• 한국임상수의학회지
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• 제34권6호
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• pp.445-448
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• 2017

A 1.5-year-old neutered male domestic short hair cat was presented with multiple nodular mass, and suspected mast cell tumor on the surface of the right ear, accompanied by submandibular lymph node involvement. Histopathological Examinations and KIT (CD117) immunohistochemical staining was performed after the surgical resection of the entire right ear pinna. This patient was diagnosed with an anaplastic mast cell tumor with a diffuse positive cytoplasmic expression of KIT. Imatinib mesylate was prescribed after surgical resection; the patient presented without recurrence or metastasis for 2 years. Mild leukopenia was observed as the only side effect of imatinib mesylate during medication.

• 농촌의학ㆍ지역보건
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• 제3권1호
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• pp.10-17
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• 1978

There are numerous reports on menarche age in korea and other countries but only few reports are available on menopausal age. This is a result of surveys on 509 women for menarche and 341 women for manopause among the rural areas of Choongnam and Kyungbuk province. For those born between 1894 and 1929. aver age ageof menarche was 16.63 years. The earliest was 13 years and latest was 22 years old. Majority (78.8%) had their menarohe at the age of between 15 and 18. It was noted that there was gradual advancement of menarche age among those born in later years than earlier. More menarche started in the months of October and April and fewest was in the month of June. Spring was the time when the largest number of women had menarche and this was followed by Autumn. Winter, and Summer. The most common menstrual cycle was 39 days type which is followed by 28 days and 26 days. The average monpausal age among rural korean women was 46.97 years. The number of years between menarche and menopause appears to be dependent upon individual physical and mental condition. socioeconomical circumstances. and also hereditary as well as ethnic differences. 87.1 % of rural korean women had menstrual ages of between 20 to 35 years according to this statistics and the average was 29.67 years.

• Transactions on Electrical and Electronic Materials
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• 제8권1호
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• pp.36-40
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• 2007

Inorganic layers, such as SiOxNy and SiOx deposited using plasma sublimation method, were tested as passivation layer for organic thin-film-transistors (OTFTs). OTFTs with bottom-gate and bottom-contact structure were fabricated using pentacene as organic semiconductor and an organic gate insulator. SiOxNy layer gave little change in characteristics of OTFTs, but SiOx layer degraded the performance of OTFTs severely. Inferior barrier properties related to its lower film density, higher water vapor transmission rate (WVTR) and damage due to process environment of oxygen of SiOx film could explain these results. Polyurea and polyvinyl acetates (PVA) were tested as organic passivation layers also. PVA showed good properties as a buffer layer to reduce the damage come from the vacuum deposition process of upper passivation layers. From these results, a multilayer structure with upper SiOxNy film and lower PVA film is expected to be a superior passivation layer for OTFTs.

• 대한의생명과학회지
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• 제21권4호
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• pp.172-180
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• 2015

It is well reported that tumor cells can regulate host immune systems. To identify the detailed changes of immune cells between tumor bearing mice and normal mice, we evaluated the systemic immune cell phenotype of B16F10 tumor bearing mice in a time dependent manner. The lymphocytic population (CD4+ and CD8+ T cells) of tumor bearing mice significantly decreased compared to that of normal mice. We found that the Foxp3+CD25+ CD4 T cell decreased, but the Foxp3+$CD25^{high}$ CD4 T cell significantly increased. All subpopulations of CD8 T cells decreased, except the CD62L-CD44+ CD8 T cell subpopulation. The myeloid cell population (CD11b+ and Gr-1+ cells) of tumor bearing mice significantly increased. Specifically, Foxp3+$CD25^{high}$ CD4 T cell and CD11b+Gr-1+ cells significantly increased in early phase of tumor progression. These results are helpful to understand the change of the systemic immune cell subpopulation of tumor bearing mice in a time-dependent manner.

• 대한의생명과학회지
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• 제20권3호
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• pp.147-155
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• 2014

It has well studied that immune cells are strongly related to tumor progression and tumor suppression. To identify the difference of immune cell between tumor bearing mice and normal mice, we examined systemically the immune cell of CT26 tumor bearing mice on 21 days after tumor cell administration. As previously reported, CD4+ and CD8+ T cells population of tumor bearing mice significantly decreased 38% and 30% on day 21 compared to that of normal mice, respectively. All subpopulation of CD4 and CD8+ T cell significantly decreased, except CD49b+ T cell subpopulation. But, myeloid cell population ($CD11b^{high}$ and all Gr-1+ subpopulation) of tumor bearing mice significantly increased on day 21. Especially, all subpopulation of CD11b+Gr-1+ cell of tumor bearing mice significantly increased on day 21. Also, Foxp3+$CD25^{high}$ CD4 T cell (regulatory T cells) population significantly increased on day 21. These results suggest that tumor can induce the decline of T lymphocyte and the expansion of myeloid cells and regulatory T cells, and provide the basic information for the study of tumor immunology.

• Natural Product Sciences
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• 제20권4호
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• pp.262-268
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• 2014

Rutaecarpine is one of the major alkaloids present in the fruits of Evodia rutaecarpa. In this study, rutaecarpine was evaluated, both in vitro and in vivo, for its hepatoprotective properties against thioacetamide (TAA)-induced hepatic fibrosis. The results showed that rutaecarpine inhibited TAA-induced cytotoxicity, reduced the expression of the fibrogenic cytokine transforming growth factor ${\beta}1$ ($TGF-{\beta}1$), and induced the expression of bcl-2. To evaluate its in vivo effects, animal models with TAA-induced hepatic fibrosis were utilized. Levels of liver tissue injury-associated enzymes, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were monitored. $TGF-{\beta}1$ and the ${\alpha}$-smooth muscle actin (${\alpha}$-SMA) were measured as markers of the protective effects on hepatic fibrosis. The AST and ALT levels in blood were greatly enhanced by TAA and completely blunted by rutaecarpine. Rutaecarpine led to the down-regulation of $TGF-{\beta}$ and Bax mRNA expression, as well as the up-regulation of Bcl-2 and $Bcl-X_L$ mRNA levels. In conclusion, rutaecarpine inhibited TAA-induced hepatic fibrosis and apoptosis by inducing the expression of Bcl-2 while blocking $TGF-{\beta}1$ in our TAA-intoxicated model.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1996년도 하계학술대회 논문집 C
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• pp.1804-1806
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• 1996

For the rather complicated and time-consuming three-dimensional electric field calculation in the vicinity of substations, this paper proposes a numerical calculation method based on charge simulation method(CSM). In order to represent non-uniform charge distribution on an electrode better, it is subdivided into small segments with linear charge density. Non-uniform arrangement of subdivided segments makes it possible to obtain high accuracy with a small number of variables. As for the arrangement of subdivided segments, effective formulars were derived from multiple regression analysis of many simulations. These formulars make the arrangement of segments fast and effective. The proposed method is applied to the electric field calculation around the 345kV Sinmasan Substation busbars and the distribution of calculated electric fields is compared with that of the measured electric fields.

• Radiation Oncology Journal
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• 제5권2호
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• pp.137-140
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• 1987

자궁경부암의 고선량율 강내치료의 매 분할 치료시마다 강내 applicator의 위치 차이로 인하여 조사 선량이 치료전 계획된 선량과 차이가 있을 수 있다. 저자는 자궁경부암 환자의 강내치료시 치료전 계획된 A점 선량 500 cGy와 치료직후에 촬영한 전후 및 측면 선 사진을 이용하여 계산된 A점 선량을 비교한 결과, 82예의 강내치료에서 치료 후 계산된 조사 선량과 계획 선량은 $500\pm18 cGy$이었으며 $84\%$에서 $500\pm25 cGy$의 범위에 포함되었다. 이러한 결과에서 계획 선량과 치료 후 계산된 조사 선량사이에 비교적 높은 일치율을 확인할 수 있었다.

• 대한골관절종양학회지
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• 제13권2호
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• pp.142-145
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• 2007

위장관이외의 장소에서 위장관 간질 종양(Gastrointestinal stromal tumor, GIST)이 발생하는 경우는 매우 드물기 때문에 일차적 병소가 아닌 전이 병소로 진단되는 경향이 있다. 이에 본 저자들은 25세 남자에서 좌측 둔부 중둔근, 소둔근에서 발생한 위장관 간질 종양이 복부의 일차 병소없이 인접한 장골 및 천골을 침범한 1례를 경험하였다. 이에 위장관외 간질종양(Extragastrointestinal stromal tumor, EGIST)이라는 진단명과 함께 보고하고자 한다.

• 한국식품과학회지
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• 제35권2호
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• pp.306-308
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• 2003

국내산 주요 포도 품종에 대해서 부위별 레스베라트롤 함량을 HPLC 분석법을 이용하여 측정하였다. 거봉, 캠벨, 세리단 포도의 과육, 과피, 씨, 송이가지에 함유되어 있는 레스베라트롤의 함량은 품종간 차이는 거의 나타나지 않았으나 부위별로 차이가 매우 큰 것으로 나타났다. 송이가지에 함유되어 있는 레스베라트롤의 함량은 과피에 비해 $34{\sim}55$배나 많고 씨에 비해서는 $43{\sim}73$배나 많은 수준이었다. 레스베라트롤을 생산하기 위한 자원으로서 포도를 활용하기 위해서는 송이가지가 적합한 것으로 나타났다.