• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7489-7496
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• 2013

This study was conducted to investigate enhancement of anti-tumor effects of the lentogenic Newcastle disease virus Clone30 strain (NDV rClone30) expressing cytosine deaminase (CD) gene against tumor cells and in murine groin tumor-bearing models. Cytotoxic effects of the rClone30-CD/5-FC on the HepG2 cell line were examined by an MTT method. Anti-tumor activity of rClone30-CD/5-FC was examined in H22 tumor-bearing mice. Compared to the rClone30-CD virus treatment alone, NDV rClone30-CD/5-FC at 0.1 and 1 MOIs exerted significant cytotoxic effects (P<0.05) on HepG2 cells. For treatment of H22 tumor-bearing mice, recombinant NDV was injected together with 5-FC given by either intra-tumor injection or tail vein injection. When 5-FC was administered by intra-tumor injection, survival for the rClone30-CD/5-FC-treated mice was 4/6 for 80 days period vs 1/6, 0/6 and 0/6 for the mice treated with rClone30-CD, 5-FC and saline alone, respectively. When 5-FC was given by tail vein injection, survival for the rClone30-CD/5-FC-treated mice was 3/6 vs 2/6, 0/6 and 0/6 for the mice treated with rClone30-CD, 5-FC or saline alone, respectively. In this study, NDV was used for the first time to deliver the suicide gene for cancer therapy. Incorporation of the CD gene in the lentogenic NDV genome together with 5-FC significantly enhances cell death of HepG2 tumor cells in vitro, decreases tumor volume and increases survival of H22 tumor-bearing mice in vivo.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.8 no.1
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• pp.70-82
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• 1997

Objective：This study was performed to identify and understand the characteristics of adolescents who had a history of police arrest and/or were adjudicated unruly/delinquent by the juvenile court. Method：The study employed a retrospective reivew of coumputer-recorded data set on 210 consecutive admissions to an adolescent psychiatric inpatient unit. Three groups(No Police Contact, N=115；Police Contact Only, N=60；Adjudicated, N=35) were compared on the areas of a) cognitive and educational performance b) emotion：anxiety, depression, suicidality c) personality d) family and life experiences. Standardized assessments were administered to all subjects using WISC-Ⅲ, Kaufman Test of Educational Achievement, Millon Adolescent Personality Inventory, Reynolds Adolescent Depression Scale, Revised-Chilren’s Manifest Anxiety Scale, Suicide Ideation Questionnarie, Suicide Behavior Interive, Life Events Checklist, and Family Environmental Scale. A subgroup of the subjects, 60 cases also received a standardized interview by Child Assessment Schedule. Results：The characteristic findings of the delinquent group(the police contact only and adjudicated subjects combined) included (1) a high rate of adoption, sexual promiscuity, out of home placement, and repeated psychiatric hospitalization, (2) low verbal IQ scores and educational achievements, (3) high impulsivity, low social conformity, and high forcefulness in personality inventory, (4) low activityrecreation orientation and low moral religious emphasis in family environment, (5)a high frequency of adverse life experiences, (6) among 3 groups, the Police Contact Only group showed the lowest depression, anxiety and suicidal ideation scores, (7) a high diagnostic frequency of conduct disorder, ODD, and ADHD. Conclusions：The adolescent psychiatric inpatients with a delinquent history presented with a certain clinical, family, psychometric characteristics that warrant specific clinical intervention strategies for their cognitive deficits, an impulsive personality style, family dysfunction with adverse life experiences and disruptive behavioral disorders, different from the rest of adolescent psychiatric inpatients.

• Journal of Digital Convergence
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• v.12 no.11
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• pp.395-405
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• 2014

This study tends to grasp the physical activity on its influences and effect s to the mental health of middle school students and we tried to look for a specific plan that will help to improve middle school students' mental health. We analyzed 36,530 students in middle school using a basic data "9th (2013) health behavior of juvenile on the online". The study is analyzed by complex sample data analysis method. The degree of euphoria recognition showed the low feeling of happiness when students exercise directly below two times rather than three times a week in the Physical Education class at school. On the other hand, the possibility of stress perception degree and suicide attempt is lowered. If the number of sports team participating is below one team, euphoria would be lowered and the limit of stress perception is high. However, the participation of one or two teams make the possibility of suicide lessens rather than students taking part in more 4 teams. In order to help middle school students reduce their stress and improve their happiness, they need to participate in sports as a regular team and join intramural games more than three times a week. In this case of the lower grade, it is considered that it is necessary for them to combine the educational program for the emotional support to control their extreme behavior.

• The Journal of the Korea Contents Association
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• v.18 no.11
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• pp.516-526
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• 2018

Purpose: This study is to identify how depression, anxiety and social support influence on suicidal ideation of Parkinson disease patients related to general characteristics. Methods: This descriptive correlative study was conducted through an organized and structured questionnaire and 120 sampled Parkinson disease patients. Collected data was analyzed by t-tests, ANOVA, and Preason's correlation coefficient and multiple regression analysis using SPSS 19.0. Results : Finding revealed 1) The degrees of suicidal ideation were significantly different upon the martial status(F=3.37, p=.021) among groups, drinking(F=4.97, p=.008) and smoking history(F=4.77, p=.010): 2) Pearson's correlation coefficient indicated significant association among the depression, anxiety, social support and suicidal ideation 3) Multiple regression analysis showed depression(${\beta}=.58$ t=7.77, p<.001), social support(${\beta}=-.21$, t=-2.69, p=.008) and alcohol drinking(${\beta}=.17$ t=2.61, p=.010). Depression was the major influencing factor and it has 54% of explanation power. Conclusion: Based on the findings of this study, health professionals should provide parkinson disease patients with comprehensive and appropriate management method to prevent suicide ideation upon factors: depression, anxiety and social support to prevent suicide ideation. Especially, implement of self-help group program to parkinson disease patients is very needed.

• The Journal of the Korea Contents Association
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• v.21 no.5
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• pp.765-775
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• 2021

The purpose of this study is to investigate factors that affect the suicidal ideation of the people with mental disabilities. To this end, the independent variables were analyzed by categorizing them into individual psychological factors, social factors, and demographic characteristics. The analysis data include 969 people with mental disabilities who participated in the 2017 Ministry of Health and Welfare's Research, 'Survey on the Current Status of Mental Disabilities in Community'. The analysis method was frequency analysis, descriptive statistics, and hierarchical multiple regression analysis with SPSS 23.0. As a result of the study, in terms of individual psychological factors, the higher the depression and the lower the mental health confidence, the more suicidal ideation increase. In terms of social factors, the more unregistered disabled groups, the more exposure to violence and discrimination, and the more they live in large cities, the higher their ideation of suicidal. The regression model explained 26.9% of suicidal ideation. The practical and policy implications for the prevention of suicide of the people with mental disabilities based on these results are as follows: First, social factors should be evaluated and considered together, rather than focusing only on individual psychological factors, in seeking policies and intervention programs that reduce suicidal ideation in the people with mental disabilities. Second, in seeking suicide prevention policies for the people with mental disabilities, Protection & Advocacy services should be provided to reduce violence and discrimination experiences. Third, in order to reduce the suicidal ideation of the people with mental disabilities, the mental disability registration system should be reorganized, and policy alternatives should be devised so that those experiencing mental distress can be included into the system.

• Journal of Internet of Things and Convergence
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• v.8 no.5
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• pp.63-70
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• 2022

This study is a study that collects and analyzes data through An autoethnographyon as one of method of qualitative research, through which researcher have experienced firsthand in the process of developmenting and counseling there a new concept professional mental health mobile service platform as a mental health social welfare expert. The results of this study are as follows.First, there are people in Korea who are directly exposed to mental health issues and need to receive professional medical services, but there are also quite a few members of the public who have a desire for general mental health services, although the level of therapeutic intervention is not required. Second, considering the characteristics of modern society and especially in the pandemic situation of infectious diseases such as COVID-19, more and more people are preferring various mental health service platforms using mobile devices. Third, all generations complain of mental health issues such as family problems, stress, interpersonal relationships, and occupations, and other mental health problems such as self-harm and suicide accidents are frequently mentioned in connection with mental disorders such as depression, anxiety disorder, addiction, and post-traumatic stress disorder. Fourth, youngth s were exposed to various mental health-related issues, and above all, they were complaining of serious mental health problems such as self-harm and suicide accidents. Fifth, in delivering professional mental health services, mental health experts with the ability also to provide professional services online through mobile devices are needed as well offline. Finally, based on the results of this study, policy and practical suggestions related to the provision of mental health services in the future, and directions for follow-up studies were suggested.

• Korean Journal of Social Welfare Studies
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• v.42 no.2
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• pp.467-491
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• 2011

The purpose of this study is to examine relationship between social strains such as status strains and relational strains and adolescent suicidality by gender. As method, a self-report survey was completed by students (n = 819) from 3 middle schools in Seodaemun area, Seoul, Korea. Logistic regression analyses were conducted to identify factors associated with adolescent suicidality, t-test analyses were used to verify gender difference. Results show that male adolescents are more likely to experience abuse from their father, and school violence related to relational strains than female. Differences were found in strains for males and females contributing to suicidality; male are responsive to economic status, a dimension of status strain, whereas female are reactive to non-physical abuse from father, a type of relational strains. Non-physical school violence was appeared to be a significant factor influencing suicidality for both genders. Based on these findings, research draws implications for social work interventions. First, different approaches by gender are needed to prevent adolescent suicide in consideration of the tendency that men are status-oriented and women are relationship-oriented. Second, it is suggested to hire full-time school social worker to provide consistent social service for students. Third, intensive effort is necessary to reduce non-physical school violence.

• Korean Journal of Health Education and Promotion
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• v.31 no.3
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• pp.73-81
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• 2014

Objectives: This study examined how adolescents' cognitive stress relates to suicidal thought, thereby offering basic data about social and institutional ways to reduce adolescent suicide. Methods: In this study, data from an online survey on adolescents' health conducted by Korea Center for Disease Control(2013, 9th) was used after altering it to fit the purpose of the study. The data was analysed using the complex sampling method and structural equation model(SEM). Results: Whilst adolescents' cognitive stress had positive effects on suicidal thought, problem drinking and cognitive depression, it had a negative effect on physical activity. The structural equation model from cognitive stress, problem drinking, cognitive depression, physical activity influenced suicidal thought. Problem drinking on the other hand had an influence on cognitive depression. Conclusion: These findings suggest that future intervention programs for prevention of adolescents' suicidal thought should also address problem drinking, cognitive depression, and cognitive stress.

• The Journal of Korean Academic Society of Nursing Education
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• v.14 no.2
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• pp.176-187
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• 2008

Purpose: The purpose of this study was to identify the factors that influence depression, suicidal thought, and life satisfaction of Korean elders. Method: The subjects for this study were 219 Korean elders living in three different provinces. The data was collected using structured questionnaires from October through December, 2007. Result: There were statistically significant differences in the levels of depression, suicidal thought, and life satisfaction according to age, health state, sleep state, economic state, feeling of loneliness, feeling of abuse, and having friends or neighbors. Suicidal thoughts correlated less with the above factors than depression did. Depression significantly correlated with age, life satisfaction, loneliness and suicidal thought. Suicidal thought was influenced significantly by depression. Life satisfaction was influenced significantly by depression, health state, and economic state. Conclusion: It could be concluded that nursing interventions for reducing depression and suicidal thought should be developed to improve life satisfaction and the health state of Korean elders as well as to relieve their feelings of loneliness.

• Journal of Korean Public Health Nursing
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• v.21 no.2
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• pp.217-229
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• 2007

Purpose: This study sought to investigate the relationship between smoking, drinking and the mental health of adolescents. Method: The study subjects included 1,092 randomly sampled third-year middle and high school students from N-City and the L-Kun area in Chonbuk Province. The data were collected using an anonymous questionnaire developed by the Ministry of Health and Welfare(2005). The data were analyzed using the SPSSWIN 15.0 Program. Result: The smoking rate in the adolescents was 10.1%, and the drinking rate was 43.2%. The stress recognition rate in normal daily life was 45.5%, the frequency of depressive symptoms was 33.2% and 40.0% of the subjects reported that they wanted to die at some point within the past year. The rate of stress recognition, depressive symptom experience, suicidal planning and attempt in smokers and drinkers was higher than that in non-smokers and non-drinkers (p<.05). Especially, the frequency of suicidal thoughts was higher in the drinkers than in the non-drinkers (p<.05). Conclusion: The smoking and drinking status of the adolescents was correlated with their mental health a sit relates to stress, depression and suicide. Therefore, an effective program for the prohibition of cigarette smoking and alcohol consumption is needed in order to prevent smoking and alcohol consumption in adolescents and improve their mental health status.