• KSBB Journal
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• v.26 no.1
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• pp.78-82
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• 2011

In this study, we investigated the effects of silybin on body weight and glucose tolerance in mice fed high fat diet mice. We found that body weight, plasma TG contents, fat size, glycerol, 3-hydroxybutyrate and total cholesterol were significantly decreased in silybin (500 mg/kg) supplemented groups compared to high fat diet group. Whereas, total food intake was not changed between high fat diet group and high fat diet plus silybin group. Futhermore, supplement of high fat elevated the glucose intolerance and was improved in silybin supplement group. Finally, we examined the effect of silybin on circulating adipocytokine level to explore the possible mechanism by which silybin improves high fat diet-induced obesity and diabetes. The silybin supplement significantly reduced the level of adipocytokine, such as leptin, resistin, IL-6, and MCP-1 induced by high fat diet. These results suggest that silybin can be used to improve obesity and diabetes.

• Korean Journal of Pharmacognosy
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• v.19 no.3
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• pp.193-200
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• 1988

Immunopotentiating activity of water extract of Lycii Fructus, Rubus Fructus, Torilis Fructus, Schizandrae Fructus and Cuscutae Semen were investigated using mouse fed with normal diet and protein deficient diet. Body weight, ratio of spleen or thymus to body weight, number of total peritoneal exudate cell, content of total serum protein and albumin content were decreased in the mouse fed with protein deficient diets as compared to the mouse fed with normal diet. Regardless of the nutritional condition, the supplement of the water extract of Lycii, Rubus Torilis, Schizandrae Fructus or Cuscutae Semen increased the ratio of spleen to body weight. The increment of this ratio was significant by the supplement of water extracts of Lycii and Torilis Fructus in mouse fed with protein deficient diet. The supplement of water extracts of Torilis Fructus to the mouse fed with protein deficient diet increased the content of total serum protein and albumin content significantly. Similar results were obtained with Lycii, Rubus, Schizandrae Fructus and Cuscutae Similar. The electrophorogram shows the difference in the concentration of some serum protein constituents between the mouse fed with normal diet and protein deficient diet.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.4
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• pp.197-203
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• 2020

This study investigates graduate competencies that can improve the uptake of higher education graduate outcomes in the working environment in Indonesia. This research was conducted by collecting data through sending questionnaires directly by the research team, via courier, or via postal service to respondents. A survey with questionnaire is carried out on April 2019, and the data from 117 respondents was analyzed. The sample population was all private higher education in the area of the I-XIV Higher Education Service Institution in Indonesia. This study employs factor analysis and structural equation modelling. The results show that the Graduates' competencies had a significant direct effect on the uptake of higher education graduates in the job market. The indirect effect of a Diploma Supplement and networking as mediation has a level of influence that is higher than the direct effect of graduate competence on the uptake of higher education graduate outcomes in the job market. The findings suggest that the Diploma Supplement and networking can increase the uptake of higher education graduates in Indonesia as expected by stakeholders and be able to compete in the global or international scale of environmental working. The professionalism of lecturers has a significant influence on the quality of learning.

• Journal of the Korean School Mathematics Society
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• v.2 no.1
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• pp.167-179
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• 1999

The aim of this study is to improve the basic learning ability of those who make poor progress in mathematics and to keep positive and active learning attitudes in class afterward by using problems whith both make them advance their basic learning ability and supplement lack of previous learning in class or after school. supplementary problems were developed by focusing the ability of basic calculation, the comprehension of concepts, principles, and rules by analyzing necessary contents precisely each domain after itemizing learning contents each unit. the results of the study are this: 1) The students who solved the problems, that were developed to improve the basic learning ability and to supplement the earlier learning during their classes or giving homework, made significant progress in their scholastic achievement; more than those who were not involved. 2) Meaningful changes were demonstrated in the motivation for achievement among the domains of learning attitudes before and after the experiment but, not in their interest, the consciousness of purpose, attention, voluntary and efficient learning as shown in their learning habits. In this study, therefore, the problems which were developed to improve the basic learning ability and to supplement the earlier learning by focusing on the competence for basic calculation, and the comprehension of concepts, principles and rules were effective positively only in the area of motivation for achievement. there were no meaningful differences in the other domains.

• Food Science and Biotechnology
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• v.16 no.6
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• pp.894-901
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• 2007

This study investigated the effects of cell cultured Acanthopanax senticosus extract (ASE) supplementation and swimming exercise on lipid profiles and carnitine concentrations in C57BL/6J mice fed high fat diets. Male C57BL/6J mice (n=50), aged 4 weeks, were divided into 5 groups based on exercise and/or ASE supplementation (0.5 g/kg of body weight): normal diet (N-C), high fat diet (H-C), high fat diet non-supplement & exercise (H-NSE), high fat diet supplement & no exercise (H-SNE), high fat diet supplement & exercis (H-SE). Liver nonesterified carnitine (NEC) was significantly higher in the H-SNE group than in the H-C group, and liver total carnitine (TCNE) levels were significantly higher in the H-SNE group than in the H-NSE and H-SE groups. Liver and muscle carnitine palmitoyltransferase-I (CPT-I) mRNA levels tended to be higher with ASE supplementation and/or exercise. These results suggest that supplementation with ASE and/or exercise might have a role in improving lipid oxidation.

• KSBB Journal
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• v.32 no.1
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• pp.54-62
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• 2017

This study aimed to estimate the measurement uncertainty related to determination of hyaluronic acid used as a dietary supplement by high-performance liquid chromatography. According to the guidelines of the Association of Official Analytical Chemists, the analytical processes for determination of hyaluronic acid were performed. And the measurement uncertainty obtained during the analytical processes were expressed in accordance with mathematical/ statistical guidances of GUM (Guide to the Expression of Uncertainty in Measurement) & EURACHEM (Focus for Analytical Chemistry in Europe) for the analytical operations. For the uncertainty in measurement produced based on this analytical method, the expanded uncertainty was calculated by using the relative standard uncertainty between analytical results and sources of uncertainty in measurement (sample weight, final volume, extraction volume, standard solution, matrix and instrument etc). In the results of 95% confidence interval, it was calculated that the uncertainty in measurement was $57.75{\pm}8.76{\mu}g/kg$ (k=2.0). Therefore, it showed that the measurement uncertainty obtained by this analytical method influences on 15.2% of the contents of hyaluronic acid as the analytical results.

• Korean journal of food and cookery science
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• v.24 no.5
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• pp.672-681
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• 2008

The principal objective of this study was to assess the current status of elementary students' intake of dietary supplements, in an effort to diagnose any overnutrition, and to employ the results as basic data for the establishment of a balanced nutritional education. A survey was conducted by using a questionnaire administered to 734 elementary students’ parents in Seoul, and the analyzed results were as follows: Most parents believed that their nutritional knowledge was better than the norm(91.5%). However, almost half of the parents(49.2%) were feeding certain dietary supplements to their children, despite their perception that their children were already healthy, and were not recognizing any significant beneficial effects from those supplements. The most popular dietary supplements being fed were vitamin complexes. The majority of children took at least one type of dietary supplements at a monthly cost of approximately 10,000${\sim}$30,000 won. These results revealed the potential for overnutrition in some of the elementary students as the result of dietary supplement intake; thus, further studies involving assessments of risk for dietary supplement overconsumption in children and proper dietary education for the parents are suggested.

• Journal of Korean Medical classics
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• v.20 no.3
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• pp.67-77
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• 2007

Through the translation and comparative study of the enriching blood and nourishing vital essence(補陰血方劑) in "The Elimination & Supplement about the Famous Prescription Comments(刪補名醫方論)" of "The Golden Mirror of Medicine(醫宗金鑑)" with "The Famous Prescription Comments on Ancient and Modern Times(古今名醫方論)", we confirmed that about 50% of the sentences from "The Elimination & Supplement about the Famous Prescription Comments(刪補名醫方論)" were quoted in "The Famous Prescription Comments on Ancient and Modern Times(古今名醫方論)", and that many of the text were not quoted unchanged, but were revised and supplemented. In organization, the prescription with the fewer number of component drugs is given first, followed by that with more component drugs, and that with similar component drugs is explained subsequently to facilitate understanding. In the prescription notes, it is emphasized that when enriching blood, the invigorative method(補氣法) is very important and that cold or pungent herb should be very carefully used.

• Journal of Nutrition and Health
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• v.27 no.2
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• pp.153-161
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• 1994

We fed high trypotophan diet(3.5% tryptophan/diet(w/w) to mice for 7 days and treated then with 3 hour immobilization(IMMB) stress to investigate tryptophan metabolism and immunomodulation. The levels of serum tryptophan, brain tryptophan, serotonin(5HT) and 5-hydroxyindoleacetic acid(5HIAA) in the tryptophan diet fed animals were higher than those of the normal diet fed animals. Feeding tryptophan supplemented diet to stressed animal significantly decreased the levels of serum and brain tryptophan and 5HT levels. However, the amount of 5HIAA which is the metabolite of serotonin was increased in brain. Plasma corticosterone level was increased by the stress in both groups but the degree of this increase was smaller in high tryptophan fed animals. The relative numbers of CD8+ T cells, CD4+ T cells and B cells in spleen were decreased in high tryptophan diet fed and stressed animals compared to control diet fed and no stressed animals. CD8+ T cells decreased more than CD4+ T cells. The decrease of CD8+ T cells in high tryptophan fed and stressed animals was similar to that in high tryptophan fed animals or normal diet fed and stressed animals. Stress and tryptophan supplement acted synergistically to decrease the number of B cells. This study suggests that stress and tryptophan supplement could modify the number of lymphocyte cells, and indicates that the interaction of stress and tryptophan supplement on immune fuction depends on the types of immune cells.

• Nutritional Sciences
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• v.3 no.1
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• pp.36-41
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• 2000

The aim of this study was to evalute the effect of multivitamin-mineral supplementation during pregnancy on plasma levels of antioxidants, erythrocyte antioxidant enzyme activities, and lipid peroxidation. A controlled, semi-randomized, prospective trial was performed by comparing the supplement group, which received multivitamin-mineral tables once daily for 10 weeks, with the control group. Plasma levels of $\beta$-carotene, tocopherol, coenzyme Q10, ascorbate, folate, zinc, and selenium and malondialdehyde (MDA), as well as the activities of superocxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in erythrocytes were measured initially (20 wk gestation) and at the end of the intervention (34 wk gestation). In the control group, plasma ascorbate and selenium levels decreased and tocopherol levels increased. In the supplement group, a significant increase in plasma $\beta$-carotene(46%), conenzyme Q10 (42%), and zinc (24%) was observed after 10 weeks of supplementation. No changes were observed in the plasma levels of MDA, and erythrocyte GSH-Px activity, while SOD activity increased in both control group and the supplement group during the intervention. These data suggest that multivitamin-mineral supplementation during pregnancy produced moderate increases in plasma $\beta$-carotens, coenzyme Q10, and zinc concentrations but the enhancement of those plasma antioxidants had on direct on the plasma level of MDA, erythrocytes SOD or GSH-Px activities.