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http://dx.doi.org/10.1016/j.jiec.2018.07.017

Cancer-targeted photothermal therapy using aptamer-conjugated gold nanoparticles  

Hong, Eun Ji (Division of Bioengineering, Incheon National University)
Kim, Yoon-Seok (Division of Bioengineering, Incheon National University)
Choi, Dae Gun (Division of Bioengineering, Incheon National University)
Shim, Min Suk (Division of Bioengineering, Incheon National University)
Publication Information
Journal of Industrial and Engineering Chemistry / v.67, no., 2018 , pp. 429-436 More about this Journal
Abstract
Targeted intracellular delivery of therapeutic agents is one of the great challenges for cancer treatment. Aptamers that bind to a variety of biological targets have emerged as new targeting moieties with high specificity for targeted cancer therapy. In this study, near-infrared (NIR) light-absorbing hollow gold nanocages (AuNCs) were synthesized and conjugated with AS1411 aptamer to achieve cancer-targeted photothermal therapy. AuNC functionalized with PEG and AS1411 (AS1411-PEG-AuNC) exhibited selective cellular uptake in breast cancer cells due to selective binding of AS1411 to nucleolin, a protein that is over-expressed in cancer cells over normal cells. As a result, AS1411-PEG-AuNC showed cancer-targeted photothermal activity. This study demonstrates that aptamer-conjugated AuNCs are effective tumor-targeting photothermal agents.
Keywords
Aptamer; AS1411; Gold nanoparticle; NIR light; Photothermal therap;
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