• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5513-5518
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• 2013

IFN-${\gamma}$ plays an indirect anti-cancer role through the immune system but may have direct negative effects on cancer cells. It regulates the viability of gastric cancer cells, so we examined whether it affects their proliferation and how that might be brought about. We exposed AGS, HGC-27 and GES-1 gastric cancer cell lines to IFN-${\gamma}$ and found significantly reduced colony formation ability. Flow cytometry revealed no effect of IFN-${\gamma}$ on apoptosis of cell lines and no effect on cell aging as assessed by ${\beta}$-gal staining. Microarray assay revealed that IFN-${\gamma}$ changed the mRNA expression of genes related to the cell cycle and cell proliferation and migration, as well as chemokines and chemokine receptors, and immunity-related genes. Finally, flow cytometry revealed that IFN-${\gamma}$ arrested the cells in the G1/S phase. IFN-${\gamma}$ may slow proliferation of some gastric cancer cells by affecting the cell cycle to play a negative role in the development of gastric cancer.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.11
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• pp.3087-3093
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• 2009

Digital filters are indispensible element in digital signal processing area. The performance of digital filter based on adding and multiplying operation, such as computational speed and power consuming is determined by the orders and coefficients of filter which has on effect area of semiconductor chip when it is implemented by VLSI technology. In this research, in order to performance improvement of digital filter, we proposed the algorithm to speed-up the operation of digital filter associated with the minimum signed digit representation of binary number system and method to simplify the digital filter design associated with common subexpression elimination. The performance of proposed method is evaluated by the computational speed and design-simplicity by experimental implemented digital filter on FPGA.

• Journal of the Institute of Convergence Signal Processing
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• v.6 no.4
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• pp.206-211
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• 2005

We describe the design for a correlator and an access code generator in bluetooth system. These are used for a connection setting, a packet decision and a clock synchronization between Bluetooth units. The correlator consists of two blocks; carry save adder based on Wallace tree and threshold-value decision block. It determines on an useful packet and clock-synchronization for input signal of 1.0Mbps through the sliding-window correlating. The access-code generator also consists of two blocks; BCH(Bose-Chadhuri-Hocquenghem) cyclic encoder and control block. It generates the access-codes according to four steps' generation process based on Bluetooth standard. In order to solve synchronization problem, we make use of any memory as a pseudo random sequence. The proposed correlator and access-code generator were coded with VHDL. An FPGA Implementation of these modules and the simulation results are proved by Xilinx chip. The critical delay and correlative margin based on synthesis show the 4.689ns and the allowable correlation-error up to 7-bit.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.441-452
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• 2020

In vivo animal models are limited in their ability to mimic the extremely complex systems of the human body, and there is increasing disquiet about the ethics of animal research. Many authorities in different geographical areas are considering implementing a ban on animal testing, including testing for cosmetics and pharmaceuticals. Therefore, there is a need for research into systems that can replicate the responses of laboratory animals and simulate environments similar to the human body in a laboratory. An in vitro two-dimensional cell culture model is widely used, because such a system is relatively inexpensive, easy to implement, and can gather considerable amounts of reference data. However, these models lack a real physiological extracellular environment. Recent advances in stem cell biology, tissue engineering, and microfabrication techniques have facilitated the development of various 3D cell culture models. These include multicellular spheroids, organoids, and organs-on-chips, each of which has its own advantages and limitations. Organoids are organ-specific cell clusters created by aggregating cells derived from pluripotent, adult, and cancer stem cells. Patient-derived organoids can be used as models of human disease in a culture dish. Biomimetic organ chips are models that replicate the physiological and mechanical functions of human organs. Many organoids and organ-on-a-chips have been developed for drug screening and testing, so competition for patents between countries is also intensifying. We analyzed the scientific and technological trends underlying these cutting-edge models, which are developed for use as non-animal models for testing safety and efficacy at the nonclinical stages of drug development.

• Journal of Korean Medical Science
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• v.33 no.52
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• pp.337.1-337.14
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• 2018

Background: Mitochondrial heteroplasmy, the co-existence of different mitochondrial polymorphisms within an individual, has various forensic and clinical implications. But there is still no guideline on the application of massively parallel sequencing (MPS) in heteroplasmy detection. We present here some critical issues that should be considered in heteroplasmy studies using MPS. Methods: Among five samples with known innate heteroplasmies, two pairs of mixture were generated for artificial heteroplasmies with target minor allele frequencies (MAFs) ranging from 50% to 1%. Each sample was amplified by two-amplicon method and sequenced by Ion Torrent system. The outcomes of two different analysis tools, Torrent Suite Variant Caller (TVC) and mtDNA-Server (mDS), were compared. Results: All the innate heteroplasmies were detected correctly by both analysis tools. Average MAFs of artificial heteroplasmies correlated well to the target values. The detection rates were almost 90% for high-level heteroplasmies, but decreased for low-level heteroplasmies. TVC generally showed lower detection rates than mDS, which seems to be due to their own computation algorithms which drop out some reference-dominant heteroplasmies. Meanwhile, mDS reported several unintended low-level heteroplasmies which were suggested as nuclear mitochondrial DNA sequences. The average coverage depth of each sample placed on the same chip showed considerable variation. The increase of coverage depth had no effect on the detection rates. Conclusion: In addition to the general accuracy of the MPS application on detecting heteroplasmy, our study indicates that the understanding of the nature of mitochondrial DNA and analysis algorithm would be crucial for appropriate interpretation of MPS results.

• Korean Journal of Remote Sensing
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• v.36 no.5_2
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• pp.881-891
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• 2020

Recently, the Ministry of Land, Infrastructure and Transport and the Ministry of Science and ICT are developing the Land Observation Satellite (CAS-500) to meet increased demand for high-resolution satellite images. Expected image products of CAS-500 includes precision orthoimage, Digital Surface Model (DSM), change detection map, etc. The quality of these products is determined based on the geometric accuracy of satellite images. Therefore, it is important to make precision geometric corrections of CAS-500 images to produce high-quality products. Geometric correction requires the Ground Control Point (GCP), which is usually extracted manually using orthoimages and digital map. This requires a lot of time to acquire GCPs. Therefore, it is necessary to automatically extract GCPs and reduce the time required for GCP extraction and orthoimage generation. To this end, the Precision Image Processing (PIP) System was developed for CAS-500 images to minimize user intervention in GCP extraction. This paper explains the products, processing steps and the function modules and Database of the PIP System. The performance of the System in terms of processing speed, is also presented. It is expected that through the developed System, precise orthoimages can be generated from all CAS-500 images over the Korean peninsula promptly. As future studies, we need to extend the System to handle automated orthoimage generation for overseas regions.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2002.05a
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• pp.130-133
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• 2002

As a society advances, an aging phenomenon and many diseases which did not exist in old times are happening. Especially, in case of the aged patient, because we cant know the time the condition of the patients health become worse, the study of the Tele-information system has been actively carried out by the necessity of a persistent observation. A ECG signal a kind of a vital signals has been widely used to the medical information system as an usual clinical diagnosis for the patients who possess heart diseases. BlueTooth is a close range wireless communication technology which uses a wireless frequency 2.4GHz and has a high trust and self - error correction technology according to a low power consumption quality and a high-speed frequency hopping. This makes get a high trust concerning a data transmission than an existing modem. In addition, though wireless modem is restricted by a minimal of a wireless terminal, It will be possible to coincide with the function of the portable with the low power consumption quality by using Bluetooth. And as the system on a chip of module progresses, the possibility of the small size is present According to this, Bluetooth module transmits the medical information, which is input from the outside among the operations that use the Bluetooth to the Bluetooth module that is connected the host PC. And the system that the host PC transmits the medical information from the connected Bluetooth module to the Internet has once embedded. this study let the host PC embedded in advance of the existing system and transmit the medical information by the addition of the Tcp/Ip protocol stark under all embedded environments to internet.

• Journal of the Microelectronics and Packaging Society
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• v.23 no.2
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• pp.73-78
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• 2016

An increase in the transistor density of integrated circuit devices leads to a very high increase in heat dissipation density, which causes a long-term reliability and various thermal problems in microelectronics. In this study, liquid cooling method was investigated using straight microchannels with various metal bumps. Microchannels were fabricated on Si wafer using deep reactive ion etching (DRIE), and Ag, Cu, or Cr/Au/Cu metal bumps were placed on Si wafer by a screen printing method. The surface temperature of liquid cooling structures with various metal bumps was measured by infrared (IR) microscopy. For liquid cooling with Cr/Au/Cu bumps, the surface temperature difference before and after liquid cooling was $45.2^{\circ}C$ and the power density drop was $2.8W/cm^2$ at $200^{\circ}C$ heating temperature.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.1
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• pp.364-370
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• 2011

The Hilbert transform performs a role to transform band pass signals into low pass signals in wireless communication systems. The operation of Hilbert transform is based on a convolution process which is required adding and multiplying calculations. When the Hilbert transform is designed and hardware-implemented at gate level, the adding and multiplying operation requires a high power consumption and a occupation of wide area on a chip. So the results of adding and multiplying operation cause to degrade the performance of implemented system. In this paper, the new Hilbert transformer is proposed, which has a low hardware complexity by application of MAG(Minimum Adder Graph) algorithm. The proposed Hilbert transformer was simulated in ISE environment of Xilinx and showed the reduction of hardware complexity comparing with the number of gate in the conventional Hilbert transformer.

• The KIPS Transactions:PartB
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• v.9B no.4
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• pp.429-436
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• 2002

In order to apply the artificial neural network to the practical application, it is needed to implement it with the hardware system. It is most promising to make it with the hybrid VLSI among various possible technologies. When we Implement a trained network into the hybrid neuro-chips, it is to be performed the process of the quantization on its neuron outputs and its weights. Unfortunately this process cause the network's outputs to be distorted from the original trained outputs. In this paper we analysed in detail the statistical characteristics of the distortion. The analysis implies that the network is to be trained using the normalized input patterns and finally into the solution with the small weights to reduce the distortion of the network's outputs. We performed the experiment on an application in the time series prediction area to investigate the effectiveness of the results of the analysis. The experiment showed that the network by our method has more smaller distortion compared with the regular network.