• Environmental Engineering Research
• /
• 제18권2호
• /
• pp.91-94
• /
• 2013

Recently Ibadan in southwestern Nigeria has been facing severe water shortage due to the increase of population, social and economic activities. In order to meet the shortfall, attempts to utilize rainwater harvesting (RWH) have been made to provide an alternative source of water supply. A desk study was conducted to review various RWH technologies locally, regionally and globally. A hydrological analysis was also carried out using rainfall data for 30 years from two meteorological stations, with the aim of providing a more sustainable RWH system for water supply to private individuals, organizations, and government agencies. RWH is found to be technically feasible based on the prevailing rainfall pattern with over 90% of households having a rooftop constructed from technically appropriate materials. Results of the study indicate that an average roof of $80m^2$ will collect 82,835 L/yr (45 L/person/day) for a family of five people which is about the required water demand for drinking and cooking purposes. Hence, the capacity of storage tanks and the catchment area required for an all-purpose water supply system based on RWH are quite large. These can be reduced to affordable sizes, by collecting and storing water for cooking and drinking only while non-potable uses are supplemented by water from other sources. However, it must be highlighted that due to the type of roofing material, rainwater should go through proper treatment in order to be used for potable purposes. This study clearly shows that Ibadan city has a good rainwater harvesting potential.

• 한국시스템다이내믹스연구
• /
• 제13권2호
• /
• pp.47-71
• /
• 2012

The purpose of this research is the examination of validity of data as well as simulation model, i.e. to simulate the real data in the SD model with the least error using the adjustments for the faithful reflection of real data to the simulation. In general, SD programs (e.g. VENSIM) utilize the Euler or Runge-Kutta method as an algorithm. It is possible to reflect the trend of real data via these two estimation methods however can cause the validity problem in case of the simulation requiring the accuracy as they have endogenous errors. In this article, the future population estimated by the Korea National Statistical Office (KNSO) to 2050 is simulated by the aging chain model, dividing the population into three cohorts, 0-14, 15-64, 65 and over cohorts by age and offering the adjustments to them. Adjustments are calculated by optimization with three different methods, optimization in EXCEL, manual optimization with iterative calculation, and optimization in VENSIM DSS, the results are compared, and at last the optimal adjustment set with the least error are found among them. The simulation results with the pre-determined optimal adjustment set are validated by methods proposed by Barlas (1996) and other alternative methods. It is concluded that the result of simulation model in this research has no significant difference from the real data and reflects the real trend faithfully.

• BMB Reports
• /
• 제53권1호
• /
• pp.47-55
• /
• 2020

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease and has become a major socioeconomic issue in many developed countries. Currently available therapeutic agents for AD provide only symptomatic treatments, mainly because the complete mechanism of the AD pathogenesis is still unclear. Although several different hypotheses have been proposed, mitochondrial dysfunction has gathered interest because of its profound effect on brain bioenergetics and neuronal survival in the pathophysiology of AD. Various therapeutic agents targeting the mitochondrial pathways associated with AD have been developed over the past decade. Although most of these agents are still early in the clinical development process, they are used to restore mitochondrial function, which provides an alternative therapeutic strategy that is likely to slow the progression of the disease. In this mini review, we will survey the AD-related mitochondrial pathways and their small-molecule modulators that have therapeutic potential. We will focus on recently reported examples, and also overview the current challenges and future perspectives of ongoing research.

• Journal of Semiconductor Engineering
• /
• 제1권1호
• /
• pp.57-63
• /
• 2020

Complementary metal-oxide-semiconductor (CMOS) technology is now facing a power scaling limit to increase integration density. Since 1970s, multi-valued logic (MVL) has been considered as promising alternative to resolve power scaling challenge for increasing information density up to peta-scale level by reducing the system complexity. Over the past several decades, however, a power-scalable and mass-producible MVL technology has been absent so that MVL circuit and system implementation have been delayed. Recently, compact MVL device researches incorporating multiple-switching characteristics in a single device such as 2D heterojunction-based negative-differential resistance (NDR)/transconductance (NDT) devices and quantum-dot/superlattices-based constant intermediate current have been actively performed. Meanwhile, wafer-scale, energy-efficient and variation-tolerant ternary-CMOS (T-CMOS) technology has been demonstrated through commercial foundry. In this review paper, an overview for MVL development history including recent studies will be presented. Then, the status and its future research direction of MVL technology will be discussed focusing on the T-CMOS technology for peta-scale information processing in semiconductor chip.

• 통상정보연구
• /
• 제6권1호
• /
• pp.99-126
• /
• 2004

E-Trade is expected to dominate the global trade in the 21st century and thus is being introduced as a major policy assignment for each development country. e-trade has the potential to accelerate existing trends and introduce new ways of conducting trade. and e-trade is an alternative to strengthen international competitiveness. therefore, we needs to quickly adjust to this new method of e-trade and provide a number of policy suggestions that it can make best use of. However, successful implemetation, diffusion and usage of e-trade system require cooperation, commitment and the trust of all participating members in international trade process. A number of interorganizational, intraorganizational and innovation factors can influence both the extent to which e-trade is diffused and the level of subsequent performance that accure to participating firms. Considering the characteristics of e-trade, the proposed factors are based on an interdisciplinary study. The research model is based on the theories of innovation diffusion, inter-organizational system, and IS implementation. The factors proposed for this study of external firm factors, internal firm and perception factors.

• Journal of mucopolysaccharidosis and rare diseases
• /
• 제3권2호
• /
• pp.37-40
• /
• 2017

Mucopolysaccharidosis (MPS) is caused by accumulation of the glycosaminoglycans in all tissues due to decreased activity of the lysosomal enzyme. Patients exhibit multisystemic signs and symptoms in a chronic and progressive manner, especially with changes in the skeleton, cardiopulmonary system, central nervous system, cornea, skin, liver, and spleen. In the past, treatment of MPS was limited to enzyme replacement therapy (ERT). The outcome for affected patients improved with the introduction of new technologies as hematopoietic stem cell transplantation, relegated to specific situations after ERT became available. Intrathecal ERT may be considered in situations of high neurosurgical risk but still it is experimental in humans. New insights on the pathophysiology of MPS disorders are leading to alternative therapeutic approaches, as gene therapy, inflammatory response modulators and substrate reduction therapy. In this paper, we will highlight the recent novel treatment and clinical trials for MPS and discuss with the goal of fostering an understanding of this field.

• 의학교육논단
• /
• 제15권1호
• /
• pp.9-18
• /
• 2013

An outcome-based curriculum is perceived to be one alternative educational approach in medical education. Nonetheless, it is difficult for curriculum developers to convert from traditional curriculum to an outcome-based curriculum because research documenting its development process is rare. Therefore, this study aims to introduce the development process and method of outcome-based curriculum. For the purpose of this study, we used diverse data analyses, such as an existing literature search, development model analysis, and case analysis. We identified five phases from the analysis. First, the curriculum developers analyze the physician's job or a high performer in a medical situation. Second, curriculum developers extract outcomes and competencies through developing a curriculum, affinity diagraming, and critical incident interviews. Third, curriculum developers determine the proficiency levels of each outcome and competency evaluation methods. Fourth, curriculum developers conduct curriculum mapping with outcomes and competencies. Fifth, curriculum developers develop an educational system. Also, it is important to develop an assessment system for the curriculum implementation in the process of developing the outcome-based curriculum. An outcome-based curriculum influences all the people concerned with education in a medical school including the professors, students, and administrative staff members. Therefore, curriculum developers should consider not only performance assessment tools for the students but also assessment indicators for checking curriculum implementation and managing curriculum quality.

• 동남아시아연구
• /
• 제28권2호
• /
• pp.85-117
• /
• 2018

이 논문은 1998년 레포르마시(Reformasi) 이후 인도네시아에서 이루어진 노동법의 발전에 대해 논의한다. 권위주의 정권의 종식과 이에 따른 민주적 제도의 도입은 노사 관계를 재구성하기 위한 새로운 공간을 열었다. 정부는 고용제도와 노동분쟁해결 체계에 엄청난 변화를 가져 온 새로운 일련의 노동법들을 공포했다. 이러한 변화가 창출한 도전에 직면한 노동조합들은 구성원들의 이익을 방어하기 위해 대안적 수단을 사용하고 있다. 이 논문은 노동법 개혁이 정부, 기업인단체들과 노동운동 사이에서 어떻게 새로운 사회적 계약을 수립하였는지 보여준다.

• 무역학회지
• /
• 제45권2호
• /
• pp.177-189
• /
• 2020

The dispute settlement mechanism of the World Trade Organization (WTO) is in great peril. The Appellate Body has ceased to function last December as the United States has blocked the appointment of new Appellate Body members since 2017. The focus of this study is on the examination of US's discontent on the Appellate Body and various efforts to reform the Appellate Body. In a recent report, the US Trade Representative raises its concerns on the Appellate Body including 90 days mandatory deadline, transitional rules for outgoing Appellate Body members, scope of appeal, advisory opinions, precedent, recommendation, and overreach without offering any viable solutions. Some of WTO members and experts proposed several Appellate Body reform measures but agreement between WTO members is unlikely in a foreseeable future. Alternative dispute settlement mechanisms should be seriously considered such as interim appeal arbitration arrangements, separate dispute settlement mechanisms for trade remedies, unilateral retaliatory measures without WTO authorization. Rules-based multilateral dispute settlement system is imperative to small open economies like Korea. The Korean government should actively participate in Appellate Body reform discussions with other WTO members to keep the WTO dispute settlement system from collapsing.

• 한국콘텐츠학회논문지
• /
• 제22권10호
• /
• pp.506-514
• /
• 2022

형벌을 중심으로 처벌을 통해 재범을 억제하고자 하는 방식은 다수국가들의 형사정책 연구를 통해 그 한계가 나타나고 있다. 이에 대한 대안으로 지역사회구성원과 피해자, 가해자의 화해와 조정을 통해 범죄자가 사회의 일원으로 복귀하는 것을 목적으로 하는 회복적 사법이 범죄 및 재범방지의 패러다임으로 등장하고 있다. 스웨덴은 대표적인 복지국가이자 회복적 사법에 기반한 범죄자 교정을 통해 긍정적인 효과를 확인하고 있다. 또한, 법무보호복지제도와 관련해 안정된 체계를 갖추고 있으며, 운영프로그램의 평가와 인증 과정에서 증거기반의 원칙을 활용한 과학적이고 합리적인 운영으로 낮은 재범률과 사회보장을 유지하고 있다. 그러나 아직 국내에서는 스웨덴을 비롯한 복지 및 교정 선진국에서 시행되는 법무보호복지제도에 대한 연구가 미흡한 실정이다. 이에 본 연구는 스웨덴의 범죄정책과 법무보호복지제도에 관한 고찰을 통해 국내 법무보호복지제도가 나아갈 방향을 탐색하고 국내 제도의 미진한 영역 및 보완점을 파악하여 국내 법무보호복지제도의 개선 및 사업 확대를 위한 토대를 마련하고자 한다.