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http://dx.doi.org/10.17555/jvc.2017.12.34.6.445

Clinical Application of Imatinib Mesylate in a Case of Feline Cutaneous Mast Cell Tumor: Clinical Progress, Histopathological, and Immunohistochemical Findings  

Jang, Hyo-Mi (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
Song, Joong-Hyun (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
Hwang, Tae-Sung (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
Lee, Hee-Chun (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
Yu, Do-Hyeon (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
Sur, Jung-Hyang (Department of Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University)
Kang, Byeong-Teck (Laboratory of Veterinary Dermatology and Neurology, College of Veterinary Medicine, Chungbuk National University)
Jo, Yang-Rae (Joyangrae Animal Medical Center)
Jung, Dong-In (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
Publication Information
Journal of Veterinary Clinics / v.34, no.6, 2017 , pp. 445-448 More about this Journal
Abstract
A 1.5-year-old neutered male domestic short hair cat was presented with multiple nodular mass, and suspected mast cell tumor on the surface of the right ear, accompanied by submandibular lymph node involvement. Histopathological Examinations and KIT (CD117) immunohistochemical staining was performed after the surgical resection of the entire right ear pinna. This patient was diagnosed with an anaplastic mast cell tumor with a diffuse positive cytoplasmic expression of KIT. Imatinib mesylate was prescribed after surgical resection; the patient presented without recurrence or metastasis for 2 years. Mild leukopenia was observed as the only side effect of imatinib mesylate during medication.
Keywords
cat; imatinib mesylate; immunohistochemistry; KIT; mast cell tumor;
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