Browse > Article

Inhibitory Action of Cortex Phellodendris on Nicotine-induced Behavioral Sensitization  

Lee Bom Bi (Department of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University)
Chae Yun Byung (Department of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University)
Kwon Young Kyu (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
Yang Cae Ha (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
Kim Mi Ryo (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
Kim Kwang Jung (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
Hahm Dae Hyun (Department of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University)
Lee Hye Jeong (Department of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University)
Shim In Sub (Department of Oriental Medicine Science, Graduate School of East-West Medical Science, Kyung-Hee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.3, 2004 , pp. 767-773 More about this Journal
Abstract
Substantial evidence suggests that repeated injections of nicotine produce increase in locomotor activity and expression of the immediate-early gene, c-fos in the dopaminergic target areas. Herbal medicine as a therapeutic intervention has been widely used for the treatment of mental dysfunction. Many studies have shown that Cortex Phellodendris (CP) can affect the biochemical balance in the central nervous system. In order to investigate whether CP have an influence on their nicotine-induced behavioral sensitization, we examined the effect of CP on nicotine-induced locomotor activity and c-Fos expression in the striatum and nucleus accumbens utilizing the Fos-like immunohistochemistry (FLI). Male SD rats received CP (200㎎/㎏, i.p.) 30 min before repeated daily injections of nicotine (0.4㎎/㎏, s.c.) for 7 days. Rats were followed withdrawal for 3 days and one challenge for 1 day. System challenge with nicotine produced a much larger increase in locomotor activity and accumbal FLI. Pretreatment with CP significanly inhibited nicotine-induced locomotor activity and FLI in the striuatum and nucleus accumbens. These results demonstrated that reduction in locomotor activity by CP may be reflected by reduction of dopamine release and postsynaptic neuronal activity in the striatum and nucleus accumbens. Our results suggest that CP may have therapeutic effect on nicotine addiction. Supported by a fund (99-PJ9-PG1-002-0004).
Keywords
nicotine, behavioral sensitization; c-Fos; striatum, nucleus accumbens; Cortex Pheliodendris(CP);
Citations & Related Records
연도 인용수 순위
  • Reference
1 Tobacco abstinence, smoking cues, and the reinforcing value of smoking. /
[ Perkin, K.A.;Epstein, L.H.;Grobe, J.;Fonte, C. ] / Pharmacol Biochem Behav
2 The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity. /
[ Benwell MEM;Balfour DJK. ] / Br. J. Pharmacol.
3 Amphetamine behavioral sensitization and the excitatory amino acids. /
[ Karler, R.;Chaudhry, I.A.;Calder, L.D.;Turkanis, S.A. ] / Brain Res
4 Differential prevalence of cigarette smoking in patients with schizophrenic vs mood disorders /
[ Diwan, A.;Castine, M.;Pomerleau, C.S.;Meador-Woodruff, J.H.;Dalack, G.W. ] / Schizophr Res
5 The role of the addictive process as a key step in causation of all tobacco-related disease. /
[ Pollin, W. ] / JAMA
6 Addiction mortality in the United States: tobacco, alcohol and other substances. /
[ Ravenholt, R.T. ] / Pop Dev Rev
7 Trends in cigarette smoking in the United States: the epidemiology of tobacco use. /
[ Fiore, M.D. ] / Med Clin North Am
8 Nicotine medications for smoking cessation. /
[ Henningfield, J. E. ] / N Engl J Med
9 A comparison of sustained-release bupropion and placebo for smoking cessation. /
[ Hurt, R.D.;Sachs, D.P.;Glover, E.D.;Offord, K.P.;Johnston, J.A.;Dale, L.C. ] / N Engl J Med
10 Nicotine likened to cocaine, heroin. /
[ Byrne, G. ] / Science
11 Effect of nicotine on the nucleus accumbens and similarity to those of addictive drugs. /
[ Pontieri, F.E.;Tanda, G.;Chiara, DG. ] / Nature
12 Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal model of amphetamine psychosis. /
[ Robinson, T.E.;Becker, T.B. ] / Brain Res Rev
13 Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunoreactivity in the nucleus accumbens of the rats. /
[ Panagis, G.;Nisell, M.;Nomikos, G.G.;Chergui, K.;Svensson, T.H. ] / Brain Res
14 Stimulant-induced psychosis: an evaluation of animal methods. /
[ Segal, D.S.;Greyer, M.A.;Schuckit, M.A ] / Essays Neurochem. Neuropharmacol
15 Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats. /
[ Clarke, P.B.S.;Fu, D.S.;Jakubovic, A.;Fibiger, H.C. ] / J Pharmacol Exp Ther
16 The mesolimbic dopamine system is implicated in the reinforcing effects of nicotine. /
[ Corrigall, W.A.;Franklin, K.B.;Coen, K.M.;Clarke, P.B. ] / Psychopharmacology
17 The use of c-fos as a metabolic marker in neuronal pathway tracing. /
[ Dragunow, M.;Faull, R. ] / J Neurosci Methods
18 Expression of c-fos protein in brain: Metabolic mapping at the cellular level. /
[ Sagar, S.M.;Sharp, F.R.;Curran, T. ] / Science
19 Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunoreactivity in the nucleus accumbens of the rats. /
[ Panagis, G.;Nisell, M.;Nomikos, G.G.;Chergui, K.;Svensson, T.H. ] / Brain Res
20 Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D1 receptor and is dependent on NMDA stimulation. /
[ Kiba, H.;Jayaraman, A. ] / Brain Res Mol Brain Res
21 Inducivility of c-Fos protein in visuo-motor system and limbic structures after acute and repeated administration of nicotine in the rat. /
[ Mathieu-Kia, A.M.; Pages, C.;Besson, M.J. ] / Synapse
22 Nicotine-induced behavioral sensitization is associated with extracellular dopamine release and expression of c-Fos in the striatum and nucleus accumbens of the rat. /
[ Shim, I.;Javaid, J.I.;Wirtshafter, D.;Jang, S.Y.;Shin, K.H.;Lee, H.J. ] / Behav Brain Res   ScienceOn
23 Chronic nicotine treatment potentiates behavioral responses to dopaminergic drugs in rats. /
[ Suemaru, K.;Gomita, Y.;Furuno, K.;Araki, Y. ] / Pharmacol Biochem Behav
24 Preparative separation of alkaloids from Cortex Phellodendri by high speed countercurrent chromatography. /
[ Yuan, L.M.;Wu, P.;Xia, T.;Chen, X.X. ] / Se Pu
25 Effects of different processing products of Cortex Phellodendri on scavenging oxygen free radicals and anti-lipid peroxidation. /
[ Kong, L.D.;Yang, C.;Qui, X.I.;Wu, H.P.;Ye, D.J. ] / Zhongguo Zhong Yao Za Zhi
26 Water extract of 1:1 mixture of Phellodendron cortex and Aralia cortex has inhibitory effects on oxidative stress in kidney of diabetic rats. /
[ Lee, Y.M.;Kim, H.;Hong, E.K.;Kang, B.H.;Kim, S.J. ] / J Ethnopharmacol
27 Neurochemical brain imaging investigations of schizophrenia. /
[ Soares, J.C.;Innis, R.B. ] / Biol. Psychiatry
28 Determination of berberine and palmatine in cortex phellodendron and Chinese patent medicines by HPLC. /
[ Wang, Y.M.;Zhao, L.B.;Lin, S.L.;Dong, S.S.;An, D.K. ] / Yao Xue Xue Bao
29 /
[ Paxinos, G.;Watson, C. ] / The rat brain in stereotaxic coordinates.
30 Studies of amphetamine or methamphetamine psychosis in Japan: relation of methamphetamine psychosis to schizophrenia. /
[ Yui, K.;Ikenoto, S.;Ishiguro, T.;Goto, K. ] / Ann N Y Acad Sci
31 Dopaminergic mechanism in the pathogenesis of schizophrenia. /
[ Goldstein, M.;Deutch, A.Y. ] / FASEB J
32 Locomotor acitivity in rats after administration of nicotine agonists intracerebrally /
[ Reavill, C.;Stolerman, I.P. ] / Br J Pharmaco
33 Studies on the role of brain dopamine system in the psychostimulant response to nicotine. /
[ Vale, A.L.;Balfour, D.J.K. ] / Br J Pharmacol
34 A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. /
[ Pierce, R. C.;Kalivas, P. W. ] / Brain Res Brain Res Rev   ScienceOn
35 On the significance of subterritories in the 'accumbens /
[ Zahm, D.S.;Borg, J.S. ] / Neuroscience
36 Specificity in the projection patterns of accumbal core and shell in the rat. /
[ Heimer, L.;Zahm, D.S.;Churchill, L.;Kalivas, P.W.;Wohltman, C. ] / Neuroscience
37 /
[ Kaliva, P.W.;Rierce, P.C.;Sorg, B.A. ] / A role for sensitization in psychostimulants-induced paranoia and psychosis.