Radiation Oncology Journal
- Volume 12 Issue 3
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- Pages.295-300
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- 1994
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- 2234-1900(pISSN)
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- 2234-3156(eISSN)
Temperature distribution in VX-2 hepatoma heated with thermoseed hyperthermia
열소자 온열요법시 VX-2 hepatoma내의 온도 변화에 대한 연구
- Choi, Ihl-Bohng (Department of radiation therapy, St. Mary's Hospital Catholic University Medical College) ;
- Bahk, Yong-Whee (Department of radiation therapy, St. Mary's Hospital Catholic University Medical College)
- Published : 1994.10.01
Abstract
It was the purpose of present study to develop a new thermoseed for heating deep-seated tumors and assessment of the effect of magnetic control on thermoseeds. Aqueous suspension of iron micro spheres (Ferropolysaccharide) was injected directly into the VX-2 hepatoma and heated with 1.2 MHz inductive radiofrequency unit. Aqueous thermoseed suspension was delivered to the tumor by simple percutaneous injection. The limitation of the thermoseed heating method is the positional change of thermoseed particles in the tumor after implantation. The thermoseed particles could enter the systemic blood circulation and cause a severe embolization of a critical organ. To minimize this limitation, we have used the magnetic control after loading the thermoseed in the tumor, W hen ferropolysaccharides were exposed to a strong magnetic field, they magnetized and subsequently exerted a magnetic force on each other, forming larger aggregates of particles. The size of aggregated Particles were too big to enter the systemic blood circulation. Thus, unlike other thermoseed method, we hold the thermoseed particles stationary in the tumor. The temperature of the injected site and immediate vicinity elevated by