• Journal of Korea Technology Innovation Society
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• v.10 no.2
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• pp.255-283
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• 2007

As of April 2006, Korea had successfully invited twelve global IT R&D centers to help implement the u-IT839 strategy, but there have also been some worries about their research and collaboration performance in Korea. Although it is too early to judge the invitation outcome only after two years or less of their working, the Korean government is being advised to employ a more customized invitation strategy. In this paper, an analytic framework for the attraction of global R&D centers is developed based on the attractiveness-competitiveness matrix, and is applied empirically to the IT industry. Fourteen major IT technology categories and their sub-technological areas are classified into four strategic groups (priority group, wish group, consideration group, and hold group) along the framework via expert surveys and the Analytic Hierarchy Process (AHP) technique. This study is expected to help the government to implement the 'select and focus' strategy in inviting global R&D centers and creating synergy effects between them by providing basic data on global R&D partnership priorities. The implications and limitations of the research and future research directions are discussed at the final section.

• Journal of Digital Contents Society
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• v.3 no.2
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• pp.211-220
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• 2002

It has not been long since the current form of PDA began to be used widely. The PDA, which first came out in a recognizable form in the market a decade ago, multiplying the number of users, has recently been developed in various forms. It began to make cutting-edge technology available in PDA, and to be subdivided into various forms appropriate for special purposes, which reflected the recent intense competition in the market. It included the function of mobile phone, in tandem with the original function of PDA, by which it brought about other synergy effects and corresponded with the purpose more solidly. Due to these recent changes, PDA has had a dramatically increasing number of users, as well as the wider scope of usage and practical application by introducing new technology. However, research is required in the fields of basic usage and interface. It is important to recognize that PDA is an apparatus that stores for the users contents and information suitable for them, and that responds to them in case of need. PDA therefore needs to convey what the users require more easily and speedily without errors, and to provide them with appropriate information and contents. This paper examined the extent to which the interface of PDA including the input of contents required by the user would be efficient by questionnaires. In addition, alternatives concerning a general application environment of PDA were suggested based on the result of this survey.

• Journal of Periodontal and Implant Science
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• v.39 no.sup2
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• pp.213-222
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• 2009

Purpose: Recently, interest in chitosan has increased due to its excellent biological properties such as biocompatibility, antibacterial effect, and rapid healing capacity. On the other hand, hydroxyapatite is used as a bone substitute in the fields of orthopedics and dentistry. The hydroxyapatite-chitosan (HA-CS) complex containing hydroxyapatite nanoparticles was developed for synergy of both biomaterials. The objective of this study was to evaluate the effect of hydroxyapatite (HA)-chitosan (CS) membrane on bone regeneration in the rat calvarial defect. Methods: Eight-millimeter critical-sized calvarial defects were created in 70 male Sprague-Dawley rats. The animals were divided into 7 groups of 10 animals and received either 1) chitosan (CS) 100% membrane, 2) hydroxyapatite (HA) 30%/CS 70% membrane, 3) HA 30%/CS 70%, pressed membrane, 4) HA 40%/CS 60% membrane, 5) HA 50%/CS 50% membrane, 6) HA 50%/CS 50%, pressed membrane, or 7) a sham . surgery control. The amount of newly formed bone from the surface of the rat calvarial defects was measured using histomorphometry, following 2- or 8- week healing intervals. Results: Surgical implantation of the HA - CS membrane resulted in enhanced local bone formation at both 2 and 8 weeks compared to the control group. The HA - CS membrane would be significantly more effective than the chitosan membrane in early bone formation. Conclusions: Concerning the advantages of biomaterials, the HA-CS membrane would be an effective biomaterial for regeneration of periodontal bone. Further studies will be required to improve the mechanical properties to develop a more rigid scaffold for the HA-CS membrane.

• Journal of the Economic Geographical Society of Korea
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• v.16 no.2
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• pp.182-197
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• 2013

This paper deals with the relationship between cultural factor and economic factor in the spread of Hallyu(Korean Wave). To do so, the paper defines the traditional Hallyu items, drama and K-Pop, as 'cultural Hallyu' and other Popular industrial products such as electronics and mobile products as 'business Hallyu'. Based on this definition, the paper analyzes the relationship between the two Hallyu's in Thailand. The analysis has been conducted as follows. First, the paper describes the history of 'cultural Hallyu' and 'business Hallyu' in Thailand by reviewing their introduction and current situations in Thailand market. Secondly, using various aggregate data, the paper analyzes the causality of the two Hallyu's, focusing on the period of their Popularity and growth in Thailand. In addition to the macro-level analysis, the paper researched individual opinions of Thai people about the influence of Hallyu on the success of Korean companies, as well as about the influence of the Korean business companies on the success of Hallyu. This analysis has been conducted using the results of focus group discussion(FGD) of 17 Bangkok people. In both macro and individual level analyses, we found that the 'cultrual Hallyu' has influenced on the success of the 'business Hallyu' rather than vice versa. For further research, it is necessary to analyze the reciprocal influences and synergy effects between the 'cultural Hallyu' and 'business Hallyu'.

• Journal of Life Science
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• v.19 no.9
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• pp.1209-1217
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• 2009

Many cancer cells are sensitive to the TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. However, some cancer cells show either partial or complete resistance to TRAIL. Human colon carcinoma KM12 cells have been shown to be insensitive to TRAIL-induced apoptosis. To overcome TRAIL resistance in KM12 cells, we targeted key anti-apoptotic molecules involved in the modulation of TRAIL resistance in the cells, and evaluated the effects of quercetin as a TRAIL sensitizer in the cells. We found that quercetin acted in synergy with TRAIL to enhance TRAIL-induced apoptosis in KM12 cells by the down-regulation of c-FLIP and DNA-PKcs/Akt and up-regulation of death receptors (DR4/DR5), which led to the enhancement of TRAIL-mediated activation of caspases and subsequent cleavage of PARP, as well as up-regulation of Bax. These findings suggest that the DNA-PKcs/Akt signaling pathway, as well as c-FLIP, play essential roles in regulating cells in the escape from TRAIL-induced apoptosis. Based on these results, this study provides a potential application of quercetin in combination with TRAIL in the treatment of human colon cancer.

• Asia pacific journal of information systems
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• v.19 no.1
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• pp.83-111
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• 2009

Despite the growing emphasis on the importance of knowledge exchange among supply chain participants, few companies have fully exploited the knowledge resources held by their supply chain partners. Among many reasons for this phenomenon, recent literature on inter-firm knowledge exchange identifies knowledge complementarities between the supply channel partners as an important determinant of knowledge exchange. Firms participating in a supply chain are likely to exchange partners' complementary knowledge. In order to extract value from them, it is important to recognize the difference between the potential value and the implementation of this potential value. However, the literature fails to distinguish between potential knowledge complementarities and implemented knowledge complementarities. In order to realize the value of potential knowledge complementarities, knowledge should be exchanged and effectively integrated in the supply channel. Further, investigating inter-firm knowledge exchange from both partners' perspectives is important especially when there are interdependencies between the channel partners. The purpose of this research is to investigate the impact of potential knowledge complementarities on knowledge exchange in buyer-supplier relationships by looking at both partners' perspectives. This research also includes trust in partner's competence and inter-organizational information systems (IOIS) as they are relevant when the complementary knowledge flows between organizations. The data required for this field study was collected from 70 buyers and their suppliers in three multinational enterprises in two different industries (Automobile manufacturing and Telecommunication services) headquartered in Korea. The results indicate that potential knowledge complementarities between buyer and supplier do not directly influence knowledge exchange, but indirectly through trust in partner's competence. And the results indicate that competence-based trust and IOIS have direct effects on knowledge exchange. Empirical results also show that IOIS moderates the relationship between potential knowledge complementarities and knowledge exchange. This study is a first attempt to empirically verify the theoretical model about potential knowledge complementarities and to investigate the impact of potential knowledge complementarities on interfirm knowledge exchange. From a theoretical perspective, this study not only clarifies the distinction between potential knowledge complementarities and implemented knowledge complementarities, but also develops an instrument to measure the concept of potential knowledge complementarities in the context of operational and planning knowledge in a supply chain. Further, we develop a theoretical framework suggesting that potential knowledge complementarities of partners in a supply chain affect knowledge exchange directly and indirectly through competence-based trust. The findings from this study have some managerial implications for practicing managers as well. First, buyers should search for suppliers that have potential complementary knowledge, which can be integrated to create synergy through interfirm knowledge exchange. Furthermore, firms must develop mechanisms to identify potential complementary knowledge of partners. Second, firms should continue their endeavor to develop their own unique knowledge so that their knowledge can benefit the entire supply channel. Finally, trust among supply chain partners turns out to be an important factor for interfirm knowledge exchange. Therefore, effective management for engendering trustworthy buyer-supplier relationships should receive appropriate attention from managers.

• Journal of the Korean Geosynthetics Society
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• v.4 no.4
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• pp.23-37
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• 2005

The factors affecting the long-term design strength of geogrid can be classified into factors on creep deformation, installation damage, temperature, chemical degradation and biological degradation. Especially, creep deformation and installation damage are considered as main factors to determine the long-term design strength of geogrid. Current practice in the design of a reinforced soil structures is to calculate the long-term design strength of a geosynthetic reinforcement damaged during installation by multiplying the two partial safety factors, $RF_{ID}$ and $RF_{CR}$. This method assumes that there is no evaluation of synergy effect between installation damage and creep deformation of geogrids. This paper describes the results of a series of experimental study, which are carried out to assess the combined effect of the installation damage and the creep deformation for the long-term design strength of geogrid reinforcements. A series of field tests was carried out to assess installation damage of various geogrids with respect to different fill materials, and then creep tests are conducted to evaluate the creep deformation of both undamaged and damaged geogrids. The results indicated that the tensile strength reduction factors, RF, considering the combined effect between the installation damage and the creep deformation is less than that calculated by the current design method.

• The Korean Society of Law and Medicine
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• v.17 no.2
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• pp.315-346
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• 2016

With the development of big data processing technology, the potential value of healthcare big data has attracted much attention. In order to realize these potential values, various research using the healthcare big data are essential. However, the big data regulatory system centered on the Personal Information Protection Act does not take into account the aspect of big data as an economic material and causes many obstacles to utilize it as a research purpose. The regulatory system of healthcare information, centered on the primary purpose of patient treatment, should be improved in a way that is compatible with the development of technology and easy to use for public interest. To this end, it is necessary to examine the trends of overseas legal system reflecting the concerns about the balance of protection and utilization of personal information. Based on the implications of the overseas legal system, we can derive improvement points in the following directions from our legal system. First, a legal system that specializes in healthcare information and encompasses protection and utilization is needed. De-identification, which is an exception to the Privacy Act, should also clearly define its level. It is necessary to establish a legal basis for linking healthcare big data to create synergy effects in research. It is also necessary to examine the introduction of the opt-out system on the basis of the discussion on the foreign debate and social consensus. But most importantly, it is the people's trust in these systems.

• Journal of the Korean association of regional geographers
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• v.9 no.1
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• pp.53-65
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• 2003

The aim of this study is to examine the regional features of shipbuilding-allied industries comprehensively. Inaddition, this study would offer groundwork to construct spatial networks of shipbuilding-allied industries. Relatively in short term, large modem shipbuilding firms of South Korea have developed under the national strategic support, around southeast coast region. Although small shipbuilding firms and marine equipment firms have supported regional economy, these firms have scaled down their functions and roles due to the national policy. In the long tenn, Korean shipbuilding-allied industries have limitations in stable development, because they have separated their roles. Consequently it is necessary the balanced development of large, medium, and small shipbuilding firms and linkage system with marine equipment firms for overall development of shipbuilding-allied industries. This study suggests two spatial strategy for shipbuilding-allied industries development. First, we need to construct a shipbuilding specialization area which agglomerates competent parts firms adjacent to large shipyards. Second, in national strategy, a long term strategy is required to utilize extremely synergy and external effects induced from a shipbuilding duster of southeast coast region which systematically combines shipbuilding-allied industries, universities, the government authorities, and research institutions.

• Korean Journal of Food Science and Technology
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• v.44 no.2
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• pp.257-262
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• 2012

Currently, various treatments available for alleviating hair loss and combination treatments are commonly used, which are frequently questionable and in effective. We aimed to investigate the synergistic effect regarding the combination of oral herbal composition and topical hair tonic on anagen induction and hair restoration in a shaving model of C57BL/6 mice. Seven-week old mice were trimmed by electric clippers and treated with oral herbal composition and topical hair tonic either alone or in combination. The combination treatment showed the highest hair growth promoting effect. Moreover, it significantly improved total blood antioxidant capacity and reduced lipid peroxidation and triglyceride level, which was not observed in the topical hair tonic treated group. These results suggest that the combination of oral herbal composition and topical hair tonic has a synergistic hair growth promoting effect and such synergism may be the result of the differing hair regrowth mechanisms concerning treatments.