• Natural Product Sciences
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• v.10 no.1
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• pp.48-53
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• 2004

Two galloyl monosaccharides, 1,2,6-trigalloylglucose (1, TRgG) and 1,2,3,6- tetragalloylglucose (2, TEgG), were isolated from the stem-bark of Juglans mandshurica. Two galloylglucoses showed cytotoxic effects on human promyelocytic leukemia HL-60 cells. In order to elucidate their mechanism of action, we have investigated the flow cytometric analysis after Annexin V-FITC and PI staining, caspase-3 activity, and internucleosomal DNA fragmentation in HL-60 cells. HL-60 cells treated with both compounds 1 and 2 at 150 and $100\;{\mu}M$, respectively, led to a morphological features of apoptosis, such as plasma membrane blebbing and cell shrinkage. TRgG (1) and TEgG (2) increased the percentage of $FITC^+\;and\;FITC^+PI^+$ cells in flow cytometry after Annexin V-FITC and PI staining. The increase of apoptotic cells was preceded by the activation of caspase-3 reported to play a central role in apoptotic process and inducing internucleosomal DNA fragmentation. TEgG (2) showed to have stronger apoptosis inducing activity in HL-60 cell lines as compared with TRgG (1).

• Journal of IKEEE
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• v.21 no.1
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• pp.66-69
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• 2017

In recent year, energy harvesting technologies from the ambient environments such as light, motion, wireless waves, and temperature again a lot of attraction form research community [1-5] due to its efficient solution in order to substitute for conventional power delivery methods, especially in wearable together with on-body applications. The drawbacks of battery-powered characteristic used in commodity applications lead to self-powered, long-lifetime circuit design. Thermoelectric generator, a solid-state sensor, is useful compared to the harvesting devices in order to enable self-sustained low-power applications. TEG based on the Seebeck effect is utilized to transfer thermal energy which is available with a temperature gradient into useful electrical energy. Depending on the temperature difference between two sides, amount of output power will be proportionally delivered. In this work, we illustrated a low-input voltage energy harvesting circuit applied discontinuous conduction mode (DCM) method for getting an adequate amount of energy from thermoelectric generator (TEG) for a specific wearable application. With a small temperature gradient harvested from human skin, the input voltage from the transducer is as low as 60mV, the proposed circuit, fabricated in a $0.6{\mu}m$ CMOS process, is capable of generating a regulated output voltage of 4.2V with an output power reaching to $40{\mu}W$. The proposed circuit is useful for powering energy to battery-less systems, such as wearable application devices.

• Journal of Convergence for Information Technology
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• v.11 no.2
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• pp.90-97
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• 2021

In this study, a Bi2Te3 thermoelectric generator (TEG) was fabricated to convert unused thermal energy into useful electrical energy. For the performance test, a dedicated experiment device consisting of a heating block operating with cartridge heaters and a cooling block through which a refrigerant flows was constructed. A 3×3 array of thermocouples was mounted on the heating block and the cooling block, respectively, to derive the temperature fields and heat transfer rate onto both sides of the TEG. Experiments were conducted for a total of 9 temperature differences, obtaining V-I and P-R curves. The results of 7 variables including Seebeck coefficients that have a major effect on performance were presented as a function of the temperature difference. The feasibility of the energy recovery performance of the developed TEG was verified from the maximum power output of 7.5W and conversion efficiency of 11.3%.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.05a
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• pp.1033-1034
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• 2010

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.11
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• pp.2487-2494
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• 2012

In this paper, a thermal energy harvesting circuit with MPPT control is designed. MPPT(Maximum Power Point Tracking) control function is implemented using the linear relationship between the open-circuit voltage of a thermoelectric generator(TEG) and its MPP voltage. The designed MPPT control circuit traces the maximum power point by periodically sampling the open circuit voltage of a TEG, makes the reference voltages using sampled voltage and delivers the maximum available power to load. Simulation results show that the maximum power efficiency of the designed circuit is 94%. The proposed thermal energy harvesting circuit is designed with $0.35{\mu}m$ CMOS process, and the chip area except PAD is $1168.7{\mu}m{\times}541.3{\mu}m$.

• Journal of IKEEE
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• v.19 no.2
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• pp.210-218
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• 2015

In this paper an auto-switching energy harvesting circuit using vibration and thermoelectric energy is proposed. Since the maximum power point of a thermoelectric generator(TEG) output and a vibration device(PEG) output is 1/2 of their open-circuit voltage, an identical MPPT controller can be used for both energy sources. The proposed circuit monitors the outputs of the TEG and PEG, and chooses the energy source generating a higher output voltage using an auto-switching controller, and then harvests the maximum power from the selected device using the MPPT controller. The proposed circuit is designed in a $0.35{\mu}m$ CMOS process and its functionality has been verified through extensive simulations. The designed chip occupies $1.4mm{\times}1.2mm$ including pads.

• Journal of Power Electronics
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• v.15 no.4
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• pp.899-909
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• 2015

A dual-input boost-buck converter with coupled inductors (DIBBC-CI) is proposed as a thermoelectric generator (TEG) power conditioner with a wide input voltage range. The DIBBC-CI is built by cascading two boost cells and a buck cell with shared inverse coupled filter inductors. Low current ripple on both sides of the TEG and the battery are achieved. Reduced size and power losses of the filter inductors are benefited from the DC magnetic flux cancellation in the inductor core, leading to high efficiency and high power density. The operational principle, impact of coupled inductors, and design considerations for the proposed converter are analyzed in detail. Distributed maximum power point tracking, battery charging, and output control are implemented using a competitive logic to ensure seamless switching among operational modes. Both the simulation and experimental results verify the feasibility of the proposed topology and control.

• Bulletin of the Korean Mathematical Society
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• v.60 no.4
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• pp.1003-1016
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• 2023

In this paper, we introduce the idea of twisted product lightlike submanifolds of semi-Riemannian manifolds and provide non-trivial examples of such lightlike submanifolds. Then, we prove the non-existence of proper isotropic or totally lightlike twisted product submanifolds of a semi-Riemannian manifold. We also show that for a twisted product lightlike submanifold of a semi-Riemannian manifold, the induced connection ∇ is not a metric connection. Further, we prove that a totally umbilical SCR-lightlike submanifold of an indefinite Kaehler manifold ${\tilde{M}}$ does not admit any twisted product SCR-lightlike submanifold of the type M_⊥×_ϕM_T, where M_⊥ is a totally real submanifold and MT is a holomorphic submanifold of ${\tilde{M}}$. Consequently, we obtain a geometric inequality for the second fundamental form of twisted product SCR-lightlike submanifolds of the type M_T×_ϕM_⊥ of an indefinite Kaehler manifold ${\tilde{M}}$, in terms of the gradient of ln ϕ, where ϕ stands for the twisting function. Subsequently, the equality case of this inequality is discussed. Finally, we construct a non-trivial example of a twisted product SCR-lightlike submanifold in an indefinite Kaehler manifold.

• Journal of Chest Surgery
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• v.30 no.7
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• pp.677-685
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• 1997

Thromboelastography(TEG) is the unique measure that gives rapid information about the whole clotting process. Simplifying the diagnosis of coagulopathy during operations, TEG can provide an adequate therapy for postoperative bleeding. Remarkable improvement in hemostasis after cardiopulmonary bypass(CPB) has been achieved by the treatment with proteinase inhibitor aprotinin, but the hemostatic mechanism of aprotinin during CPB is still unclear. This study was designed to evaluate the effects of aprotinin on coagulation system during CPB by using TEG. Forty patients who underwent CPB were divided into two groups: aprotinin(2u 106 kallikrein inhibition units, as a single dose into the cardiopulmonary bypass priming solution) treatment group(male 14, female 8, mean age=50.Byears) and no aprotinin treatment(control) group(male 10, female 8, mean age=53.4 years). TEG, activated clotting time, prothrombin time, activated partial thromboplastin time, platelet counts, fibrinogen an (ibrinogen degradation product(FDP) concentrations were checked before and after CPB(30 minutes after neutralization of heparin effect by protamine sulfate). There was no significant difference in other conventional coagulation tests of two groups except postcardiopulmonary bypass FDP concentration in control group, which was significantly increased compared to that in aprotinin group(p<0.05). In TEG variables of both groups, clot formation time(K) and alpha $angle(\alpha^{\circ})$ were significantly increased and decreased, respectively, after CPB(p<0.05), but fibrinolytic index(LYS60) was not changed during CPB. In aprotinin group, reaction time(R) was decreased significantly after CPB(p<0.05) but maximum amplitude(MA) was not changed(p>0.05). On the contrary, R was not changed markedly but MA was decreased significantly in control group after CPB(p<0.05). This result shows that main change in coagulation system during CPB is not hyperfibrinolysis but cecrease in clot strength by platelet dys unction, and the main effect of aprotinin during cardiopulmonary bypass is the maintenance of clot strength to the pre-CPB level by the preservation of platelet function.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.569-575
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• 2020

Recently, research on renewable energy technologies has come into the spotlight due to rising concerns over the depletion of fossil fuels and greenhouse gas emissions. Demand for portable electronic and wearable devices is increasing, and electronic devices are becoming smaller. Energy harvesting is a technology for overcoming limitations such as battery size and usage time. In this paper, the V-I characteristic curve and internal resistance of thermal electric devices were analyzed, and MPPT control methods were compared. The Perturbation and Observation (P&O) control method is economically inefficient because two sensors are required to measure the voltage and current of a Thermoelectric Generator(TEG). Therefore, this paper proposes a new MPPT control method that tracks MPP using only one sensor for the regulation of the output voltage. The proposed MPPT control method uses the relationship between the output voltage of the load and the duty ratio. Control is done by periodically sampling the output voltage of the DC-DC converter to increase or decrease the duty ratio to find the optimal duty ratio and maintain the MPP. A DC-DC converter was designed using a cascaded boost-buck converter, which has a two-switch topology. The proposed MPPT control method was verified by simulations using PSIM, and the results show that a voltage, current, and power of V=4.2 V, I=2.5 A, and P=10.5 W were obtained at the MPP from the V-I characteristic curve of the TEG.