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http://dx.doi.org/10.7314/APJCP.2015.16.6.2307

Curcumol Induces Apoptosis in SPC-A-1 Human Lung Adenocarcinoma Cells and Displays Anti-neoplastic Effects in Tumor Bearing Mice  

Tang, Qi-Ling (College of Chinese Medicine, Guangdong Pharmaceutical University)
Guo, Ji-Quan (Department of Respiration, Guangdong General Hospital)
Wang, Qi-You (Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-Sen University)
Lin, Hai-Shu (Department of Pharmacy, Faculty of Science, National University of Singapore)
Yang, Zhou-Ping (Novel Drug Screening Center, Department of Pharmacology, Guangdong Pharmaceutical University)
Peng, Tong (College of Chinese Medicine, Guangdong Pharmaceutical University)
Pan, Xue-Diao (Novel Drug Screening Center, Department of Pharmacology, Guangdong Pharmaceutical University)
Liu, Bing (Novel Drug Screening Center, Department of Pharmacology, Guangdong Pharmaceutical University)
Wang, Su-Jun (Novel Drug Screening Center, Department of Pharmacology, Guangdong Pharmaceutical University)
Zang, Lin-Quan (Novel Drug Screening Center, Department of Pharmacology, Guangdong Pharmaceutical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.16, no.6, 2015 , pp. 2307-2312 More about this Journal
Abstract
Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remedies commonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interest recently. In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. It was found that curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses. Interestingly, curcumol did not display growth inhibition in MRC-5 human embryonic lung fibroblasts, suggesting the anti-proliferative effects of curcumol were specific to cancer cells. Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/ kg daily) significantly reduced tumor size without causing notable toxicity. In conclusion, curcumol appears a favorable anti-cancer candidate for further development.
Keywords
Curcumol; anti-proliferation; apoptosis; lung adenocarcinoma; tumor bearing mice;
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