• Journal of agricultural medicine and community health
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• v.24 no.1
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• pp.35-47
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• 1999

Medication non-compliance among the elderly results in medical problems and substantial cost to the health care system. This study investigate predicted variable related to the medication task ability among elderly. This study was done in the selected 4 villages in Kimchun County of Kyungbuk Province from July to August, 1996. The subject was the resident that 202 adults above 60 years of age. The questionnaire of interview included medication task ability, socio-demographic data, COOP/WONCA chart, family ABGAR score. BDI(Beck depression inventory), ADL(activities of daily living), IADL(instrumental activities of daily living), and MMSE-K(minimental state examination-Korean version). The results were as followed : 1. Approximately 49% of study population was taking drug medication currently. We found that 93% of study population was successful at the medication task all alone, 6% was failure at the medication task all alone, so need help partly or completely. 2. Significant variables between group of medication task ability were age, educational attainment, IADL, and MMSE-K in univariate analysis. And significant correlated variables with medication task ability were ADL, IADL, MMSE-K, and BDI in correlation analysis. 3. Major predictors to medication task ability on multiple logistic regression were IADL and sex finally. Findings suggest that IADL is related to medication task ability than other test battery of health status, so IADL could be used to necessary for medication management and add information to conventional methods of assessing mental status.

• Journal of the Korea Institute of Building Construction
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• v.16 no.6
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• pp.535-544
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• 2016

Korean government is promoting "K-Smart City" to overseas market which is an integrated solution of construction industry with ICT(Information and Communciations Technologies) industry. Due to nature of Smart City, construction quality and the development quality of the facilities need to be established to improve the overall quality. However, guidelines and regulations to initiate quality control for Smart City are behind the actual demand. This deficiency is bringing quality control for construction and ICT to be controlled separately causing lack of synergy and resulting in overall quality degradation. This research is designed to improve the construction quality of Smart City during its establishment stage by integrating ICT system with on-site construction (Integrated control center and on-site equipment). The adoption of this research to a real Smart City case had resulted in 22% reduction of construction inspection failure (Audit), and also allowed Construction Company to pre-align quality control of all purchased items of ICT Infra that resulted in 18% reduction of nonconformity, thus contributing to an overall quality improvement. This research is expected to be used widely among all construction industry of Smart City.

• Korean Journal of Clinical Pharmacy
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• v.22 no.3
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• pp.220-227
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• 2012

Kidney and liver are the major organs of metabolism and excretion of drugs. Renal and Hepatic impairment may affect the pharmacokinetics/pharmacodynamics and the safety of drugs. Adjusting the dosage based on organ function is the essential role of pharmacists. However, differences have been noted on the recommended dosage among the literatures. We compared and analyzed the recommendations of 4 literature sources which are commonly used for dosage adjustment. From April, 2011 to August, 2011, we selected data on recommendations for dosage adjustment for impaired renal and hepatic function of 100 drugs through a protocol. We analyzed the definition terms of renal and hepatic impairment, recommendations for dosage adjustment, evidenced references in four literature sources: Korean National Formulary (KNF), American Hospital Formulary System Drug Information (AHFS), Micromedex (MM) and Drug Prescribing of Renal Failure (DPRF). We further examined the data homogeneity by comparing how drugs that required no adjustment according to one source were categorized by the other. Sources use different definition terms among themselves except DRPF. Presence or absence of evidenced references about renal/hepatic functional states are KNF (0%/0%), AHFS (78%/62.6%), MM (87.5%/65.6%) and DPRF (93.2%/no recommendation) respectively. Recommendations of specific dosage and dosing interval are KNF (24%/13%), AHFS (39.6%/12.1%), MM (50%/17.7%), and DPRF (55.4%/no recommendation) respectively. Regarding the data homogeneity, the differences were remarkable. Drugs with no adjustment according to AHFS were categorized to be adjusted/ contraindicated by KNF, MM, DPRF and the values were (44%/5.6%), (22%/0%), and (36%/0%) in renal function, (39%/6.5%), (19%/3.2%), and (no recommendation/no recommendation) in hepatic function respectively. Our study shows remarkable definite variation in definitions and recommendations about definition terms, information of dosage and interval, presence or absence of evidenced references. Especially for KNF, quantitative recommendations on dosages and dosing intervals should be made in the near future. To maximize the drug effect and safety and to minimize the heterogeneity of the literature sources, reviewing at least two sources are suggested when recommending the proper dosage adjustment based on organ function.

• Journal of Applied Tourism Food and Beverage Management and Research
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• v.8
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• pp.21-33
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• 1997

This study reviews the scientific management theories and discusses those theories within the food service industry. By providing the principles and the practical implications of the theories on the food service industry, this study tries to identify their philosophies and usefulness to the industry so that the managers in the industry use them in their dylmanic operations. In the fastly changing modern globalized world, we now face a situation where it's becoming more and more difficult to mange a restaurant business. In order to build a food industry business that can maintain a continuous development in today's business environment, one will have to apply the professional management theory in a cost-reduce strategy. It is more important though to have managers, organization members, in short, any person who can work to be motivated in accomplishing these two major issues-income increase and cost reduction. In this erawhere it's getting so difficult for researches on possible strategies for these business managers to overcome their difficulties. It is for certain that in the upcoming second millenium the travel and tourism industry will be one of the world's biggest industry worldwide. Korea's hotel industry has developed since the 1988 Seoul Olympic Games and has shown great amount of competition within the same business. Thus managers have become acquainted with the "know-how" strategy and the practical and scientific managemnet theories were introduced. This helped not only to increase income but also to maximize profit. However, rather than concentration on the "Hard-ware" aspect "Soft-ware" related professional management strategies were developed along with professionalism and human service were emphazied. As such, the actual cost of food and beverages are for the hotel industry business managers the biggest shortterm expense item. Due to the natural state of food items, there is a great chance of "Loss" in preservance, and this is the reason it is complicated to effectively maintain food. As a consequence, very often, the failure to managea hotel or restaurant depends on the capability of the food and beverage preservance mangement: on how they are able to manage effectively the original price of food and beverage. Finally, the main problem of the original price management of food and beverage in Korean hotels are: a) No fixation of set price b) The difficulty to calculate the price difference between a set price and an original price. c) Lack of professinalism in managing the food and beverage original price. d) Lack of perception of the highest ranking management personnels. So as to reform these matters it is necessary to : a) Reform on the management accounting system b) Emphasize to the people in charge on the idea of original price management c) Reinforce original price mangement prevention and assurance of indepedent inspection rights d) Reat manpower

• Journal of Environmental Policy
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• v.6 no.1
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• pp.61-81
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• 2007

Types of agricultural policy can be catagorized into two general cases: price and income supports. Income supports are any government program designed to provide farmers with higher incomes than they would receive otherwise. These direct cash payments to farmers are known as "deficiency payment" or "direct payment" because they compensate the farmer for the failure of the market to provide farmers with adequate prices. The direct payment to environment-friendly agriculture is a form of income supports for the agriculture production using less pesticides and chemical fertilizers. Because no significant regulation exists on the use of fertilizers substituting chemical fertilizers for crop, the role of the payment on reducing environmental impacts of agriculture is not entirely clear. This uncertainty is likely to be particularly severe in the case that farmers with low-quality land showing greater demand for fertiliser have an incentive to transition to environment-friendly agriculture. The paper shows the case of the current payment system in Korea.

• BMB Reports
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• v.50 no.9
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• pp.460-465
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• 2017

Polycystic kidney disease (PKD) is one of the most common inherited disorders, involving progressive cyst formation in the kidney that leads to renal failure. FK506 binding protein 12 (FK506BP) is an immunophilin protein that performs multiple functions, including regulation of cell signaling pathways and survival. In this study, we determined the roles of PEP-1-FK506BP on cell proliferation and cyst formation in PKD cells. Purified PEP-1-FK506BP transduced into PKD cells markedly inhibited cell proliferation. Also, PEP-1-FK506BP drastically inhibited the expression levels of p-Akt, p-p70S6K, p-mTOR, and p-ERK in PKD cells. In a 3D-culture system, PEP-1-FK506BP significantly reduced cyst formation. Furthermore, the combined effects of rapamycin and PEP-1-FK506BP on cyst formation were markedly higher than the effects of individual treatments. These results suggest that PEP-1-FK506BP delayed cyst formation and could be a new therapeutic strategy for renal cyst formation in PKD.

• Molecules and Cells
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• v.43 no.4
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• pp.408-418
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• 2020

The sinus node (SN) is located at the apex of the cardiac conduction system, and SN dysfunction (SND)-characterized by electrical remodeling-is generally attributed to idiopathic fibrosis or ischemic injuries in the SN. SND is associated with increased risk of cardiovascular disorders, including syncope, heart failure, and atrial arrhythmias, particularly atrial fibrillation. One of the histological SND hallmarks is degenerative atrial remodeling that is associated with conduction abnormalities and increased right atrial refractoriness. Although SND is frequently accompanied by increased fibrosis in the right atrium (RA), its molecular basis still remains elusive. Therefore, we investigated whether SND can induce significant molecular changes that account for the structural remodeling of RA. Towards this, we employed a rabbit model of experimental SND, and then compared the genome-wide RNA expression profiles in RA between SND-induced rabbits and sham-operated controls to identify the differentially expressed transcripts. The accompanying gene enrichment analysis revealed extensive pro-fibrotic changes within 7 days after the SN ablation, including activation of transforming growth factor-β (TGF-β) signaling and alterations in the levels of extracellular matrix components and their regulators. Importantly, our findings suggest that periostin, a matricellular factor that regulates the development of cardiac tissue, might play a key role in mediating TGF-β-signaling-induced aberrant atrial remodeling. In conclusion, the present study provides valuable information regarding the molecular signatures underlying SND-induced atrial remodeling, and indicates that periostin can be potentially used in the diagnosis of fibroproliferative cardiac dysfunctions.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.5
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• pp.553-562
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• 2012

Computational Fluid Dynamics (CFD) analysis has been performed to estimate the air temperature inside an Auxiliary Feed Water (AFW) Motor-Driven (MD) pump room for the case where there is loss of Heating, Ventilation, and Air-Conditioning (HVAC). A transient calculation for the closed pump room without cooling by any HVAC system shows that the volume-averaged air temperature reaches around $60^{\circ}C$ for a transient period of 8.0 h. From previous studies, the external air and surface boundary temperatures are assumed to increase slowly starting from an initial temperature of $35^{\circ}C$. For the cases where the door is opened at 2, 4, and 6 h after the initiation of HVAC failure, the average air temperature promptly drops by about $4^{\circ}C$ when the door is opened and then slowly increases. The current calculations based on the CFD technique predict the rate of increase of air temperature to be lower than that determined by previous conservative calculations on the basis of a lumped model.

• Journal of Applied Reliability
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• v.15 no.2
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• pp.90-100
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• 2015

Reliability growth rate (or reliability growth curve slope) have the two cases of trend as a constant or changing one during the reliability growth testing. The changing case is very common situation. The reasons of reliability growth rate changing are that the failures to follow the NHPP (None-Homogeneous Poisson Process), and the solutions implemented during test to break out other problems or not to take out all of the root cause permanently. If the changing were big, the "Goodness of Fit (GOF)" of reliability growth curve to test data would be very low and then reduce the accuracy of assessing result with test data. In this research, we are using Duane model and AMSAA model for assessing test data and projecting the reliability level of complex and repairable system as like construction equipment and vehicle. In case of no changing in reliability growth rate, it is reasonable for reliability engineer to implement the original Duane model (1964) and Crow-AMSAA model (1975) for the assessment and projection activity. However, in case of reliability growth rate changing, it is necessary to find the method to increase the "GOF" of reliability growth curves to test data. To increase GOF of reliability growth curves, it is necessary to find the proper parameter calculation method of interesting reliability growth models that are applicable to the situation of reliability growth rate changing. Since the Duane and AMSAA models have a characteristic to get more strong influence from the initial test (or failure) data than the latest one, the both models have a limitation to contain the latest test data information that is more important and better to assess test data in view of accuracy, especially when the reliability growth rate changing. The main objective of this research is to find the parameter calculation method to reflect the latest test data in the case of reliability growth rate changing. According to my experience in vehicle and construction equipment developments over 18 years, over the 90% in the total development cases are with such changing during the developing test. The objective of this research was to develop the newly assessing method and the process for GOF level increasing in case of reliability growth rate changing that would contribute to achieve more accurate assessing and projecting result. We also developed the new evaluation method for GOF that are applicable to the both models as Duane and AMSAA, so it is possible to compare it between models and check the effectiveness of new parameter calculation methods in any interesting situation. These research results can reduce the decision error for development process and business control with the accurately assessing and projecting result.

• Nuclear Engineering and Technology
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• v.28 no.2
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• pp.129-136
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• 1996

Influence diagram method is applied to containment performance analysis of Young-Gwang 3&4 in an effort to overcome some drawbacks of current containment performance analysis method. Event tee methodology has been adopted as a containment performance analysis method. There are, however, some drawbacks on event tree methodology. This study is to overcome three major drawbacks of the current containment performance analysis method : 1) Event tree cannot express dependency between events explicitly. 2) Accident Progression Event Tree (APET) cannot represent entire containment system. 3) It is difficult to consider decision making problem. To resolve these problems, influence diagrams, is proposed. In the present ok, the applicability of the influence diagrams has been demonstrated for YGN 3&4 containment performance analysis and accident management strategy assessments of this study are in good agreement with those of YGN 3&4 IPE. Sensitivity analysis has been peformed to identify relative important variables for each early containment failure, late containment and basemat melt-though. In addition, influence diagrams are used to assess two accident management strategies : 1) RCS depressurization, 2) cavity flooding. It is shown that influence diagrams can be applied to the containment performance analysis.