• 수완나부미
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• 제10권2호
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• pp.57-85
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• 2018

The debates continue on the conceptualization of Southeast Asia and the ways in which those of us who are concerned to attempt scholarly interventions in the region define, conceive, understand and engage with it. But, in an important sense, the region has now been defined for us by the Association of Southeast Asian Nations (ASEAN), and whatever academic researchers might wish to impose on Southeast Asia in regard to their priorities and interests, it may make little difference. Given the politically-derived, nation-state definition of Southeast Asia, are all our problems of regional definition resolved? In some respects, they have been. ASEAN has constructed and institutionalized a regional organization and an associated regional culture. But in certain fields of research we still require academic flexibility. We cannot always be confined by an ASEAN-derived regional definition. The paper will explore other configurations of 'region' and its sub-divisions and propose, that in the spirit of academic freedom, we can continue to generate imaginative depictions of Southeast Asia and its constituents both within and beyond the region.

• Genomics & Informatics
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• 제19권3호
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• pp.29.1-29.10
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• 2021

In our previous studies, we have demonstrated the association of certain variants of the thyroid-stimulating hormone receptor (TSHR), thyroid peroxidase (TPO), and thyroglobulin (TG) genes with congenital hypothyroidism. Herein, we explored the mechanistic basis for this association using different in silico tools. The mRNA 3'-untranslated region (3'-UTR) plays key roles in gene expression at the post-transcriptional level. In TSHR variants (rs2268477, rs7144481, and rs17630128), the binding affinity of microRNAs (miRs) (hsa-miR-154-5p, hsa-miR-376a-2-5p, hsa-miR-3935, hsa-miR-4280, and hsa-miR-6858-3p) to the 3'-UTR is disrupted, affecting post-transcriptional gene regulation. TPO and TG are the two key proteins necessary for the biosynthesis of thyroid hormones in the presence of iodide and H₂O₂. Reduced stability of these proteins leads to aberrant biosynthesis of thyroid hormones. Compared to the wild-type TPO protein, the p.S398T variant was found to exhibit less stability and significant rearrangements of intra-atomic bonds affecting the stoichiometry and substrate binding (binding energies, ΔG of wild-type vs. mutant: -15 vs. -13.8 kcal/mol; and dissociation constant, K_d of wild-type vs. mutant: 7.2E^-12 vs. 7.0E^-11 M). The missense mutations p.G653D and p.R1999W on the TG protein showed altered ΔG(0.24 kcal/mol and 0.79 kcal/mol, respectively). In conclusion, an in silico analysis of TSHR genetic variants in the 3'-UTR showed that they alter the binding affinities of different miRs. The TPO protein structure and mutant protein complex (p.S398T) are less stable, with potentially deleterious effects. A structural and energy analysis showed that TG mutations (p.G653D and p.R1999W) reduce the stability of the TG protein and affect its structure-functional relationship.

• Journal of Rhinology
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• 제59권1호
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• pp.49-58
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• 2021

Background: Nasal polyps in the nasal cavity and mucous discharge inside the maxillary sinus exhibit compressive stress on the nasal mucosal epithelium. However, there have been only a few studies on how compressive stress impacts the human nasal mucosal epithelium. Methodology: We investigated the effect of compressive stress on collective migration, junctional proteins, transepithelial electrical resistance, epithelial permeability, and gene expression in well-differentiated normal human nasal epithelial (NHNE) cells and human nasal polyp epithelial (HNPE) cells. Results: NHNE cells barely showed collective migration at compressive stress up to 150 mmH₂0. However, HNPE cells showed much greater degree of collective migration at a lower compressive stress of 100 mmH₂0. The cell migration of HNPE cells subjected to 100 mmH₂O compression was significantly decreased at day 3 and was recovered to the status prior to the compressive stress by day 7, indicating that HNPE cells are relatively more sensitive to mechanical pressure than NHNE cells. Compressive stress also increased transepithelial electrical resistance and decreased epithelial permeability, indicating that the compressive stress disturbed the structural organization rather than physical interactions between cells. In addition, we found that compressive stress induced gene expressions relevant to airway inflammation and tissue remodelling in HNPE cells. Conclusion: Taken together, these findings demonstrate that compressive stress on nasal polyp epithelium is capable of inducing collective migration and induce increased expression of genes related to airway inflammation, innate immunity, and polyp remodelling, even in the absence of inflammatory mediators.

• 한국IT서비스학회지
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• 제12권4호
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• pp.187-204
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• 2013

In this study, we developed a comprehensive model to measure the National Information Security Level based on PRM framework. The proposed model reflected a rapidly changing technology environments such as social network service, mobile devices, and etc. This new model consists of three layers:Infrastructure Layer, the Action Layer and the Performance Layer, and there are 16 sub-indexes under the 3 layers. To develop new model and sub-indexes for measuring the National Information Security Level, much amounts of documents related to security indexes or deliberation criteria and security guidelines from international organization were reviewed and then most probable index pool were composed. The Index pool were verified by expert group consisting of professors and specialists. Through five times of screening and having an evaluation review, 16 sub-indexes were deduced and then Delphi and AHP have been conducted to obtain validity and objectiveness of the indexes. Thus the new proposed national information security index will show more exact national information security level and we expect that the indexes give much implications for establishing information protection policy.

• Journal of Advanced Marine Engineering and Technology
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• 제35권6호
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• pp.773-778
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• 2011

선박용 소각기는 각종 폐기물의 연소로 인한 해양환경 오염 우려로 국제해사기구에 의한 기준이 점점 강화되어지고 있다. 본 연구는 배기가스의 온도를 낮추고 연소실의 연소가스가 원활하게 배출되도록 배기가스의 배출 유로를 3개로 하고, 배기통로 내에 보조 이젝터를 설치한 시스템의 성능 향상에 대하여 Ansys를 사용하여 유동 해석을 수행하였다. 해석결과, 배기가스 유로의 다채널화에 의하여 배기가스 온도가 국제해사기구 기준보다 낮게 유지되었으며, 통로에 설치한 보조 이젝터가 배기가스 배출에 매우 효과적인 장치인 것으로 분석되었다.

• 상하수도학회지
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• 제34권4호
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• pp.289-301
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• 2020

Since sewer rehabilitation program requires long construction period and enormous capital investment, determination of rehabilitation priorities is important with systematic planning considering appropriate evaluation parameters. In this research, we applied PROMETHEE(Preference Ranking Organization METHod for Evaluations) known as very objective and scientific multi-criteria decision-making analysis, using the weights determined by AHP(Analytic Hierarchy Process) for the selected sewer evaluation items to calculate the rehabilitation priorities for each sewer sub-catchment in basin Gusan 1 of Seoul. Preference functions and preference thresholds were estimated for each criterion of ratio of lack of hydraulic capacity of sewers, defect ratio, ratio of sewers with velocity less than its minimum criteria, and density of sewers in the sub-catchment. As a result, it was found that region d had the first priority among four sub-catchments. For each and every sewer located in region d, we could also rank sewers to be rehabilitated urgently.

• 가정∙방문간호학회지
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• 제20권1호
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• pp.44-52
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• 2013

Purpose: To identify factors that affect the job stress of visiting nurses at health centers in Seoul, Korea, who perform home care services. Methods: Data were collected in the period from November 20 to December 10, 2008, from 206 visiting nurses working at 25 health centers in Seoul metropolitan city. Self-report questionnaires of the Organization-Based Self-Esteem (OBSE) and the Korean Occupational Stress Scale (KOSS) were used. Data were analyzed by the SPSS win 15.0. Results: Several findings were obtained from the study. First, the mean of job stress was 52.4 points, which was higher than that of Korean women. Second, it was shown that by the sub-domain of job stress, the mean value belonged to the top 50% in the four sub-domains of physical environment, job demand, interpersonal conflict, and organizational system. Additionally, it belonged to the top 25% in the sub-domain of job insecurity, wherein the job stress was the highest. Third, the self-esteem of the nurses had the most significant effect on their job stress. Conclusion: Stress related to job insecurity was the highest among the visiting nurses at health centers in Seoul who perform the custom home care service thus, institutional support is urgently needed to alleviate such stress and secure their employment.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2023년도 임시총회 및 춘계학술대회
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• pp.15-15
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• 2023

The chloroplast (cp) is an autonomous plant organelle with an individual genome that codes for essential cellular functions. The architecture and gene content of the cp genome is highly conserved in angiosperms. The plastome of Corydalis belongs to the Papaveraceae family, and the genome is comprised of unusual rearrangements and gene content. Thus far, no extensive comparative studies have been carried out to understand the evolution of Corydalis chloroplast genomes. Therefore, the Corydalis platycarpa cp genome was sequenced, and wide-scale comparative studies were conducted using publicly available twenty Corydalis plastomes. Comparative analyses showed that an extensive genome rearrangement and IR expansion occurred, and these events evolved independently in the Corydalis species. In addition, the protein-coding genes accD and the ndh gene loss events occurred in the common ancestor of the Corydalis and sub-clade of the Corydalis lineage, respectively. The gene ndh lost in the Corydalis-sub clade species is distributed predominantly in the Qinghai-Tibetan plateau (QTP) region. The molecular clock analysis suggests that the divergence time of all the ndh gene lost Corydalis sub-clade species occurred in the 44.31 - 15.71 mya. These results coincide very well with the uplift of the Qinghai-Tibet Plateau in the Oligocene and Miocene periods, and maybe during this period, it probably triggered the radiation of the Corydalis species. To the best of the authors' knowledge, this is the first large-scale comparative study of Corydalis plastomes and their evolution. The present study may provide insights into the plastome architecture and the molecular evolution of Corydalis species.

• 한국컴퓨터정보학회논문지
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• 제20권2호
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• pp.169-180
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• 2015

본 연구는 지식관리시스템을 도입하여 운영 중인 기업체와 기관들을 대상으로 지식관리시스템의 도입요인이 조직성과에 미치는 영향을 실증적으로 검증하였다. 본 연구의 목적은 지식관리시스템의 도입요인들이 조직의 성과에 어떠한 영향을 미치는지를 실증적으로 분석하여 조직에서 지식관리시스템도입과 운영에서 고려할 전략적 지침을 제시하고자 함이다. 연구결과, 관리요인의 하위변수인 학습의 조직화, 평가와 보상체계, 조직의 신뢰, 지식의 공유 활동은 조직성과에 모두 유의한 영향을 미치는 것으로 분석되었고, 정보기술특성의 하위변수 중 정보기술 기반구조도 통계적으로 유의한 결과를 보여 조직성과에 영향을 주는 것으로 분석되었다. 그러나 정보기술 성숙도와 시스템 구성의 우수성은 조직성과에 영향을 미치지 않는 것으로 분석되었다.

• 정보보호학회논문지
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• 제13권4호
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• pp.37-45
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• 2003

역할기반 접근통제 모델(RBAC)은 역할 계층구조에서 권한의 상속과 임무분리와 같은 제약조건을 다룸으로써 접근권한의 관리를 수월하게 하는 장점이 있다. 하지만 기존의 RBAC 연구에서는 현실세계의 기업 환경에서 일어나는 역할계층을 제대로 반영한다고 볼 수 없다. 역할 계층에서, 하위의 접근 권한이 모두 상위 역할로 상속된다는 것은 최소권한(least privilege) 원칙이 위배로 인한 권한 남용의 문제를 일으킬 수 있다. 본 논문에서는 기업 환경에서 조직체계를 유지하면서 역할을 여러 개의 부역한(sub role)로 세분화하여 전체 상속, 부분 상속, 상속되지 않는 역할로 나누어 부역할 간 계층관계를 새롭게 정의함으로써 무조건적인 권한의 상속을 제한하는 모델을 제시한다. 특히, 권한 상속제한에 있어서는 역할 계층 내에서 상속되는 상위역할을 명시함으로써 불필요한 권한 상속으로 인한 권한남용을 방지한다.