• Title/Summary/Keyword: SystemC

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Oxidative Modification of Neurofilament-L by the Cytochrome c and Hydrogen Peroxide System

  • Kang, Jung-Hoon
    • Bulletin of the Korean Chemical Society
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    • v.28 no.1
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    • pp.77-80
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    • 2007
  • As neurofilament proteins are major cytoskeletal components of neuron, abnormality of neurofilament is proposed in brain with neurodegenerative disorders such as Parkinson's disease (PD). Since oxidative stress might play a critical role in altering normal brain proteins, we investigated the oxidative modification of neurofilament-L (NF-L) induced by the reaction of cytochrome c with H2O2. When NF-L was incubated with cytochrome c and H2O2, the protein aggregation was increased in cytochrome c and H2O2 concentrationsdependent manner. Radical scavengers, azide, formate and N-acetyl cysteine, prevented the aggregation of NFL induced by the cytochrome c/H2O2 system. The formations of carbonyl group and dityrosine were obtained in cytochrome c/H2O2-mediated NF-L aggregates. Iron specific chelator, desferoxamine, prevented the cytochrome c/H2O2 system-mediated NF-L aggregation. These results suggest that the cytochrome c/H2O2 system may be related to abnormal aggregation of NF-L which may be involved in the pathogenesis of PD and related disorders.

A Study on the Translation Rule from SystemC to Blif-MV : SC2MV (내장헝 시스템 설계 언어인 SystemC로 부터의 Blif-MV 변환 규칙 연구)

  • 김민숙;안영정;방기석;최진영
    • Proceedings of the Korean Information Science Society Conference
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    • 2002.10d
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    • pp.76-78
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    • 2002
  • 내장형 시스템의 개발에 있어서 자원의 효율적인 활용과 정확한 설계를 위해 SystemC를 이용한 통합설계 방식이 많이 사용되고 있다. 하지만 시스템이 점점 복잡해 지면서 단순한 언어차원에서의 개발 뿐 아니라 개발 이전에 시스템의 정확성을 검증해야 할 필요성이 대두되었다. 이를 위해 정형기법 및 테스팅과 같은 방법을 사용하게 되었다. 본 논문에서는 SystemC로부터 정형기법 도구인 VIS의 입력 언어인 BLIF-MV로 자동 변환하는 알고리즘을 제시하고, SystemC 코드로부터의 자동 검증 방법을 제안하고자 한다.

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Formal Verification of Hardware Implemented in SystemC (SystemC로 구현된 하드웨어 명세의 정형 검증)

  • 김민숙;안영정;방기석;최진영
    • Proceedings of the Korean Information Science Society Conference
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    • 2003.04a
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    • pp.37-39
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    • 2003
  • 내장형 시스템의 개발에 있어서 자원의 효율적인 활용과 정확한 설계를 위해 SystemC를 이용한 통합설계 방식이 많이 사용되고 있다. 하지만 시스템이 점점 복잡해지면서 단순한 언어차원에서의 개발 뿐 아니라 개발 이전에 시스템의 정확성을 검증해야 할 필요성이 대두되었다. 이를 위해 정형기법 및 테스팅과 같은 방법을 사용하게 되었다. 본 논문에서는 SystemC로부터 정형기법 도구인 VIS의 입력 언어인 BLIF-MV로 자동 변환하는 알고리즘을 제시하고, SystemC 코드의 자동 검증 방법을 제시하고 실제 시스템에 적용해 보았다.

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Effects of Green Tea Catechin on Mixed Function Oxidase System and Antioxidative Defense System in Rat Lung Exposed to Microwave

  • Kim, Mi-Ji;Rhee, Soon-Jae
    • Preventive Nutrition and Food Science
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    • v.9 no.1
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    • pp.53-57
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    • 2004
  • The purpose of this study was to investigate the effects of green tea catechin on mixed function oxidase system (MFO), lipofuscin contents, carbonyl value, oxidative damage and the antioxidative defense system in lung of microwave exposed rats. Experimental groups were divided to normal group and microwave exposed group. The microwave exposed groups were subdivided into three groups: catechin free diet (MW-0C) group, 0.25% catechin (MW-0.25C) group and 0.5 % catechin (MW-0.5C) group according to the levels of dietary catechin supplementation. The rats were irradiated with microwave at frequency of 2.45 GHz for 15 min. Experimental animals were sacrificed at 6th day after microwave irradiation. The contents of cytochrome P$_{450}$ contents in MW-0C group was increased to 95% , compared with normal group. MW-0.25C and MW-0.5C groups were reduced to 16% and 31%, respectively, compared with MW-0C group. The activity of NADPH-cytochrome P$_{450}$ reductase in MW-0C group was increased to 44%, compared with normal group. MW-0.25C and MW-0.5C groups were reduced to 12% and 17%, respectively, compared with MW-0C group. The activity of superoxide dismutase (SOD) in MW-0C group was decreased to 21 %, compared with normal group. MW-0.25C and MW-0.5C group were significantly (p < 0.05) increased, compared with MW-0C group. The activity of glutathione peroxidase (GSHpx) in MW-0C group was significantly decreased, compared with normal group. MW-0.25C and MW-0.5C groups were recovered to the level of normal group. The thiobarbituric acid reactive substances (TBARS) content in MW-0C group was increased to 34 %, compared with normal group. Catechin supplementation groups were maintained the level of normal group. The levels of caybonyl value in MW-0C group was increased to 21 %, compared with normal group. MW-0.25C and MW-0.5C groups were reduced to 14% and 12%, respectively, compared with MW-0C group. The lipofuscin contents in MW-0C group were increased to 23.4 %, compared with normal group. That of MW-0.5C group was significantly reduced, compared with MW-0C group. In conclusion, MFO system was activated and the formation of oxidized protein, lipofuscin was increased and antioxidative defense system was weakened of lung tissue in microwave exposed rats, thus oxidative damage was increased. But it was rapidly recovered to normal level by green tea catechin supplementation.n.

Sizing System for Medical Compression Stockings -Focus on Imported Medical Compression Stockings in the Korean Market- (의료용 압박스타킹의 사이즈 체계에 관한 연구 -한국 시장에서의 수입 의료용 압박스타킹을 중심으로-)

  • Do, Wol-Hee;Kim, Nam-Soon
    • Journal of the Korean Society of Clothing and Textiles
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    • v.36 no.8
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    • pp.860-874
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    • 2012
  • This study provides size information on current imported medical compression stockings in Korea. A total 20 brands from 6 countries imported and sold in the Korean on-off line markets were selected for this study and the sizing system of medical compression stockings was researched. The results of this study were as follows: there were size differences among different USA brands according to product type or compression class of medical compression stockings. To establish the sizing system for medical stockings of the German brands, the basic body measurements standard was set as cA, cY, cB, cB, cC, cD, cE, cF, cG, cH, cT, lD, lG, and lT. Italian brands developed the sizing system for medical compression stockings by compression class. In the Swiss brands, size types were sub-divided as 'Normal', 'Plus', 'Short', and 'Long'. The sizing 1 were confined within very narrow limits. There were differences of the basic body measurements between Taiwan brands. The results of the comparison of the size range of the imported brands with Size Korea (KATS, 2010) by two-way size distribution shows that the sizing systems of the imported brands were unsuitable for Koreans. To enhance the suitability of the sizing system for medical compression stockings, a new sizing system for Korean adult males and females needs to be established.

Preparation of Sialyloligosaccharide from Raw Egg Yolk in Biphasic System (Biphasic system에 의한 생난황으로부터 시알산 함유 올리고당의 제조)

  • 김상진;임한진;안병용;최동성
    • KSBB Journal
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    • v.15 no.1
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    • pp.55-59
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    • 2000
  • Protease-catalyzed liberation of sialyloligosaccharide from raw egg yolk was investigated in biphasic system, water-immiscible hexane system. Biphasic system 1, in which water was the continuous phase, was better than the opposite biphasic system ll in sialyloligosaccharide liberation. The optimal conditions of temperature, water content and reaction time were $30^{\circ}C$, 20% and 12 hours, respectively. Protease activity was strongly influenced by the amount of water present in the reaction mixture. The liberation of sialyloligosaccharide was accelerated by protease pre-treatment at $30^{\circ}C$ in 0.2 M NaCl solution, prior to addition of hexane (Biphasic system I).

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Analyzing the Performance of a Temperature and Humidity Measuring System of a Smart Greenhouse for Strawberry Cultivation (딸기재배 스마트 온실용 온습도 계측시스템의 성능평가)

  • Jeong, Young Kyun;Lee, Jong Goo;Ahn, Enu Ki;Seo, Jae Seok;Kim, Hyeon Tae;Yoon, Yong Cheol
    • Journal of Bio-Environment Control
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    • v.28 no.2
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    • pp.117-125
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    • 2019
  • This study compared the temperature and humidity measured by an aspirated radiation shield (ARS), the accuracy of which has been recently verified, and those measured by a system developed by the parent company (Company A) to investigate and improve the performance of the developed system. The results are as follows. Overall, the two-plate system had a lower radiation shielding effect than the one-plate system but showed better performance results when excluding the effect of strawberry vegetation on the systems. The overall maximum temperature ranges measured by company A's system and the ARS were $20.5{\sim}53.3^{\circ}C$ and $17.8{\sim}44.1^{\circ}C$, respectively. Thus, the maximum temperature measured by company A's system was $2.7{\sim}9.2^{\circ}C$ higher, and the maximum daily temperature difference was approximately $12.2^{\circ}C$. The overall average temperature measured by company A's system and the ARS was $12.4{\sim}38.6^{\circ}C$ and $11.8{\sim}32.7^{\circ}C$, respectively. Thus, the overall average temperature measured by company A's system was $0.6{\sim}5.9^{\circ}C$ higher, and the maximum daily temperature difference was approximately $6.7^{\circ}C$. The overall minimum temperature ranges measured by company A's system and the ARS were $4.2{\sim}28.6^{\circ}C$ and $2.9{\sim}26.4^{\circ}C$, respectively. Thus, the minimum temperature measured by company A's system was $1.3{\sim}2.2^{\circ}C$ higher, and the minimum daily temperature difference was approximately $2.9^{\circ}C$. In addition, the overall relative humidity ranges measured by company A's system and the ARS were 52.9~93.3% and 55.3~96.5%, respectively. Thus, company A's system showed a 2.4~3.2% lower relative humidity range than the ARS. However, there was a day when the relative humidity measured by company A's system was 18.0% lower than that measured by the ARS at maximum. In conclusion, there were differences in the relative humidity measured by the two company's devices, as in the temperature, although the differences were insignificant.

Reactive ion Etching Characteristics of 3C-SiC Grown on Si(100) Wafers (Si(100) 기판위에 성장된 3C-SiC의 RIE 특성)

  • Jung, Soo-Yong;Woo, Hyung-Soon;Jin, Dong-Woo;Chung, Gwiy-Sang
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2003.07b
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    • pp.892-895
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    • 2003
  • This paper describes on RIE(Reactive Ion Etching) characteristics of 3C-SiC(Silicon Carbide) grown on Si(100) wafers. During RIE of 3C-SiC films in this work, $CHF_3$ gas is used to form of polymer as a side wall for excellent anisotropy etching. From this process, etch rates are obtained a $60{\sim}980{\AA}/min$ by various conditions such as $CHF_3$ gas flux, $O_2$ addition ratio, RF power and electrode distance. Also, approximately $40^{\circ}$ mesa structures are successfully formed at 100 mTorr $CHF_3$ gas flow ratio, 200 W RF power and 30 mm electrode distance. Moreover, vertical side wall is fabricated by anisotropy etching with 50% $O_2$ addition ratio and 25 mm electrode distance. Therefore, RIE of 3C-SiC films using $CHF_3$ could be applicable as fabrication process technology for high-temperature 3C-SiC MEMS applications.

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Accurate Extraction of Crosstalk Induced Dynamic Variation of Coupling Capacitance for Interconnect Lines of CMOSFETs

  • Kim, Yong-Goo;Ji, Hee-Hwan;Yoon, Hyung-Sun;Park, Sung-Hyung;Lee, Heui-Seung;Kang, Young-Seok;Kim, Dae-Byung;Kim, Dae-Mann;Lee, Hi-Deok
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.4 no.2
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    • pp.88-93
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    • 2004
  • We, for the first time, present novel test patterns and conclusive on-chip data indicating that the variation of coupling capacitance, ${\Delta}C_C$ by crosstalk can be larger than static coupling capacitance, $C_C$. The test chip is fabricated using a generic 150 nm CMOS technology with 7 level metallization. It is also shown that ${\Delta}C_C$ is strongly dependent on the phase of aggressive lines. For antiphase crosstalk ${\Delta}C_C$ is always larger than $C_C$ while for in-phase crosstalk $D_{\Delta}C_C$is smaller than $C_C$.