Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Sarcoidosis Induced by Adalimumab in Rheumatoid Arthritis

류마티스 관절염 환자에서 Adalimumab 사용 후 발생한 사르코이드증 1예

  • Lee, Seung-Ho (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Sa-Il (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Song, June-Seok (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Tae-Hyung (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Sohn, Jang-Won (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Sang-Heon (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Yoon, Ho-Joo (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Tae-Hwan (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Shin, Dong-Ho (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Park, Sung-Soo (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kwak, Hyun-Jung (Department of Internal Medicine, Hanyang University College of Medicine)
  • 이승호 (한양대학교 의과대학 내과학교실) ;
  • 김사일 (한양대학교 의과대학 내과학교실) ;
  • 송준석 (한양대학교 의과대학 내과학교실) ;
  • 김태형 (한양대학교 의과대학 내과학교실) ;
  • 손장원 (한양대학교 의과대학 내과학교실) ;
  • 김상헌 (한양대학교 의과대학 내과학교실) ;
  • 윤호주 (한양대학교 의과대학 내과학교실) ;
  • 김태환 (한양대학교 의과대학 내과학교실) ;
  • 신동호 (한양대학교 의과대학 내과학교실) ;
  • 박성수 (한양대학교 의과대학 내과학교실) ;
  • 곽현정 (한양대학교 의과대학 내과학교실)
  • Received : 2011.07.11
  • Accepted : 2011.08.16
  • Published : 2011.12.30
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Abstract

Adalimumab is a full human monoclonal antibody that inhibits tumor necrosis factor-alpha (TNF-${\alpha}$). This has recently been shown to be effective in the treatment of rheumatoid arthritis (RA), ankylosing spondylitis, and other conditions. Sacoidosis is known to be the target for adalimumab but we describe a patient who has developed sarcoidosis with lung involvement during adalimumab therapy for RA. A 48-year-old woman, who was treated with adalimumab for 5 months, was admitted because of chronic cough and both hilar lymphadenopathy on chest radiography. Chest computed tomography revealed the enlargement of multiple lymph nodes in the right supraclavicular, subcarinal, both hilar and right axillary area. She was diagnosed with sarcoidosis based on the biopsy of supraclavicular lymph node, skin and lung through video-associated thoracoscopic surgery, which was non-caseating epitheloid cell granuloma and excluded from a similar disease. She was treated for sarcoidosis with prednisolone and methotrexate instead of adalimumab.

Keywords

References

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