• Journal of Pharmaceutical Investigation
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• v.29 no.3
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• pp.179-184
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• 1999

Phannacokinetics of epigallocatechin gallate(EGCG) was studied following i.v. bolus and oral administration in rats. The values of systemic clearance(CL) were $67.9{\pm}5.2$ and $26.5{\pm}1.4\;ml/min/kg$ following i.v. bolus administration of 1 mg and 5 mg EGCG, respectively. The values of volume of distribution at steady state (Vss) were $380{\pm}56$ and $835{\pm}84\;ml/kg$ after i.v. bolus administration of 1 mg and 5 mg EGCG, respectively. The decrease in the value of CL and the increase in the value of $V_{ss}$ as a function of EGCG dose (1 mg to 5 mg) suggest saturable mechanism(s) responsible for the distribution and elimination of EGCG. The fraction absorbed of EGCG after oral and intraduodenal administration of GTC were 13% and 22% of the dose, respectively. This result suggests a considerable degradation or elimination of EGCG in the gastrointestinal absorption after oral administration in rats.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.5 no.2
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• pp.1-8
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• 2002

The aim of this study was to generate systemic data for the aquatic plant distribution according to water depth and crossing slope in the shoreline. The results of this study were as follows; 1. Anxiety to 0 near area Bidens frondosa, Scirpus tabernaemontani, Carex dispalata etc. total class 21 observe, and Phragmites communis, Iris pseudoacorus etc. class 6 of anxiety 0-70cm extent examined. Class 21 of anxiety observed all such as Bidens frondosa, Scirpus tabernaemontani, Carex dispalata in near area to 0, and Phragmites communis, Iris pseudoacorus etc. class 6 of anxiety 0-70cm extent examined. Anxiety 70-100cm extent Nymphoides indica, Ttapa japonica etc.. class 2 appeared to line Zizania latifolia, Typha angustata back 2 papers, 130cm and examined that Nelumbo nucifera was limit anxiety state 230cm. 2. Aquatic plants of Phragmites communis, Zizania latifolia, Typha angustata etc. range mainly to gentle gradient of slant 10 degree low and distribution pattern was ranging by Zizania latifolia, Typha angustata, Phragmites communis period of ten days from deepwater place. Nelumbo nucifera was forming become independent stock keeping away invasion of plant that ability to breed was different because was prosperous. Slant 10 bores was growing near sleep in been strange steep slope earth and distribution of emerged plant appeared punily and emerged plant and swampy land plant were ranged extensively in gentle gradient of 10 degree low. 3. On lake surrounding plant when wish to do distribution of natural conditions reference need to. That is, gentle gradient and distribution form of steep slope earth are different, and same pitch must consider enough this because appear as distribution, distribution according to that some plant species were growing was different.

• Korean Journal of Veterinary Research
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• v.12 no.2
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• pp.165-175
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• 1972

The frequency distribution and morphological characteristics of tissue mast cells in the various tissues of normal domestic animals (bovine, swine, dog and chicken) and systematically infected (Hog cholera, Canine distemper and Newcastle disease) animals were studied. The results were as follows: 1 In cattle, density of mast cells was higher in foetus (bovine) and young animals than in adults Differences in frequency distribution among individual animals were also observed. 2. In chicken, the highest number of mast cells was found in age group of 15 to 40 days, the moderate number in age group of one to 10 days, and the lowest number in age group of 40 days or older. 3. The morphologically, mast cells were usually round, ovoid, spindle, oval and irregular, and particularly in ovary of bovine, it was usually round and ovoid forms. 4. The largest numbers of mast cells were shown in ovary of bovine, intestine of swine and dog, and proventriculum of chicken. 5. In the systemic infections, the number of mart cells usually tends to increase.

• Journal of Distribution Science
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• v.13 no.1
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• pp.19-25
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• 2015

Purpose - This study aims to explore students'perceptions of different quality aspects in Indian higher education, viz. tangible facilities, competence, attitudes, content, delivery, and reliability. Research design, data, and methodology - Following a comprehensive literature review, the researchers used a well-structured questionnaire and in-depth personal interviews with 500 students. The selected sample was chosen from graduate and postgraduate programs in the south Indian state of Andhra Pradesh, using convenience sampling; data were analyzed using Microsoft Excel and frequency distribution. Hypotheses were based on the literature and empirical studies. Result - 50.28 and 49.88 percent of students were positive towards tangible facilities and competence, respectively. Further, 48.92 percent and 48.97 percent were negative towards faculty attitudes and course content, respectively. Finally, 48.72 percent reacted positively on the overall quality, while 51.28 were discontented. Conclusion - This study provides reliable and conclusive information to all stakeholders, facilitating systemic improvements. It reveals students'perceptions of different quality aspects of the higher education system, and is the first study of its kind in this part of the world.

• Land and Housing Review
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• v.11 no.4
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• pp.67-74
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• 2020

Despite its ecological importance of wetlands in our life, wetlands around cities and villages have been steadily disappearing. It is mainly due to either natural geological changes or man-made causes such as permitted land zone changes for the purpose to convert to agriculture land. This study aims to establish a comprehensive database of wetlands using GIS in a historic conservation city Gongju City. The systemic data management would enable to identify distribution of wetlands and their ecological attributes, and to estimate the conservation value of the wetlands. The data base will be able to use in strategic way to preserve the local ecological areas for local residents and tourists and manage the quality of wetlands in the historic and conservation city. For the purpose, it is suggested organising a wider network with not only local residents but local authorities and relevant stakeholders would be beneficial. This study also recommends that long-term strategic plan to preserve the existing wetlands. This study findings as a seminal case example can be used to apply to other geographical areas of the country and can contribute to create a national ecological nature map as well as evaluate the attributes and quality of natural ecosystem service of the region.

• The Journal of Pediatrics of Korean Medicine
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• v.16 no.2
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• pp.143-161
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• 2002

We proceeded the judgement of Sasang constitution of 79 children(the age 101 between 15) who have visited Dongguk Bundang Oriental Medical Hospital during 3 months from August 2002 to October 2002 by Questionnaire of Sasang Constitution Classification and conducted questionnaire survey about the type of disease and symptom occurred frequently. The conclusion is following. 1. The distribution of Sasang constitution: Soeum group(少陰人) 32, Taeeuml group(太陰人) 29, Soyang group(少陽人) 18. 2. The distribution of systemic disease occurred frequently : in digestive system, Soeum (46.9%) & Soyang(44.4%) group more than Taeeum group(34.5%) and in genitourinary system and others, Soeum(28.1%) more than Taeeum group(17.2%). 3. The distribution of symptom occurred frequently : in rhinitis and sinusitis, Taeeum(60.0%) & Soeum(60.0%) more than Soyang(45.5%), in abdominal pain, Soeum(58.8%) & Soyang(62.5%) more than Taeeum(36.4%), and in diarrhea, Taeeum(45.5%) more than Soeum(123.5%) & Soyang group(25.0%). Headache & vexation(心煩) are almost found in Soeum group with abdominal pain and excessive sweating is only found in Taeeum group. 4. The efficacy of herbal medication combined with Cervix Cornu Pranum (鹿茸加味劑) : after the medication, change of condition have showed in Taeeum group at the most high rate(31.0%) and showed in Soeum(15.6%) and Soyang(11.1%) group. 5. The distribution of allergic disease: allergic rhinitis and atopic dermatitis took up the majority of all allergic diseases. In morbidity of allergic rhinitis, Taeeum(62.1%) & Soyang(55.6%) more than Soeum(37.5%). In morbidity of other allergic diseases and degree of severity, it has no difference among three Sasang constitution groups.

• Radiation Oncology Journal
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• v.12 no.3
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• pp.295-300
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• 1994

It was the purpose of present study to develop a new thermoseed for heating deep-seated tumors and assessment of the effect of magnetic control on thermoseeds. Aqueous suspension of iron micro spheres (Ferropolysaccharide) was injected directly into the VX-2 hepatoma and heated with 1.2 MHz inductive radiofrequency unit. Aqueous thermoseed suspension was delivered to the tumor by simple percutaneous injection. The limitation of the thermoseed heating method is the positional change of thermoseed particles in the tumor after implantation. The thermoseed particles could enter the systemic blood circulation and cause a severe embolization of a critical organ. To minimize this limitation, we have used the magnetic control after loading the thermoseed in the tumor, W hen ferropolysaccharides were exposed to a strong magnetic field, they magnetized and subsequently exerted a magnetic force on each other, forming larger aggregates of particles. The size of aggregated Particles were too big to enter the systemic blood circulation. Thus, unlike other thermoseed method, we hold the thermoseed particles stationary in the tumor. The temperature of the injected site and immediate vicinity elevated by $4-5^{\circ}C$. The temperature of the surrounding normal hepatic tissue elevated by $1-2^{circ}C$ only. The heating effect within the tumor was variable depending on the density of ferromagnetic aqueous suspension. Our results suggest that inductive heating of tumor injected with ferropolysaccharide solution offers the possibility of effective heat delivery to the defined tumor volume, which is difficult to heat with other heating devices.

• The Journal of Pediatrics of Korean Medicine
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• v.24 no.3
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• pp.121-137
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• 2010

Objectives: The purpose of this study is investigate about chief complaints of pediatric outpatients in the oriental medicine hospital and search for a latest of patients and their symptom. Methods: The study was composed of 3024 new patients aged between 0 and 20 who had been visited pediatrics in Kyung Hee oriental medicine hospital from 2009 March to 2010 February. Results: In age distribution, 1 year old child have most visited, and the number of the patients have fallen sharply as age have increased. The most visited month is August, and the least is November. In systemic division of chief complaints, in order of respiratory part, growth part, restorative herb medicine part, digestive part, neurologic & psychologic part, dermatologic part visited in patients number, and in single chief complaints, in order of growth, restorative herb medicine, anorexia, rhinosinusitis, cold, atopic dermatitis, seizure & epilepsy have visited. As for age and systemic division, between 1 and 6 years old, the patients of respiratory division have most visited, more than 7 years old, growth division. As for age and single chief complaints, in 0 year old, seizure & epilepsy have most visited, between 4 and 6 years old, rhinosinusitis, more than 7 years old, growth. Growth and respiratory division have increased the most in August, restorative herb medicine and digestive division have increased the most in September. In single chief complaints, patients of growth have most visited in most of time, but in September and November patients of restorative herb medicine have visited the most. Conclusions: The most visited division was respiratory part, and the most visited chief complaints was growth. More data of patients should be accumulated for further study, and we expect more specific study would be done about many kinds of disease in basis of this study.

• Korean Journal of Veterinary Service
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• v.21 no.4
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• pp.413-429
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• 1998

Escherichia coli is recovered from a wide variety of infections in many animals species. It may be a primary or secondary agent. Nursing and young animals are particularly susceptible, and urinary tract infections are frequent. The various serotypes of E coli are intestinal inhabitants of animals including humans and probably infect most mammals and birds : therefore, they have a cosmopolitan distribution. Colibacillosis refers to any totalized or systemic infection caused entirely or partly by E coli. Collibacillosis in mammals is most often a primary enteric disease, whereas collibacillosis in poultry is typically a secondary located or systemic disease occurring when host defenses have been impaired or overwhelmed. Other opportunistic bacteria, which can be identified by culture, may play a similar role to that of I coli in secondary infections. Collectively, infections caused by E coli are responsible for significant economic losses to the animal performance. From the standpoint of pathogenic mechanisms and diseases, four major categories of E coli are recognized : enterotoxigenic(ETEC), enteropathogenic (EPEC), enteroinvasive(EIEC), and enterohemorrhagic(EHEC). In addition, two less-well-defined E coli categories are recognized in animals and humans : enteroaggregative and cytotoxin necrotizing factor-positive. The aforementioned categories are represented by different serotypes. Certain serotypes show a host preference and are encountered more frequently in some disease syndromes. Of the four major categories, ETEC is the most common cause of diarrhea in calves, lambs, and pigs. Strains in the other categories cause the less-common diarrhea and other disease syndromes. Enterotoxins and pilus antigens are the two most prominent virulence factors thus far identified for ETEC. Two enterotoxins, one heat-stable(ST) and one heat-labile(LT), are produced by enterotoxigenic strains of E coli : not all culture produce both of these plasmid-based enterotoxins.

• Biomedical Science Letters
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• v.24 no.4
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• pp.372-379
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• 2018

Korean society is experiencing rapid growth due to industrialization and urbanization, and the aging of population is emerging. Degradation of the masticatory muscle due to aging and reduction of the number of mastications causes dry mouth syndrome with decreased saliva in the elderly. Changes in the amount and composition of saliva cause various oral diseases, especially, periodontal disease is closely related to the microorganisms that form the plaque. In the elderly education, stimulation saliva was collected at the first visit and the last visit to observe changes in microorganisms in the oral cavity. For the collection of the probes, the paraffin wax was chewed for 5 minutes. The samples were immediately refrigerated in a 50 cc plastic tube and then stored at $-20^{\circ}C$ until the next use. The subjects of this study were the elderly people aged 65 years or older, and the study was conducted on 16 persons, 3 males and 13 females. The distribution of saliva microorganisms according to rolling brushing method showed significant difference in all three groups (Aa & Red complex, Orange complex and Green complex) before and after the education. In the group who answered that they had dentures, it was confirmed that the amount of microorganisms before and after education was significantly reduced in all three groups. There was a significant decrease in the amount of microorganisms in the Aa & Red complex and Orange complex group in the case of hypertension related to systemic disease. In conclusion, the higher the interest of oral health and general health of the subjects, the more effective the education.