• Development and Reproduction
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• v.11 no.1
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• pp.13-20
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• 2007

In all female mammals, reproductive system is one of the first biological systems to show age-related decline. Female mammals in reproductive aging, though the phenomena is somewhat species-specific, start to show declining fertility and changes of numerous physiological functions. This review will present a current information on the aging of the female reproductive hormonal axis and introduce three useful rodent models for studying this field. Middle age($8{\sim}12$ months old) in female rats and mice is comparable to the stage prior to the entry of menopause in human. In this period pulsatile and surge GnRH secretion from hypothalamus gradually attenuated, then reduced pulsatile and surge LH secretion is followed consequently. This age-related defects in GnRH-LH neuroendocrine axis seem to be highly correlated with the defects in brain signals which modulate the activities of GnRH neuron. Many researchers support the idea which the age-related hypothalamic defects are the main cause of reproductive aging, but some ovarian factors such as inhibin response also could contribute to the induction of reproductive senescence. Some rodent models are quite valuable in studying the reproductive aging. The follitropin receptor knockout(FORKO) mice, both of null and haploinsufficient state, could produce depletion of oocyte/follicle with age. Dioxin/aryl hydrocarbon receptor(AhR) knockout mice also show severe ovarian defects and poor reproductive success early in their life compared to the age-matched normal mice. Further studies on the reproductive aging will be a great help to evaluate the benefits and risks of hormone replacement therapy(HRT) and to improve the safety of HRT.

• The Journal of the Korea Contents Association
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• v.9 no.5
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• pp.61-75
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• 2009

Generally, the development of the database application includes the requirement analysis phase of creating ERD (Entity Relationship Diagram) and process models, coding, and testing. From the above phases, the analysis phase is not most formalized. It is usually hard task because (1) customers don't know the details of the desired system; (2) developers can't with ease understand the business logic of the customers; (3) the outcomes of the analysis, which are ERD and process models, are not easy to understand to the customers. This paper propose that the executional forms, which are better to understand the systems, should be presented to the customers instead of the ERD. These forms should accept the data input so that customers can review the various aspects of the outcome models. The developers should be able to instantly implement the business logic and also should be able to visually demonstrate the logic in order to get the details of it. For this goal, the customer supplied business logic should be able to be implemented by the references between forms, actions, constraints from the perspective of the data flow. The customers try to execute the forms implementing the business logic and review their supplied logic find new necessary business logic of their own. Iterating these processes for the requirement analysis would result in the success of the analysis which is sufficiently detailed without conflicts.

• The korean journal of orthodontics
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• v.41 no.1
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• pp.25-35
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• 2011

Objective: The purpose of this study was to optimize the thread pattern of orthodontic microimplants. Methods: In search of an optimal thread for orthodontic microimplants, an objective function stability quotient (SQ) was built and solved which will help increase the stability and torsional strength of microimplants while reducing the bone damage during insertion. Selecting the AbsoAnchor SH1312-7 microimplant (Dentos Inc., Daegu, Korea) as a control, and using the thread height (h) and pitch (p) as design parameters, new thread designs with optimal combination of hand p combination were developed. Design soundness of the new threads were examined through insertion strain analyses using 3D finite element simulation, torque test, and clinical test. Results: Solving the function SQ, four new models with optimized thread designs were developed (h200p6, h225p7, h250p8, and h275p8). Finite element analysis has shown that these new designs may cause less bone damage during insertion. The torsional strength of two models h200p6 and h225p7 were significantly higher than the control. On the other hand, clinical test of models h200p6 and h250p8 had similar success rates when compared to the control. Conclusion: Overall, the new thread designs exhibited better performance than the control which indicated that the optimization methodology may be a useful tool when designing orthodontic microimplant threads.

• The Journal of the Korea Contents Association
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• v.9 no.3
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• pp.305-311
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• 2009

The bankruptcy in Korea affects to all stakeholder of firms. Companies listed in KOSDAQ have high technology but the possibilities for success of business are low. The purpose of this study is to develop and to applicate falling prediction model of KOSDAQ firms using logistic regression analysis. The results of this study are as follows. First, the accuracy of classification of the models by years was between 76.5% and 77.5%, and that of the mean model was between 70.6% and 83.4%. Among the models, the mean model of -three years, -two years, and -one year was highest in the accuracy of classification (83.4%). Second, when the mean model of -three year, -two years, and -one years, the highest model in accuracy of classification, was selected to be verified on validation samples, the accuracy of prediction increased from -three years to -one year (71.7% for -three years, 75.0% for -two years, 90.0% for -one year). In indicating the superiority of developed model.

• Archives of Plastic Surgery
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• v.38 no.2
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• pp.135-142
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• 2011

Purpose: Deficiencies of the abdominal wall can be the a result of infection, surgery, trauma, or primary herniation. For abdominal wall reconstruction, synthetic materials have been shown to provide a better long-term success rate than primary fascial repair. But, synthetic materials cannot elicit angiogenesis or produce growth factor and are therefore plagued by an inability to clear infection. As a result of the inherent drawbacks of synthetic, significant effort has been spent on the identification of new bioprosthetic materials. The aim of our study is to evaluate the effectiveness of a synthetic material (PROCEED$^{(R)}$) and an ADM ($SureDerm^{TM}$) to repair abdominal wall defects in a rabbit models. Methods: We measured the tensile strength of the $SureDerm^{TM}$ and PROCEED$^{(R)}$ by a Tension meter (Instron 4482). 16 Rabbit models were assigned to this study for abdominal wall reconstruction. Abdominal defect of 8 rabbits were reconstructed by PROCEED$^{(R)}$ and the rest were reconstructed by $SureDerm^{TM}$. We assessed gross and histologic examinations for the reconstructed abdominal wall. Results: The tensile strength of $SureDerm^{TM}$ and Gore Tex$^{(R)}$ is $14.64{\pm}0.51Mpa$, $8.54{\pm}0.45Mpa$. PROCEED$^{(R)}$ was estimated above the limits of measurement. Inflammatory reaction of PROCEED$^{(R)}$ persisted for 32weeks, but $SureDerm^{TM}$ decreased after 16weeks. Vascular ingrowth into the $SureDerm^{TM}$ was seen after 32 weeks. The basement membrane of $SureDerm^{TM}$ changed into a form of pseudoperitoneum. In PROCEED$^{(R)}$, it seemed like pseudoepithelial lining was made from the fibrosis around the mesh. Conclusion: In our study, the $SureDerm^{TM}$ not only have less inflammatory reaction and presented more angiogenesis than the PROCEED$^{(R)}$, but also have pseudoperitoneum formation. It is expected that $SureDerm^{TM}$ is useful for abdominal wall reconstruction. However, a long-term study of its usage consequences are thought to be needed.

• The Korean Journal of Applied Statistics
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• v.37 no.3
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• pp.323-338
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• 2024

This study analyzes the Korean professional volleyball league and predict match outcomes using popular machine learning classification methods. Match data from the 2012/2013 to 2022/2023 seasons for both male and female leagues were collected, including match details. Two different data structures were applied to the models: Separating matches results into two teams and performance differentials between the home and away teams. These two data structures were applied to construct a total of four predictive models, encompassing both male and female leagues. As specific variable values used in the models are unavailable before the end of matches, the results of the most recent 3 to 4 matches, up until just before today's match, were preprocessed and utilized as variables. Logistc Regrssion, Decision Tree, Bagging, Random Forest, Xgboost, Adaboost, and Light GBM, were employed for classification, and the model employing Random Forest showed the highest predictive performance. The results indicated that while significant variables varied by gender and data structure, set success rate, blocking points scored, and the number of faults were consistently crucial. Notably, our win-loss prediction model's distinctiveness lies in its ability to provide pre-match forecasts rather than post-event predictions.

• International Commerce and Information Review
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• v.15 no.4
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• pp.481-508
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• 2013

The purpose of this study is to research the specific ways of successful localization by analyzing the success and failures case for localization through the theoretical background and the strategic models of localization. The strategic models of localization are divided by management aspects such as the localization of production and sourcing, the localization of human resources, the localization of marketing, the localization of R&D, harmonious relationship with the local community and authority transfer between headquarters and local subsidiaries. And the specific measures of the successful localization are proposed within the framework of the strategic models by comparing and analyzing the success and failures case for localization of individual companies operating in Indonesia. The results indicate that there are successful companies which develop a suitable products for the local climate and failed automobile company which is weak for assembly of complete vehicle in terms of localization of production and sourcing. In case of localization of human resources, most companies recognize the importance of this part and endeavor to secure superior human resource through a related education. It is found that most of the companies perform R & D in their native country. In part of a harmonious relationship with the local community, Korean companies should contribute to the community and be friendly with local residents and make a good image of the company focusing on the cultural environment. In aspect of authority transfer between headquarters and local subsidiaries, there is a tendency to be determined by the head office rather than the joint participation. In the future, in order for Korean enterprise to be successful one in Indonesia market, a highly interdependent and complex forms between headquarters and local subsidiaries shall be performed and an active exchange of information and the selection of best talent regardless of nationality shall be promoted.

• Journal of the korean academy of Pediatric Dentistry
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• v.44 no.4
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• pp.461-468
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• 2017

Autotransplantation of teeth with complete roots is being increasingly performed for orthodontic treatment or for replacement of unsalvageable teeth, but this procedure has lower survival and success rates than those obtained following transplantation of teeth with incomplete root formation. While previous autotransplantation procedures used only models of the donor tooth and recipient site, surgical guide templates created using 3D-printing technology are now available. They allow shaping of the recipient site in proper direction and to the correct depth, thereby reducing the treatment time and improving the success and survival rates. Herein, we report a case involving autotransplantation of a tooth with complete roots at the site of a congenitally missing permanent tooth using surgical guide templates generated with 3D-printing technology. The procedure resulted in favorable healing of the transplanted tooth.

• Journal of Distribution Science
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• v.13 no.2
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• pp.105-112
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• 2015

Purpose - There is a recent social trend that is focused on the revitalization of business-founding. Business-founding now has an important impact on the progress of the national economy because of youth unemployment and an increase in baby-boom generation retirees. However, the support and infrastructure required for business-founding of the disabled are very insufficient. Since most supporting policies are on youth or middle-aged business-founding, business-founding by the disabled and the socially weak is losing competitiveness. Accordingly, this study diagnosed the issues by analyzing the current status of business-founding by the disabled and suggested a fostering direction for the advance of business-founding by the disabled. An idea for the founding of various business items is required for the competitiveness of business-founding by the disabled and the establishment of a growth-model based on marketing is required so that business-founding by the disabled would advance toward commercialization with growth potential. Research design, data, and methodology - Regarding the study method, the existing study literature on the status and issues in business-founding was mainly explored. In addition, the existing literature on the status and issues in business-founding by the disabled was also studied. The support on business-founding by the disabled by policy enforced by the 'Welfare Service Agency for the Disabled'and the support of related agencies including financial support on the commercialization of business-founding by the disabled were also examined. Results - Existing studies on business-founding by the disabled are very insufficient. It is very difficult to study a viable business-founding by the disabled fostering policy without thorough learning on the difficulties of business-founding by the disabled. Therefore, this study suggested a direction for the resolution of various issues such as market, funds, item, operational matters, and service by analyzing the difficulties in business-founding by the disabled until now. Particularly, this study suggested that building a commercialization model from the aspect of marketing strategy and the effort to change the growth aspect of the disabled into competitiveness are essential. Conclusions - This study examined the aspect of developing an item-development process for the growth and founding of disabled-owned businesses and the requirement of a government support system by multiple policies. Since the number of studies on business-founding by the disabled is very small, it is expected that this study would become an important study in the field of business-founding by the disabled. The revitalization of business-founding by the disabled substantially contributes to the progress of the state of the economy and continuous interest is required from the viewpoint of equal advance in the society. Success models in business-founding by the disabled should be created continuously and active publicizing of them to the disabled business-founders by analyzing the success cases would also be required. In addition, it is believed that a market entry strategy by way of a win-win strategy and cooperative relation with big companies should be also developed in the future.

• Journal of Distribution Science
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• v.17 no.2
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• pp.53-69
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• 2019

Purpose - National scientific technology R&D investment is exceeding 60 trillion won per year, and the results of patent applications and technology transfers are visually improving. However, despite the improving research results of national R&D, the practical results of technology startups are mediocre. It is now time to expand the construction of the technology commercialization ecosystem, where the expansion of national R&D leads to the results of technology startups. Therefore, this study discussed the measures to increase the competitiveness of technology startups through the factual survey of the companies that benefitted from R&D support programs. Research design, data, and methodology - This study targeted 996 companies that benefitted from the R&D projects of the Technology Transfer Center for National R&D Programs, and deducted itemized issues through the survey replies. Survey questions were prepared to estimate the national R&D results, and the technology recognition path, the purpose of detailed introduction of the technology, investment of the commercialization fund, economic results, and the factors of success and failure were analyzed. Results - As for the recognition rate of technology during the process of corporate technology commercialization through the technology transfer, recognition through project participation showed a high response rate, and diverse implications of technology commercialization were deducted through the analysis of economic results. As for the resolution alternatives, the proliferation of technology commercialization platform that can create excellent technology for the companies in early stages and the measure of expanding the distribution of technology infrastructure were suggested. In this study, public technology commercialization strategy is established, and the innovative marketing strategy is presented. Conclusions - This study reveal that the result of creating scientific technology jobs should be deducted, in order to produce the revolutionary results of job creation by suggesting the success models of technology commercialization based on domestic scientific technology. In particular, even though the support systems for public research results are being diversely suggested, accurate studies on their actual conditions are currently lacking. Therefore, this study suggest realistic political alternatives to assure results in the process of public technology commercialization, by examining the current state of public research results of R&D support institutions and diagnosing the issues.