTLE4 are required for binding. Additionally, phosphorylation of EphrinB1 by a constitutively activated fibroblast growth factor receptor resulted in loss of the interaction, suggesting that the interaction is modulated by tyrosine phosphorylation of the EphrinB1 ICD.

• Journal of Astronomy and Space Sciences
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• v.19 no.3
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• pp.197-206
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• 2002

NORAD Two Line Elements (TLE) are widely used for the increasing number of small satellite mission operations and analysis. However, due to the irregular periodicity of generation of the NORAD TLE, a new TLE that is independent of NORAD is required. A TLE type Orbit Determination (TLEOD) has been developed for the generation of a new TLE. Thus, the TLEOD system can provide an Antenna Control Unit (ACU) with the orbit determination result in the type of a TLE, which provides a simple interface for the commercialized ACU system. For the TLEOD system, NORAD SGP4 was used to make a new orbit determination system. In addition, a least squares method was implemented for the TLEOD system with the GPS navigation solutions of the KOMPSAT-1. Considering both the Orbit Propagation (OP) difference and the tendency of $B^{*}$ value, the preferable span of the day in the observation data was selected to be 3 days. Through the OD with 3 days observation data, the OP difference was derived and compared with that of Mission Analysis and Planning (MAPS) for the KOMPSAT-1. It has the extent from 2 km after sit days to 4 km after seven days. This is qualified enough for the efficiency of an ACU in image reception and processing center of the KOMPSAT-2.

• Journal of Astronomy and Space Sciences
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• v.19 no.4
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• pp.395-402
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• 2002

The NORAD type Two Line Element (TLE) was obtained from the osculating orbital elements by an iterative approximation procedure. The mathematical model was presented and computer program was developed for the conversion. The osculating orbital elements of the KOMPSAT-1 were converted into the NORAD TLE. Then the effect of the SGP4 atmospheric drag coefficient ($B^*$) was analyzed by comparison of the orbit propagation results with different $B^*$ values.