Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Effects of Cell Cultured Acanthopanax senticosus Extract Supplementation and Swimming Exercise on Lipid and Carnitine Profiles in C57BL/6J Mice Fed a High Fat Diet

  • Park, Jeong-Eun (Department of Food Science and Human Nutrition and Research Institute of Human Ecology, Chonbuk National University) ;
  • Soh, Ju-Ryoun (Department of Food Science and Human Nutrition and Research Institute of Human Ecology, Chonbuk National University) ;
  • Rho, Jeong-Ok (Department of Food Science and Human Nutrition and Research Institute of Human Ecology, Chonbuk National University) ;
  • Cha, Youn-Soo (Department of Food Science and Human Nutrition and Research Institute of Human Ecology, Chonbuk National University)
  • Published : 2007.12.31
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Abstract

This study investigated the effects of cell cultured Acanthopanax senticosus extract (ASE) supplementation and swimming exercise on lipid profiles and carnitine concentrations in C57BL/6J mice fed high fat diets. Male C57BL/6J mice (n=50), aged 4 weeks, were divided into 5 groups based on exercise and/or ASE supplementation (0.5 g/kg of body weight): normal diet (N-C), high fat diet (H-C), high fat diet non-supplement & exercise (H-NSE), high fat diet supplement & no exercise (H-SNE), high fat diet supplement & exercis (H-SE). Liver nonesterified carnitine (NEC) was significantly higher in the H-SNE group than in the H-C group, and liver total carnitine (TCNE) levels were significantly higher in the H-SNE group than in the H-NSE and H-SE groups. Liver and muscle carnitine palmitoyltransferase-I (CPT-I) mRNA levels tended to be higher with ASE supplementation and/or exercise. These results suggest that supplementation with ASE and/or exercise might have a role in improving lipid oxidation.

Keywords

References

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