• 생물정신의학
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• 제17권2호
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• pp.65-69
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• 2010

Gene-environment interactions are important in pathogenesis of suicide or suicidal behavior. Twin and adoption studies and family studies show that genetic factors play a critical role in suicide or suicidal behavior. Given the strong association between serotonergic neurotransmission and suicide, recent molecular genetic studies have focused on polymorphisms of serotonin genes, especially on serotonin transporter and tryptophan hydroxylase genes. Some studies have revealed a significant interaction between s allele of the serotonin transporter gene and the risk of suicide attempt associated with childhood trauma. In addition, the polymorphism of brain-derived neurotrophic factor gene also may influence the effect of childhood trauma in relation to the risk of attempting suicide. Future studies should explore genetic and environmental factors in suicide or suicidal behavior and examine for gene and environment interaction.

• 대한불안의학회지
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• 제14권1호
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• pp.21-27
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• 2018

Objective : The purpose of this study was to examine the relationship between self-reported sleep duration and depression or suicidal ideation in Korean adolescents. Methods : The data obtained from the 11th Korea Youth Risk Behavior Web-Based Survey (KYRBWS) were analysed. 68,043 students from 797 schools participated in this nationwide survey. Results : 53.7% of male students and 68.4% of female students had reported that a weekday sleeping duration of less than 6 hours. When the depression and suicidal ideation were analyzed by age, the odds ratio was higher in middle-school students than in high-school students. Both male and female students showed a higher risk of depression and suicidal ideation when sleeping duration was less than 5 hours and the risk was slightly higher in boys than in girls. Conclusion : Insufficient sleep duration in Korean adolescents increases depression and suicidal ideation, and these results differ according to age and gender.

• 생물정신의학
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• 제12권1호
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• pp.3-12
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• 2005

Most suicides(about 90%) occur in the context of psychiatric disorders. Prediction of suicide risk in patients with mental illness is very important in preventing suicide attempts. However, current approaches to predict suicidality are based on clinical history and have low specificity and biological markers are not yet included. Many studies have explored the association between different biological parameters and suicidality. Studies of cerebro-spinal fluid(CSF) demonstrated that 5-HIAA and HVA levels were lower in patients with a history of suicide. Platelet serotonin transporter and the 5-HT2 serotonin receptor have also been studied in relation to violence and suicide. Depressive patients with greater suicidal tendency had significantly lower cholesterol concentrations but some researchers failed to find the correlation. DST non-supression is reported to predict suicidality in major depression. Several studies demonstrated a relationship between intron 7 polymorphism of tryptophan hydroxylase and suicidal behavior. Since suicide is not occurred in a single disease, the systematic and comprehensive study in large samples with various diagnoses is necessary to find the biological and genetic predictors of suicidal behavior.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제34권2호
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• pp.125-132
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• 2023

Objectives: This study investigated the relationship between suicidal behavior and the use of methylphenidate (MPH) or atomoxetine (ATX) in patients with attention deficit hyperactivity disorder (ADHD). Methods: The Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines were used to conduct a meta-analysis. The Physiotherapy Evidence Database scale was used to score the quality of the studies. Results: Nine studies were included in this quantitative analysis. The analysis included 602864 patients with ADHD (521125 and 81739 patients were taking methylphenidate [MPH group] and atomoxetine [ATX group], respectively) and 19230 healthy controls. The overall estimates were in the order of the control, MPH, and ATX groups; however, no statistically significant between-group difference was observed in the incidence of events (p=0.553 for control vs. MPH; p=1.000 for control vs. ATX; p=1.000 for MPH vs. ATX). Conclusion: The rate of suicidal behavior was higher in the ADHD groups treated with MPH and ATX than in the control group. However, no statistically significant difference was observed between the ADHD groups treated with MPH and ATX, and the control group. Therefore, MPH and ATX did not increase suicidal behavior.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제26권3호
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• pp.149-158
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• 2015

Objectives : The objective of this study was to identify the risky behavior subtypes in adolescents with depression, and the relationship between those subtypes and suicide attempt. Methods : Ninety adolescents who met the Diagnostic and Statistical Manual of Mental Disorders-4th edition criteria for major depressive disorder, dysthymia, or depressive disorder not otherwise specified participated in the study. Participants were interviewed about suicidal attempts, non-suicidal self-injuries. Smoking, drinking behaviors, and searching for the word "suicide" on the internet, negative life events including bulling-bullied experiences, and history of abuse were also included with questionnaires. Results : The results of cluster analysis showed that four risky behaviors were divided into three clusters : non-risky type, characterized by few risky behaviors ; delinquency type, which was characterized by smoking and drinking ; non-suicidal self-injury type. In non-suicidal self-injury type, percentage of girls was higher and clinical symptoms were more severe than delinquency type. In addition, delinquency type members could be a bully, while non-suicidal self-injury type members could be abused by a family member. Logistic regression analysis showed that both risky behavior subtypes were significant predictors of suicide attempt. Conclusion : These results suggest that two types of risky behaviors of depressed adolescents have an effect on the suicide attempts independently. Then, the implications and limitations of the study were discussed and directions for future studies were suggested.

• 한국학교보건학회지
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• 제29권3호
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• pp.189-200
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• 2016

Purpose: The purpose of the study is to examine the factors that influence Korean adolescents' depression and suicidal ideation from individual, social and environmental perspectives by gender. The study used the date of the 2015 Korea Youth Risk Behavior Web-based Survey and the subjects were 68,043 middle and high school students. The levels of depression and suicidal ideation were the dependent variables and the factors influencing the dependent variables included 11 individual factors, 3 social factors and 7 environmental factors. The data were analyzed using odds ratios (OR) from multi-variable logistic regression analysis. As a result, the most significant individual factors that influenced both depression and suicidal ideation were stress and subjective happiness both in boy and girls, the most significant social factor was participation in violence treatment programs, and the most significant environmental factors were economic status, father's educational level, and whether or not they lived with their family. Therefore, programs and policies to improve adolescents' mental health should be developed considering individual, social, and environmental factors.

• Journal of Preventive Medicine and Public Health
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• 제46권6호
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• pp.329-335
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• 2013

Objectives: To comprehensively examine the relationship between current sleep duration and past suicidal idea or attempt among Korean adolescents. Methods: Data came from the 2009 Korea Youth Risk Behavior Web-based Survey with 75 066 participants (with the participation rate of 97.6%) in 800 middle and high schools. Binary logistic regression was conducted by gender and depressed mood to identify significant factors for suicidal ideation/attempt. The dependent variable was the log odds of suicidal ideation/attempt, while the independent/control variables were sleep duration and other demographic, socio-economic and health-related factors. Results: A negative association between sleep duration and suicidal ideation or attempt was weaker for those with depressed mood than for those without such experience in Korea for Year 2009. The odds ratio of suicidal ideation/attempt regarding less than 4 hours of sleep compared to 6 to 7 hours of sleep, was smaller in a group with depressed mood than in a group without such experience, for example, 1.64 (95% confidence interval [CI], 1.29 to 2.08) vs. 2.06 (95% CI, 1.34 to 3.17) for men's suicidal ideation, 2.50 (95% CI, 1.69 to 3.69) vs. 3.89 (95% CI, 1.74 to 8.66) for men's suicidal attempt. A negative association between age (or self-rated health) and suicidal ideation/attempt was also weaker for those with depressed mood than for those without such experience in the nation for the year. Conclusions: There was a negative association between sleep duration and suicidal ideation/attempt in Korea for Year 2009 and this association was weaker for those with depressed mood than for those without such experience. Based on the findings of this study, adolescents' better mental health and longer, more comfortable sleep might help to prevent their suicidal ideation and attempt in Korea.

• 아동학회지
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• 제37권1호
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• pp.61-71
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• 2016

Objective: The purpose of this study was to confirm if there are gender differences in influences of parental support, control, and school life adjustment on suicidal ideation of adolescents and to examine the mediating effect of depression on the influences of independent variables on their suicidal ideation. Methods: This study comprised a total of 671 students in seventh and eighth grades in Seoul and Gyeonggi-do. The data were analyzed for frequency, average, and standard deviation, using the t-test, Pearson's correlation analysis, stepwise regression analysis, hierarchical multiple regression analysis, and the Sobel test. Results and Conclusion: First, significant differences among adolescents' gender were shown in fathers' psychological control, mothers' behavior control, and suicidal ideation. Second, in the case of male adolescents, all independent variables were found to have a full mediating effect on their suicidal ideation. Meanwhile, in the case of female adolescents, independent variables except for mothers' psychological control were found to have a full mediating effect on their suicidal ideation. Mothers' psychological control was found to have a partial mediating effect on suicidal ideation of adolescents for both genders.

• 생물정신의학
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• 제12권2호
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• pp.189-195
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• 2005

Objects:Some studies have suggested that brain-derived neurotrophic factor(BDNF), one of the most important neurotrophins, is involved in pathophysiology of depression and suicide. This study was performed to determine whether there is an abnormality in plasma BDNF concentration in suicidal attempters. Methods:The subjects were 71 suicidal attempters who visited emergency rooms in multi-medical centers. All subjects had been interviewed by using Structured Clinical Interview for DSM-IV(SCID), Hamilton Depression Rating Scale(HDRS), Young Mania Rating Scale(YMRS), and Positive And Negative Syndrome Scale(PANSS). The severity of the suicidal behavior was measured by Lethality of Suicide Attempt Rating Scale(LSARS) and Risk-Rescue Rating(RRR) system. Seventy-one age, sex, and diagnosis matched non-suicidal psychiatric patients who were consecutively admitted to a psychiatric ward during the same period recruited as psychiatric controls. They were drug-naive or drug-free at least more than 2 months. In addition, 80 healthy controls were randomly selected as normal controls. Plasma BDNF level was measured by the enzyme linked immunosorbent assay(ELISA) methods. Results:In overall F-test, differences of the plasma BDNF levels among the groups were statistically significant(F=20.226, p<0.001). In the multiple comparisons(Scheffe), while mean levels of plasma BDNF between normal controls and non-suicidal psychiatric patients were similar(p=0.984), the BDNF levels of suicidal attempters were lower than those of other two groups(p<0.001). LSARS and RRR did not reveal any significant correlations with BDNF levels in suicidal attempters. Conclusion:These results suggest that reduction of plasma BDNF level is related to suicidal behavior and BDNF level may be a biological marker of suicidal behavior.

• 한국융합학회논문지
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• 제12권12호
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• pp.499-507
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• 2021

본 연구는 한국의료패널 2017년도 연간 통합 데이터를 활용하여 베이비붐세대 여성의 자살생각의 현황을 살펴보고, 건강행위와 건강상태가 자살생각에 미치는 영향 요인을 규명하기 위해 시행되었다. 한국의료패널 2017년도 연간 통합 데이터는 2017년 2월부터 6월까지 조사되었으며, SPSS WIN version 25.0을 이용하여 카이제곱(chi-square) 검정, t-test 및 다중로지스틱 회귀분석(multiple logistic regression)을 실시하였다. 연구대상은 자살생각 경험에 대한 질문에 응답한 베이비붐세대 여성 1,319명이었고 자살생각 경험은 3.1%로 나타났다. 베이비붐세대 여성의 자살생각은 배우자가 없는 경우가 그렇지 않은 경우보다 2.71배(CI=1.15-6.36, p=.047), 섭식문제가 있는 경우가 그렇지 않은 경우보다 4.44배(CI=2.05-9.61, p<.001), 활동제한이 있는 경우가 그렇지 않은 경우보다 4.63배(CI=1.63-13.16, p=.004), 우울한 경우가 그렇지 않은 경우보다 12.12배(CI=5.36-27.37, p<.001) 자살생각을 더 많이 하는 것으로 나타났다. 따라서 베이비붐세대 여성의 특성과 자살생각에 영향을 미치는 요인을 고려한 자살예방 프로그램의 개발이 요구된다.