• The Journal of Korean Medicine
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• v.26 no.1 s.61
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• pp.26-36
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• 2005

Objective : Many traditional herbal remedies exhibit several beneficial effects including anti-inflammation. Euonymus alatus (Thunb.) Sieb (EA), known as Gui jun woo in Korea, has long been used in folk medicine to regulate Qi (bodily energy) and blood circulation, relieve pain, eliminate stagnant blood, and treat dysmenorrhea in oriental countries. The exact mechanism of the anti-inflammatory action of Euonymus alatus (Thunb.) Sieb (EA), however, has not been determined. Methods: Since there is increasing evidence that nitric oxide (NO) plays a crucial role in the pathogenesis of inflammatory diseases, this study was undertaken to address whether the methanol (MeOH) extract and its fractions of the bark of EA could modulate the expression of inducible NO synthase (iNOS) in thioglycollate-elicited murine peritoneal macrophages and murine macrophage cell line, RA W264.7 cells. Results: Stimulation of the peritoneal macrophages and RAW264.7 cells with $interferon-\gamma\;(IFN-\gamma)$ and lipopolysaccharide (LPS) resulted in increased production of NO in the medium. However, the butanol (BuOH) fraction of the MeOH extract of EA barks showed marked inhibition of NO synthesis in a dose-dependent manner. The inhibition of NO synthesis was reflected in the decreased amount of iNOS protein, as determined by Western blotting. The BuOH fraction did not affect the viability of RA W264.7 cells, as assessed by methylthiazol-2-yl-2, 5-diphenyl tetrazolium bromide (MTT) assay; rather, it reduced endogenous NO-induced apoptotic cell death via inhibition of NO synthesis in RAW264.7 cells. On the other hand, the MeOH and BuOH fraction showed no inhibitory effect on the synthesis of NO by RAW264.7 cells, when iNOS was already expressed by the stimulation with $IFN-\gamma$ and LPS. Conclusion: Collectively, these results demonstrate that the MeOH and BuOH fraction inhibits NO synthesis by inhibition of the induction of iNOS in murine macrophages.

• Journal of Oral Medicine and Pain
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• v.48 no.1
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• pp.31-36
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• 2023

This report presents the case of a 14-year-old male with rheumatoid arthritis (RA) in both temporomandibular joints (TMJs), in whom a bone scan and laboratory tests were used to confirm the diagnosis. The patient visited the Department of Orofacial Pain and Oral Medicine at the affiliation hospital with a complaint of a 1-year history of bilateral TMJ pain and sound. Clinical examination revealed bilateral TMJ and masseter muscle pain during mouth opening and palpation. Radiological examination revealed no significant morphological changes in either TMJ. The patient was prescribed medications at the first visit to address the pain, inflammation, and stiffness. A bone scan and laboratory tests were planned/scheduled for differential diagnosis between simple arthralgia and osteoarthritis. The bone scan revealed increased radiotracer uptake in both TMJs. The laboratory tests revealed a RA factor of 82.4 IU/mL, which is more than four times the normal range. The final diagnoses were bilateral TMJ early rheumatoid arthritis (ERA) and juvenile idiopathic arthritis. We created a stabilization splint and referred the patient to the Department of Rheumatology for further evaluation of the ERA. After fitting of the stabilization splint and giving instructions regarding its use, the patient has been receiving monthly follow-up checks for symptoms and undergoes follow-up blood tests every 3 months. About 14 months after the initial visit, the pain had significantly decreased from a Visual Analog Scale score of 5 to 1, and the RA factor decreased to 66.6 IU/mL. A regular follow-up check will continue until the end of growth.

• Journal of Hydrogen and New Energy
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• v.34 no.3
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• pp.274-282
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• 2023

This study conducted direct numerical simulations of the natural convection phenomena of gaseous hydrogen in a physical storage container containing four circular cylinders. Rayleigh numbers (Ra) in the range of 10⁴≤Ra≤10⁶ and a Prandtl number (Pr)=0.69 (gaseous hydrogen) were considered. The main parameter is a horizontal distance of four circular cylinders and the values of ε_h=0.1, 0.2, 0.3, 0.4, and 0.5 are considered. The flow and thermal structures and corresponding heat transfer characteristics are investigated with respect to the transition of the flow regime. The time- and surface-averaged Nusselt number on the cylinder surface and the wall of physical storage container increased by about 57% and 69% according to the Ra and ε_h, respectively. Thus, the horizontal distance has an influence on the heat transfer characteristics on natural convection of gaseous hydrogen.

• Journal of Korean Physical Therapy Science
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• v.31 no.2
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• pp.30-40
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• 2024

Background: The purpose of this study is to identify the difference in muscle activity and muscle contraction onset time according to a LLD and object weight When subjects performed a lifting task. Design: Repeated measure design Methods: 15 male adults participated in this study. When subjects performed a lifting task, we measured a difference of muscle activity and muscle contraction onset time in the rectus abdominis(RA), the erector spinae(ES), and the rectus femoris(RF) between both legs using the surface electromyogram (Telemyo DTS, Noraxon Inc., USA). When subjects performed a lifting task, the weight of the object was set to 0% kg, 10% kg, and 20% kg of the subject's body weight, excluding the weight of the box. Results: The difference in muscle activity in the RA, the ES, and the RF between both legs when lifting an object was larger in LLD condition than in non-LLD condition(p<0.05). In all of muscles, the difference of contraction onset time was generally increased as the object's weight increased. Specially, the difference in muscle contraction onset time in the RA, the ES between both legs was larger in the LLD condition than in the non-LLD condition(p<0.05). Conclusion: This study suggests that LLD affects the muscle activity and muscle contraction onset time during lifting objects. It can be used as data to prevent joint damage and muscle due to the LLD during work and movements of daily living.

• Tuberculosis and Respiratory Diseases
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• v.71 no.6
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• pp.464-469
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• 2011

Adalimumab is a full human monoclonal antibody that inhibits tumor necrosis factor-alpha (TNF-${\alpha}$). This has recently been shown to be effective in the treatment of rheumatoid arthritis (RA), ankylosing spondylitis, and other conditions. Sacoidosis is known to be the target for adalimumab but we describe a patient who has developed sarcoidosis with lung involvement during adalimumab therapy for RA. A 48-year-old woman, who was treated with adalimumab for 5 months, was admitted because of chronic cough and both hilar lymphadenopathy on chest radiography. Chest computed tomography revealed the enlargement of multiple lymph nodes in the right supraclavicular, subcarinal, both hilar and right axillary area. She was diagnosed with sarcoidosis based on the biopsy of supraclavicular lymph node, skin and lung through video-associated thoracoscopic surgery, which was non-caseating epitheloid cell granuloma and excluded from a similar disease. She was treated for sarcoidosis with prednisolone and methotrexate instead of adalimumab.

• Proceedings of the PSK Conference
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• 2003.04a
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• pp.151.2-152
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• 2003

Bee venom (BV) has been utilized to relieve pain and to treat inflammatory diseases such as rheumatoid arthritis (RA). BV contains a variety of different peptides including melittin, apamin, adolapin and mast cell degranulating (MCD) peptide. In addition, it also contains enzyme (i.e. phospholipase A2), biologically active amines and non-peptide components. (omitted)

• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.45.2-45
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• 2002

$\textbullet$ Uncertainties are described by sum quadratic constraint(SQC) $\textbullet$ SQC is converted into an indefinite quadratic cost function $\textbullet$ A Kalman filter developed in indefinite inner product space is Krein space Kalman filter $\textbullet$ To minimize the SQC, the Krein space Kalman filter is used $\textbullet$ The proposed robust filter outperforms the standard Kalman filter and existing robust Kalman filter $\textbullet$ The proposed filter has the same recursive, simple structure as the standard Kalman filter $\textbullet$ Easy to design, adequate for on-line implementation

• Proceedings of the Korea Contents Association Conference
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• 2013.05a
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• pp.199-200
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• 2013

최근 우리 사회는 국제화, 세계화, 개방화, 정보화 추세에 부응하여 취학 전 유아나 초등학교 저학년 아동을 대상으로 한 조기영어 교육이 실시되고 있으며, 이에 본 논문에서는 저학년 아동을 대상으로 영어학습을 할 수 있도록 동화를 이용한 e-러닝 콘텐츠를 분석하고 모형을 제시하고자 한다.

• Bulletin of the Korean Chemical Society
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• v.23 no.8
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• pp.1116-1119
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• 2002

Monoclonal antibodies have been generated against a generic hapten, ο,ο-diethyl ο-(5-carboxy-2-fluorophenyl) phosphorothioate, for the determination of organophosphorus (OP) pesticides in a class-specific manner. In an indirect competitive enzyme-linked immunosorbent assay (ELISA) format, employing a heterologous coating antigen, these monoclonal antibodies showed desirable properties for use in the class-specific determination, i.e., broad specificity and high sensitivity. The IC50 values of four commonly used ο,ο-diethyl OP pesticides were fairly uniform ranging from 0.1 to 0.3 ㎛/mL. The IC50 values of three ο,ο-dimethyl derivatives were between 0.3 and 1.4 ㎛/mL. These values, together with the limits of detection (LOD), were better, in terms of the specificity and sensitivity, compared with the values obtained previously with polyclonal antibodies.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2010.04a
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• pp.145-148
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• 2010

항만 구조물의 건전성 평가 기술의 개발을 위한 기초 연구로서, 강제진동해석을 통하여 케이슨 구조-지반 경계부의 손상에 대한 진동응답을 분석하고자 한다. 이를 위해 세 단계의 연구를 수행하였다. 첫째, 케이슨 구조물의 진동특성 분석을 위해 시간영역기반의 AR(auto-regressive)모델을 선정하였다. 둘째, 모형 케이슨 구조물을 대상으로 진동응답 계측실험을 수행하였으며, AR-모델을 통해 진동특징을 실험적으로 분석하였다. 셋째, 대상 케이슨 시스템의 유한요소모델을 구성하고, 구조-지반 경계부의 손상에 따른 동적응답 특성의 변화를 수치적으로 분석하였다. 이를 위해 강제진동을 모사 하였으며, 구조-지반 경계부의 강성변화에 따른 케이슨 구조물의 진동응답의 변화를 분석하였다.