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Effect of Feelch on Blood Alcohol Concentration in Human and Hepatic Alcohol Metabolizing Enzyme Activity in Alcohol-Fed Rats  

Lee O Mi (Department of R&D Center, Tae Young E&T Co. Ltd.)
Ye Choong Min (Department of R&D Center, Tae Young E&T Co. Ltd.)
Choi Byung Chul (College of Pharmacy, Chung-Ang University)
Lee Ji Yun (College of Pharmacy, Chung-Ang University)
Kang Hye Jeong (College of Pharmacy, Chung-Ang University)
Choi Yun Kyoung (College of Pharmacy, Chung-Ang University)
Kim Chang Jong (College of Pharmacy, Chung-Ang University)
Sim Sang Soo (College of Pharmacy, Chung-Ang University)
Publication Information
YAKHAK HOEJI / v.49, no.4, 2005 , pp. 340-346 More about this Journal
Abstract
To investigate the effect of Feelch on alcohol metabolism, we measured both blood alcohol concentration in human and hepatic alcohol metabolizing enzyme activity in rats. The blood alcohol concentration in Feelch-ingested group was significantly lower than that in water-ingested group at 0, 40, and 80 minute after alcohol intake. The blood alcohol concentration between male and female taken 300ml of $21\%$ alcohol showed the significant differences; the peak value of blood alcohol concentration in male and female were $0.083\pm0.014\%\;and\;0.108\pm0.018\%$, respectively. In alcohol-fed rats, aldehyde dehydrogenase (ALDH) activity was significantly increased, whereas alcohol dehydrogenase (ADH) activity was not changed. In both Feelch-fed group and Feelch plus alcohol-fed group, ADH and ALDH activity were significantly increased as compared with each control group. Feelch decreased phospholipase $A_2$ activity and lipid peroxidation in hepatic tissue and activities of serum aminotransferases as compared with control. These results suggest that Feelch may have a hepatoprotective effects and this is likely due to lower blood alcohol concentration via the increment of hepatic ADH and ALDH activity.
Keywords
Feelch; alcohol; ADH; ALDH; liver;
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