• BMB Reports
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• 제51권5호
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• pp.211-218
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• 2018

Chromatin is an intelligent building block that can express either external or internal needs through structural changes. To date, three methods to change chromatin structure and regulate gene expression have been well-documented: histone modification, histone exchange, and ATP-dependent chromatin remodeling. Recently, a growing body of literature has suggested that histone tail cleavage is related to various cellular processes including stem cell differentiation, osteoclast differentiation, granulocyte differentiation, mammary gland differentiation, viral infection, aging, and yeast sporulation. Although the underlying mechanisms suggesting how histone cleavage affects gene expression in view of chromatin structure are only beginning to be understood, it is clear that this process is a novel transcriptional epigenetic mechanism involving chromatin dynamics. In this review, we describe the functional properties of the known histone tail cleavage with its proteolytic enzymes, discuss how histone cleavage impacts gene expression, and present future directions for this area of study.

• 한국정밀공학회지
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• 제17권5호
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• pp.93-99
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• 2000

In many dynamic structural optimization problems, the goal is to reduce the total weight of the structure without causing the resonance. Up to now, gradient informations(i.e., design sensitivity) have been used to achieve the goal. For some class of dynamic problems, especially coalescent eigenvalue Problems with multiobjective optimization, the design sensitivity analysis is too much complicated mathematically and numerically. Therefore, this article proposes a new technique fur structural dynamic modification using a mode modification method with Genetic Algorithm(GA). In GA formulation, fitness is defined based on penalty function approach. Design variables are iteratively improved by using genetic algorithm. Two numerical examples are shown, (ⅰ) a cantilevered plate, and (ⅱ) H-shaped structure. The results demonstrate that the proposed method is highly efficient.

• International Journal of Automotive Technology
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• 제8권1호
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• pp.75-82
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• 2007

This paper presents practical work on the reduction of gear whine noise. In order to identify the source of the gear whine noise, transfer paths are searched and analyzed by operational deflection shape analysis and experimental modal analysis. It was found that gear whine noise has an air-borne noise path instead of structure-borne noise path. The main sources of air-borne noise were the two global modes caused by the resonance of an axle system. These modes created a vibro-acoustic noise problem. Vibro-acoustic noise can be reduced by controlling the vibration of the noise source. The vibration of noise source is controlled by the modification of structure to avoid the resonance or to reduce the excitation force. In the study, the excitation force of the axle system is attenuated by changing the tooth profile of the hypoid gear. The modification of the tooth profile yields a reduction of transmission error, which is correlated to the gear whine noise. Finally, whine noise is reduced by 10 dBA.

• 소음진동
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• 제7권5호
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• pp.847-852
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• 1997

Many investigations about the dynamic analysis of the structural system based on the BBA(Building Block Approach) method which predict dynamic characteristics of synthesized structures from each structure. But it is actually sometimes difficult to remove mounts from structures. In this paper, TFSM(The Transfer Function Separation Method) is developed which can predict dynamic characteristics of separated structures from the data of vibrational experiment of the synthesized structures. By combining TFSM with BBA, this paper also proposes the method which can predict dynamic characteristics of mount-modified structure without removing mounts from structures. And the proposed method is verified by the experimental data of plates.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2004년도 유체기계 연구개발 발표회 논문집
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• pp.70-77
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• 2004

Comprehensive investigation on the outlet's geometric shapes of a centrifugal blower with higher inlet resistance than an atmospheric pressure is carried out for improvements of its performance. Most unwanted behaviors of such blower are pulsating flows because of unbalance between inflows and outflows in a scroll casing. In order to reduce this undesirable phenomenon a triump is made for both the shape of outlet duct and an accessory structure inserted in the outlet port of the blower. The modification on the shape is concerned with the contraction of cross sectional area and the attached structure is for an intentional obstruction to cause a flow resistance. The details of the modification are examined for different cases and results. The methodologies for the work are performance evaluations including noise level and velocity measurements with PIV Consequently, the performance of improved system is close to that of the system operating with atmospheric pressure at the inlet.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1998년도 봄 학술발표회 논문집
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• pp.25-32
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• 1998

Most recent seismic design codes include Response Modification Factor(RMF) for determining equivalent lateral forces. The RMF is used to reduce the linear elastic design spectrum to account for the energy dissipation capacity, overstrength and damping of the structure. In this study the RMF is defined as the ratio of the absolute maximum linear elastic base shear to the absolute maximum nonlinear base shear of a structure subject to the same earthquake accelerogram. This study investigates the effect of hysteretic model, as well as target ductility ratio and natural period on duct based RMF using nonlinear dynamic analyses of the SDOF systems. Special emphasis is given to the effects of the hysteretic characteristics such as strength deterioration and stiffness degradation. Results indicate that RMFs are dependent on ductility, period and hysteretic model.

• 대한공간정보학회지
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• 제3권2호
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• pp.151-158
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• 1995

Change detection기법은 영상에서 차이를 알아내기 위하여 가장 많이 사용되는 방법이며 다양한 영상환경에 사용된다. 수치지형모델과 수치영상은 같은 수치격자데이타 구조를 가지므로 Change detection기법을 수치지형모델에 적용할 측량결과의 표고데이타를 불규칙삼각형(TIN)으로부터 격자구조로 변환하고 수치지형모델화하여 구조물의 변형지점을 찾는데 사용함으로 많은 소모성 자재와 인력을 줄일 수 있었다. 그 결과를 가시화하여 건물의 변형이 발생한 지점과 변형향을 수치적으로 나타낼 수 있었다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집B
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• pp.335-340
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• 2001

It is important to model the mechanical structure precisely and reasonably in predicting the dynamic characteristics, controlling the vibration, and designing the structure dynamics. In the finite element modeling, the errors can be contained from the physical parameters, the approximation of the boundary conditions, and the element modeling. From the dynamic test, more precise dynamic characteristics can be obtained. Model updating using parameter modification is appropriate when the design parameter is used to analyze the input parameter like finite element method. Finite element analysis for cantilever and simply supported beams with uniform area and shape change are carried out as model updating examples. Mass and stiffness matrices are updated by comparing test and analytical modal frequencies. The result shows that the updated frequencies become closer to the test frequencies.

• The Journal of the Acoustical Society of Korea
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• 제19권3E호
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• pp.3-11
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• 2000

A structural modification technique for reducing structure-borne noise of vehicles using a sensitivity analysis is suggested. To estimate the noises generated by the vibration response, a semi structure-acoustic coupling analysis was exploited. As a result of the coupling analysis, severe noise generating positions are identified whose vibrations should be cured through structural modifications. Formulation for the sensitivity analysis of those severe vibration responses with respect to the design changes is derived to enhance the vibration response. Special attention is given in this paper to the use of the experimentally measured vibration responses in the sensitivity analysis. As a result of the proposed method, the structural modifications can be peformed accurately by using experimental data instead of using the finite element method though the higher vibration modes are considered as long as the vibration measurement and acoustic mode calculations are accurate. Effectiveness of this method was examined using an example model by experiments.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2005년도 추계학술대회논문집
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• pp.830-833
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• 2005

SDM(Structural Dynamics Modification) is to improve dynamic characteristics of a structure, more specifically of a base structure, by adding or deleting auxiliary(modifying) structures. In this paper, I will focus on the optimal layout of the stiffeners which are attached to the plate to maximize 1st natural frequency. Recently, a new topology method was proposed by yamazaki. He uses growing and branching tree model. I modified the growing and branching tree model. The method is designated modified tree model. To expand the layout of stiffeners, I will consider non-matching problem. The problem is solved by using local lagrange multiplier without the mesh regeneration. Moreover The CMS(Component mode synthesis) method is employed to reduce the computing time of eigen reanalysis using reduced componet models.