• Title/Summary/Keyword: Systemic analysis

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A case of primary central nervous system lymphoma diagnosed with cerebrospinal fluid analysis: replacement brain biopsy with cerebrospinal fluid immunohistochemistry and immunoglobulin gene rearrangement

  • Lee, Jun Ho;Yu, Shinae;Lee, Ja Young;Kim, Yeon Mee;Lee, Dong Ah;Kim, Sung Eun
    • Annals of Clinical Neurophysiology
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    • v.24 no.2
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    • pp.63-67
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    • 2022
  • Primary central nervous system lymphoma (PCNSL) is a type of non-Hodgkin lymphoma confined to the central nervous system. Its diagnosis requires a stereotactic biopsy, which is an invasive procedure. Cerebrospinal fluid (CSF) analysis is less invasive and easier to perform than a stereotactic biopsy. We hereby report a PCNSL case diagnosed using CSF analysis and treated with systemic chemotherapy.

A Systemic Review of Body Awareness Therapy in Patients with Musculoskeletal Disorders

  • Ahn, Si-Nae
    • International Journal of Internet, Broadcasting and Communication
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    • v.14 no.4
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    • pp.154-162
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    • 2022
  • This study aimed to systematically review the available body awareness interventions in patients with musculoskeletal disorders. A total of 3,462 studies were searched in relevant databases using the search keywords, and six studies that met the selection criteria after review were included in the final analysis. The qualitative level of the studies was classified using the five levels of evidence-based classification, and systematic analysis was conducted according to PICO model (patient/population, intervention, comparison and outcomes). Of the six studies included in the final analysis, there were one, three, and two randomized controlled trials, non-randomized two-group studies, and case reports, respectively. Body awareness therapy was applied to patients with idiopathic scoliosis, non-specific musculoskeletal disorder, hip osteoarthritis, and amputation, who showed positive improvements after the interventions. Our results suggested that body awareness therapy is an important intervention with positive effects on the recovery of patients with musculoskeletal disorders.

Discourse Analysis for Deriving Characteristics of Science-gifted Elementary Students in Inquiry Activities (초등과학영재 특성 도출을 위한 탐구활동에서의 담화분석)

  • Choi, Mi-Hyang;Jhun, Young-Seok
    • Journal of Gifted/Talented Education
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    • v.20 no.1
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    • pp.369-388
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    • 2010
  • A Discourse Analysis tool has been developed and has been applied in the cooperative group inquiry activities in order to derive the characteristics of elementary gifted students in science. We recorded and videotaped the whole group problem-solving processes where 4 elementary students worked together to solve given problems as a group for one year in a gifted education center attached to a university in Seoul. We analyzed recorded discourses using systemic functional linguistics with a focus on the structure of information and topic. The discourse analysis tool was developed with the cooperation of science education and gifted education experts. In discourse analysis, we focused on meaning development processes rather than grammatical analysis. Through application of newly developed discourse analysis tool, we confirmed that the tool is useful in understanding the characteristics of science-gifted elementary students. We also founded that the interaction between students has significant effects on problem-solving processes by comparing two students who showed contradictory features in the share of dialogue. In addition, the result suggested that we need to provide students with proper training for ways to communicate with others for effective science-gifted instruction.

Analysis of Systemic Pesticide Imidacloprid and Its Metabolites in Pepper using QuEChERS and LC-MS/MS (QuEChERS 전처리와 LC-MS/MS를 이용한 고추 중 침투성농약 Imidacloprid 및 대사물질 동시분석법)

  • Seo, Eun-Kyung;Kim, Taek-Kyum;Hong, Su-Myeong;Kwon, Hye-Yong;Kwon, Ji-Hyung;Son, Kyung-Ae;Kim, Jang-Eok;Kim, Doo-Ho
    • The Korean Journal of Pesticide Science
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    • v.17 no.4
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    • pp.264-270
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    • 2013
  • Imidacloprid is a systemic insecticide which act as an insect neurotoxin. It used for control of pest such as aphids and other sucking insects in fruits and vegetables. Systemic pesticides move inside a crop following absorption by the plant, and these were converted into a variety of metabolites. Sometimes these metabolites make a problem about safety of agricultural products. So a simultaneous determination method of pesticide and its metabolites is needed, to monitor their presence in agricultural product and study on the fate of pesticide in a plant. This study's aim is to investigate simultaneous analysis method of imidacloprid and its metabolites, imidacloprid guanidine, imidacloprid olefin, imidacloprid urea, and 6-chloronicotinic acid in red pepper using QuEChERS method and LC-MS/MS systems. QuEChERS method was modifed beacuase $MgSO_4$ salts decreased the recoveries of 6-chloronicotinic acid in extraction procedure. Imidacloprid and its metabolites were extracted by acetonitrile with 1% glacial acetic acid and the extracts were purified through QuEChERS with primary secondary amine (PSA) and $C_{18}$ and analyzed with LC-MS/MS in ESI positive mode. Standard calibration curves were made by matrix matched standards and their correlation coefficients were higher than 0.999. Recovery studies were carried out on spiked pepper blank sample at four concentration levels (0.01, 0.04 and 0.1, 0.4 mg/kg). The average recoveries of imidacloprid and its metabolites were in the range of 70~120% with < 20% RSD. This result indicated that the method using QuEChERS and LC-MS/MS was suitable for the simultaneous determination of imidacloprid and its metabolites in red pepper.

Life-Sustaining Procedures, Palliative Care, and Cost Trends in Dying COPD Patients in U.S. Hospitals: 2005~2014

  • Kim, Sun Jung;Shen, Jay;Ko, Eunjeong;Kim, Pearl;Lee, Yong-Jae;Lee, Jae Hoon;Liu, Xibei;Ukken, Johnson;Kioka, Mutsumi;Yoo, Ji Won
    • Journal of Hospice and Palliative Care
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    • v.21 no.1
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    • pp.23-32
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    • 2018
  • Purpose: Little is known regarding the extent to which dying patients with chronic obstructive pulmonary disease (COPD) receive life-sustaining procedures and palliative care in U.S. hospitals. We examine hospital cost trends and the impact of palliative care utilization on the use of life-sustaining procedures in this population. Methods: Retrospective nationwide cohort analysis was performed using National Inpatient Sample (NIS) data from 2005 and 2014. We examined the receipt of both palliative care and intensive medical procedures, defined as systemic procedures, pulmonary procedures, or surgeries using the International Classification of Diseases, 9th revision (ICD-9-CM). Results: We used compound annual growth rates (CAGR) to determine temporal trends and multilevel multivariate regressions to identify factors associated with hospital cost. Among 77,394,755 hospitalizations, 79,314 patients were examined. The CAGR of hospital cost was 5.83% (P<0.001). The CAGRs of systemic procedures and palliative care were 5.98% and 19.89% respectively (each P<0.001). Systemic procedures, pulmonary procedures, and surgeries were associated with increased hospital cost by 59.04%, 72.00%, 55.26%, respectively (each P<0.001). Palliative care was associated with decreased hospital cost by 28.71% (P<0.001). Conclusion: The volume of systemic procedures is the biggest driver of cost increase although there is a cost-saving effect from greater palliative care utilization.

A Microstructural Analysis for Preventive Treatments of Vertebral Fracture (척추 골절의 예방적 치료법에 관한 미세 구조해석)

  • 김형도;탁계래;김한성;이성재
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2002.05a
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    • pp.146-149
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    • 2002
  • It is reported that the mechanical properties of vertebral trabecular bone depend on the density and the mass of bones. Osteoporosis is a systemic skeletal disease caused by low bone mass and microstructure deterioration of trabecular bone. Silva and Gibson (1997) studied the treatment of age-related bone loss using drug therapy. Vertebroplasty is a minimally invasive surgery for the treatment of osteoporosis vertebrae. This procedure includes puncturing vertebrae and filling with Polymethylmethacrylate (PMMA). However, the relative effect of drug therapy and bone cement for osteoporosis treatment is not reported yet. In this study, several 2D models of human vertebral trabecular bone are analyzed by finite element method. The mechanical behaviors of the vertebral trabecular bone treated by the drug therapy and the bone cement are compared. This study shows that bone cement treatment is more effective strategy than drug therapy to prevent the degradation of bone strength.

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A Study on Load Evaluation and Analysis for Foundation of the Offshore Wind Turbine System (해상풍력 하부구조물 하중영향평가 및 해석기술연구)

  • Kwon, Dae-Yong;Park, Hyun-Chul;Chung, Chin-Wha;Kim, Yong-Chun;Lee, Seung-Min;Shi, Wei
    • New & Renewable Energy
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    • v.6 no.3
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    • pp.39-46
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    • 2010
  • With growing of wind turbine industry, offshore wind energy is getting more attention in recent years. Among all the components of offshore wind turbines, the foundation of the offshore wind turbine plays a key role in stability of whole system. In this work, the 5 MW NREL reference wind turbine with rated speed of 11.4 m/s is used for load calculation. Wind and wave loads are calculated using GH-Bladed (Garard Hassan) and FAST (NREL). Additionally, FE simulation is carried out to investigate the wave effect on the support structure. Meanwhile, this work is to simulate systemic and optimized load cases for the foundation analysis of wind turbine system.

Analysis of Consuming Behavior of Environment-Friendly Agricultural Products for Housewives in Daegu (친환경농산물 구매 및 소비행태 분석 -대구광역시 가정주부들을 중심으로-)

  • Kim, Tae-Young;Jang, Woo-Whan
    • Korean Journal of Organic Agriculture
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    • v.19 no.2
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    • pp.145-156
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    • 2011
  • This research targets housewives residing in Daegu among whole consumers. The first step is to divide housewives into two groups, group 1 which has experience of purchasing environment-friendly agricultural products and group 2 which has no experience. Then in the next step, research proceeds to investigate perception, present behavior and future intention of purchasing environment-friendly agricultural products. Based on this, it intends to provide both basic information which is needed for producers and distributors to set their systemic marketing strategy to increase consumption of environment-friendly agricultural products and effective way to vitalize the consumption.

Determination of Sulfamethazine Using High Performance Liquid Chromatography and Several Screening Methods (HPLC 및 신속검출방법을 이용한 우유내 Sulfamethazine의 분석에 관한 연구)

  • 김철현;백승천;문지웅
    • Journal of Food Hygiene and Safety
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    • v.12 no.1
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    • pp.71-77
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    • 1997
  • Sulfonamides, a therapeutically important group of antimicrobial drugs, are widely used to treat and prevent the acute systemic and skin infections in dairy cattle. They also pose an economic hazard through inhibition of growth of dairy starter cultures. This study was carried out to compare four screening methods for detection of sulfamethazine in milk and determine the positive milk sample by HPLC method. Sulfamethazine was used to spike at five levels of sulfamethazine. The Lac-Tek test and CharmII test were also consistent better than TTCII test and Delvo SP test in sulfamethazine detection. Analysis probabilities of obtaining a positive response with TTCII test and Delvo SP test assay at 50 ppb sulfamethazine level in milk samples were only 14%, 42% each. Whereas using the Lac-Tek test and CharmII test would have resulted in 100% identification of the five levels. Determination of sufamethazine using the HPLC method in the spiked milk were 10.64, 19.30, 30.76,38.83 and 50.23 ppb, respectively.

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Isolation and characterization of the rice NPR1 promoter

  • Hwang, Seon-Hee;Hwang, Duk-Ju
    • Plant Biotechnology Reports
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    • v.4 no.1
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    • pp.29-35
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    • 2010
  • NPR1 is a positive regulator of systemic acquired resistance in Arabidopsis and rice. Expression of the rice gene OsNPR1 is induced by salicylic acid (SA). To identify the region of the OsNPR1 promoter involved in response to SA, we carried out deletion mutagenesis of the region 1005 bp upstream of the OsNPR1 start codon. Ciselement analysis revealed that the OsNPR1 promoter contains W-boxes and ASF1 motifs, both of which are known to be functional cis-elements of the WRKY and bZIP proteins, respectively. The deletion constructs 1005:LUC and 752:LUC, were induced by up to 4.3- and 3.8-fold, respectively, following SA treatment, suggesting that W-boxes and ASF1 motifs may play an important role in the strong induction of these constructs by SA. Using mutation analysis, we also showed that both the W-box and ASF1 motif are necessary for SA-induced expression of OsNPR1.