Browse > Article

Right Amygdalar Laterobasal Subregional Differences in Healthy Adults with Different Novelty Seeking Tendencies  

Cho, Han-Byul (Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences)
Kim, Bin-Na (Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences)
Choi, Ji-Hye (Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences)
Jeon, Yu-Jin (Department of Psychiatry, Seoul National University College of Medicine)
Kim, Ji-Hyun H. (Department of Psychiatry, Seoul National University College of Medicine)
Jung, Ji-Young J. (Department of Psychiatry, Seoul National University College of Medicine)
Im, Joo-Yeon Jamie (Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences)
Lee, Sun-Hea (Department of Psychiatry, Seoul National University College of Medicine)
Publication Information
Korean Journal of Biological Psychiatry / v.19, no.2, 2012 , pp. 71-76 More about this Journal
Abstract
Objectives : Novelty seeking (NS) represents a dopaminergically modulated tendency toward frequent exploratory activity. Considering the reports showing the relationship between exploratory activity and amygdalar function and structure, and the fact that amygdala is one of the key structures that constitute the dopaminergic pathway in the brain, amygdala might be closely related to NS tendencies. Amygdalar subregional analysis method, which has the enhanced sensitivity compared to the volumteric approach would be appropriate in investigating the subtle differences of amygdalar structures among healthy individuals. The aim of the current study was to examine whether amygdalar subregional morphometric characteristics are associated with the NS tendencies in healthy adults using the amygdalar subregional analysis method. Methods : Twenty-six healthy adults (12 males, 14 females ; mean age $29.8{\pm}6.2$ years) were screened for eligibility. All subjects completed the Korean version of the Temperament and Character Inventory (TCI) and underwent high-resolution brain magnetic resonance imaging. Individuals were divided into 2 groups according to NS scores of the TCI. Results : Individuals of the high NS group had significantly larger laterobasal subregions in right amygdala, after adjustment with the brain parenchymal volumes. Sensitivity analyses for each potential confounding factor such as age, education years and Hamilton Depression Rating Scale (HDRS) scores demonstrated consistent results. Conclusions : This study suggests that NS differences are associated with the laterobasal subregion of the amygdala.
Keywords
Novelty seeking; Amygdala; Laterobasal subregion; Temperament and character inventory; Magnetic resonance imaging;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Cloninger CR, Svrakic DM, Przybeck TR. A psychobiological model of temperament and character. Arch Gen Psychiatry 1993;50:975-990.   DOI   ScienceOn
2 Cloninger CR. Temperament and personality. Curr Opin Neurobiol 1994;4:266-273.   DOI   ScienceOn
3 Mulder R. The biology of personality. Aust N Z J Psychiatry 1992;26:364-376.   DOI   ScienceOn
4 Cloninger CR. Neurogenetic adaptive mechanisms in alcoholism. Science 1987;236:410-416.   DOI
5 Bardo MT, Donohew RL, Harrington NG. Psychobiology of novelty seeking and drug seeking behavior. Behav Brain Res 1996;77:23-43.   DOI
6 Keltikangas-Jarvinen L, Raikkonen K, Ekelund J, Peltonen L. Nature and nurture in novelty seeking. Mol Psychiatry 2004;9:308-311.   DOI   ScienceOn
7 Han DH, Yoon SJ, Sung YH, Lee YS, Kee BS, Lyoo IK, et al. A preliminary study: novelty seeking, frontal executive function, and dopamine receptor (D2) TaqI A gene polymorphism in patients with methamphetamine dependence. Compr Psychiatry 2008;49:387-392.   DOI   ScienceOn
8 Nam YW, Lee SI, Shin CJ, Son JW, Kim SK. The association among the genetic polymorphism of dopamine D4 receptor, temperament and alcohol drinking behavior in young Korean adults. Korean J Biol Psychiatry 2011;18:101-108.
9 Jacob CP, Romanos J, Dempfle A, Heine M, Windemuth-Kieselbach C, Kruse A, et al. Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center. Eur Arch Psychiatry Clin Neurosci 2007;257:309-317.   DOI   ScienceOn
10 Downey KK, Stelson FW, Pomerleau OF, Giordani B. Adult attention deficit hyperactivity disorder: psychological test profiles in a clinical population. J Nerv Ment Dis 1997;185:32-38.   DOI   ScienceOn
11 Anckarsater H, Stahlberg O, Larson T, Hakansson C, Jutblad SB, Niklasson L, et al. The impact of ADHD and autism spectrum disorders on temperament, character, and personality development. Am J Psychiatry 2006;163:1239-1244.   DOI   ScienceOn
12 Williams SM, Goldman-Rakic PS. Widespread origin of the primate mesofrontal dopamine system. Cereb Cortex 1998;8:321-345.   DOI
13 Demarest KT, Moore KE. Comparison of dopamine synthesis regulation in the terminals of nigrostriatal, mesolimbic, tuberoinfundibular and tuberohypophyseal neurons. J Neural Transm 1979;46:263-277.   DOI
14 Bjorklund A, Dunnett SB. Dopamine neuron systems in the brain: an update. Trends Neurosci 2007;30:194-202.   DOI   ScienceOn
15 Bardo MT. Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens. Crit Rev Neurobiol 1998;12:37-67.   DOI   ScienceOn
16 Wise RA. Drug-activation of brain reward pathways. Drug Alcohol Depend 1998;51:13-22.   DOI   ScienceOn
17 Reuter J, Raedler T, Rose M, Hand I, Glascher J, Buchel C. Pathological gambling is linked to reduced activation of the mesolimbic reward system. Nat Neurosci 2005;8:147-148.   DOI   ScienceOn
18 Sheth A, Berretta S, Lange N, Eichenbaum H. The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty. Hippocampus 2008;18:169-181.   DOI   ScienceOn
19 Rolls ET. Neurophysiology and cognitive functions of the striatum. Rev Neurol (Paris) 1994;150:648-660.
20 Cohen MX, Schoene-Bake JC, Elger CE, Weber B. Connectivity-based segregation of the human striatum predicts personality characteristics. Nat Neurosci 2009;12:32-34.   DOI   ScienceOn
21 Langer LF, Graybiel AM. Distinct nigrostriatal projection systems innervate striosomes and matrix in the primate striatum. Brain Res 1989;498:344-350.   DOI   ScienceOn
22 Bjorklund A, Moore RY, Nobin A, Stenevi U. The organization of tubero-hypophyseal and reticulo-infundibular catecholamine neuron systems in the rat brain. Brain Res 1973;51:171-191.   DOI
23 Grace AA, Rosenkranz JA. Regulation of conditioned responses of basolateral amygdala neurons. Physiol Behav 2002;77:489-493.   DOI   ScienceOn
24 Marowsky A, Yanagawa Y, Obata K, Vogt KE. A specialized subclass of interneurons mediates dopaminergic facilitation of amygdala function. Neuron 2005;48:1025-1037.   DOI   ScienceOn
25 Floresco SB, Tse MT. Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway. J Neurosci 2007;27:2045-2057.   DOI   ScienceOn
26 Yang Y, Raine A, Narr KL, Colletti P, Toga AW. Localization of deformations within the amygdala in individuals with psychopathy. Arch Gen Psychiatry 2009;66:986-994.   DOI   ScienceOn
27 Kim JE, Lyoo IK, Estes AM, Renshaw PF, Shaw DW, Friedman SD, et al. Laterobasal amygdalar enlargement in 6- to 7-year-old children with autism spectrum disorder. Arch Gen Psychiatry 2010;67:1187-1197.   DOI   ScienceOn
28 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Press;1994.
29 Sung SM, Kim JH, Yang E, Abrams KY, Lyoo IK. Reliability and validity of the Korean version of the Temperament and Character Inventory. Compr Psychiatry 2002;43:235-243.   DOI   ScienceOn
30 Hyler SE, Skodol AE, Kellman HD, Oldham JM, Rosnick L. Validity of the Personality Diagnostic Questionnaire--revised: comparison with two structured interviews. Am J Psychiatry 1990;147:1043-1048.   DOI
31 Watson C, Andermann F, Gloor P, Jones-Gotman M, Peters T, Evans A, et al. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology 1992;42:1743-1750.   DOI
32 Convit A, McHugh P, Wolf OT, de Leon MJ, Bobinski M, De Santi S, et al. MRI volume of the amygdala: a reliable method allowing separation from the hippocampal formation. Psychiatry Res 1999;90:113-123.   DOI   ScienceOn
33 Lorensen WE, Cline HE. Marching cubes: a high resolution 3D surface construction algorithm. Comput Graph (ACM) 1987;21:163-169.   DOI
34 Besl PJ, McKay ND. A method for registration of 3-D shapes. IEEE Trans Pattern Anal Mach Intell 1992;14:239-256.   DOI   ScienceOn
35 Kim NK, Kim HJ, Yoon SJ, Lyoo IK, Kang SH, Dager SR, et al. Amygdala shape analysis and parametric surface visualization using iterative closest point algorithm and spherical mapping. IEICE Technical Report 2007;106:271-274.
36 Kim N, Kim HJ, Hwang J, Yoon SJ, Cho HB, Renshaw PF, et al. Amygdalar shape analysis method using surface contour aligning, spherical mapping, and probabilistic subregional segmentation. Neurosci Lett 2011;488:65-69.   DOI   ScienceOn
37 Athinoula A. Martinos Center for Biomedical Imaging. FreeSurfer. Available from: http://surfer.nmr.mgh.harvard.edu/.
38 Kashdan TB, Hofmann SG. The high-novelty-seeking, impulsive subtype of generalized social anxiety disorder. Depress Anxiety 2008;25:535-541.   DOI   ScienceOn
39 Wills TA, Vaccaro D, McNamara G. Novelty seeking, risk taking, and related constructs as predictors of adolescent substance use: an application of Cloninger's theory. J Subst Abuse 1994;6:1-20.   DOI   ScienceOn
40 Wang S, Mason J, Charney D, Yehuda R, Riney S, Southwick S. Relationships between hormonal profile and novelty seeking in combatrelated posttraumatic stress disorder. Biol Psychiatry 1997;41:145-151.   DOI   ScienceOn
41 Aggleton JP. The Amygdala: A Functional Analysis. Oxford: Oxford University Press;2000.
42 Bloom FE, Bjorklund A, Hokfelt T. The primate nervous system, Part III. 1st ed. Amsterdam: Elsevier Science BV;1999. p.93-145.
43 Whalen PL, Phelps EA. The human amygdala. New York: The Guilford Press;2009. p.3-42.
44 Rosenkranz JA, Grace AA. Modulation of basolateral amygdala neuronal firing and afferent drive by dopamine receptor activation in vivo. J Neurosci 1999;19:11027-11039.