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Inhibitory Action of Cortex Phellodendris on Nicotine-induced Behavioral Sensitization (황백의 니코틴의 활성 억제에 미치는 효과)

  • Lee Bom Bi;Chae Yun Byung;Kwon Young Kyu;Yang Cae Ha;Kim Mi Ryo;Kim Kwang Jung;Hahm Dae Hyun;Lee Hye Jeong;Shim In Sub
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.3
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    • pp.767-773
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    • 2004
  • Substantial evidence suggests that repeated injections of nicotine produce increase in locomotor activity and expression of the immediate-early gene, c-fos in the dopaminergic target areas. Herbal medicine as a therapeutic intervention has been widely used for the treatment of mental dysfunction. Many studies have shown that Cortex Phellodendris (CP) can affect the biochemical balance in the central nervous system. In order to investigate whether CP have an influence on their nicotine-induced behavioral sensitization, we examined the effect of CP on nicotine-induced locomotor activity and c-Fos expression in the striatum and nucleus accumbens utilizing the Fos-like immunohistochemistry (FLI). Male SD rats received CP (200㎎/㎏, i.p.) 30 min before repeated daily injections of nicotine (0.4㎎/㎏, s.c.) for 7 days. Rats were followed withdrawal for 3 days and one challenge for 1 day. System challenge with nicotine produced a much larger increase in locomotor activity and accumbal FLI. Pretreatment with CP significanly inhibited nicotine-induced locomotor activity and FLI in the striuatum and nucleus accumbens. These results demonstrated that reduction in locomotor activity by CP may be reflected by reduction of dopamine release and postsynaptic neuronal activity in the striatum and nucleus accumbens. Our results suggest that CP may have therapeutic effect on nicotine addiction. Supported by a fund (99-PJ9-PG1-002-0004).

Study on the Characterization of Oxidative Degradation of Automotive Gasoline (자동차용휘발유의 산화열화특성 규명 연구)

  • Min, Kyong-Il;Yim, Eui Soon;Jung, Chung-Sub;Kim, Jae-Kon;Na, Byung-Ki
    • Korean Chemical Engineering Research
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    • v.51 no.2
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    • pp.250-256
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    • 2013
  • Gasoline generates organic acid and polymer (gum) by hydrocarbon oxidation depending on the storage environment such as temperature and exposure to sunlight, which can cause metal corrosion, rubber and resin degradation and vehicle malfunction caused by accumulation in fuel supply system. The gasoline which has not been used for a long time in bi-fuel (LPG-Gasoline) vehicle causes problems, and low octane number gasoline have evaporated into the field, but the exact cause has not been studied yet. In this study, we suggest a plan of quality management by investigating the gasoline oxidation behavior. In order to investigate the oxidation behavior of gasoline, changes of gasoline properties were analyzed at various storage conditions such as storage time, storage vessel type (vehicle fuel tank, PE vessel and Fe vessel) and storage circumstances (sunlight exposure and open system, etc.). Currently distributing gasoline and bioethanol blended fuel (blended 10%) were stored for 18 weeks in summer season. The sample stored in PE vessel was out of quality standard (octane number, vapor pressure, etc.) due to the evaporation of the high octane number and low boiling point components through the vessel cap and surface. Especially, the sunlight exposure sample stored in PE vessel showed rapid decrease of vapor pressure and increase of gum. Bioethanol blended fuel showed similar results as gasoline.

Field Study on Wireless Remote Sensing for Stability Monitoring of Large Circular Steel Pipe for Marine Bridge Foundation (해상 교량기초용 대형 원형강관 가설공법의 무선 원격 안정성 모니터링을 위한 현장실험)

  • Park, Min-Chul;Lee, Jong-Sub;Yu, Jung-Doung
    • Journal of the Korean Geotechnical Society
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    • v.36 no.11
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    • pp.71-81
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    • 2020
  • The large circular steel pipe for a marine bridge foundation has been developed as a construction method capable of performing the role of the working platform and cofferdam. The objective of this study is to demonstrate the wireless remote sensing system for monitoring the stability of the large circular steel pipe during construction and operation through field tests. The artificial seabed ground with an water level of 4 m is constructed for field tests. The large circular steel pipe with a diameter of 5 m and height of 9.5 m is installed into the ground by suction, and the embedded depth is 5 m. The inclinometer and strain gauges are installed on different surfaces of the upper module, and the tilt angle and stress are monitored throughout the entire construction process. As results, tilt angles are measured to be constant during the suction penetration. However, the tilt angle is larger in the x-axis direction. In addition, even when installed on different surfaces, the tilt angle in the same axial direction is measured to be almost the same. The stresses measured by strain gauges increase during suction penetration and decrease during pull-out. Based on measured stresses, it is found that the eccentricity is acting on the large circular steel pipe. This study shows that a wireless remote sensing system built with an inclinometer and strain gauge can be a useful tool for the stability monitoring of the large circular steel pipe.

Construction of Artificial Intelligence Training Platform for Multi-Center Clinical Research (다기관 임상연구를 위한 인공지능 학습 플랫폼 구축)

  • Lee, Chung-Sub;Kim, Ji-Eon;No, Si-Hyeong;Kim, Tae-Hoon;Yoon, Kwon-Ha;Jeong, Chang-Won
    • KIPS Transactions on Computer and Communication Systems
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    • v.9 no.10
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    • pp.239-246
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    • 2020
  • In the medical field where artificial intelligence technology is introduced, research related to clinical decision support system(CDSS) in relation to diagnosis and prediction is actively being conducted. In particular, medical imaging-based disease diagnosis area applied AI technologies at various products. However, medical imaging data consists of inconsistent data, and it is a reality that it takes considerable time to prepare and use it for research. This paper describes a one-stop AI learning platform for converting to medical image standard R_CDM(Radiology Common Data Model) and supporting AI algorithm development research based on the dataset. To this, the focus is on linking with the existing CDM(common data model) and model the system, including the schema of the medical imaging standard model and report information for multi-center research based on DICOM(Digital Imaging and Communications in Medicine) tag information. And also, we show the execution results based on generated datasets through the AI learning platform. As a proposed platform, it is expected to be used for various image-based artificial intelligence researches.

Convergence factor Influencing Job Satisfaction of Radiographer (방사선사의 직무만족도에 영향을 미치는 융복합요인)

  • Lee, Mi-Hwa
    • Journal of Digital Convergence
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    • v.13 no.8
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    • pp.357-368
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    • 2015
  • This cross-sectional study was performed to offer radiographer who registered to the Korean Association of Radiographers as a basic material promote job satisfaction and lower job stress. A total of 213 radiographer were surveyed using a self-administered questionnaire. The 105 questionnaires consist of general characteristics, job characteristics, job stress, and job satisfaction. The job satisfaction was categorized into 3 sub-scales; psychological variables, environmental variables, and structural variables. The job stress insufficient job control, interpersonal conflict, job insecurity, organizational system, lack of reward, and occupational climate. Job satisfaction in psychological variables of radiographer was higher in the radiographers who have a high level of education, work in seoul,have a high sense of mission, don't have job leaving attitude, have a lower job insecurity. Job satisfaction in environmental variables of radiographer was higher in the radiographers who get lower salary. Job satisfaction in structural variables of radiographer was higher in the radiographers who have a high sense of mission, don't have job leaving attitude, have a lower organizational system, lack of reward, and occupational climate. Job satisfaction of radiographer was higher in th radiographers who don't have job leaving attitude, have a high sense of mission, have a lower lack of reward, and occupational climate.

A Study on Land Acquisition Priority for Establishing Riparian Buffer Zones in Korea (수변녹지 조성을 위한 토지매수 우선순위 산정 방안 연구)

  • Hong, Jin-Pyo;Lee, Jae-Won;Choi, Ok-Hyun;Son, Ju-Dong;Cho, Dong-Gil;Ahn, Tong-Mahn
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.17 no.4
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    • pp.29-41
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    • 2014
  • The Korean government has purchased land properties alongside any significant water bodies before setting up the buffers to secure water qualities. Since the annual budgets are limited, however, there has always been the issue of which land parcels ought to be given the priority. Therefore, this study aims to develop efficient mechanism for land acquisition priorities in stream corridors that would ultimately be vegetated for riparian buffer zones. The criteria of land acquisition priority were driven through literary review along with experts' advice. The relative weights of their value and priorities for each criterion were computed using the Analytical Hierarchy Process(AHP) method. Major findings of the study are as follows: 1. The decision-making structural model for land acquisition priority focuses mainly on the reduction of non-point source pollutants(NSPs). This fact is highly associated with natural and physical conditions and land use types of surrounding areas. The criteria were classified into two categories-NSPs runoff areas and potential NSPs runoff areas. 2. Land acquisition priority weights derived for NSPs runoff areas and potential NSPs runoff areas were 0.862 and 0.138, respectively. This implicates that much higher priority should be given to the land parcels with NSPs runoff areas. 3. Weights and priorities of sub-criteria suggested from this study include: proximity to the streams(0.460), land cover(0.189), soil permeability(0.117), topographical slope(0.096), proximity to the roads(0.058), land-use types(0.036), visibility to the streams(0.032), and the land price(0.012). This order of importance suggests, as one can expect, that it is better to purchase land parcels that are adjacent to the streams. 4. A standard scoring system including the criteria and weights for land acquisition priority was developed which would likely to allow expedited decision making and easy quantification for priority evaluation due to the utilization of measurable spatial data. Further studies focusing on both point and non-point pollutants and GIS-based spatial analysis and mapping of land acquisition priority are needed.

The Effect of Switching Costs on user Resistance in the Adoption of Open Source Software (오픈소스 소프트웨어 도입 시 전환비용이 사용자 저항에 미치는 영향)

  • Kim, Hee-Woong;Noh, Seung-Eui;Lee, Hyun-Lyung;Kwahk, Kee-Young
    • Information Systems Review
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    • v.11 no.3
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    • pp.125-146
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    • 2009
  • The emergence of open source software(OSS) with its most prominent advantages creates a vast interest among practitioners. A study on Linux, the most well-known OSS, estimated that it would cost as 5.4 billion Euros taking over 73,000 person-years if it had been developed by conventional means. However, Linux has achieved only 0.65 percent of the operating system market for individual users while Microsoft windows family counts for nearly 90 percent of the market. Much of the effort being spent in the development of OSS is going to waste and potential value that OSS can bring to users is not being realized. Adoption of OSS is often accompanied by the discontinuance of existing software that is already in place. If users resist changing, they may not adopt OSS. Using the case of Linux, this study examines user resistance to change from the commercial operating software to the free operating system. This study identifies six sub-types of switching costs (uncertainty, emotional, setup, learning, lost benefit, and sunk costs) and tests their effects on user resistance to change based on a survey of 201 users. The results show that user resistance to change has a negative impact on the adoption of OSS. Further, this study shows that uncertainty and emotional costs have significant effects on user resistance to change. Beyond previous research on technology adoption, this research contributes towards an understanding of the switching costs leading to user resistance to change and offers suggestions to OSS practitioners for developing strategies to improve the adoption of OSS.

A Study on the Stylistic Expression of Late 20th Century Interior Design (현대(現代) 후기(後期) 실내디자인의 표현성(表現性))

  • Lee Choon-Sub
    • Journal of Science of Art and Design
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    • v.1
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    • pp.189-226
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    • 1999
  • The purpose of this paper is to examine the common characteristics of late 20th century interior design style and the post-modern thinking system. A period has its own predominant spirit which determine the tendency of art, and the ubiquitous power in the spirit decides the period's pattern of art. Therefore the interior design style belongs to general art sphere that has its own individual character derived from the dominant power of the controlling system. Paying special attention to this understanding, the auther has processed this paper by combining the post-modem thinking with special characteristics of each of the 20th century interior design style. Until now, researches have been focused on the individual style of post-modern design; however, a general research comprising the whole characteristics of expression has not been made. Accordingly, the rationale of emphasizing the general point of view is establshed. Also, this study suggests a model applicable to studies concerning other art area. This type of methodology is receving more attention as an approach investigating new art ideology for researching post-modern thinking and late 20th century art styles. The conclusions are as follows: First, the distinctive expressions of postmodernism appear to be characteristic of illusion, metaphor, pluralism, decoration, and symmetry, Those of late modernism appear to be the characteristic of complicated simplicity and symplified complexity, passiveness of symbolism and harmony, indeterminacy of form and space, and unintentional decorativeness. And the characteristics of deconstructionism are spatial difference and temporal defferal, and un-reductive and non formal abstractiveness of the space, unfinishness, chance, and secretiveness of individual style. Second, the disinctive expression seems to share common characteristics with postmodern thinking. The best examples are pluralism, non-formalism, populism, and historicism, originating from the deconstruction of 'meta-narrative'. Third, based on the second conclusion, general distinctive expression could be simplified as chacteristics of plurality, hybridity, and indeterminacy. These expressive chacteristics appear to be automatically connected with general postmodern thinking. Last, in consideration of the above conclusion, the extreme generality could be distinctively clarified as 'textural co-exsistence'. Accordingly, the author might confirm that 'textural co-existence' originated from the text that comes from postmodern thinking. In conclusion, design expression of late 20th century interior design accepts the ?universal theme of ubiquitous postmodern thinking. And universal expressions and supreme generality can be common analysis tools for understanding and studying complicated late 20th century interior design.

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Robust Semi-auto Calibration Method for Various Cameras and Illumination Changes (다양한 카메라와 조명의 변화에 강건한 반자동 카메라 캘리브레이션 방법)

  • Shin, Dong-Won;Ho, Yo-Sung
    • Journal of Broadcast Engineering
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    • v.21 no.1
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    • pp.36-42
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    • 2016
  • Recently, many 3D contents have been produced through the multiview camera system. In this system, since a difference of the viewpoint between color and depth cameras is inevitable, the camera parameter plays the important role to adjust the viewpoint as a preprocessing step. The conventional camera calibration method is inconvenient to users since we need to choose pattern features manually after capturing a planar chessboard with various poses. Therefore, we propose a semi-auto camera calibration method using a circular sampling and an homography estimation. Firstly, The proposed method extracts the candidates of the pattern features from the images by FAST corner detector. Next, we reduce the amount of the candidates by the circular sampling and obtain the complete point cloud by the homography estimation. Lastly, we compute the accurate position having the sub-pixel accuracy of the pattern features by the approximation of the hyper parabola surface. We investigated which factor affects the result of the pattern feature detection at each step. Compared to the conventional method, we found the proposed method released the inconvenience of the manual operation but maintained the accuracy of the camera parameters.

Fire Detection Signal Processing Method Using an Optical Fiber Linear Detector and the Development of an Optical Signal Processing Test Module (광섬유선형감지기를 이용한 화재감지 신호처리방법 및 광신호처리 시험모듈 개발에 관한 연구)

  • Kim, Si-Kuk;Lee, Young-Sin;Kim, Dong-Eun;Lim, Woo-Sub;Lee, Chun-Ha
    • Fire Science and Engineering
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    • v.30 no.2
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    • pp.27-34
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    • 2016
  • This paper studies a fire detection system using an optical fiber linear detector which can minimize damage from a fire by the most adaptable even in poor environmental conditions such as a tunnel or utility-pipe conduit vulnerable to fire. Using a strand of optical fiber, temperature can be displayed in intervals of meters and a fire can be detected remotely from a distance of several kilometers. Thanks to its strengths such as high reliability and long life, it is widely applied in harsh environments in the overseas. Therefore demands are expected to grow greatly in Korea as well. However, all optical signal drive and analysis module except for the optical fiber linear detector, tend to rely on import. Firstly this study deduced the location and the method of processing signals measuring temperature by using the optical fiber linear detector in order to develop a technology for a domestic model of fire detection system. Secondly this study designed and manufactured the optical analysis test module, and then we checked its performance.