• 생물정신의학
• /
• 제19권2호
• /
• pp.71-76
• /
• 2012

Objectives : Novelty seeking (NS) represents a dopaminergically modulated tendency toward frequent exploratory activity. Considering the reports showing the relationship between exploratory activity and amygdalar function and structure, and the fact that amygdala is one of the key structures that constitute the dopaminergic pathway in the brain, amygdala might be closely related to NS tendencies. Amygdalar subregional analysis method, which has the enhanced sensitivity compared to the volumteric approach would be appropriate in investigating the subtle differences of amygdalar structures among healthy individuals. The aim of the current study was to examine whether amygdalar subregional morphometric characteristics are associated with the NS tendencies in healthy adults using the amygdalar subregional analysis method. Methods : Twenty-six healthy adults (12 males, 14 females ; mean age $29.8{\pm}6.2$ years) were screened for eligibility. All subjects completed the Korean version of the Temperament and Character Inventory (TCI) and underwent high-resolution brain magnetic resonance imaging. Individuals were divided into 2 groups according to NS scores of the TCI. Results : Individuals of the high NS group had significantly larger laterobasal subregions in right amygdala, after adjustment with the brain parenchymal volumes. Sensitivity analyses for each potential confounding factor such as age, education years and Hamilton Depression Rating Scale (HDRS) scores demonstrated consistent results. Conclusions : This study suggests that NS differences are associated with the laterobasal subregion of the amygdala.

• 생물정신의학
• /
• 제26권1호
• /
• pp.22-31
• /
• 2019

Objectives Previous studies have revealed inconsistent results on amygdala volume in adult bipolar disorder (BD) patients compared to healthy controls (HC). Since the amygdala encompasses multiple subregions, the subtle volume changes in each amygdala nucleus might have not been fully reflected in the measure of the total amygdala volume, causing discrepant results. Thus, we aimed to investigate volume changes in each amygdala subregion and their association with subtypes of BD, lithium use and clinical status of BD. Methods Fifty-five BD patients and 55 HC underwent T1-weighted structural magnetic resonance imaging. We analyzed volumes of the whole amygdala and each amygdala subregion, including the anterior amygdaloid area, cortico-amygdaloid transition area, basal, lateral, accessory basal, central, cortical, medial and paralaminar nuclei using the atlas in the FreeSurfer. The volume difference was analyzed using a one-way analysis of covariance with individual volumes as dependent variables, and age, sex, and total intracranial volume as covariates. Results The volumes of whole right amygdala and subregions including basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area in the right amygdala of BD patients were significantly smaller for the HC group. No significant volume difference between bipolar I disorder and bipolar II disorder was found after the Bonferroni correction. The trend of larger volume in medial nucleus with lithium treatment was not significant after the Bonferroni correction. No significant correlation between illness duration and amygdala volume, and insignificant negative correlation were found between right central nucleus volume and depression severity. Conclusions Significant volume decrements of the whole amygdala, basal nucleus, accessory basal nucleus, anterior amygdaloid area, and cortico-amygdaloid transition area were found in the right hemisphere in adult BD patients, compared to HC group. We postulate that such volume changes are associated with altered functional activity and connectivity of amygdala nuclei in BD.

• 한국정보통신학회논문지
• /
• 제10권10호
• /
• pp.1829-1834
• /
• 2006

물체의 경계로부터 거리에 따라 다른 크기의 창을 사용함으로써 물체의 경계를 정확히 찾는 새로운 스테레오정합 알고리즘을 제안한다. 원 영상을 같은 크기의 작은 부분으로 나누고, 이 작은 영역들의 중앙 화소들의 시차를 구한 표본 시차 지도로부터 축소된 물체의 경계를 찾는다. 경계로부터의 거리에 따라 크기가 다른 창을 원 영상에 적용하여 시차를 구한다. 원 영상의 시차를 구할 때 작은 영역 내에 있는 화소들의 시차는 이미 구한 중앙화소의 시차와 유사하다는 기울기 제한 조건을 이용하였다. 실험결과로부터 제안한 알고리즘이 다른 알고리즘 보다 우수함을 확인하였다.

• Journal of Computing Science and Engineering
• /
• 제9권2호
• /
• pp.39-50
• /
• 2015

Genetic algorithm (GA) and particle swarm optimization (PSO) are two excellent approaches to multimodal optimization problems. However, slow convergence or premature convergence readily occurs because of inappropriate and inflexible evolution. In this paper, a novel optimization algorithm with a flexible grid optimization (FGO) is suggested to provide adaptive trade-off between exploration and exploitation according to the specific objective function. Meanwhile, a uniform agents array with adaptive scale is distributed on the gird to speed up the calculation. In addition, a dominance centroid and a fitness center are proposed to efficiently determine the potential guides when the population size varies dynamically. Two types of subregion division strategies are designed to enhance evolutionary diversity and convergence, respectively. By examining the performance on four benchmark functions, FGO is found to be competitive with or even superior to several other popular algorithms in terms of both effectiveness and efficiency, tending to reach the global optimum earlier. Moreover, FGO is evaluated by applying it to a parameter decision in a least squares support vector machine (LS-SVM) to verify its practical competence.

• Fisheries and Aquatic Sciences
• /
• 제2권2호
• /
• pp.142-148
• /
• 1999

Monthly changes in the gonad index (GI), egg-diameter composition, gonadal development, reproductive cycle of the ark shell, Scapharca subcrenata, were investigated by histological method and morphometric data. This species is dioecious and oviparous. The gonad is located among the subregion of mid-intestinal gland, digestive diverticula and the outer fibromuscular layers compacted by the fibrous connective tissues and muscle fibers. The gonad index sharply increased in May, reached the maximum value in June, and then gradually decreased from July to December. The reproductive cycle of this species can be divided into six successive stages: early active stage (January to May), late active stage (June to July), ripe stage (June to August), partially spawned stage (July to September), degenerative stage (August to December), and resting stage (January to April). S. subcrenata spawns once a year between July and early September, and the main spawning occurred between July and August when the water temperatures were above $20^{\circ}C$. This evidence suggest that timings of maturation and spawning are closely related to water temperatures. Even though the spawning period was once a year, it is assumed that the number of spawning frequencies (broods) may occur more than twice during the spawning season.

• 한국전산구조공학회:학술대회논문집
• /
• 한국전산구조공학회 1992년도 봄 학술발표회 논문집
• /
• pp.58-64
• /
• 1992

It is usual that underground structures are constructed within multi-layered medium. In this paper, an efficient numerical model ling of multi-layered structural systems is studied using coupled analysis of finite elements and boundary elements. The finite elements are applied to the area in which the material nonlinearity is dominated, and the boundary elements are applied to the far field area where the nonlinearity is relatively weak. In the boundary element model 1 ins of the multi-layered medium, fundamental solutions are restricted. Thus, methods which can utilize existing Kelvin and Melan solution are sought for the interior multi-layered domain problem and semi infinite domain problem. Interior domain problem which has piecewise homogeneous layers is analyzed using boundary elements with Kelvin solution; by discretizing each homogeneous subregion and applying compatibility and equilibrium conditions between interfaces. Semi-infinite domain problem is analyzed using boundary elements with Melan solution, by superposing unit stiffness matrices which are obtained for each layer by enemy method. Each methodology is verified by comparing its results which the results from the finite element analysis and it is concluded that coupled analysis using boundary elements and finite elements can be reasonable and efficient if the superposition technique is applied for the multi-layered semi-infinite domain problems.

• 천문학회보
• /
• 제41권2호
• /
• pp.30.1-30.1
• /
• 2016

We have estimated a metallicity map of the Large Magellanic Cloud (LMC) using the Magellanic Cloud Photometric Survey (MCPS) and Optical Gravitational Lensing Experiment (OGLE III) photometric data. This is a first of its kind, high-spatial resolution map of metallicity up to a radius of $4^{\circ}-5^{\circ}$, derived using large area photometric data and calibrated using spectroscopic data of Red Giant Branch (RGB) stars. The RGB is identified in the V, (V - I) colour- magnitude diagrams of small subregions of varying sizes in both data sets. The slope of the RGB is used as an indicator of the mean metallicity of a subregion, and it is calibrated to metallicity using spectroscopic data for field and cluster red giants in selected subregions. The mean metallicity of the LMC is found to be [Fe/H] = -0.37 dex (${\sigma}[Fe/H]=0.12$) from MCPS data, and [Fe/H] = -0.39 dex (${\sigma}[Fe/H]=0.10$) from OGLE III data. The bar is found to have an uniform and higher metallicity compared to the disk, and is indicative of an active bar in the past. Both the data sets suggest a shallow radial metallicity gradient up to a radius of 4 kpc ($-0.049{\pm}0.002$ dex kpc-1 to $-0.066{\pm}0.006$ dex kpc-1). This metallicity gradient of the LMC disk, though shallow, resembles the gradient seen in spiral galaxies, and similar to that found in our Galaxy.

• 한국패류학회지
• /
• 제4권1호
• /
• pp.30-41
• /
• 1988

The gonadal development, the annual reproductive cycle and the first sexual maturity of surf clam, Mactra veneriformis Reeve were studied histologically. Speciemens were monthly collected at the intertidal zone of Naechodo, Chollabuk-do, Korea, for one year from March 1986 to February 1987. Sexuality of the clam is dioecious. The gonads were located between the subregion of mid-intestinal gland in the visceral cavity and the reticular connetive tissues of the foot, The ovary is composed of a number of ovarian sacs, and the testis comprise several testiculat lobules. The undifferentiated mesenchymal tissues and eosinophilic granular cells function as nutritive cells in the early stage. The ripe eggs were about 50-60${\mu}{\textrm}{m}$ in diameter, and they were wurroundedby the gelatinous membranes. The spawing period was from early June to September the main spawning occurred beetween July and August when the water temperature reached above 24$^{\circ}C$. The annual reproductive cycle of this species could be classified into five successive stages: multiplicative(January to March), growing(March to May), mature(April to August), spent(June to September), degenerative and resting(September to February). The monthly changes of fatness coefficient closely correlated with the annual reproductive cycle. Percentages of the first sexual maturity of female and male clams were over 50% among those individals ranging from 2.1 To 2.5cm, and 100% in those over 2.6cm in shell length.

• 한국컴퓨터산업학회논문지
• /
• 제3권2호
• /
• pp.217-226
• /
• 2002

3차원 공간에 물체를 입체감 있게 표현하는 것은 중요한 일이다. 물체를 사실적으로 보이게 하기 위해서는 원근감, 입체감, 물체의 재질, 그림자, 빛의 세기 등 여러 요소가 고려되어야 한다. 그 중 그림자는 물체의 사실적 표현에 중요한 역할을 한다. 그림자를 그리기 위한 방법에는 반복적인 수많은 연산을 해야하고 이것은 많은 처리 시간을 필요로 한다. 즉 수많은 점들에 대한 그림자 영역 판단과 빛의 세기 판단 등을 해야하고 이것으로 인해 시간이 많이 걸리게 된다. 본 논문에서는 물체에 대한 사실적인 표현을 어느 정도 유지하는 범위내에서 그림자를 영역별로 분리해 빠르게 계산하여 표현해 주는 방법을 제시한다.

• Tribology and Lubricants
• /
• 제21권4호
• /
• pp.177-184
• /
• 2005

The molecular dynamics simulation of nanoimprint lithography (NIL) using $SiO_2$ stamp and amorphous poly-(methylmethacrylate) (PNMA) film is performed to study pattern transfer in NIL. Force fields including bond, angle, torsion, van der Waals and electrostatic potential are used to describe the intermolecular and intramolecular force of PMMA molecules and $SiO_2$ stamp. Nose-Hoover thermostat is used to control the system temperature and cell multipole method is adopted to treat long range interactions. The deformation of PMMA film is observed during pattern transfer in the NIL process. For the detail analysis of deformation characteristics, the distributions of density and stress in PMHA film are calculated. The adhesion and friction forces are obtained by dividing the PMMA film into subregions and calculating the interacting force between subregion and stamp. Their effects on the pattern transfer are also discussed as varying the indentation depth and speed.