• 한국도서관정보학회지
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• 제45권1호
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• pp.81-102
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• 2014

이 논문은 지난 1978년 서광탑의 수리를 위한 조사과정에서 3층 탑심부의 천궁에서 다량의 불교문화재를 수습하였다. 당시 수습한 문화재에는 당대에서 북송초기에 조성된 귀중한 불교문헌 123점이 포함되어 있다. 소주 서광사는 적조(赤鳥) 4(241)년에 오나라 첫 번째 왕이었던 손권(孫權)이 강거국에서 온 승려 성강(性康)을 맞이하기 위해서 세워진 사찰이며, 창건 당시에는 보제선원(普濟禪院)으로 부르다가 북송 초기 원희 연간에 와서 대대적으로 중창하고 지금의 서광사(瑞光寺)로 개명하였다. 서광탑은 서광사가 완공된 직후인 적조(赤鳥) 10(247)년에 손권이 모친의 극락왕생과 국태민안을 기원하기 위해 사찰 내에 13층탑을 세웠으며, 이후 오랜 세월이 지나 이 탑이 크게 파손되어 천희(天禧) 1 (1017)년에 새로 중건하고 이름을 다보탑(多寶塔)이라 하였다. 서광탑에서 출토된 불교문헌은 크게 다라니류 3건 107점과 전적류 5종 16권 등 모두 123점으로 파악되었다. 특히 전적류 가운데 법화경사경은 당대에 감지에 금자로 조성된 것으로 전 7권이 비교적 완전한 상태이며, 동아시아 국가에 현존하는 감지금자사경 가운데 최선본으로 평가할 만하다. 또한 북송초기에 간행된 목판본이 6권이나 완전한 상태로 발견되었다. 그동안 일본학자 나가자와(長澤)가 이와 동일본인 중촌본(中村本)을 초당본(初唐本)으로 잘 못 소개한 이후 모든 개설서에 그대로 반영하고 있는데, 이 연구를 통해 오류를 수정할 계기가 되었다는 점이 의미가 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2307-2312
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• 2015

Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remedies commonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interest recently. In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. It was found that curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses. Interestingly, curcumol did not display growth inhibition in MRC-5 human embryonic lung fibroblasts, suggesting the anti-proliferative effects of curcumol were specific to cancer cells. Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/ kg daily) significantly reduced tumor size without causing notable toxicity. In conclusion, curcumol appears a favorable anti-cancer candidate for further development.

• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10115-10119
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• 2015

Purpose: The aim of this study was to investigate effects of adipose-derived mesenchymal stem cells (AMSCs) on radioresistance of breast cancer cells. Materials and Methods: MTT assays were used to detect any influence of AMSC supernatants on proliferation of breast cancer cells; cell migration assays were used to determine the effect of breast cancer cells on the recruitment of AMSCs; the cell survival fraction post-irradiation was assessed by clonogenic survival assay; ${\gamma}$-H2AX foci number post-irradiation was determined via fluorescence microscopy; and expression of IGF-1R was detected by Western blotting. Results: AMSC supernatants promoted proliferation and radioresistance of breast cancer cells. Breast cancer cells could recruit AMSCs, especially after irradiation. IGF-1 derived from AMSCs might be responsible for the radioresistance of breast cancer cells. Conclusions: Our results suggest that AMSCs in the tumor microenvironment may affect the outcome of radiotherapy for breast cancer in vitro.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4871-4875
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• 2013

This meta-analysis was performed to evaluate and compare the outcomes of robotic gastrectomy (RG) and laparoscopic gastrectomy (LG) for treating gastric cancer. A systematic literature search was carried out using the PubMed database, Web of Knowledge, and the Cochrane Library database to obtain comparative studies assessing the safety and efficiency between RG and LG in May, 2013. Data of interest were analyzed by using of Review Manager version 5.2 software (Cochrane Collaboration). A fixed effects model or random effects model was applied according to heterogeneity. Seven papers reporting results that compared robotic gastrectomy with laparoscopic gastrectomy for gastric cancer were selected for this meta-analysis. Our metaanalysis included 2,235 patients with gastric cancer, of which 1,473 had undergone laparoscopic gastrectomy, and 762 had received robotic gastrectomy. Compared with laparoscopic gastrectomy, robotic gastrectomy was associated with longer operative time but less blood loss. There were no significant difference in terms of hospital stay, total postoperative complication rate, proximal margin, distal margin, numbers of harvested lymph nodes and mortality rate between robotic gastrectomy and laparoscopic gastrectomy. Our meta-analysis showed that robotic gastrectomy is a safe technique for treating gastric cancer that compares favorably with laparoscopic gastrectomy in short term outcomes. However, the long term outcomes between the two techniques need to be further examined.

• BMB Reports
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• 제52권9호
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• pp.566-571
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• 2019

Lymphoma is one of the most curable types of cancer. However, drug resistance is the main challenge faced in lymphoma treatment. Peroxisomal acyl-CoA oxidase 1 (ACOX1) is the rate-limiting enzyme in fatty acid ${\beta}$-oxidation. Deregulation of ACOX1 has been linked to peroxisomal disorders and carcinogenesis in the liver. Currently, there is no information about the function of ACOX1 in lymphoma. In this study, we found that upregulation of ACOX1 promoted proliferation in lymphoma cells, while downregulation of ACOX1 inhibited proliferation and induced apoptosis. Additionally, overexpression of ACOX1 increased resistance to doxorubicin, while suppression of ACOX1 expression markedly potentiated doxorubicin-induced apoptosis. Interestingly, downregulation of ACOX1 promoted mitochondrial location of Bad, reduced mitochondrial membrane potential and provoked apoptosis by activating caspase-9 and caspase-3 related apoptotic pathway. Overexpression of ACOX1 alleviated doxorubicin-induced activation of caspase-9 and caspase-3 and decrease of mitochondrial membrane potential. Importantly, downregulation of ACOX1 increased p73, but not p53, expression. p73 expression was critical for apoptosis induction induced by ACOX1 downregulation. Also, overexpression of ACOX1 significantly reduced stability of p73 protein thereby reducing p73 expression. Thus, our study indicated that suppression of ACOX1 could be a novel and effective approach for treatment of lymphoma.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 정기총회 및 추계학술대회 논문집
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• pp.1092-1099
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• 2011

This paper is concerned with the ATO speed profile generation method in the moving block system. The ATO speed profile is calculated using the acceleration limit and the jerk limit to improve ride comfort. In addition, the speed limit and stop distance provided from ATP profile should be considered to ensure safety. In the moving block system, the speed limit and the stop position are frequently changed in real-time. Therefore, the ATO speed profile should be regenerated immediately according to change of the speed limit and the stop position, within the acceleration limit and the jerk limit. In this paper, the ATO speed profile generation method is proposed, which considers not only frequent changes of the speed limit and the stop position but also acceleration limit and jerk limit. Futhermore the simulation result is presented to verify usefulness of this method.

• 한국멀티미디어학회:학술대회논문집
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• 한국멀티미디어학회 2012년도 춘계학술발표대회논문집
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• pp.34-37
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• 2012

초점거리, 노출 및 백색 평형이 자동으로 조절되는 PTZ 카메라에서는 회전각도에 따라 각 장면의 조명이 변화하기 때문에 각 장면에서 부동한 노출과 백색평형 값을 가지게 되며 때로는 인접 이미지의 색상도 큰 차이가 있을 수 있다. 그러므로 파노라마 배경에서 현재 입력영상의 대응 배경을 추출하여 픽셀 차분하면 에러가 많이 발생할 수 있다. 본 논문에서는 조도변화에 강인한 Haar-Like 특징을 이용하여 넓은 시야 범위를 감시할 수 있는 PTZ 카메라에서 이동 객체를 검출하는 새로운 방법을 제안한다.

• 천문학회지
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• 제44권6호
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• pp.209-215
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• 2011

In this paper, the long-term hemispheric variation of the polar faculae is investigated. It is found that, (1) both the N-S asymmetry and N-S asynchrony of the polar faculae exhibit a long-term persistence, which suggests that they should not be regarded as a stochastic phenomenon; (2) both the N-S asynchrony and N-S asymmetry of the polar faculae are functions of the latitude, implying that the N-S asynchrony of the polar faculae is related to the N-S asymmetry of the polar faculae; (3) from a long-term view, the dominant hemisphere of the polar faculae seems to have close connection with the phase-leading hemisphere of the polar faculae.

• Bulletin of the Korean Chemical Society
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• 제34권4호
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• pp.1023-1024
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• 2013

• 한국자기학회지
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• 제5권5호
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• pp.507-510
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• 1995

A heat-treatment method of pre-annealing and then flash annealing(FA) has been used to improve the soft magnetic properties of nanocrystalline $Fe_{76}CuSi_{13}B_{10}$ and $Fe_{74}CuNb_{3}Si_{12}B_{10}$ alloys. Outstanding magnetic properties of nanocrystalline $Fe_{74}CuNb_{3}Si_{12}B_{10}$ alloy were attained by flash-annealing in air after annealed at $500^{\circ}C$ for 0.5hr below the crystallization temperature. The same results were obtained for $Fe_{74}CuSi_{13}B_{10}$ alloy. The measurment of relief of stress and X-ray diffraction were used to analyze the effect of flashannealing.