• Journal of Korean Association for Spatial Structures
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• v.10 no.2
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• pp.105-115
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• 2010

Recently, High-rise building are irregular-shaped to be city landmarks and function as vertical cities to enable the efficient use of land. 3T (Twisted, Tilted & Tapered) designs are being suggested for irregular buildings and studies to develop new structural system have been actively made to satisfy slender shape ratio. In diagrid system, not only gravity load but also lateral load is delivered based on the triangular shape of diagrid, so most of columns are eliminated. Because shearing force is delivered by the axial behavior (tensile/compressive) of diagrid to minimize shearing deformation, the system is more applicable to irregular buildings than existing system where shearing force is delivered by the columns. In this study, the process of selecting connection details and the structural safety of the selected details are verified using the finite element analysis with focus given to the construction overview of the Cyclone Tower. However, the relersed methods of stress concentration are suggested and the performance of stress concentration relieves that it's suggested for the appropriate cap plate thickness and extended length.

• Journal of Periodontal and Implant Science
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• v.26 no.1
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• pp.216-229
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• 1996

Interferon(IFN) is a sort of glycoproteins that are produced by activated lymphocyte, monocyte and fibroblast. IFN has anti-viral effects, immuno-defensive mechanism and regulating properties to the several kinds of cells that includes affect on the bone formation and resorption. The effect of IFN on the osteoclast & other tissue cells has been studied in a number of researchers with the limited reports on the osteoblast. The purpose of this study was to evaluate the effects of IFN on the osteoblastic function. The MC3T3/El cell(Mouse osteoblast) was incubated in ${\alpha}-minimum$ essential medium containing 10% FBS. To detect the cytotoxic effect of $IFN-{\gamma}$ on osteoblast, the cells were cultured in 96-well plate to which $IFN-{\gamma}$ of various concentrations were added for 2 days. After staining with trypan blue, total cells and living cells were counted under microscope. To determine the activity of alkaline phosphataset(ALP), various concentrations of $IFN-{\gamma}$ were treated to culture medium, and biochemical assay was performed. $IFN-{\gamma}$ and $IFN-{\gamma}$ plus cycloheximide were added to culture medium separately and then ALP activity were determined. To detect the effect of the $IFN-{\gamma}$ on the bone formation of osteoblast, long-term culture was performed, and calcified nodule formation were observed using von Kossa's staining. After the addition of $IFN-{\gamma}$ with various concentrations to the medium, no cytotoxic effect of $IFN-{\gamma}$ was detected at any concentration. The significant increase in ALP activity of osteoblast were found the concentration of $IFN-{\gamma}$ 500-2500U/ml and the culture time of 24-48 hours respectively. The enhancement of ALP activity by $IFN-{\gamma}$ of osteoblast was decreased significantly by the treatment of cycloheximide. After long-term culture of osteoblast, the nodule formation was found to be increased in number and density by the addition of 500 U/ml $IFN-{\gamma}$. These results suggest that $IFN-{\gamma}$ was affected on the bone formation of osteoblast. Forthemore this kind of study or $IFN-{\gamma}$ to osteoblast will be held continuously.

• KSBB Journal
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• v.21 no.3
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• pp.224-229
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• 2006

FEMLAB is a powerful interactive environment for modeling, solving all kinds of scientific and engineering problems based on partial differential equations(PDEs). Separation process of chiral compound in HPLC columns was simulated by FEMLAB. To study change of elution profile with isotherm models, non-competitive and competitive Langmuir adsorption isotherm were adopted. Separated material was (R, S)-ibuprofen [(R, S)-2-(4-isobutyl phenyl) propionic acid], an anti-inflammatory agent, which retain the pharmacological activity in the (S)-(+)-enantiomer. Sample concentrations were changed from 0.5 mg/ml to 2.0 mg/ml at a flow rate of 1 ml/min and flow rate varied from 1 ml/min to 3 ml/min at an ibuprofen concentration of 2.0 mg/ml and $20{\mu}l$ of injection volume. Simulated results were well fitted with experimental data.

• Experimental and Molecular Medicine
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• v.50 no.11
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• pp.3.1-3.11
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• 2018

This study aimed to verify the effects of estrogen on the onset and development of adolescent idiopathic scoliosis and the mechanisms associated with these effects by constructing a pubescent bipedal rat model. Experiments were conducted to investigate whether scoliosis progression was prevented by a Triptorelin treatment. One hundred twenty bipedal rats were divided into female, OVX (ovariectomy), OVX + E2, Triptorelin, sham, and male groups. According to a spinal radiographic analysis, the scoliosis rates and curve severity of the female and OVX + E2 groups were higher than those in the OVX, Triptorelin, and male groups. The measurements obtained from the sagittal plane of thoracic vertebrae CT confirmed a relatively slower growth of the anterior elements and a faster growth of the posterior elements between T11 and T13 in the female and OVX + E2 groups than in the OVX and Triptorelin groups. Histomorphometry and immunohistochemistry revealed a significantly longer hypertrophic zone of the vertebral cartilage growth plates that expressed more type X collagen and less type II collagen in the OVX and Triptorelin groups than in the female and OVX + E2 groups. Ki67 immunostaining confirmed an increase in the proliferation of vertebral growth plate chondrocytes in the OVX group compared with the female and OVX + E2 groups. In conclusion, estrogen obviously increased the incidence of scoliosis and curve severity in pubescent bipedal rats. The underlying mechanism may be a loss of coupling of the endochondral ossification between the anterior and posterior columns. Triptorelin decreased the incidence of scoliosis and curve magnitudes in bipedal female rats.

• Journal of Environmental Impact Assessment
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• v.27 no.6
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• pp.595-603
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• 2018

This study was conducted to understand the growth of attached microbial community in small and medium streams of Gyeonggi-do and the removal efficiency of fluoride with changes in growth. The sites monitoring were carried out for 12 weeks at the P1 and P2(P1 is the point where the discharge water flows. P2 is the downstream point of about 2 km flow), and investigated the water quality and the biomass analysis of the attached microbial community. The growth of the attached microbial community increased up to the 7th investigation, and it was observed that detachment phenomenon occurred. Influencing factors about growth of the attached microbial community were flow rate, velocity, and organic material(T-N & T-P). Meanwhile, fluoride content of attached microbial community also tended to increase until the 7th investigation, and decrease from the 8th. It is assumed that fluoride content has also be reduced with the detachment phenomenon of the attached microbial community. It is expected that this will contribute to the evaluation and management of the use of attached microbial community as a means of stream management. The application of techniques using the attached microbial community should include basic investigation of factors that may affect the growth of the attached microbial community and replacement of the attachment plate according to the time of removal.

• Journal of the Korea institute for structural maintenance and inspection
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• v.24 no.5
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• pp.111-118
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• 2020

The U-shaped composite beam used in this study consist of a reinforced concrete structure, a beam steel structure supporting the slab, a reinforced concrete structure, and a U-shaped steel plate. The U-shaped composite beam was developed for the purpose of using it as a parking lot because it is highly constructible and has low floor height and long span. For the improvement of constructivity, the U-shaped composite beam ends are planned with standardized H-shaped steel and connected directly to the columns, and the middle of the U-shaped composite beam consists of U-shaped steel plates folded in U-shaped form using thin steel plates (t=6) instead of H-shaped steel. In the middle of the composite beam, where U-shaped steel plates are located, the depth of U-shaped beam may be planned to be small so as to satisfy the height limit of the parking lot. It is important to grasp the structural performance according to the change of depth because low beam depth is advantageous for the reduction of the floor height, but it is a inhibitor to the structural behaviors of U-shaped composite beam. In addition, since U-shaped composite beams are a mixture of steel frame structures, reinforced concrete structures and U-shaped steel plates, securing unity has a great influence on securing structural performance. Therefore, in this study, a structural experiment was conducted to understand the structural performance according to the depth change for U-shaped composite beam. A total of three specimens were planned, including two specimens that changed the depth using a criteria specimen planned for a general parking lot. The results of the experiment showed that the specimens who planned the depth greatly had better structural performance such as yield strength, maximum strength, and energy than the standard specimen.

• Proceedings of the Mineralogical Society of Korea Conference
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• 2001.06a
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• pp.95-95
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• 2001

The Yeongdong basin is one of the pull-apart basins in the southwestern part of the Korean Peninsula that has developed during Cretaceous sinistal fault movement. The bimodal igneous activities (basalts and rhyolites) in the basin appear to be closely associated with the basin development. Here, we discuss the origin of the igneous rocks using chemical and radiogenic isotope data. Basaltic (48.4-52.7 wt% SiO$_2$) and rhyolitic (70.3-70.8 wt% SiO$_2$) rocks are slightly alkalic in a total alkali-silica diagram. The rhyolitic rocks with have unusually high K$_2$O contents (5.2-6.0 wt%). The basaltic rocks show an overall pattern of within-plate basalt in a MORB-normalized spider diagram, but have distinct negative anomaly of Nb, which indicates a significant amount of crustal component in the magma. The basaltic rocks plot within the calc-alkaline basalt field in the Hf/3-Th-Ta and Y/l5-La/10-Nb/8 discrimination diagrams. The eNd(T) values of the basaltic rocks (-13.6 to 14.3) are slightly higher than those of the rhyolitic rocks (-14.1 to 15.2), and the initial Sr isotopic ratios of the former (0.7085-0.7093) are much lower than those of the latter (0.7140-0.7149). However, the initial Nd and Sr isotope ratios of the igneous rocks in the Yeongdong basin are similar to those of the nearby Cretaceous igneous rocks in the Okcheon belt. The Pb isotope ratios plot within the field of Mesozoic granitoids outside of the Gyeongsang basin in Pb-Pb correlation diagrams. Since a basaltic magma requires the mantle source, the enriched isotopic signatures and negative Nb anomaly of the basaltic rocks suggest two possibilities for their origin: enriched mantle lithospheric source, or depleted mantle source with significant amount of crustal contamination. However, we prefer the first possibility since it would be difficult for a basaltic magma to maintain its bulk composition when it is significantly contaminated with granitic crustal material. The slightly more enriched isotopic signatures of rhyolitic rocks also suggest two possibilities: differentiate of the basaltlc magma with some crustal contamination, or direct partial melting of the lower crust. Much larger exposed volume of the rhyolitic rocks, compared with the basaltic rocks, indicates the latter possibility more favorable.

• Geophysics and Geophysical Exploration
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• v.27 no.2
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• pp.119-128
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• 2024

Marine magnetic surveys provide a rapid and cost-effective method for pioneer geophysical survey for many purposes. Sea-surface magnetometers offer high accuracy but are limited to measuring the scalar total magnetic field and require dedicated cruise missions. Shipboard three-component magnetometers, on the other hand, can collect vector three components and applicable to any cruise missions. However, correcting for the ship's magnetic field, particularly viscous magnetization, still remains a challenge. This study proposes a new additional correction method for ship's viscous magnetization effect in vector data acquired by shipboard three-component magnetometer. This method utilizes magnetic data collected simultaneously with a sea-surface magnetometer providing total magnetic field measurements. Our method significantly reduces deviations between the two datasets, resulting in corrected vector anomalies with errors as low as 7-25 nT. These tiny errors are possibly caused by the vector magnetic anomaly and its related viscous magnetization. This method is expected to significantly improve the accuracy of shipborne magnetic surveys by providing corrected vector components. This will enhance magnetic interpretations and might be useful for understanding plate tectonics, geological structures, hydrothermal deposits, and more.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.40 no.3
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• pp.206-213
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• 2004

As far as an opening device of fishing gears is concerned, applications of a kite are under development around the world. The typical examples are found in the opening device of the stow net on anchor and the buoyancy material of the trawl. While the stow net on anchor has proved its capability for the past 20 years, the trawl has not been wildly used since it has been first introduced for the commercial use only without sufficient studies and thus has revealed many drawbacks. Therefore, the fundamental hydrodynamics of the kite itself need to ne studied further. Models of plate and canvas kite were deployed in the circulating water tank for the mechanical test. For this situation lift and drag tests were performed considering a change in the shape of objects, which resulted in a different aspect ratio of rectangle and trapezoid. The results obtained from the above approaches are summarized as follows, where aspect ratio, attack angle, lift coefficient and maximum lift coefficient are denoted as A, B, $C_L$ and $C_{Lmax}$ respectively : 1. Given the triangular plate, $C_{Lmax}$ was produced as 1.26${\sim}$1.32 with A${\leq}$1 and 38$^{\circ}$B${\leq}$42$^{\circ}$. And when A${\geq}$1.5 and 20$^{\circ}$${\leq}$B${\leq}$50$^{\circ}$, $C_L$ was around 0.85. Given the inverted triangular plate, $C_{Lmax}$ was 1.46${\sim}$1.56 with A${\leq}$1 and 36$^{\circ}$B${\leq}$38$^{\circ}$. And When A${\geq}$1.5 and 22$^{\circ}$B${\leq}$26$^{\circ}$, $C_{Lmax}$ was 1.05${\sim}$1.21. Given the triangular kite, $C_{Lmax}$ was produced as 1.67${\sim}$1.77 with A${\leq}$1 and 46$^{\circ}$B${\leq}$48$^{\circ}$. And when A${\geq}$1.5 and 20$^{\circ}$B${\leq}$50$^{\circ}$, $C_L$ was around 1.10. Given the inverted triangular kite, $C_{Lmax}$ was 1.44${\sim}$1.68 with A${\leq}$1 and 28$^{\circ}$B${\leq}$32$^{\circ}$. And when A${\geq}$1.5 and 18$^{\circ}$B${\leq}$24$^{\circ}$, $C_{Lmax}$ was 1.03${\sim}$1.18. 2. For a model with A=1/2, an increase in B caused an increase in $C_L$ until $C_L$ has reached the maximum. Then there was a tendency of a very gradual decrease or no change in the value of $C_L$. For a model with A=2/3, the tendency of $C_L$ was similar to the case of a model with A=1/2. For a model with A=1, an increase in B caused an increase in $C_L$ until $C_L$ has reached the maximum. And the tendency of $C_L$ didn't change dramatically. For a model with A=1.5, the tendency of $C_L$ as a function of B was changed very small as 0.75${\sim}$1.22 with 20$^{\circ}$B${\leq}$50$^{\circ}$. For a model with A=2, the tendency of $C_L$ as a function of B was almost the same in the triangular model. There was no considerable change in the models with 20$^{\circ}$B${\leq}$50$^{\circ}$. 3. The inverted model's $C_L$ as a function of increase of B reached the maximum rapidly, then decreased gradually compared to the non-inverted models. Others were decreased dramatically. 4. The action point of dynamic pressure in accordance with the attack angle was close to the rear area of the model with small attack angle, and with large attack angle, the action point was close to the front part of the model. 5. There was camber vertex in the position in which the fluid pressure was generated, and the triangular canvas had large value of camber vertex when the aspect ratio was high, while the inverted triangular canvas was versa. 6. All canvas kite had larger camber ratio when the aspect ratio was high, and the triangular canvas had larger one when the attack angle was high, while the inverted triangluar canvas was versa.

• The Korean Journal of Nuclear Medicine
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• v.38 no.1
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• pp.74-84
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• 2004

Purpose: Since I-125 emits low energy (27-35 keV) radiation, thinner crystal and collimator could be employed and, hence, it is favorable to obtain high quality images. The purpose of this study was to derive the optimized parameters of I-125 SPECT using a new simulation tool, GATE (Geant4 Application for Tomographic Emission). Materials and Methods: To validate the simulation method, gamma camera developed by Weisenberger et al. was modeled. Nal(T1) plate crystal was used and its thickness was determined by calculating detection efficiency. Spatial resolution and sensitivity curves were estimated by changing variable parameters for parallel-hole and pinhole collimator. Peformances of I-125 SPECT equipped with the optimal collimator were also estimated. Results: in the validation study, simulations were found to agree well with experimental measurements in spatial resolution (4%) and sensitivity (3%). In order to acquire 98% gamma ray detection efficiency, Nal(T1) thickness was determined to be 1 mm. Hole diameter (mm), length (mm) and shape were chosen to be 0.2:5:square and 0.5:10:hexagonal for high resolution (HR) and general purpose (GP) parallel-hole collimator, respectively. Hole diameter, channel height and acceptance angle of pinhole (PH) collimator were determined to be 0.25 mm, 0.1 mm and 90 degree. The spatial resolutions of reconstructed image of the I-125 SPECT employing HR:GP:PH were 1.2:1.7:0.8 mm. The sensitivities of HR:GP:PH were 39.7:71.9:5.5 cps/MBq. Conclusion: The optimal crystal and collimator parameters for I-125 Imaging were derived by simulation using GATE. The results indicate that excellent resolution and sensitivity imaging is feasible using I-125 SPECT.