• Journal of the Earthquake Engineering Society of Korea
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• v.9 no.6 s.46
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• pp.13-19
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• 2005

Floor response spectra for dynamic response of subsystem such as equipment, or piping in nuclear power plants are usually generated without considering dynamic interaction between main structure and subsystem. This study describes the analytic method in which equipment response spectra can be obtained through dynamic analysis considering equipment-structure Interaction(ESI). In this method, dynamic response of the equipment by this method is based on a dynamic substructure method in which the equipment-structure system is partitioned into the single-degree-ol-freedom system(SDOF) representing the equipment and the equipment support impedance representing the dynamic charactenstics of the structure ai the equipment support. A family of equipment response spectra is developed by applying this method to calculate the maximum responses of a family of SDOF equipment systems with wide banded equipment frequency, damping ratio, and mass. The method is validated by comparing the floor response spectrum from this method with the floor response spectrum generated from the rigorous analysis including equipments on the containment building of a prototypical nuclear power plant. in order to Investigate ESI effect in the response of equipment, response values from the method and the conventional approach without considering ESI are compared for the equipment having the mass less than 1% of the total structural mass. Response spectra from the method showed lower spectral amplitudes than those of the conventional floor response spectra around controlling frequencies.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.3
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• pp.328-337
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• 2017

Objective: An experiment was conducted to determine the relationship between the KAP11.1 and the regulation wool fineness. Methods: In previous work, we constructed a skin cDNA library and isolated a full-length cDNA clone termed KAP11.1. On this basis, we conducted a series of bioinformatics analysis. Tissue distribution of KAP11.1 mRNA was performed using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis. The expression of KAP11.1 mRNA in primary and secondary hair follicles was performed using real-time PCR (real-time polymerase chain reaction) analysis. The expression location of KAP11.1 mRNA in primary and secondary hair follicles was performed using in situ hybridization. Results: Bioinformatics analysis showed that KAP11.1 gene encodes a putative 158 amino acid protein that exhibited a high content of cysteine, serine, threonine, and valine and has a pubertal mammary gland) structural domain. Secondary structure prediction revealed a high proportion of random coils (76.73%). Semi-quantitative RT-PCR showed that KAP11.1 gene was expressed in heart, skin, and liver, but not expressed in spleen, lung and kidney. Real time PCR results showed that the expression of KAP11.1 has a higher expression in catagen than in anagen in the primary hair follicles. However, in the secondary hair follicles, KAP11.1 has a significantly higher expression in anagen than in catagen. Moreover, KAP11.1 gene has a strong expression in inner root sheath, hair matrix, and a lower expression in hair bulb. Conclusion: We conclude that KAP11.1 gene may play an important role in regulating the fiber diameter.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.10
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• pp.1471-1477
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• 2017

Objective: Since athletic performance is a most importance trait in horses, most research focused on physiological and physical studies of horse athletic abilities. In contrast, the molecular analysis as well as the regulatory pathway studies remain insufficient for evaluation and prediction of horse athletic abilities. In our previous study, we identified AXL receptor tyrosine kinase (AXL) gene which was expressed as alternative spliced isoforms in skeletal muscle during exercise. In the present study, we validated two AXL alternative splicing transcripts (named as AXLa for long form and AXLb for short form) in equine skeletal muscle to gain insight(s) into the role of each alternative transcript during exercise. Methods: We validated two isoforms of AXL transcripts in horse tissues by reverse transcriptase polymerase chain reaction (RT-PCR), and then cloned the transcripts to confirm the alternative locus and its sequences. Additionally, we examined the expression patterns of AXLa and AXLb transcripts in horse tissues by quantitative RT-PCR (qRT-PCR). Results: Both of AXLa and AXLb transcripts were expressed in horse skeletal muscle and the expression levels were significantly increased after exercise. The sequencing analysis showed that there was an alternative splicing event at exon 11 between AXLa and AXLb transcripts. 3-dimentional (3D) prediction of the alternative protein structures revealed that the structural distance of the connective region between fibronectin type 3 (FN3) and immunoglobin (Ig) domain was different between two alternative isoforms. Conclusion: It is assumed that the expression patterns of AXLa and AXLb transcripts would be involved in regulation of exercise-induced stress in horse muscle possibly through an $NF-{\kappa}B$ signaling pathway. Further study is necessary to uncover biological function(s) and significance of the alternative splicing isoforms in race horse skeletal muscle.

• Korean Journal of Cognitive Science
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• v.14 no.2
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• pp.49-56
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• 2003

In this article, we investigate some structural properties of head-internal relative clauses in Korean and their development in Korean-speaking children. In this study, we found head-internal relative clauses in Korean has a more limited domain than head-external relative clauses with respect to positions that can be relativized and clause boundaries that the head can move across: in head-internal relative clauses, only a subject or an object can be relativized and doubly embedded clause constitutes a barrier to the movement of the head. We also found that head-internal relative clauses are easier to understand and produce than head-external relative clauses. In addition, we found that head-internal relative clauses emerge earlier than head-external relative clauses in the acquisition of relative clauses in Korean. The preference of young children (aged 4 and 5) for head-internal relative clauses over head-external relative clauses suggests that children like to use head-internal relative clauses at an early developmental stage when they have difficulty in using head-external relative clauses.

• Korean Journal of Microbiology
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• v.44 no.3
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• pp.186-192
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• 2008

For the development of specific and effective basic genetic materials to inhibit replication of hepatitis C virus (HCV), HCV genome-targeting trans-splicing aptazyme, which activity is allosterically regulated by a specific ligand, was developed. The aptazyme was designed to be comprised of sequence of RNA aptamer to the ligand, communication module sequence which can transfer structural transition for inducing ribozyme activity upon binding the ligand to the aptamer, and trans-splicing ribozyme targeting +199 nt of HCV IRES. Especially, when the aptamer and the communication module was inserted at both P6 and P8 catalytic domain of the specific ribozyme, allosteric activity of the aptazyme was the most induced. The aptazyme was shown to induce activity of trans-splicing reaction specifically and efficiently only in the presence of the specific ligand, but neither in the absence of any ligand nor in the presence of control ligand. This aptazyme can be used as a specific and effective genetic agent against HCV, and a tool for the isolation of anti-HCV lead compounds.

• Economic and Environmental Geology
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• v.50 no.6
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• pp.525-535
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• 2017

Exhumation mechanism of migmatite in orogenic belts provides insights into thermo-mechanical evolution of lithosphere in association with orogeny. This study deals with kinematics of structures in and around the Gwangcheon Gneiss, as a preliminary study on exhumation mechanism, which is a main constituent of a domal structure (viz., Oseosan Dome) in the Hongseong area, southwestern margin of the Gyeonggi massif. Geological structures in the Gwangcheon Gneiss, which mainly comprises southern and northwestern part of the Oseosan Dome, generally have kinematic component of top-outward shear. This feature is likely to represent diapiric dome-up movement. In addition, a high strain zone, by which the tectonic domain involving the Gwangcheon Gneiss is bounded on the west, show structural features with normal sense of shear component. Taking available (thermo)chronological data into account, it is interpreted that activation of the high strain zone and exhumation of the Gwangcheon Gneiss occurred during Late Triassic, when the Gyeonggi massif was widely affected by post-collisional processes. It means that the Gwangcheon Gneiss was diapirically moved up and exhumed in the footwall of extensional high strain zone in association with Triassic post-collisional processes.

• Journal of Digital Contents Society
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• v.10 no.1
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• pp.147-157
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• 2009

Configuration and data management system to support processes for the weapon system should support the concurrent engineering and collaborative activities for various documents, drawings, part informations and structural informations, etc. which are produced through R&D processes for a long time. This thesis attempts to identify major functions in the configuration and data management system to support processes for the weapon system R&D into services based on a service oriented architecture. In order to identify major services in the configuration and data management system to support processes for the weapon system R&D, a configuration and data management system to support processes for the weapon system R&D was proposed with a service oriented architecture with four layers including a service consumer layer, a business service layer, an application service layer and a application layer, and major services were identified for each layer. In order to identify major services in four layers, this thesis adopted a bottom-up approach to identify the necessary business services from a well-defined domain implementation system rather than a top-down identification method in general. This thesis tried to identify the essential services in implementing the configuration and data management system to support processes for the weapon system R&D as a system based on the service oriented architecture using such a bottom-up service identification method while limiting those services to the general PDM system aspects and the business areas of the configuration and data management system to support processes for the weapon system R&D.

• Journal of the Earthquake Engineering Society of Korea
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• v.3 no.2
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• pp.87-96
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• 1999

To analyze the dynamic behavior of structure, direct integration and mode superposition may be utilized in time domain analysis. As finite number of frequencies can give relatively exact solutions, mode superposition is preferable in analyzing structural behavior. In non-linear analysis, however, mode superposition is seldom used since time-varying element stiffness changes stiffness matrix, and the change of stiffness matrix leads to the change of essential constants - natural frequencies and mode shapes. In spite of these difficulties, there are some attempts to adopt mode superposition because of low cost compared to direct integration, but the result is not satisfactory. In this paper, a method using mode superposition in non-linear analysis is presented by separating local element stiffness from global stiffness matrix with the difference between linear and non-linear restoring forces to the external force vectors included. Moreover, the hysteresis model changing with the relative deformation in each floor makes it possible to analyze non-linear behavior of structure. The proposed algorithm is applied to shear beam model and the maximum displacement is compared with the result using direct integration method.

• Korean Journal of Optics and Photonics
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• v.18 no.6
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• pp.383-388
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• 2007

A color filter was demonstrated incorporating a patterned metal grating in a quartz substrate. The filter is created in a metal layer perforated with a symmetric two-dimensional array of circular holes, with the pitch smaller than the wavelength of the visible light. A finite-difference time-domain simulation was performed to analyze the device by investigating the effect of structural parameters like the grating height, the period, the hole size, and the refractive index of the hole-filling material on its performance. The device performance was especially optimized by controlling the refractive index of the material comprising the holes of the grating. And two different devices were fabricated by means of the e-beam direct writing with the following design parameters: the grating height of 50 nm, the two pitches of 340 nm for the red color and 260 nm for the green color. For the prepared device with the period of 340 nm, the center wavelength was 680 nm and the peak transmission 57%. And for the other device with the pitch of 260 nm, the center wavelength was 550 nm and the peak transmission was 50%. The filling of the hole with a material whose refractive index is matched to that of the substrate has led to an increase of ${\sim}15%$ in the transmission efficiency.

• The Journal of the Acoustical Society of Korea
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• v.33 no.3
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• pp.191-199
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• 2014

Wave reflection and transmission characteristics in waveguides are an important issue in many engineering applications. A combined spectral element and finite element (SE/FE) method is used to investigate the effects of local non-uniformities but limited at relatively low frequencies because the SE is formulated by using a beam theory. For higher frequency applications, a method named a combined spectral super element and finite element (SSE/FE) method was presented recently, replacing spectral elements with spectral super elements. This SSE/FE approach requires a long computing time due to the coupling of SSE and FE matrices. If a local non-uniformity has a uniform cross-section along its short length, the FE part could be further replaced by SSE, which improves performance of the combined SSE/FE method in terms of the modeling effort and computing time. In this paper SSEs are combined to investigate the characteristics of waves propagating along waveguides possessing geometric non-uniformities. Two models are regarded: a rail with a local defect and a periodically ribbed plate. In the case of the rail example, firstly, the results predicted by a combined SSE/FE method are compared with those from the combined SSEs in order to justify that the combined SSEs work properly. Then the SSEs are applied to a ribbed plate which has periodically repeated non-uniformities along its length. For the ribbed plate, the propagation characteristics are investigated in terms of the propagation constant.