• Fire Science and Engineering
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• v.34 no.4
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• pp.115-124
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• 2020

The purpose of this study was to provide an operational model of the rehabilitation room for fire officers at disaster sites to improve the safety and resilience of fire officers. Therefore, we analyzed the operation related elements of the rehabilitation room-such as overseas rehabilitation room operation cases and previous studies- and managed different factors including, but not limited to, management and human resources, equipment and facility, and accessibility and convenience factors; afterward, the relative importance and importance of sub-layers in each field were measured. The priority of items for the operation of the rehabilitation room for fire officers at disaster sites was elucidated; after expert analysis, it was found that human resources were the most crucial factor. Finally, it was found that, in descending order, accessibility and convenience, administrative, equipment, and facility factors were also essential. Based on this, we proposed a rehabilitation room operation guideline for disaster sites.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.3
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• pp.137-142
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• 2011

Extremely low frequency magnetic fields (ELF-MF) have the ability to produce a variety of behavioral and physiological changes in animals. The stomach, as the most sensitive part of the neuroendocrine organ of the gastrointestinal tract, is crucial for the initiation of a full stress response against all harmful stress. Thus, the purpose of this study was to examine whether ELF-MF stimuli induce changes in the activity of neuroendocrine cells, considering their involvement in endocrine or paracrine effect on surrounding cells. The exposure to ELF-MF (durations of 24 h and 1 or 2 weeks, 60 Hz frequency, 0.1 mT intensity) altered the distribution and occurrence of gastrin, ghrelin and somatostatinpositive endocrine cells in the stomach of rats. The change, however, in the secretion of those hormones into blood from endocrine cells did not appear significantly with ELF-MF exposure. Comparing with sham control, ELF-MF exposure for 1 and 2 week induced an increase in $BaSO_4$ suspension propelling ratio of gastrointestinal tract, indicating that ELF-MF affects gastrointestinal motility. Our study revealed that ELF-MF exposure might influence the activity of endocrine cells, an important element of the intrinsic regulatory system in the digestive tract. The pathophysiological character of these changes and the mechanism responsible for neuroendocrine cell are still unclear and require further studies.

• Archives of Pharmacal Research
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• v.28 no.2
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• pp.195-202
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• 2005

Free radicals and reactive oxygen species (ROS) caused by UV exposure or other environmental factors are critical players in cellular damage and aging. In order to develop a new antiphotoaging agent, this work focused on the antioxidant effects of the extract of tinged autumnal leaves of Acer palmatum. One compound was isolated from an ethyl acetate soluble fraction of the A. palmatum extract using silica gel column chromatography. The chemical structure was identified as apigenin-8-C-beta-D-glucopyranoside, more commonly known as vitexin, by spectral analysis including LC-MS, FT-IR, UV, $^{1}H-$, and $^{13}C-NMR$. The biological activities of vitexin were investigated for the potential application of its anti-aging effects in the cosmetic field. Vitexin inhibited superoxide radicals by about $70\%$ at a concentration of $100\;{\mu}g/mL$ and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals by about $60\%$ at a concentration of $100\;{\mu}g/mL$. Intracellular ROS scavenging activity was indicated by increases in dichlorofluorescein (DCF) fluorescence upon exposure to UVB $20\;mJ/cm^2$ in cultured human dermal fibroblasts (HDFs) after the treatment of vitexin. The results show that oxidation of 5-(6-)chloromethyl-2',7'-dichlo-rodihydrofluorescein diacetate ($CM-H_{2}DCFDA$) is inhibited by vitexin effectively and that vitexin has a potent free radical scavenging activity in UVB-irradiated HDFs. In ROS imaging using a confocal microscope we visualized DCF fluorescence in HDFs directly. In conclusion, our findings suggest that vitexin can be effectively used for the prevention of UV-induced adverse skin reactions such as free radical production and skin cell damage.

• Archives of Pharmacal Research
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• v.25 no.1
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• pp.11-24
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• 2002

The antitumor antibiotic (+)-CC-1065 can alkylate N3 of guanine in certain sequences. A previous high-field $^1H$ NMR study on the$(+)-CC-1065d[GCGCAATTG*CGC]_2$ adduct ($^*$ indicates the drug alkylation site) showed that drag modification on N3 of guanine results in protonation of the cross-strand cytosine [Park, H-J.; Hurley, L. H. J. Am. Chem. Soc.1997, 119,629]. In this contribution we describe a further analysis of the NMR data sets together with restrained molecular dynamics. This study provides not only a solution structure of the (+)-CC-1065(N3- guanine) DNA duplex adduct but also new insight into the molecular basis for the sequence- specific interaction between (+)-CC-1065 and N3-guanine in the DNA duplex. On the basis of NOESY data, we propose that the narrow minor groove at the 7T8T step and conformational kinks at the junctions of 16C17A and 18A19T are both related to DNA bending in the drugDNA adduct. Analysis of the one-dimensional $^1H$ NMR (in $H_2O$) data and rMD trajectories strongly suggests that hydrogen bonding linkages between the 8-OH group of the (+)-CC-1065 A-sub-unit and the 9G10C phosphate via a water molecule are present. All the phenomena observed here in the (+)-CC-1065(N3-guanine) adduct at 5'$-AATTG^*$are reminiscent of those obtained from the studies on the (+)-CC-1065(N3-adenine) adduct at $5'-AGTTA^*$, suggesting that (+)-CC-1065 takes advantage of the conformational flexibility of the 5'-TPu step to entrap the bent structure required for the covalent bonding reaction. This study reveals a common molecular basis for (+)-CC-1065 alkylation at both $5'-TTG^*$ and $5'-TTA^*$, which involves a trapping out of sequence-dependent DNA conformational flexibility as well as sequence-dependent general acid and general base catalysis by duplex DNA.

• Journal of Digital Convergence
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• v.18 no.1
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• pp.199-209
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• 2020

This study was done to explore deeply the essence and meaning of gratitude experience of mothers who cares child with schizophrenia. This study was analysed through the use of the phenomenological method of Giorgi. Data was collected through in-depth interviews, observation, and field records with five motheres who cares child with schizophrenia. Data analysis revealed 18 sub-components, 5 components: 'I'm like fallen seed on barren soil without gratitude', 'gratitude coming into bud like sprout,' 'gratitude grown up into a tree through tolerance', 'gratitude bearing fruit of self-sufficiency and desire', and 'gratitude getting much richer with giving. The results from the study contribute to promoting understanding of the gratitude experience of mothers who cares child with schizophrenia and will be helpful for development of positive family nursing intervention.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.973-976
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• 2008

Recently, it is increasingly reported that the deterioration of concrete structure under marine environments is due to diffusion and penetration of chloride ions. It is very important to estimate the diffusion coefficient of chloride ion in concrete. Estimation methods of chloride diffusivity by concentration difference is time-consuming. Therefore, chloride diffusivity of concrete is mainly conducted by electrically accelerated method, which is accelerating the movement of chloride ion by potential difference. However, there has not been any proper method for field quality control to closely determine the diffusion coefficient of chloride ion through accelerated tests using potential difference. In this paper, the various test methods for determination of chloride diffusion coefficient in concrete were investigated through comparison accelerated tests. From the results of estimated diffusion coefficient of chloride ion, relationship between the ponding test and acceleration test was examined.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.1001-1004
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• 2008

This study reviewed the results of utilization of insulation heat curing method using double layer bubble sheet in slab concrete and mass concrete in cold weather environment. First of all, when double layer bubble sheets are applied, it was shown that slab concrete was protected from early freezing by remaining between 6 and $10^{\circ}C$ even in case outside temperature drops $10^{\circ}C$ below zero until the 2nd day from piling, and in the case of mass concrete, with the maximum temperature difference between the center and surface less than $6^{\circ}C$, crack occurrence index was close to 2 and no hydration heat crack occurred by internal constraint. The insulation heat preservation curing method using the double bubble sheet applied in this field prevented early freezing owing to stable curing temperature management, deterring concrete strength development delay at low temperature, and obtained the needed strength. Also, it was proven that the method is highly effective and economic for cold weather concrete quality maintenance through curing cost reduction like construction period shortening and labor cost reduction, etc by reducing the process of temporary equipment installation and disassembling.

• Journal of the Korean Institute of Landscape Architecture
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• v.24 no.2
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• pp.74-85
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• 1996

The objective of this study is to investigate the influence of viewing aspects based on formal aesthetics and psychophysica approaches of the MAISAN provincial park for landscape management. Two methods are applied in this study. First, according to the field study with map the quantitative analyses of the viewshed area, visual section and scenery types were achieved, herein the visual landscape characteristics is found. Second, based upon visual preference evaluation of the relationships between the viewing aspects and visual preference scores to landscape slides were measured by questionnaires. The main conclusions obtained by the research are as follows. Visual area of MAISAN has a quite wide viewshed though itself is surrounded. The preference for the visual terminal were change by its characteristics to the visual corridors, view points, viewing types and viewing distance. Especially, the regression analysis between visual preference and viewing distance indicated Y=-3.20X\sup 2\+18.64X+20.64. In this case, viewing distance 794m from O\sub p\ is more important point for visual experience. The viewing types B·C and famous view A obtained a high visual preference score. A visual terminus are viewed along an entire RouteA, so revealed by its evolving spatial containment as to exact the full potential of its changing perspectives. Also we conducted the degree of visual influence by the shade in visual area at MAISAN and clarified viewing vantage Route and point in LSH being necessary for landscape preservation.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.18 no.5
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• pp.389-395
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• 2005

The etching technology of the high aspect ratio contact(HARC) is necessary at the critical contact processes of semiconductor devices. Etching the $SiO_{2}$ contact hole with the sub-micron design rule in manufacturing VLSI devices, the unexpected phenomenon of 'profile tilting' or 'bottom distortion' is often observed. This makes a short circuit between neighboring contact holes, which causes to drop seriously the device yield. As the aspect ratio of contact holes increases, the high C/F ratio gases, $C_{4}F_{6}$, $C_{4}F_{8}$ and $C_{5}F_{8}$, become widely used in order to minimize the mask layer loss during the etching process. These gases provide abundant fluorocarbon polymer as well as high selectivity to the mask layer, and the polymer with high sticking yield accumulates at the top-wall of the contact hole. During the etch process, many electrons are accumulated around the asymmetric hole mouth to distort the electric field, and this distorts the ion trajectory arriving at the hole bottom. These ions with the distorted trajectory induce the deformation of the hole bottom, which is called 'profile tilting' or 'bottom distortion'. To prevent this phenomenon, three methods are suggested here. 1) Using lower C/F ratio gases, $CF_{4}$ or $C_{3}F_{8}$, the amount of the Polymer at the hole mouth is reduced to minimize the asymmetry of the hole top. 2) The number of the neighboring holes with equal distance is maximized to get the more symmetry of the oxygen distribution around the hole. 3) The dual frequency plasma source is used to release the excessive charge build-up at the hole mouth. From the suggested methods, we have obtained the nearly circular hole bottom, which Implies that the ion trajectory Incident on the hole bottom is symmetry.

• Korean Journal of Construction Engineering and Management
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• v.13 no.5
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• pp.125-134
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• 2012

In the construction industry, "Green" is emerging as a keyword of new growth engine. Since green construction competitiveness is essential for contractors' survival and growth, it is important to understand what constitutes green construction competitiveness. The objective of the study is to identify elements of green construction competitiveness and to discuss relationships between their importance and current level based on the Gap analysis. A better understanding of the elements of green construction competitiveness assists contractors in formulating green strategies. It also provides insight into what motivates contractors in establishing related policies and regulations. The study identifies that in general there exists a gap between the importance and current level of green construction competitiveness. It also demonstrates that CEO' competence shows a less gap between the importance and current level but firms' competence is an area of weakness. Finally a substantial gap is observed in the field of green R&D strategies and sub-contracting partners.