• Journal of the Mineralogical Society of Korea
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• v.30 no.2
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• pp.71-81
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• 2017

Rock properties and the effects of chemicals that were used for conservation were studied for effective conservation treatment of Seated Buddha rock carving, which is composed of grayish white tuff, at Golguram Hermitage, Gyeongju. The rocks contain 3-5% montmorillonite, a swelling mineral and reacting with water, the d spacing of swelling minerals was increased (1.54-2.69%). On the one hand, the physical properties of the rock samples, such as surface hardness, water absorption rate, and porosity improved after the application of ethyl silicate-based stone strengthener. On the other, the interlayer of swelling minerals decreased and greater the of swelling mineral content, the greater is the extent of swelling (4.23-12.12%). When the ethyl silicate-based stone strengthener was applied after pretreatment with a swelling inhibitor, the physical properties were similar to those of the stone strengthener alone. There was no interlayer spacing change of swelling minerals due to swelling inhibition treatment; however, when the stone strengthener was applied after the swelling inhibitor, interlayer changes were similar to those when only the stone strengthener was treated (4.10-11.85%). Though the peak intensity of swelling minerals in X-ray diffraction pattern decreased, the effect of the swelling inhibitor was almost negligible. Therefore, it is not appropriate to use ethyl silicate-based stone strengthener for Golgulam rock containing swelling minerals and supplementing them with a swelling inhibition system is not effective. Because weathering rapidly progresses when swelling minerals contact moisture, for now, measures to prevent water contact, such as expansion of the canopy, are needed in the lower and side parts of the carving.

• Korean Journal of Mineralogy and Petrology
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• v.35 no.1
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• pp.51-64
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• 2022

For effective preservation of the rocks, which bearing plant fossils at Gumkwangdong Formation, Pohang, the properties of rock and treatment of chemicals were examined in an artificial weathering test. The rocks are diatomaceous siliceous mudstone, which contain a small amount of smectite and has developed laminated layers. The rocks react with water, the d₀₀₁ spacing of smectite was increased. On the one hand, the physical properties of the rock samples, such as surface hardness, improved after the application of ethyl silicate-based stone strengthener. On the other hand, the spacing of interlayer of swelling clay minerals decreased and spacing of laminae layer increased. When the ethyl silicate-based stone strengthener was applied after pretreatment with a swelling inhibitor, interlayer and spacing of laminae changes were similar to those when only the stone strengthener was treated. The effect of the swelling inhibitor was almost negligible. When the rocks that have been conserved with chemicals react with water, spacing of laminae has widened much, whereas when the rocks was in contact with moisture only, there was little change. In addition, if it is placed in the outdoor after conservation treatment, although it occurs slightly slower than the untreated rock, the separation of the lamination layer and the pulverization of the rock occur within a very short time. Consolidation is required to improve the physical properties of fossil rock, but when exposed to rain and undergoing freeze-thaw process, the effect is lost very quickly. Therefore, regardless of the chemical treatment, it is a priority to prevent direct rainfall contact with the rock.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 1996.12a
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• pp.70-70
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• 1996

The cytotoxicological effect of Bt 1-endotoxin, well-known as a bioinsecticide, was investigated on ion channel of insect cell lines. This study attempted to evaluted the specificity by simple experiment to measure the cell swelling using lepidopteran cell lines in isotonic solution containing only one cation. Cell swelling was stimulated in KCI-sucrose isotonic solution as well as TC-100 media containg in solubilized crystal 5-endotoxin. It suggested that the cell swelling by Bt toxin have a relation to K+ channel. The cell swelling may be due to the stimulation K+ influx and simultaneously the penetration of H2O induced by Bt toxin, because the stimulation of swelling was observed with the solubilized toxin in KCI-sucrose isotonic solution, but not in sucrose isotonic solution. Moreover the specific K+ channel blocker, such as 4-arnjnopyrimidine(4-AP) and ouabain, showed the significant effect on the cell swelling induced by Bt toxin. The increasement of the cell swelling induced by 4-AP suggested to be caused by the block of K+ efflux through K+ leak channels. The inhibition of cell swelling by ouabain, which is the well-known inhibitor of Na+, K+-ATPase, suggested to be due to decreasement of K+ influx following diminishment of Na+, K+-ATPase activities.

• The Journal of Internal Korean Medicine
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• v.28 no.2
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• pp.399-407
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• 2007

Angioedema is a localized transient swelling of sudden onset that can occur in the face, lips, tongue, hand, feet, respiratory system and gastrointestinal system. Angioedema is classified as allergy, hereditary, idiopathic or induced by medication as like aspirin, nonsteroidal anti-inflammatory agents, opiates, antibiotics, and angiotensin-converting enzyme. Angiotensin-converting enzyme inhibitors are widely prescribed for hypertension and heart failure. This drug is commonly associated with angioedema which may be potentially life threatening. We experienced a case of angioedema induced by ACE inhibitor (angiotensin-converting enzyme inhibitor) in a 74-year-old patient who took ACE inhibitor to control hypertension during hospitalization. We thought the angioedema in the face had relation to myenzhong (面腫, mienjong) in oriental medicine. Weiling-tang (Wiryung-tang) was effective for angioedema in the face. As a result the symptoms disappeared rapidly. After 6 days, the patient's symptoms had notably improved.

• Journal of the Korean Applied Science and Technology
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• v.35 no.1
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• pp.284-291
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• 2018

In this study, a dust inhibitor for road dust was prepared by using molecular structure, molecular weight, viscosity, hydrophilicity, swelling, wetting and moisturizing properties of natural polysaccharide which is widely used as food and cosmetic materials. Various dust control effects were confirmed and superior results were obtained than simple water spraying and synthetic for control(PVA). In addition, the comparison of water evaporation, scattering inhibition rate, Field test, and determining acute lethality of effluents to Daphnia magna were studied and the safety of soil and water quality was studied. The availability of the dust inhibitor was confirmed.

• Biomolecules & Therapeutics
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• v.28 no.2
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• pp.172-183
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• 2020

Phosphoinositide 3-kinase (PI3K) is considered as a promising therapeutic target for rheumatoid arthritis (RA) because of its involvement in inflammatory processes. However, limited studies have reported the involvement of PI3KC2γ in RA, and the underlying mechanism remains largely unknown. Therefore, we investigated the role of PI3KC2γ as a novel therapeutic target for RA and the effect of its selective inhibitor, PBT-6. In this study, we observed that PI3KC2γ was markedly increased in the synovial fluid and tissue as well as the PBMCs of patients with RA. PBT-6, a novel PI3KC2γ inhibitor, decreased the cell growth of TNF-mediated synovial fibroblasts and LPS-mediated macrophages. Furthermore, PBT-6 inhibited the PI3KC2γ expression and PI3K/AKT signaling pathway in both synovial fibroblasts and macrophages. In addition, PBT-6 suppressed macrophage migration via CCL2 and osteoclastogenesis. In CIA mice, it significantly inhibited the progression and development of RA by decreasing arthritis scores and paw swelling. Three-dimensional micro-computed tomography confirmed that PBT-6 enhanced the joint structures in CIA mice. Taken together, our findings suggest that PI3KC2γ is a therapeutic target for RA, and PBT-6 could be developed as a novel PI3KC2γ inhibitor to target inflammatory diseases including RA.

• Journal of Korean Society of Environmental Engineers
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• v.39 no.2
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• pp.59-65
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• 2017

In this study, A dust inhibitor for $PM_{10}$ was prepared by using molecular structure, molecular weight, viscosity, hydrophilicity, swelling and wetting / moisturizing properties of natural polysaccharide which is widely used as food and cosmetic materials. Various dust control effects were confirmed and superior results were obtained than simple water spraying and synthetic PVA as a control. In addition, the comparison of water evaporation, pot test of cabbage seed germination, effects on fish and aquatic plants, and effects on herb plant growth were studied and the safety of soil and water quality was studied. The availability of the dust inhibitor was confirmed.

• Journal of the Korean Wood Science and Technology
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• v.47 no.3
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• pp.336-343
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• 2019

Effects of a novel mold inhibitor specifically for bamboo, on the properties of composite products have been confirmed in this study. The mechanical and dimensional stability properties of bamboo fiber-based composites (BFBCs) from different bamboo species were also investigated. The results showed that Burmanica Gamble possessed the highest values of modulus of elasticity (MOE) of 33.2 GPa, modulus of rupture (MOR) of 286.9 MPa, compressive strength of 182.6 MPa and shear strength of 24.0 MPa. By contrast, Phyllostochys heterocycla among all of species showed the lowest MOE of 16.3 GPa, MOR of 170.3 MPa and compressive strength of 128.9 MPa were the lowest among all of species. Moreover, there is a remarkable variation in the swelling and water absorption between the samples with 4 h and 28 h water immersion treatment, especially Phyllostachys iridenscens. Overall, the results suggested that TCIT (Tebuconazole and 3(2H)-isothiazolone) had no significant effect on the mechanical properties compared with the control condition, and it would be utilized as an antimould of BFBCs manufacturing.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.6
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• pp.363-369
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• 2011

The present study elucidated the effect of the selective inducible nitric oxide synthase (iNOS) inhibitor $N^6$-(1-iminoethyl)-L-lysine (L-NIL) on monosodium urate (MSU) crystal-induced inflammation and edema in mice feet. L-NIL (5 or 10 mg/kg/day) was administered intraperitoneally 4 h before injection of MSU (4 mg) into the soles of mice hindlimb feet. Twenty-four hours after MSU injection, foot thickness was increased by 160% and L-NIL pretreatment reduced food pad swelling in a dose dependent manner. Pretreatment of 10 mg/kg/day L-NIL significantly suppressed the foot pad swelling by MSU. Plasma level of nitric oxide (NO) metabolites and gene expression and protein level of iNOS in feet were increased by MSU, which was suppressed by L-NIL pretreatment. Similar pattern of change was observed in nitrotyrosine level. MSU increased the gene expression of tumor necrosis factor (TNF)-${\alpha}$ and interleukin (IL)-$1{\beta}$ and L-NIL pretreatment suppressed MSU-induced cytokines expression. The mRNA levels of superoxide dismutase and glutathione peroxidase1 were increased by MSU and L-NIL pretreatment normalized the gene expression. Phosphorylation of extracellular signal-regulated kinase 1/2 and p38 was increased by MSU, which was suppressed by L-NIL pretreatment. The mRNA levels of iNOS, TNF-${\alpha}$, and IL-$1{\beta}$ were increased by MSU in human dermal fibroblasts, C2C12 myoblasts, and human fetal osteoblasts in vitro, which was attenuated by L-NIL in a dose dependent manner. This study shows that L-NIL inhibits MSU-induced inflammation and edema in mice feet suggesting that iNOS might be involved in MSU-induced inflammation.

• Textile Coloration and Finishing
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• v.35 no.1
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• pp.8-19
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• 2023

Silicone rubber is widely used in most industries due to diverse advantages like heat stability, UV stability, durability, chemical resistance, environment friendliness, inertness and so on. But there is limitation to expand applications due to relatively weak rubber strengths such as tensile strength and tear strength, especially in fabric coating applications. The purpose of this study is to find influence of coating agent on performances of rubber and coated fabrics and their correlation according to different crosslinking densities of silicone rubbers. Addition cure type of silicones were formulated using crosslinked MQ-type silicone resin consisting of M (R₃SiO_1/2) and Q (SiO_4/2) and linear polymers. Raw materials used were; 1) linear vinyl endblocked polymers and vinyl functional MQ resin as main polymers, 2) linear silicone hydride polymers as crosslinkers, 3) platinum catalyst and 4) inhibitor to control curing speed. Rubber specimens were prepared to check mechanical strength using universal testing machine (UTM). Crosslinking density was calculated using Flory-Rhener equation using solvent swelling method. Differential scanning calorimetry (DSC) and scanning electron microscope (SEM-EDS) were used to characterize rubbers. Consequently, it was found that physical properties of silicone rubbers and coated fabrics can be expected by crosslinking density of rubbers. Silicone rubber formulations that contain 20 ~ 30 wt% of vinyl MQ resin showed strongest balanced performances.