Preventive effect of whole bee venom on arthritis and its mechanism: inhibition of COX-2 and iNOS expression through inactivation of NF-$\kappa$B

  • Park, Hye-Ji (College of Pharmacy, Chungbuk National University) ;
  • Kim, Su-Jin (College of Pharmacy, Chungbuk National University) ;
  • Kim, Tae-Myung (College of Pharmacy, Chungbuk National University) ;
  • Hong, Jin-Tae (College of Pharmacy, Chungbuk National University) ;
  • Ha, Seang-Jong (Department of Oriental Medicine, Graduate School of Kyungwon University) ;
  • Song, Jong-Yeol (Department of Oriental Medicine, Graduate School of Kyungwon University) ;
  • Kim, Kee-Hyun (Department of Oriental Medicine, Graduate School of Kyungwon University)
  • Published : 2003.04.01

Abstract

Bee venom (BV) has been utilized to relieve pain and to treat inflammatory diseases such as rheumatoid arthritis (RA). BV contains a variety of different peptides including melittin, apamin, adolapin and mast cell degranulating (MCD) peptide. In addition, it also contains enzyme (i.e. phospholipase A2), biologically active amines and non-peptide components. (omitted)

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