• 약학회지
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• 제49권4호
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• pp.340-346
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• 2005

To investigate the effect of Feelch on alcohol metabolism, we measured both blood alcohol concentration in human and hepatic alcohol metabolizing enzyme activity in rats. The blood alcohol concentration in Feelch-ingested group was significantly lower than that in water-ingested group at 0, 40, and 80 minute after alcohol intake. The blood alcohol concentration between male and female taken 300ml of $21\%$ alcohol showed the significant differences; the peak value of blood alcohol concentration in male and female were $0.083\pm0.014\%\;and\;0.108\pm0.018\%$, respectively. In alcohol-fed rats, aldehyde dehydrogenase (ALDH) activity was significantly increased, whereas alcohol dehydrogenase (ADH) activity was not changed. In both Feelch-fed group and Feelch plus alcohol-fed group, ADH and ALDH activity were significantly increased as compared with each control group. Feelch decreased phospholipase $A_2$ activity and lipid peroxidation in hepatic tissue and activities of serum aminotransferases as compared with control. These results suggest that Feelch may have a hepatoprotective effects and this is likely due to lower blood alcohol concentration via the increment of hepatic ADH and ALDH activity.

• 수산해양기술연구
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• 제33권4호
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• pp.275-284
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• 1997

우리 나라 남해안 연안에 부설된 소형정치망을 실험 수조의 크기 등을 고려하여 그 의 1/50의 크기로 Tauti의 어구 비교법칙에 따라 모형어구를 제작하여 유향 R(원통에서 헛통방향으로).L(헛통에서 원통방향으로)방향과 각각의 유속에 따라 그물 형상의 변화, 각 뜸의 침하량, 멍줄 장력의 변화 들을 측정, 관찰한 결과를 요약하면 다음과 같다. 1. 그물형상의 변화는 유향 R의 경우 유속 0.2m/sec에서 헛통 끝그물이 조하쪽으로 20mm, 상방으로 10mm 이동어구 전체가 바닥으로부터 부상하였고, 유속 0.6m/sec에서는 원통에서 헛통 까지 거의 일직선을 이루었다. 유향 L의 경우는, 상방으로 18mm 이동하여 어구 전체가 바닥으로부터 부상하였고, 유속 0.5m/sec이상에서는 헛통에서 원통까지 거의 일직선을 이루었다. 2. 긱 뜸의 침하량은 유향 R의 경우 머리뜸은 유속 0.2m/sec부터 서서히 침하하시 시작하여, 유속 0.3m/sec에서는 20mm 정도 침하하고, 유속 0.6m/sec에서는 99mm 정도 침하하였다. 그러나, 끝뜸은 유속 0m/sec부터 0.6m/sce까지 침하하지 않고 약간의 요동만 일으켰다. 유향 L의 경우 끝뜸은 유속 0.1m/sec에서부터 서서히 침하하기 시작하여, 0.2m/sec에서는 5mm정도 침하하였고, 0.6m/sec에서는 108mm 정도 침하하였으며, 0.5m/sec에서 머리뜸만 남기고 어구전체가 수몰되기 시작하였다. 3. 멍줄 장력의 변화는 유향 R의 경우 머리뜸 멍줄에 작용한 장력은 유속 0.1m/sec에서 273.51g이며, 0.6m/sec에서는 1298.40g 정도로 증가하였다. 유향 L의 경우 한쪽 끝뜸줄에 걸리는 장력은 유속 0.1m/sec에서 137.08g이며, 0.6m/sec에서 646.00g 정도로 증가하였다. 멍중 장력의 분포는 유속의 증대와 함게 유향 RL 향 모두 조상측 멍줄에 집중하여 나타났으며, 다른 멍줄에는 현저한 장력의 증가는 관측되지 않았다.되지 않았다.

• 분석과학
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• 제22권1호
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• pp.101-108
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• 2009

다케다약품공업주식회사의 "액토스정$^{(R)}$ 30 mg"을 대조약으로 하고 보령제약주식회사의 "염산피오글리타존정 30 mg"을 시험약으로 하여, $2{\times}2$ 교차시험법에 따라 지원자 28 명을 대상으로 생물학적동등성시험을 실시하였다. 이를 위하여 피오글리타존 30 mg을 각 지원자에게 경구 투여한 후, 0-36 시간 동안 채혈한 혈장 시료를 확보하였다. 혈장 중 피오글리타존을 분석하기 위하여, LC-MS/MS 분석법을 확립하였으며 분석결과의 신뢰성을 높이기 위하여 분석법 검증을 수행하였다. 그 결과, 5-2000 ng/mL의 농도범위에서 우수한 직선성을 나타내었으며, 생물학적동등성시험에 이용될 수 있는 충분한 감도와 특이성, 정밀성 및 정확성을 확인하였다. 각 피험자들의 혈중 약물농도 데이터로부터 구한 혈중약물농도-시간곡선하면적($AUC_t$)과 최고혈중농도($C_{max}$) 등의 약물속도론적 파라미터에 대해 통계학적으로 고찰한 결과, 판정기준을 만족 시켰으며, 따라서 두 제제는 생물학적으로 동등한 것으로 평가하였다.

• 대한화학회지
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• 제44권2호
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• pp.102-108
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• 2000

고속액체크로마트그래피에서 RAH분자들이 상대적 용리시간을 다변량선형회귀분석과 인공신경망분석방법을 사용하여 학습시킨 후, 시험 세트의 상대적 용리시간을 예측하였다. PAH의 QSRR에서 주요한 설명인자는 분자연결지수($^1X_v,\;^2X_v$),길이와 폭의 비율(L/B) 및 분자 쌍극자 모멘트(D)이었다, 슬롯 모델과 관계깊은 L/B은 인공신경망분석방법에서는 적절한 설명인자로 작용하나, 다변량회귀분석에서는 그러하지 못하다. 시험세트에서 용리시간 예측도를 나타내주는 분산은 각각 인공신경망분석방법에서 0.0099, 다변량회귀분석방법에서 0.0114이었다. 인공신경망분석방법이 다변량회귀분석보다 더 좋은 결과를 보여준다.

• 성인간호학회지
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• 제24권2호
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• pp.99-108
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• 2012

Purpose: The study was done to identify factors influencing the quality of life of elderly in non-paid or paid assisted living facilities. Methods: Data were collected by questionnaires from 634 elderly in Seoul and Gyeonggi province. Measures were self-esteem, activities of daily living, depression, family support, health status, facility adaptation, care facility's quality, and quality of life. Data were analyzed using $x^2$-test, independent t-test, ANCOVA, Pearson correlation coefficients, and stepwise multiple regression with SPSS/WIN 15.0 version. Results: The significant factors influencing quality of life of elderly in non-paid assisted living facilities were care facility's quality, depression, self-esteem, family support, education, and activity of daily living, which explained about 40.4% of the variance. The significant factors influencing quality of life of elderly in paid assisted living facilities were activity of daily living, depression, family support, education, care facility's quality, and facility adaptation, which explained about 83.9% of the variance. Conclusion: The results suggest that type of assisted living facilities in developing nursing interventions to improve quality of life of elderly should be considered.

• 지역사회간호학회지
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• 제20권3호
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• pp.296-306
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• 2009

Purpose: This study was to identify variables influencing health risk behaviors in adolescents on the basis of the PRECEDE model. Methods: Data were collected from 434 middle school students in Chungbuk Province for two weeks in July 2008. The instrument for this study was a self-reported questionnaire. The SPSS/WIN 12.0 program was used for data analysis, which included t-test, one way ANOVA, Scheffe's test, Pearson's correlation coefficients, and stepwise multiple regression analysis. Results: Adolescents' level of health risk behaviors ($47.32{\pm}7.98$) was below medium. Physical inactivity ($6.73{\pm}2.23$) and Internet addictive behavior ($6.36{\pm}2.11$) were major health risk behaviors. The perceived level of school health education ($30.74{\pm}9.84$) was low. Family function and general self efficacy explained 14.3% of variance in health risk behaviors. Family function was a major predictor of health risk behaviors ($R^2$=.108, p=.000). However, the perceived level of school health education was not a significant predictor of health risk behaviors. Conclusion: For the prevention of health risk behaviors in adolescents, it is necessary that the family and the school collaborate with each other in educational strategies in order to strengthen influential factors such as family function and general self-efficacy.

• 한국물환경학회지
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• 제39권2호
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• pp.131-141
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• 2023

In this study, the relationship between organic carbon distribution characteristics and decomposition rate classified according to the particle size and biological degradation characteristics in water was investigated for the Nam river and Geumho river. The average concentrations of TOC in the Nam river and Geumho river were 2.7±1.2 mg/L and 5.0±1.2 mg/L, respectively, but the composition ratios for each type of organic carbon were similar. An average value of 80.9% of TOC was present as DOC and 72.8% of DOC consisted of Refractory-DOC (RDOC). In addition, the change in the RDOC composition ratio according to temporal and spatial distribution was the smallest. There was no difference in the decomposition rate of organic carbon except for TOC by the site (p≥0.108, one-way ANOVA), and the decomposition rates of Labile-POC (LPOC) and LDOC were similar at 0.139±0.102 and 0.137±0.149 day^-1, respectively (p=0.110, paired t-test). The coefficient of variation (CV) of the decomposition rate of DOC (average 8.1%), which had the smallest composition ratio of organic carbon, was 1.1, showing the largest temporal variation. The TOC, POC, and DOC decomposition rates showed a significant correlation with the ratio of the initial concentration to the concentration after 25 days of decomposition (OC₂₅/OC₀) (r²=0.89~0.94, p<0.001), and the decomposition rates of LPOC and LDOC were significantly correlated with the ratio of the initial concentration to the concentration after 5 days of decomposition (LOC₅/LOC₀) (r²=0.67~0.75). This suggests that it is possible to estimate the decomposition rate through the concentration of each type of organic carbon.

• 한국수산과학회지
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• 제34권4호
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• pp.299-308
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• 2001

1998년 1월 7일부터 1998년 12월 6일까지 총 333일간 경북 포항시 구룡포읍 장길리 연안에서 채묘 후 1년이 경과한 체고 $10.1\~15.8mm$ 사이의 새끼 우렁쉥이 Halocynthia roretzi (von Drasche)를 대상으로 수층별, 수하연 시설 간격별 및 종묘생산지별의 성장에 관하여 시험한 결과를 요약하면 다음과 같다. 1. 수온은 $12.07{\sim}24.14^{\circ}C$의 분포 범위로 7월의 2m층이 가장 높았고, 염분은 $32.53{\sim}33.73\%_{\circ}$의 분포 범위로 7, 8월이 낮고, 10, 11월이 높았으며, 용존산소는 $6.60{\sim}9.77mg/L$의 분포 범위로 $4\~5$월이 높고, 7월이 낮았으며, 그 외 환경도 우렁쉥이 성장에 영향을 미치는 사항은 발견할 수 없었다. 2. 종묘생산지별 월별 체고 성장은 양식 시작시 체고가 남해안산이 15.81 mm, 동해안산 10.12mm, 일본산 15.34mm인 것이 11월에는 각각 74.64mm ($\pm7.19mm$), 72.80 mm ($\pm11.67mm$), 73.90mm ($\pm5.71mm$)로 성장하여 종묘에 따른 체고 성장에 대한 통계적인 차이는 없었으며, 이들 각각에 대한 성장식은 다음과 같이 회귀직선식으로 표시할 수 있었다. 남해안산 $$TH=5.8996D+13.43\;(R^2=0.9133)$$ 동해안산 $$TH=6.1560D+5.3362\;(R^2=0.9852)$$ 일본산 $TH=6.0739D+11.743\;(R^2=0.9053)$$ 또한 체고 (TH)에 대한 체중 (TOW)의 성장식은 다음과 같이 지수곡선식으로 표시되었다. 남해안산 $$TOW=0.0008TH^{2.6042}\;(R^2=0.9567)$$ 동해안산 $$TOW=0.0005TH^{2.7284}\;(R^2=0.9638)$$ 일 본 산 $4TOW=0.001TH^{2.5677}\;(R^2=0.9666)$$ 3. 수하연 시설 간격별 체고 성장은 2.5m와 2.0m가 서로 유사한 성장을 보이면서 1.5m나 1.0m 시설구보다 높았고, 체고의 일간 성장율은 2.5m, 2.0m, 1.5 m, 1.0m 순위였으나 통계적인 차이는 없었다. 체중의 일간 성장율은 2.5m 시설구가 다른 시설구에 비해 높았다. 4. 수층별 성장은 $10\~12m$ 수층에서 성장이 가장 양호하였고, 다음이 $14\~16m$수층과 $6\~8m$수층으로 이들 두 수층간에는 유사한 성장을 보였고, $2\~4m$ 수층이 가장 낮은 성장을 보였다. 특히 $10\~12m$ 수층에서 체고의 성장률은 성장기 II와 IV구간에서 각각 $244{\mu}m/day$ 및 $338{\mu}m/day$로 비교적 높았고, I구간에서는 $108{\mu}m/day$로 가장 낮았다.

• 한국응급구조학회지
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• 제13권2호
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• pp.99-108
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• 2009

Purpose : The purpose of this study is to offer basic data in arranging the improved working environment to Emergency Medical Technicians, by analyzing the influence of job satisfaction in Emergency Medical Technician within hospital upon organizational commitment. Method : This study was carried out targeting 203 Emergency Medical Technicians who are working at hospitals in B Metropolitan City, U Metropolitan City, D Metropolitan City, an d G Province. The data collection was performed from April 1, 2009 to June 10. The statistical processing was used a program of SPSS WIN 12.0 Version. The statistical significance was set to p<.05. Results : 1. In the descriptive statistics of the job satisfaction and the organizational commitment. the whole average for job satisfaction was 3.06 points. The whole average for organizational commitment was 3.05 points. 2. In the difference between job satisfaction and organizational commitment, the group for job satisfaction was indicated to be statistically significant in job-choice motive(F=2.710, p<.05) and turnover propensity(t=.662, p<.001). The group for organizational commitment was indicated to be statistically significant in working department(F=2.871, p<.05), job-choice motive(F=2.944, p<.05), turnover propensity(t=.903, p<.001), and turnover reason(F=3.415, p<.01). 3. In the correlation between job satisfaction and organizational commitment, the job satisfaction showed positive correlation(r=.736, p<.01) with organizational commitment. 4. As for the influence of job-satisfaction factor upon organizational commitment, salary(${\beta}$=.162, t=2.739, p<.01), autonomy(${\beta}$=.372, t=4.633, p<.001), working environment(${\beta}$=.139, t=1.968, p<.05), and organizational needs(${\beta}$=.172, t=2.291, p<.05) were indicated to have significant effect on organizational commitment. Conclusion : The institutional arrangement is considered to be likely to be necessarily made highly for improving social image and enhancing salary and working environment so that Emergency Medical Technician within hospital can be enhanced job satisfaction and organizational commitment.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1737-1740
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• 2005

As the various manufacturing technology of optical glass is developed, the aspherical lenses are applied to many fields. However, It is still very difficult to manufacture glass lens because of the high cost and the short life of core. In recent years, the demands of the aspherical glass lenses increase since it is difficult to obtain the desirable performance in the plastic lens. In the glass mold lens, it has merits of high productivity and reproductivity since lens is manufactured by the only forming with high precision mold. The fabricating conditions for glass mold lens are glass surface that does not cause fusion, viscosity of 108-1013 poise for the $0.2{\mu}m$ accuracy, and viscoelasticity for the roughness less than 100 angstrom. In this thesis, ultra-precision grinding characteristics of tungsten carbide for forming the aspherical glass lens core were studied and the result of it is applied to manufacture the tungsten carbide-base core of the glass lens used to the laser scanning unit and the camera phone.