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Effects of Cell Cultured Acanthopanax senticosus Extract Supplementation and Swimming Exercise on Lipid and Carnitine Profiles in C57BL/6J Mice Fed a High Fat Diet  

Park, Jeong-Eun (Department of Food Science and Human Nutrition and Research Institute of Human Ecology, Chonbuk National University)
Soh, Ju-Ryoun (Department of Food Science and Human Nutrition and Research Institute of Human Ecology, Chonbuk National University)
Rho, Jeong-Ok (Department of Food Science and Human Nutrition and Research Institute of Human Ecology, Chonbuk National University)
Cha, Youn-Soo (Department of Food Science and Human Nutrition and Research Institute of Human Ecology, Chonbuk National University)
Publication Information
Food Science and Biotechnology / v.16, no.6, 2007 , pp. 894-901 More about this Journal
Abstract
This study investigated the effects of cell cultured Acanthopanax senticosus extract (ASE) supplementation and swimming exercise on lipid profiles and carnitine concentrations in C57BL/6J mice fed high fat diets. Male C57BL/6J mice (n=50), aged 4 weeks, were divided into 5 groups based on exercise and/or ASE supplementation (0.5 g/kg of body weight): normal diet (N-C), high fat diet (H-C), high fat diet non-supplement & exercise (H-NSE), high fat diet supplement & no exercise (H-SNE), high fat diet supplement & exercis (H-SE). Liver nonesterified carnitine (NEC) was significantly higher in the H-SNE group than in the H-C group, and liver total carnitine (TCNE) levels were significantly higher in the H-SNE group than in the H-NSE and H-SE groups. Liver and muscle carnitine palmitoyltransferase-I (CPT-I) mRNA levels tended to be higher with ASE supplementation and/or exercise. These results suggest that supplementation with ASE and/or exercise might have a role in improving lipid oxidation.
Keywords
Acanthopanax senticosus; lipid profile; carnitine; carnitine palmitoyltransferase-I (CPT-I);
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
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