• The Journal of Pediatrics of Korean Medicine
• /
• v.35 no.3
• /
• pp.118-127
• /
• 2021

Objective The purpose of this study was to confirm the effect of Scutellaria baicalensis extract on skin damage recovery and inflammation relief in atopic dermatitis-induced mice through Endocannabinoid system (ECS) control. Methods 6-week-old Balb/C mice were divided into control group (Ctrl), atopic dermatitis induced group (ADE), palmitoylethanolamide (PEA) administered group after atopic dermatitis induced (PEAT), and Scutellaria baicalensis extract administered group after atopic dermatitis induced (SBT). Seven animals were assigned for each group. After drug administration for 3 weeks after inducing atopic dermatitis, Claudin and 8-OHdG were observed to confirm the recovery of the skin damage in each group. To confirm ECS regulation, CB1, CB2, and GPR55 were observed. To confirm the anti-inflammatory effect, Fc ε receptor, and MMP-9 was observed. Results Claudin positive reaction was significantly increased in SBT compared to ADE and PEAT. 8-OHdG positive reaction was significantly decreased in SBT compared to ADE and PEAT. CB1, CB2, and GPR55 positive responses were significantly increased in SBT compared to ADE and PEAT. Fc ε receptor and MMP-9 positivity were significantly decreased in SBT compared to ADE and PEAT. Conclusion It was confirmed that the Scutellaria baicalensis extract can reduce the inflammation of atopic dermatitis by restoring the structural damage of the skin lipid barrier through ECS activity.

• Korean Journal of Materials Research
• /
• v.31 no.9
• /
• pp.525-531
• /
• 2021

Carbon-encapsulated Ni catalysts are synthesized by an electrical explosion of wires (EEW) method and applied for CO₂ methanation. We find that the presence of carbon shell on Ni nanoparticles as catalyst can positively affect CO₂ methanation reaction. Ni@5C that is produced under 5 % CH₄ partial pressure in Ar gas has highest conversions of 68 % at 350 ℃ and 70 % at 400 ℃, which are 73 and 75 % of the thermodynamic equilibrium conversion, respectively. The catalyst of Ni@10C with thicker carbon layer shows much reduced activity. The EEW-produced Ni catalysts with low specific surface area outperform Ni catalysts with high surface area synthesized by solution-based precipitation methods. Our finding in this study shows the possibility of utilizing carbon-encapsulated metal catalysts for heterogeneous catalysis reaction including CO₂ methanation. Furthermore, EEW, which is a highly promising method for massive production of metal nanoparticles, can be applied for various catalysis system, requiring scaled-up synthesis of catalysts.

• Journal of Applied Biological Chemistry
• /
• v.64 no.4
• /
• pp.375-382
• /
• 2021

Biorenovation is a microbial enzyme-based structural modification of component compounds in natural products and synthetic compounds including plant extracts with the potential benefits of improved biological activities compared with its reaction substrates. In this study, we investigated the anti-inflammatory activity of Distylium racemosum leaf extract and D. racemosum leaf biorenovation extract (DLB). As a result, DLB inhibited nitric oxide, prostaglandin E2, and inflammatory cytokines including tumor necrosis factor-α, interleukin-6, interleukin-1β at non-toxic concentrations. In addition, DLB significantly inhibited inducible nitric oxide synthase and cyclooxygenase-2 on LPS-treated RAW 264.7 macrophages. Based on these results, we suggest that the DLB could be used as a potent anti-inflammatory agents. It also suggests that the application of biological evolution has potential usefulness to increase the practical value of natural products.

• Journal of Convergence for Information Technology
• /
• v.11 no.7
• /
• pp.91-103
• /
• 2021

As knowledge management is recognized as an important competency of organizations, organizations are continuously investing in knowledge management policies and technologies. Knowledge management preemptively requires employees to share knowledge, but sharing activities for continuous knowledge management have not been performed. The purpose of this study is to verify the effect of the organization's mutual exchange efforts through collaborative communication on the knowledge sharing intention of its employees. The study surveyed workers of organizations that operate knowledge management policies and verified the research hypothesis by applying 326 samples to structural equation modeling. As a result of the analysis, factors of collaborative communication(rationality, reciprocal feedback, formality) had a positive effect on the intention to share knowledge, and task interdependence and territoriality had a moderating effect on the relationship between collaborative communication and intention to share knowledge. The study has implications in terms of suggesting an activity strategy that an organization should pursue to improve knowledge sharing among its employees.

• The Korean Journal of Archival Studies
• /
• no.9
• /
• pp.110-142
• /
• 2004

This paper treated what are congressional records which are one of core fields of national records and what kind of significant records they have. The characteristics of "substantive records" of the institution among public records are as follows: firstly, their contents depend on the inherent function of the institution; secondly, their types differ by the character of basic unit(member); thirdly, their sources are determined by the character of institution. Starting from the above points of view, the contents, characteristics, main sources, and types by sources of congressional records were presented. They are summarized as follows. In Chapter 2, the substantial records, which document the intrinsic function of congress on the basis of analyses of inherent function and structural uniqueness of congress have natures of which the contents are "legislative records", "oversight records", and "political activity records" starting from the inherency of congress as the people's representation. The typical natures of congress records are related with the specialty that the basic unit of congress structure is an individual congressman as an indepent national institution and congress is a council of these congressmen. Firstly, the records of congressmen as basic member of congress are the national records with the type of personal records. Secondly, "council records" produced by the council (commettee and main conference), which have evidencial and informative value for decision making through the process of investigating, discussing and voting bill and policy (item) of the basis for national management, are very special kind of records, such as item records, decision records, journal records, and congress assistant records. Because congressmen and councils composing congress have an equal inter-relationship in the structure of congress, the main sources of congress records are an individual congressman and all the councils. In chapter 3, the contents and sorts of main records are discribed, centering around congressmen and councils as the main sources of congress records. In chapter 4, the management of records of congressmen is issued as an urgent subject for the management of congress records, instead of conclusions.

• Journal of Korean society of Dental Hygiene
• /
• v.18 no.6
• /
• pp.1025-1035
• /
• 2018

Objectives: This study examined dental hygiene students' frequency of participation in community volunteer activities, job consciousness, depression, and self-esteem, and then identified the correlation among them. We also analyzed the moderating effect of depression and self-esteem on the correlation between participation in community volunteer activities and job consciousness. Methods: We surveyed 312 dental hygiene students attending four universities in South Chungcheong Province, Korea, from May 2 to June 15, 2016, through direct visits. They were given structured questionnaires containing four items on community volunteer activities, three on job consciousness, ten on self-esteem, and 13 on depression. To examine the moderating effect of depression and self-esteem, we performed analysis of variance, correlation analysis, and structural equation modeling analysis (based on the path analysis model and by inserting interaction terms) using SPSS and AMOS. Results: We observed a negative correlation between self-esteem and depression (r=-0.062) but a positive correlation between self-esteem and job consciousness (r=0.125). Depression and job consciousness had a negative correlation (r=-0.176). Depression had a statistically significant impact on job consciousness (r=-0.519, p<0.01). The interaction term between depression and frequency of community volunteer activities also had a statistically significant influence on job consciousness (r=0.090, p<0.05). These findings indicate that depression moderates the correlation between frequency of community volunteer activities and job consciousness at a statistically significant level. Conclusions: More frequent participation in volunteer activities enhances dental hygiene students' self-esteem, reduces depression, and raises job consciousness. The positive impact of volunteering on self-esteem, depression, and job consciousness warrants encouraging students' participation in community volunteer activities, creating supportive structures, and developing various volunteer programs relevant to the students' area of study.

• Korean Journal of Construction Engineering and Management
• /
• v.20 no.4
• /
• pp.94-103
• /
• 2019

The active engagement of the organization employees in the quality management activities of the construction project promotes the achievement of successful management performance. This study seeks to find a mechanism to promote employee engagement. The preceding factors that promote employee engagement through previous research are employee rewards system and satisfaction. In order to verify the proposed research model, sample data of 232 construction project employees were collected and analyzed through a structural equation model. As a result of the study, it was confirmed that all the proposed variables had a significant effect on the employee engagement and the moderate effect according to the employee's position and labor contract. The results of this study are expected to provide useful theoretical and practical implications for researchers and managers seeking ways to promote the engagement of organization employees from a broader perspective for the activation of quality management activities of construction companies.

• 재활복지
• /
• v.21 no.2
• /
• pp.139-167
• /
• 2017

The purpose of this study is to investigate the relationship between living satisfaction and income level and expenditure of the Disabled Households' and the mediation role of socioeconomic status in their relationship also the effect of the according to whether they receive basic living or not. The data and sample of total 2,906 households were extracted from the Panel Survey of Employment for the Disabled (PSED) 8th data, and it was analyzed by the SEM(Structural equation model). The study results are as follows. First, Household income is negative effect on Engel and Schwabe Index, Socioeconomic status is positive effect on life satisfaction. and Socioeconomic status is partially mediated in the path between household income and life satisfaction and socioeconomic status full mediates the schwabe index and life satisfaction. Overall, the study results emphasizes the importance of the economic activity for security income of the disabled households, and it discusses about policy directions.

• Journal of the Microelectronics and Packaging Society
• /
• v.26 no.1
• /
• pp.23-28
• /
• 2019

The Titanium oxide ($TiO_2$) is an attractive ceramic material which shows non-toxic, high refractive index, catalytic activity and biocompatibility, and can be fabricated at a low cost due to its high chemical stability and large anisotropy. $TiO_2$ nanoparticles have been prepared by sol-gel method. The pH of solution can affect the $TiO_2$ crystallinity during the formation of nanoparticles. The prepared nanoparticles were characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction, photoluminescence spectroscopy in order to investigate their structural and photoluminescence properties. Through these analysis, the size of $TiO_2$ nanoparticles were found to be smaller than 5 nm. As the crystallinity of the nanoparticles increased, the emission of PL in the 550 nm region increased. Therefore, luminescence characteristics can be improved by controlling the crystallinity of the $TiO_2$ nanoparticles.

• Endocrinology and Metabolism
• /
• v.33 no.4
• /
• pp.485-492
• /
• 2018

Background: Increasing evidence supports interplay between aldosterone and parathyroid hormone (PTH), which may aggravate cardiovascular complications in various heart diseases. Negative structural cardiovascular remodeling by primary aldosteronism (PA) is also suspected to be associated with changes in calcium levels. However, to date, few clinical studies have examined how changes in calcium and PTH levels influence cardiovascular outcomes in PA patients. Therefore, we investigated the impact of altered calcium homeostasis caused by excessive aldosterone on cardiovascular parameters in patients with PA. Methods: Forty-two patients (mean age $48.8{\pm}10.9$ years; 1:1, male:female) whose plasma aldosterone concentration/plasma renin activity ratio was more than 30 were selected among those who had visited Severance Hospital from 2010 to 2014. All patients underwent adrenal venous sampling with complete access to both adrenal veins. Results: The prevalence of unilateral adrenal adenoma (54.8%) was similar to that of bilateral adrenal hyperplasia. Mean serum corrected calcium level was $8.9{\pm}0.3mg/dL$ (range, 8.3 to 9.9). The corrected calcium level had a negative linear correlation with left ventricular end-diastolic diameter (LVEDD, ${\rho}=-0.424$, P=0.031). Moreover, multivariable regression analysis showed that the corrected calcium level was marginally associated with the LVEDD and corrected QT (QTc) interval (${\beta}=-0.366$, P=0.068 and ${\beta}=-0.252$, P=0.070, respectively). Conclusion: Aldosterone-mediated hypercalciuria and subsequent hypocalcemia may be partly involved in the development of cardiac remodeling as well as a prolonged QTc interval, in subjects with PA, thereby triggering deleterious effects on target organs additively.