ACOX1 destabilizes p73 to suppress intrinsic apoptosis pathway and regulates sensitivity to doxorubicin in lymphoma cells |
Zheng, Fei-Meng
(Department of Medical Oncology, The Eastern Hospital, The First Affiliated Hospital, Sun Yat-sen University)
Chen, Wang-Bing (Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology) Qin, Tao (Department of Medical Oncology, Sun Yat-sen Hospital, Sun Yat-sen University) Lv, Li-Na (Department of Hematology, Wuming Hospital of Guangxi Medical University) Feng, Bi (Department of Medical Oncology, The Eastern Hospital, The First Affiliated Hospital, Sun Yat-sen University) Lu, Yan-Ling (Department of Medical Oncology, The Eastern Hospital, The First Affiliated Hospital, Sun Yat-sen University) Li, Zuo-Quan (Department of Ultrasound, Guancheng Hospital) Wang, Xiao-Chao (Department of Hematology, Affiliated Hospital of Youjiang Medical University for Nationalities) Tao, Li-Ju (Department of Hematology, Wuming Hospital of Guangxi Medical University) Li, Hong-Wen (Department of Hematology, Wuming Hospital of Guangxi Medical University) Li, Shu-You (Department of Medical Oncology, Wuming Hospital of Guangxi Medical University) |
1 | Huh J (2012) Epidemiologic overview of malignant lymphoma. Korean J Hematol 47, 92-104 DOI |
2 | Smith A, Crouch S, Lax S et al (2015) Lymphoma incidence, survival and prevalence 2004-2014: sub-type analyses from the UK's Haematological Malignancy Research Network. Br J Cancer 112, 1575-1584 DOI |
3 | Shanbhag S and Ambinder RF (2018) Hodgkin lymphoma: A review and update on recent progress. CA Cancer J Clin 68, 116-132 DOI |
4 | Armitage JO, Gascoyne RD, Lunning MA and Cavalli F (2017) Non-Hodgkin lymphoma. Lancet 390, 298-310 DOI |
5 | Zeng J and Li D (2004) Expression and purification of his-tagged rat peroxisomal acyl-CoA oxidase I wild-type and E421 mutant proteins. Protein Expr Purif 38, 153-160 DOI |
6 | Fournier B, Saudubray JM, Benichou B et al (1994) Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy. J Clin Invest 94, 526-531 DOI |
7 | Fan CY, Pan J, Chu R et al (1996) Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem 271, 24698-24710 DOI |
8 | Fan CY, Pan J, Usuda N, Yeldandi AV, Rao MS and Reddy JK (1998) Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J Biol Chem 273, 15639-15645 DOI |
9 | Huang J, Viswakarma N, Yu S et al (2011) Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice. Am J Pathol 179, 703-713 DOI |
10 | Melino G, De Laurenzi V and Vousden KH (2002) p73: Friend or foe in tumorigenesis. Nat Rev Cancer 2, 605-615 DOI |
11 | Oberst A, Rossi M, Salomoni P et al (2005) Regulation of the p73 protein stability and degradation. Biochem Biophys Res Commun 331, 707-712 DOI |
12 | Jones EV, Dickman MJ and Whitmarsh AJ (2007) Regulation of p73-mediated apoptosis by c-Jun N-terminal kinase. Biochem J 405, 617-623 DOI |
13 | Nemajerova A, Petrenko O, Trumper L, Palacios G and Moll UM (2010) Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice. J Clin Invest 120, 2070-2080 DOI |
14 | Zorova LD, Popkov VA, Plotnikov EY et al (2018) Mitochondrial membrane potential. Anal Biochem 552, 50-59 DOI |
15 | Chao C, Herr D, Chun J and Xu Y (2006) Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J 25, 2615-2622 DOI |
16 | Antonenkov VD, Grunau S, Ohlmeier S and Hiltunen JK (2010) Peroxisomes are oxidative organelles. Antioxid Redox Signal 13, 525-537 DOI |
17 | Dahabieh MS, Di Pietro E, Jangal M et al (2018) Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism. Biochim Biophys Acta Rev Cancer 1870, 103-121 DOI |
18 | Dahabieh MS, Ha Z, Di Pietro E et al (2017) Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis. Cell Death Differ 24, 1912-1924 DOI |
19 | Ferdinandusse S, Denis S, Hogenhout EM et al (2007) Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency. Hum Mutat 28, 904-912 DOI |
20 | Yu S, Rao S and Reddy JK (2003) Peroxisome proliferatoractivated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis. Curr Mol Med 3, 561-572 DOI |
21 | Asher G, Tsvetkov P, Kahana C and Shaul Y (2005) A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73. Genes Dev 19, 316-321 DOI |
22 | Hashimoto T, Fujita T, Usuda N et al (1999) Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype. J Biol Chem 274, 19228-19236 DOI |
23 | Rossi M, De Laurenzi V, Munarriz E et al (2005) The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J 24, 836-848 DOI |
24 | Miyazaki K, Ozaki T, Kato C et al (2003) A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. Biochem Biophys Res Commun 308, 106-113 DOI |
25 | Agami R, Blandino G, Oren M and Shaul Y (1999) Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature 399, 809-813 DOI |
26 | Zheng F, Yue C, Li G et al (2016) Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nat Commun 7, 10180 DOI |
27 | Zheng FM, Long ZJ, Hou ZJ et al (2014) A novel small molecule aurora kinase inhibitor attenuates breast tumor-initiating cells and overcomes drug resistance. Mol Cancer Ther 13, 1991-2003 DOI |