• Tuberculosis and Respiratory Diseases
• /
• 제86권1호
• /
• pp.1-13
• /
• 2023

Lung cancer ranks first in cancer mortality in Korea and cancer incidence in Korean men. More than half of Korean lung cancer patients undergo chemotherapy, including adjuvant therapy. Cytotoxic agents, targeted therapy, and immune checkpoint inhibitors are used in chemotherapy according to the biopsy and genetic test results. Among chemotherapy, the one that has developed rapidly is targeted therapy. The National Comprehensive Cancer Network (NCCN) guidelines have been updated recently for targeted therapy of multiple gene mutations, and targeted therapy is used not only for chemotherapy but also for adjuvant therapy. While previously targeted therapies have been developed for common genetic mutations, recently targeted therapies have been developed to overcome uncommon mutations or drug resistance that have occurred since previous targeted therapy. Therefore, this study describes recent, rapidly developing targeted therapies.

• 항공우주정책ㆍ법학회지
• /
• 제32권1호
• /
• pp.53-81
• /
• 2017

우리나라에서 표적살인(Targeted Killing)은 많이 논의되지 않았지만 군사과학기술의 발전과 더불어 대(代)테러전쟁에서 핵심전략으로 떠올랐다. 표적살인 전략의 핵심요소인 무인항공기(UAV)는 조종사가 탑승하지 않은 채 원격조종으로 특정목표를 미사일로 공격할 수 있다. 이 전략은 국방예산의 절감하는 방안이면서 총력전에서 적의 수장을 제거하여 심리전에서 우위를 차지하기 위한 방안으로 주목을 받고 있다. 이에 우리나라도 한반도의 평화를 지키기 위한 전략으로서 도입을 고려할 필요가 있다. 그러나 무인항공기를 사용한 표적살인 전략은 전쟁행위인지 아니면 살인행위인지에 대한 크나큰 논란이 있다. 공격 대상인 테러리스트 등은 자신들이 공격대상이라는 사실을 알지도 못한 채 죽임을 당하기 때문에 미국 시민단체 등을 중심으로 생명의 윤리성에 대하여 문제의 제기를 하고 있다. 또한 미사일 공격으로 무고한 시민이 사망할 수 있다는 것과 자국군에 대한 오발을 행할 수도 있다는 점, 조종사가 심리적으로 겪을 수 있는 전투 스트레스 등이 주요 문제이다. 그래서 이러한 우려를 불식시키기 위해 투명성과 정당성의 확보가 필요하다. 나아가 무인항공기 표적살인 가이드라인을 제정하여 전략의 엄중한 실행과 남용을 막고 국민의 신뢰를 확보할 필요가 있다. 이러한 가이드라인에서는 미국과 같이 대통령이 단독으로 전략의 실행을 결정하는 것이 아니라 국회의 동의를 받아 실행하게 된다면 국민의 신뢰를 얻을 수 있을 것이라고 생각한다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권5호
• /
• pp.2789-2800
• /
• 2013

Background: The aim of this systematic review was to investigate whether stem cells could be effectively applied in targeted therapy of breast cancer. Material and Method: A systematic literature search was performed for original articles published from January 2007 until May 2012. Results: Nine studies met the inclusion criteria for phase I or II clinical trials, of which three used stem cells as vehicles, two trials used autologous hematopoetic stem cells and in four trials cancer stem cells were targeted. Mesenchymal stem cells (MSCs) were applied as cellular vehicles to transfer therapeutic agents. Cell therapy with MSC can successfully target resistant cancers. Cancer stem cells were selectively targeted via a proteasome-dependent suicide gene leading to tumor regression. $Wnt/{\beta}$-catenin signaling pathway has been also evidenced to be an attractive CSC-target. Conclusions: This systematic review focused on two different concepts of stem cells and breast cancer marking a turning point in the trials that applied stem cells as cellular vehicles for targeted delivery therapy as well as CSC-targeted therapies. Applying stem cells as targeted therapy could be an effective therapeutic approach for treatment of breast cancer in the clinic and in therapeutic marketing; however this needs to be confirmed with further clinical investigations.

• 한국수학교육학회지시리즈D:수학교육연구
• /
• 제25권4호
• /
• pp.267-284
• /
• 2022

In response to the current educational situation of students' heavy workload, the author constructs the precision-targeted classroom based on Precision Teaching (PT), Network Pharmacology, and Treatment Based on Syndrome Differentiation. The precision-targeted classroom can solve the current problems of PT and the phenomenon of the heavy academic burden on students, achieve the reduction of the burden and increase the efficiency of education. The precision-targeted classroom includes five key points: targeted goals, childlike thinking, precise intervention, intelligent homework, and stereoscopic evaluation, and the implementation process of the precision-targeted classroom is built from three aspects: before, during and after class. In addition, the author applied it to the actual mathematics classroom to test its teaching effect, and the experimental results showed that: the precision-targeted classroom significantly improved students' academic performance and thinking level; considerably improved students' classroom learning status, and facilitated teaching personalization and realized homework quantity control and quality improvement.

• 대한의생명과학회지
• /
• 제11권1호
• /
• pp.23-29
• /
• 2005

Molecular imaging with targeted contrast agents enables tissues to be distinguished by detecting specific cell-surface receptors. In the present study, a ligand-targeted acoustic nanoparticle system is used to identify angioplasty-induced expression of tissue factor by smooth muscle cell within carotid arteries. Pig carotid arteries were overstretched with balloon catheters, treated with tissue factor-targeted or a control nanoparticle system, and imaged with intravascular ultrasound before and after treatment. Tissue factor-targeted emulsion bound and increased the echogenicity and gray-scale levels of overstretched smooth muscle cell within the tunica media, versus no change in contralateral control arteries. Expression of stretch-induced tissue factor in carotid artery media was confirmed by immunohistochemistry. The potential for abnormal thrombogenicity of balloon-injured arteries, as reflected by smooth muscle expression of tissue factor, was imaged using a novel, targeted, nanoparticulate ultrasonic contrast agent.

• Journal of Microbiology and Biotechnology
• /
• 제24권9호
• /
• pp.1291-1299
• /
• 2014

Recently, multifunctional nanomaterials have been developed as nanotherapeutic agents for cellular imaging and targeted cancer treatment because of their ease of synthesis and low cytotoxicity. In this study, we developed a multifunctional, two-component nanorod consisting of gold (Au) and nickel (Ni) blocks that enables dual-fluorescence imaging and the targeted delivery of small interfering RNA (siRNA) to improve cancer treatment. Fluorescein isothiocyanate-labeled luteinizing hormone-releasing hormone (LHRH) peptides were attached to the surface of a Ni block via a histidine-tagged LHRH interaction to specifically bind to a breast cancer cell line, MCF-7. The Au block was modified with TAMRA-labeled thiolated siRNA in order to knock down the vascular endothelial growth factor protein to inhibit cancer growth. These two-component nanorods actively targeted and internalized into MCF-7 cells to induce apoptosis through RNA interference. This study demonstrates the feasibility of using two-component nanorods as a potential theranostic in breast cancer treatment, with capabilities in dual imaging and targeted gene delivery.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권4호
• /
• pp.1705-1708
• /
• 2012

The inception of targeted agents has revolutionized the cancer therapy paradigm, both for physicians and patients. A large number of molecular targeted agents for cancer therapy are currently available for clinical use today. Many more are in making, but there are issues that remain to be resolved for the scientific as well as social community before the recommendation of their widespread use in may clinical scenarios can be done, one such issue being cost and cost effectiveness, others being resistance and lack of sustained efficacy. With the current knowledge about available targeted agents, the growing knowledge of intricate molecular pathways and unfolding of wider spectrum of molecular targets that can really matter in the disease control, calls for only the just use of the agents available now, drug companies need to make a serious attempt to reduce the cost of the agents. Research should focus on agents that show sustained responses in preclinical data. More needs to be done in laboratories and by the pharmaceutical industries, before we can truly claim to have entered a new era of targeted therapy in cancer care.

• Journal of Industrial and Engineering Chemistry
• /
• 제67권
• /
• pp.429-436
• /
• 2018

Targeted intracellular delivery of therapeutic agents is one of the great challenges for cancer treatment. Aptamers that bind to a variety of biological targets have emerged as new targeting moieties with high specificity for targeted cancer therapy. In this study, near-infrared (NIR) light-absorbing hollow gold nanocages (AuNCs) were synthesized and conjugated with AS1411 aptamer to achieve cancer-targeted photothermal therapy. AuNC functionalized with PEG and AS1411 (AS1411-PEG-AuNC) exhibited selective cellular uptake in breast cancer cells due to selective binding of AS1411 to nucleolin, a protein that is over-expressed in cancer cells over normal cells. As a result, AS1411-PEG-AuNC showed cancer-targeted photothermal activity. This study demonstrates that aptamer-conjugated AuNCs are effective tumor-targeting photothermal agents.

• Radiation Oncology Journal
• /
• 제34권2호
• /
• pp.128-134
• /
• 2016

Purpose: To evaluate the clinical outcomes of patients who underwent radiation therapy with or without targeted molecular therapy for the treatment of spinal metastasis from renal cell carcinoma (RCC). Materials and Methods: A total of 28 spinal metastatic lesions from RCC patients treated with radiotherapy between June 2009 and June 2015 were retrospectively reviewed. Thirteen lesions were treated concurrently with targeted molecular therapy (concurrent group) and 15 lesions were not (nonconcurrent group). Local control was defined as lack of radiographically evident local progression and neurological deterioration. Results: At a median follow-up of 11 months (range, 2 to 58 months), the 1-year local progression-free rate (LPFR) was 67.0%. The patients with concurrent targeted molecular therapy showed significantly higher LPFR than those without (p = 0.019). After multivariate analysis, use of concurrent targeted molecular therapy showed a tendency towards improved LPFR (hazard ratio, 0.13; 95% confidence interval, 0.01 to 1.16). There was no difference in the incidence of systemic progression between concurrent and nonconcurrent groups. No grade ${\geq}2$ toxicities were observed during or after radiotherapy. Conclusion: Our study suggests the possibility that concurrent use of targeted molecular therapy during radiotherapy may improve LPFR. Further study with a large population is required to confirm these results.

• The Korean Journal of Physiology and Pharmacology
• /
• 제28권3호
• /
• pp.219-227
• /
• 2024

Bladder cancer remains the 10th most common cancer worldwide. In recent years, metformin has been found to have potential anti-bladder cancer activity while high concentration of IC₅₀ at millimolar level is needed, which could not be reached by regular oral administration route. Thus, higher efficient agent is urgently demanded for clinically treating bladder cancer. Here, by conjugating artesunate to metformin, a novel artesunate-metformin dimer triazine derivative AM2 was designed and synthesized. The inhibitory effect of AM2 on bladder cancer cell line T24 and the mechanism underlying was determined. Anti-tumor activity of AM2 was assessed by MTT, cloning formation and wound healing assays. Decreasing effect of AM2 on lipogenesis was determined by oil red O staining. The protein expressions of Clusterin, SREBP1 and FASN in T24 cells were evaluated by Western blotting. The results show that AM2 significantly inhibited cell proliferation and migration at micromolar level, much higher than parental metformin. AM2 reduced lipogenesis and down-regulated the expressions of Clusterin, SREBP1 and FASN. These results suggest that AM2 inhibits the growth of bladder cancer cells T24 by inhibiting cellular lipogenesis associated with the Clusterin/SREBP1/FASN signaling pathway.